Sometimes medications that were developed to treat one condition can end up being useful for seemingly unrelated ailments.
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ethanol doesnt interact with opioid receptors but acetaldehyde (from alcohol dehydrogenase reaction with ethanol) is known to react with enkephalins in a condensation reaction to produce opioid like compounds which do interact with opioid receptors
This is what happened with prazosin, which is an alpha blocker. Originally developed for high blood pressure, it was found to help ease PTSD related nightmares in veterans. I don't have PTSD myself, but I do have a lot of symptoms that overlap, including terrible nightmares. Prazosin has really helped with that. I still have some uncomfortable dreams but they rarely reach the point of triggering too much adrenaline response and waking me up in a panic. It's great!
Dextromethorphan actually has some very impressive anti-addictive properties as well, although it has not been FDA approved or had its mechanism thoroughly researched.
Too much money in drug addiction, I guess.
I took naltrexone for dermatillomania and it sadly didn't work but I've heard it does a lot of good for many people with skin picking/hair pulling. Another medication, Lamictal, is used for seizures at high doses but at 300 and lower its used for manic depression and it's helped my anger issues greatly. Side uses to meds ended up really helping me.
It felt weird watching you talk about spironolactone outside the context of trans people, since that's the only time I've heard it talked about. I literally cried when you mentioned its use to our community.
Although I know SciShow and Sexplanations are both under the same umbrella, so you (the writers) should do what Dr. Doe did and stop using "biosex" when you mean "cis." Dr. Doe is switching to assigned-at-birth language last I checked.
"Hair pulling" trichotillomania is an OCD though, or did they want to say that the experiment on OCD patients was only for a specific type of OCD? Because if it the third medication works for hair pulling then shouldn't it work for different OCD's too? I have dermatillomania, which is similar to trichotillomania so it got me confused when he mentioned that "hair pulling" was a "behavioural addiction" and there was medication for it but not really for OCD :)
The way I see it, treating addiction with Naltrexone (high doses only, low doses can treat addiction and still keep the pleasurable feelings intact) is going at it the wrong way. Rather than decreasing the pleasure attained by performing certain actions or taking certain drugs, decreasing the stress that maintains the addiction should be top priority. Not only that, but the physically and psychologically addictive components of drug use can be prevented while also retaining the pleasurable activity of the drug. The reason addiction is maintained - but not started - with Opiates, for example, is because of the negative feelings that occur when you stop taking the drug. Eliminating those negative feelings won't completely stop everyone from taking drugs, but what it *will* do is prevent the reasons not to take the drugs in the first place, *and* make it so much easier for people to quit when they honestly want to, or just can't afford it anymore. Also, chemicals that reduce stress often don't effect the pleasurable effects of opiates, but do decrease the dopamine release in the reward centers of the brain, effectively preventing psychological addiction. What this shows is that dopamine is likely not the main contributor to the euphoria induced by drugs. Norepinephrine seems to be the main perpetrator, here. Specifically, norepinephrine released in the Medial Prefrontal Cortex if I recall correctly. So, all the negatives of drug addiction could be eliminated while still retaining the positives. That's way more exciting than just making people's lives a little lackluster just to make them stop doing slightly bothersome things. Also, a tertiary use for Dextromethorphan is for this purpose I've just mentioned, preventing drug addiction. Dextromethorphan is not the strongest NMDA receptor antagonist, but NMDA antagonists can prevent dependence and psychological addiction to opiates without decreasing the pleasurable effects, as well. The only problem with NMDA antagonists, as a treatment for drug dependence, is that the doses required induce dissociation. So, L-type Calcium channel antagonists and some herbs that can block excitatory activity like Saffron and Ginger are a better bet. Naltrexone also works, in very small doses, to prevent dependence and psychological addiction to opiates, without antagonizing their painkilling properties. It's baffling that researchers haven't started publicizing all this amazing information. I mean, it's probably because more study is needed.
As an interesting side note, drug cravings are caused by our supposed reward/pleasure centers. Most opiate users will say that their withdrawal is manageable when they don't have cravings, but when they do, it's ten times worse. So, there's conflicting information here, right? I don't think so. Addiction can be started with dopamine release, this is true. But, eventually, you're only taking the drug to maintain the pleasurable feelings of no pain, rather than for the reward of taking the drug. Another interesting side note, dopamine has *not* been associated with drug induced pleasure, or pleasure of any kind, if I recall correctly. Only Mu Opioid receptor agonism has been associated with feelings of pleasure. Dopamine is associated with "wanting" and "liking" and whatnot, but not as much with euphoria. Dopamine receptor blockers, administered with Amphetamines, for example, have been shown not to counteract the euphoria induced, so much as the desire to seek out other rewards. Dopamine receptor blockers do, however, prevent compulsive administration of drugs. Anyway, back to opiate addiction. If dopamine release was the only thing maintaining an addiction, people would be fine with just the cravings they have for their drug of choice. But, what we see when people experience cravings is the exact opposite. You feel even worse. So, obviously, the reward centers in the brain mainly control your *desire* for a drug, and not how good it feels. So, reducing your desire for drug reward is as easy as taking an L-type Calcium Channel Antagonist or an NMDA receptor antagonist (but only concurrently with the opiate, taking it during withdrawal will still diminish withdrawal but not to nearly as much of a degree). One example of something being totally un-addictive, but also very pleasurable, is Kava. It's got a respectable level of euphoria for being entirely innocuous. The likely reason for its lack of addiction is because it antagonizes Calcium Channels like I mentioned before. The euphoria is maintained, while addiction is totally absent. That's proof enough for me that something with uncomfortable consequences can be changed to something totally fine.
