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How 6 Rare Diseases Are Changing Everyday Medicine

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To get 2 months of unlimited access to Skillshare for free, click here: http://skl.sh/scishow8 Sometimes, studying uncommon maladies can reveal larger insights into how our bodies work! Hosted by: Hank Green Head to https://scishowfinds.com/ for hand selected artifacts of the universe! ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Dooblydoo thanks go to the following Patreon supporters: Lazarus G, Sam Lutfi, Nicholas Smith, D.A. Noe, سلطان الخليفي, Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Charles Southerland, Patrick D. Ashmore, Tim Curwick, charles george, Kevin Bealer, Chris Peters ---------- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Instagram: http://instagram.com/thescishow ---------- Sources: https://rarediseases.info.nih.gov/diseases/pages/31/faqs-about-rare-diseases https://irp.nih.gov/blog/post/2015/06/top-5-reasons-to-study-rare-and-undiagnosed-diseases Osteo https://www.thebonejournal.com/article/S8756-3282(11)00969-0/fulltext https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069370/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC292015/pdf/jcinvest00194-0009.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726215/ Gaucher https://www.sciencedirect.com/science/article/pii/S0896627317300429 https://rarediseases.org/rare-diseases/gaucher-disease/ Niemann-Pick https://rarediseases.org/rare-diseases/niemann-pick-disease-type-c/ https://www.nature.com/articles/nature10348 http://www.pbs.org/wgbh/nova/next/body/the-rare-disease-thats-helping-researchers-cure-ebola/ https://www.nature.com/articles/nature10380 Leptin https://www.nature.com/articles/43185 https://www.nejm.org/doi/full/10.1056/nejmoa1406653 http://www.laskerfoundation.org/media/filer_public/82/b6/82b68546-b467-4410-a08c-a91458740306/2010_b_coleman.pdf https://www.jax.org/strain/000632 https://ghr.nlm.nih.gov/condition/congenital-leptin-deficiency Laron http://discovermagazine.com/2013/april/19-double-edged-genes https://www.nbcnews.com/health/aging/little-people-ecuador-laron-syndrome-may-unlock-cancer-diabetes-cure-n511266 https://rarediseases.info.nih.gov/diseases/6859/laron-syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531065/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943600/ plasminogen http://www.sciencemag.org/news/2017/11/mutation-blood-clotting-gene-may-extend-human-life-span http://advances.sciencemag.org/content/3/11/eaao1617 https://rarediseases.info.nih.gov/diseases/4381/plasminogen-activator-inhibitor-type-1-deficiency Images: https://commons.wikimedia.org/wiki/File:XrayRicketsLegssmall.jpg https://commons.wikimedia.org/wiki/File:1ALK.png https://commons.wikimedia.org/wiki/File:Pyrophosphate-3D-balls.png https://commons.wikimedia.org/wiki/File:Osteoporosis_Locations.png https://commons.wikimedia.org/wiki/File:Bisphosphonate_structure.jpg https://commons.wikimedia.org/wiki/File:Osteoclast.jpg https://commons.wikimedia.org/wiki/File:Animal_Cell.svg https://commons.wikimedia.org/wiki/File:Structure_of_human_beta-glucocerebrosidase_@.png https://commons.wikimedia.org/wiki/File:Protein_NPC1_PDB_3GKH.png https://commons.wikimedia.org/wiki/File:Ebola_virus_virion.jpg https://commons.wikimedia.org/wiki/File:Niemann_pick_cell_in_spleen.jpg https://commons.wikimedia.org/wiki/File:Fatmouse.jpg https://commons.wikimedia.org/wiki/File:Somatotropine.GIF https://commons.wikimedia.org/wiki/File:Endocrine_growth_regulation.svg https://commons.wikimedia.org/wiki/File:1OC0.png https://commons.wikimedia.org/wiki/File:Amish_School_near_Rebersburg_PA.jpg
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Text Comments (395)
SciShow (1 month ago)
To get 2 months of unlimited access to Skillshare for free, click here: http://skl.sh/scishow8
nukefile779 (30 days ago)
about that... I don't own a creditcard and never will be, so... I'm out...
miyo (1 month ago)
Hank seems to be emoting less in this video (just the face). Is he okay?
Bren (1 month ago)
I'd super appreciate it if you guys talked about Klien-Levin Syndrome.
Alice Bradshaw (1 month ago)
SciShow I have a somewhat mild version of hypophosotasia. My dentist actually found it out because my teeth were unuaully thin on enammal and were actually floating in my gums instead of being rooted in my jaw or something. (can't remember. Ages ago) Because of the version I have, I am prone to foot fractures in later life, but it currently already affects my hips, knees and feet after long walks. I'm not on medication, because it's only a mild gene. But I can't have certain medications if I get something like osteoarthritis (I think... Something to do with the bones....)
Batman (1 month ago)
Lol you need a credit card to even get that 2 months free. Nah, thanks.
tracy thompson (4 days ago)
Sorry Hank I could not sign up with Skill Share as I do not have a credit card.
Ariella B (11 days ago)
Thanks so much for this! I was just diagnosed at age 33 with Gaucher Disease!
rob rodriguez (13 days ago)
🤔osteoporosis?? I have osteoporosis🤣🤣🤣🤣🤣🤣🤣🤣🤣💀💀💀💀💀💀💀
Luis Gonzalez (20 days ago)
Waiting for the anti-vaxxers to imply that the possible anti-Ebola cure/vaccine causes autism.
AncientFaroe (22 days ago)
What about unique and legendary diseases? 🤔
Abhay Sharma (24 days ago)
Most of the smartest peoples including me agrees that the biggest threat to humanity are not nukes, asteroid or even an AI the biggest threat is that on a some sunny day a deadly plague will spread on earth and it would wipe out all the 8 billion peoples on earth or can even make them zombie we got to prepare for such situation and the thing that can protect the humanity from this extinction threat from diseases is having a insurance of humanity on mars. #best wishes John Greens' best friend.
Round Pi (28 days ago)
Ebola is targeting NPC 1? I hope it's not an escort mission.
Michael K (28 days ago)
It’s pronounced Gluco- cerebro - sidase (‘psy-dase’)
Herbert Spineckie (29 days ago)
i have a symbiote within me that protects against such things
Squeaky (30 days ago)
Ok where tf is Muscle Hank
Captain Raz (1 month ago)
N°1 is Mr. Glass' desease?
MeWho (1 month ago)
Ah, good ol IGF. I remember doing a mock project that focused on that and how it can be a possible target for stopping abnormal cell growth. Watching this video has me wishing that I finished that project now.
D Hatchett (1 month ago)
Can we get a blooper reel from you folk trying (and failing) to pronounce some of these scientific names?
C2L Redstone (1 month ago)
Justin Y. vs van Hendrix vs Master Therion Where can I get the infectious disease of having every comment liked a thousand times?
Lily Whetsell (1 month ago)
#4 sounds like me lol. Always hungry. Get ready to see me on my 600 lbs life haha
Mystee Pulcine (1 month ago)
Can you do an episode on "invisible diseases" like chronic fatigue syndrome.
Jamecia (1 month ago)
I have #2 Gauchers Disease
Jamecia (1 month ago)
There are three types I have type 1
Fluffy Pants (1 month ago)
What about ostiogenis imprafecta I have it. Its rare
Phazelight (1 month ago)
I once made an account on playstation I named Ebola that way whenever I got a kill online that persons screen would say "you were killed by Ebola"
Battle Ax (1 month ago)
Uh wouldn't it be dumb to get rid of igf1? Specially for exercise?
Edward Cortes (1 month ago)
I kinda loved this video! It was interesting, dynamic, expressive & most importantly informative to the minute detail! I'm digging the gusto!
InaneArtifactOH (1 month ago)
A vaccine for cancer and diabetes!? Ya, anti-vaxxer still don't care.
electric69irl (1 month ago)
I literally took some igf-1 5mins before watching this. thanks for the anxiety guys!
Phillip Lamoureux (1 month ago)
Update on Bisphosphonate treatment -- Unfortunately osteoclasts and osteoblasts have complimentary roles in bone maintenance. When bisposphonate inhibits the bone osteoclasts from their dissolving and restructuring role while the osteoblasts continue their bone formation function it is the equivalent of resurfacing a road without the preparatory step of grinding out the cracks and stabilizing the substructure of the road bed, where needed, before the new top coat. This in practice then actually causes more bone fractures and fragility. The bone density appears to be increased, but the occurrence of catastrophic fracturing is higher than in untreated osteoporosis patients.
Numitron (1 month ago)
You don't get to invent the light bulb from looking at a candle. By being too focused on a specific problem, it's easy to end up running in circles. Other horizons must be explored to find new ways to solve a problem.
Doom Metal (1 month ago)
6:45 great voice break Hank...
australobuchia (1 month ago)
Immediately signed up to skillshare, two months free is not to be sniffed at. Also I appreciate the explanation of the new sponsorship thing, changing the business model of scishow a bit to include sponsorship must have been a difficult decision. I'm not generally opposed to sponsorship because as far as I can tell it generally allows people who make good things to make great things (or in this case, continue making great things), which I think is the part we should focus on. Thanks Hank et. al. for keeping me informed and entertained
picklesthefreak (1 month ago)
I got skillshare. Thanks. I'm trying a class on adobe premier pro for 2018. Hopefull making my videos much better. also gonna try a bunch of arts and design classes.