Id mention Clomid as an alternative for low testosterone in males. The traditional treatment apparently sterilizes guys. Clomid is traditionally a female reproduction drug, and the side effects are that estrogen is lowered allowing testosterone to reclaim lost ground.
I forgot the unit (audible gasp!) Of measurement, but my testosterone was in the low 100s before. After, I was in the 850-900 range. The only negative I had was being horny to the verge of nymphomania
So far evidence also shows that drastically low doses of naltrexone (LDN) can also be used as a very effective pain treatment for the hard-to-treat pain related to a disease called Ehlers-Danlos Syndrome.
The clover can solve problems with brittle bones better than any calcium supplement (Aarhus university, 2015) - original study was on clovers effects on menopause, but it had little measurable results. However a sideeffect found in all patients bone density had increased...
Spironolactone... Heard the part about it helping hormonal acne and thought that sounds amazing right now. Then I heard it blocks androgrens so probably wouldn't work well with the testosterone and trenbolone I'm taking...
when I was little I took oxybutinin to calm my overactive bladder. now I'm an adult i take it to control my hyperhidrosis. It actually works better to control sweating than it did help my bladder spasms
Hey, long time fan. Just wanted to point out so you know for next time: "biosex" is kinda outdated/problematic, it's much better to use amab or afab (assigned male/female at birth). And there should be a space between "trans" and "women" just like you wouldnt say gaywomen lol
I take propanalol for anxiety and find it helpful. I also take mirtazapine for depression.. This medication is helpful for treating some people with depression and also it is used to help people with eating disorders such as anirexia as after taking it it gives you an appetite to scoff food.. Once you get that under control i have found it to be a life saving medication for treating my borderline personality disorder. Other anti depressants don't agree with me such as ssris like fluoxitine and citrepram ect
I know I know I can't spell these meds.
hydroxychloroquine was developed as a malaria medication, but it’s commonly prescribed (like for me) as a rheumatoid arthritis treatment! i’d assume an immunosuppressant would work for RA but wouldn’t you need an immune system to beat malaria? how does that work??
Don't give big pharma much credit. Asprin, Ibuprofen, acetaminophen, antibiotics etc came from careful refinements and research. Some like asprin having really long histories of use before any government body approved them or did any research on their effectiveness. This a whole lot different than the shitshow today where untested drugs go on the market left and right with lofty claims to cure all your problems. Some modern innovations like the synthesis of insulin are now text book examples of abuse of patents.
Hey! You are awesome. My 10 year-old son wants to know how we know what the earth's core (and other layers) are made of. We have watched a few videos and done some reading......but we think you could explain it best. Please? Thanks you! :)
Tamsulosinhydrochloride is a prostate medication that is only prescribed to male patients although it works on smooth muscle tissue regardless of gender and can help women with urethra inflammation and in some cases symptoms tied to endometriosis. Metamizol is a non opioid pain medication that can also help to prevent migraines and also helps with period cramps, however it is banned in most countries, while widely used as muscle relaxant in the german speaking part of the world, while it can have some serious side effects it does not damage your liver, stomach and kidneys as much as other non opioid analgesics. Paracetamol not only works like NSAIR without being one, it actually docks to one of our cannabinoid receptors thus it is really a prodrug having similar effects as Cannabinoids.
My muscle relaxant is also used to treat very high fevers, I'm prescribed an antihistamine for vertigo and nausea, and my grandmother was prescribed morphine for trouble breathing at the end of her life. Medicines are weird.
Back when i was doing my internship in the ER, a patient was admitted for hypoglycemia and upon doing the medication reconciliation we came to know that he's on insulin but there was no history of diabetes. Apparently he was abusing HumilinR for bodybuilding.. On the other hands some non-diabetic people even abuse exenatide, metformin and acarbose for weight reduction..
yeah but its the worst! it increases the risk of Heart attacks and irregular heart beats.. Its even fatal to use in patients with heart diseases. Unfortunately its even a constituent in some weight loss formulations sold..
The class of drugs that Levitra, Viagra, Stendra, and Cialis belong to are called PDE5 inhibitors. They work by relaxing tight blood vessels, allowing more blood to surge into the penis and cause an erection, says Gregory Bales, M.D., an associate professor of urology at the University of Chicago.
The little pills do the trick for more than two-thirds of men with Viagra protects the heart (ED). They also work for guys who simply need them for a short time to get their “confidence back,” says Michael Eisenberg, M.D., director of male reproductive medicine and surgery at Stanford University.