Stephanie Foster (1 month ago)
Please support public funding of scientific research! When our budgets get slashed, it is these kinds of breakthroughs that slip through the cracks.
DeDraconis (1 month ago)
It should be mentioned that the first thing on the list didn't have the intended positive benefit. The problem caused by osteoporosis is that your bones become weaker, more likely to break, as a result of the larger air pockets in them. Drugs like Osteobiflex fulfill the symptom of light bones by stopping the osteoclasts and making them denser, but that doesn't lead to healthier bones, nor make the bones less likely to suffer a fracture or break. Osteoclasts are important members of your team, along with the osteoblasts that build the bone. Simply preventing them from doing their job is like building a house and, instead of leveling out the ground through excavation to reveal the compacted earth that's good for building on, you just start building right on the top soil. And building and building, only adding, never subtracting, and it becomes like this awful game of stacking stones. Still cool that they found something out from the rare disease though, and hopefully they can put it to better use in the future. (Thumbs up for video)
Justin Friedman (1 month ago)
Wooo! 1st disease my fav youtuber Jimmy Dore has!! Also sad though...
Thomas Gannon (1 month ago)
I’m gonna look into skill share. Thanks. Good deal.
Odapow (1 month ago)
That's how you do an ad.
Zekrow (1 month ago)
Anyone else immediately hear idubbbz' "I have osteoporosis" in their head?
Dan Dart (1 month ago)
Did they cover hs? Please cover that.
Michelle Koh (1 month ago)
Is Hank talking really fast or am i processing things in slomo rn?
zain riaz (1 month ago)
https://www.youtube.com/watch?v=sdvzG-5-Py0
Rebecca Russell (1 month ago)
I'd like to see a video of dysautonomia and and ehlers-danlos syndrome!
ServantToTruth (1 month ago)
The study about Leptin and the Mice was referenced in a passage on the July 7th MCAT... Hope I don't get dinged for discussing test material :(
6:44 huge voice crack
Ryan Wiles (1 month ago)
7:10 C H U B B Y M O U S E Y
Kye Talks (1 month ago)
I wonder if EDS could be useful for arthritis 🤔
I love this channel. I learn something new everyday. I love learning about health, new medications, and new treatments
KeyLord (1 month ago)
Scishow is the best because it doesn't dumb stuff down
James Whang (1 month ago)
bitcon sucks
nutzeeer (1 month ago)
so basically removing IGF-1 will stop growing humans to unnecessary size while increasing lifespan? the movie akira instantly comes to mind. old young people.
Oisin Murphy (1 month ago)
Who mutes the skillshare stuff.
Awsomiihill (1 month ago)
i can't stop thinking of idubbbz when i hear the word osteoporosis
R.B. (1 month ago)
#FreeTommy
Tama E.J (1 month ago)
Can you do a vedio on congenital spyndolatheses an other congenital bone defects an maybe even its relationsh to early onset degenerative disk disease ?
Nathan Gabriel Zapata (1 month ago)
Clickbait was a virus that spreaded long before this channel existed.. Its so ancient that the virus spreaded to over a thousand channels now
Evan Hughes (1 month ago)
This is the best science channel on YouTube.
Dustin Louie (1 month ago)
What can you do to help someone who’s been attacked with sulphuric acid? No rush
Tina McLaughlin (1 month ago)
I like science! It helps us find the wonders that exhist in our Universe! We can live better!
omega shadow (1 month ago)
how would the ecosystem look with out Predators ever existing and evolving? I think it's a interesting question to ask.
isa malik (1 month ago)
muscle hank would eat those diseases for breakfast
Chromosome (1 month ago)
I haven't scroll down the comment..but I bet Justin Y. already commented here.😏
General Durandal (1 month ago)
Human's aren't meant to be immortal, if they find a way how, bad things will come our way.
The Real Mythril (1 month ago)
These advancements are amazing, but I take the opportunity to remind people that although they are good options they are not easy for the patients. Bisphosphonates do wonderful things but have absolutely terrible side effects including severe gastric bleeding and not being able to eat or drink , nor lie down for hours either side of taking them. They can also cause horrific bone pain.
Sam Kelly (1 month ago)
I just signed up for skillshare I'm keen to learn more about productivity and management.
SciShow (1 month ago)
Awesome! Let us know what you think!
Tayler Nicole (1 month ago)
Ehler's Danlos Syndrome... PLEASE. Please talk about it. It's a rare disease that's severely misdiagnosed, underdiagnosed and poorly understood. Lots of people with fibro actually have it. Many doctors think it's a circus disease that just makes you bendy and stretchy skinned. It's so much more than that. It's disabling, has every comorbidity under the sun, comes with other "sibling" diseases and vascular type inevitably kills you, as can the others indirectly. They're extremely painful and can put you in and out of the hospital your whole life, while others with EDS live completely normal and painless lives, so it has an incredibly wide spectrum of possible damage. It's SO important that this is discussed by media with large followings, we need to help those lacking answers and raise money to do research into genetic markers, and treatment plans because we currently have no set treatment or even a solid guide or help from doctors. They give us a dx and send us off without any clue how to help us. It's slowly gaining attention in the medical field and doctors are catching up to the new criteria, but we need to educate ourselves and know it exists so we can advocate.
-SakiSkai- (1 month ago)
IGF-1 is used by bodybuilders in conjunction with insulin to increase muscle & gut growth.
Eli Nope (1 month ago)
A disease is rare when it effects less than 1 in 2000 individuals. A cure for the rare disease is researched when it effects rich people and/or Israelites.
Matthew Vu (1 month ago)
Rare disease come from inbreeding
Matthew Vu (1 month ago)
2 days later I’m still loling if this was Facebook I’d friend you
erudis morningstar12 (1 month ago)
Matthew Vu I know how to have fun lol but this only made me chuckle for a second. It's the type of joke that makes people laugh at your perceived ignorance rather than the joke itself. Not my type of humour lol but that matters little if you found it funny which is more important. 😜
Matthew Vu (1 month ago)
I know this already, you sir have to learn to have fun
erudis morningstar12 (1 month ago)
Matthew Vu well that one word only shows that inbreeding can cause mutations and problems that are now rareish due to most people not inbreeding. However this does not prove inbreeding is the cause of all rare diseases. I wasn't arguing that inbreeding doesn't cause issues now was I? Now do you have proof of your actual claim that "all" rare diseases are caused by inbreeding? I study genetics in my own time and enjoy looking up rare cases such as fibrodysplasia ossificanse progressiva and I'm well aware you're indeed wrong and rather ignorant. That is fine but to parade it on a public site is not desirable if you think you're smart. In laymen terms mutations happen due to a variety of factors including inbreeding, environment, drug or alcohol abuse of the pregnant mother, and random interactions with hormones in a scenario we call non nucleotide reaction. Any of which can cause a rare disease. Cancers can also cause secondary "rare" disorders called paraneoplastic syndrome.
Matthew Vu (1 month ago)
erudis morningstar12 lol one word Habsburg
Heather Calun (1 month ago)
Do you have Recurrent Apthous Stomatitis? While some people are lucky to go their entire lives without a canker sore, most people will experience these ulcers (which are NOT herpes or Behcet's) at some point in their life, usually as the result of high stress. A handful of very unlucky people, however, may have as many as twelve in their mouth at a time, or experience an outbreak on their genitals. Due to its rarity, RAS is not widely researched. It baffled DuPont Children's hospital and University of Pennsylvania. At University of California San Fransisco, however, I've finally found knowledgeable doctors who are running research programs. I actually learned most about my disease online... from SciShow, in fact. Here is what little I know: Inflammation is supposed to appear in the mouth as the result of abrasions, I assume to prevent infection. White blood cells collect at the scene of the injury, die, and form white dots in the mouth. However, an excess (or depletion?) of the hormone cortisol can result in an autoimmune disorder where these white blood cells are released and attack the soft mucosal tissue of the body, because.... ??? Strictly going off feeling, these spontaneous ulcers hurt worse than a typical injury-based ulcer because they appear deeper, closer to major nerve endings, and they hurt both because they are putting pressure on the nerve endings, and because the immune system attacks the nerve endings as well. Cortisol is supposed to be released by the adrenal glands in response to stress, but this release may be disrupted by a dysfunction of the endocrine system. Unlike "adrenal failure", "adrenal fatigue" is not a scientifically proven disease, but I still regard the theory as plausible if misunderstood. Especially since my metabolism has rapidly fluctuated in the past. An imbalance of estrogen and/or progesterone is also likely a contributing factor to this disease, since it is notably more common in females and outbreaks tend to correlate with menstrual cycle. Vitamin B deficiency is a common cause, although supplements didn't help me. Genetics are also being identified as a factor. Celiacs/Gluten Sensitivity is common among RAS patients, and symptoms have been observed to improve on a gluten free diet. Ulcers come in three different patterns: small (most common), large (relatively exclusive to RAS sufferers), and "herpetiform" or clusters of small blisters (extremely rare). If you suffer with this, have hope that it usually becomes less severe after adolescence. Acquire a topical medication containing benzocaine and clobetasol. If you're lucky enough to just now become aware of this disease, please remember the name, repeat what you know when someone complains of canker sores, stand up for women who are accused of exaggerating their pain, and PLEASE LIKE THIS COMMENT. If this comment is pushed to the top of the thread, it might save many people thousands of dollars and decades of their lives. That's how long it took me to learn this much.
Soph Lo (1 month ago)
Thank you. I am pretty sure that I have this.
Jordan Fuel (1 month ago)
Does anyone know how to fix my dermatographia?
Mr Slinky dragon (1 month ago)
Npc is an awful disease!
undertakersarmpit (1 month ago)
is the first one the disease glass man has in that sixth sense superhero movie?
Tawhid Khan (1 month ago)
undertakersarmpit ;)
undertakersarmpit (1 month ago)
yeah that one by m night shamalalalamayana
Tawhid Khan (1 month ago)
undertakersarmpit you mean unbreakable
SuperResistant (1 month ago)
IGF1 reducing makes you extremely weak. What a stupid idea.
Cathrynne Cua (1 month ago)
Scishow is the best
Cathrynne Cua (1 month ago)
Scishow is the best
Video Gaming (1 month ago)
Thank you sci show. I am trying to get more people to watch. Including my daughter and her friends. Love your work.
meghan parris (1 month ago)
I know its awfully unhealthy, but that picture of the obese mouse was just the cutest thing Ever! 🐁❤🐭❤🐀
Heather Calun (1 month ago)
I was disappointed last time I tried to visit skillshare. There were only two channels on game design, and the audio quality was very bad on both of them. Like most platforms that use crowdsourced content to get off the ground, there's a bit of a paradox when it comes to quality assurance.
Noam Yizraeli (1 month ago)
can you SciShow guys cover what happened to the head transplant patient?
kassi man (1 month ago)
*THATS ..... ANOTHER GREAT VIDEO .... THANKS FOR THAT ...!*
MatthewsJocelyn (1 month ago)
So my step mom has Behçet's disease, and there is no known cause, origin, or cure. They suspect it is an autoimmune disorder because it causes similar symptoms, but they don't know for sure. It's crazy to think about the fact that there are people in the world that probably don't know anyone that has the same disorder or disease... It's crazier to know someone who has it, and know that I'm probably the only person I know, outside of my family, that knows someone who has Behçet's disease or has even heard of it. I absolutely love this channel, I've watched almost all of the videos. If you guys did a video about it within the list show, that would be amazing. I never see any videos of anyone talking about, or many articles about it. I feel like if more people heard about it, maybe it would inspire more people to research it.
MatthewsJocelyn (1 month ago)
erudis morningstar12 I'm glad that there are some out there. I agree, it's also scary that a someone could have it and the doctor doesn't even know what it is. So they can't even diagnose it, or they misdiagnose it. It definitely needs more coverage and research.
erudis morningstar12 (1 month ago)
MatthewsJocelyn I have watched videos and read articles on behçet disease and other rare disorders such as fibrodysplasia ossificanse progressiva. They are indeed interesting and in need of more coverage and understanding. It's unnerving to think some doctors that are diagnosing you might of never heard of some of these diseases and syndromes and could if not careful misdiagnose.
Lil Schizo (1 month ago)
NordVPN
Cimo Anto (1 month ago)
God, i love this kind of genetic episodes! More please! :)
Elon Musk (1 month ago)
as a re *SULT* 6:44
Yishai Basserabie (1 month ago)
“Rare diseases are... Rare” ~ Hank Green
Raul M. (1 month ago)
Awesome bedtime story👀😛 how cells communicate and interact is just wonderous to even imagine.. *stares off in wonder*🤔
chairshoe81 (1 month ago)
“super powers”
I had to type this I have Laron Syndrome No wonder All of my Friends are a foot(Or aleast more than half a foot) taller than me I really didn't knew It was a type of Dwarfism!
Debbie Ebbiebobebbie (1 month ago)
I have about a dozen rare diseases.
NicholasLAranda (1 month ago)
Hey can you go a week releasing 60fps video? I hope people enjoy it enough for you to always do 60 fps
Gabrielle Johnson (1 month ago)
Hank is the best
Moses Jonson (1 month ago)
I learn a lot from scishow, so great stuff always
Mark what (1 month ago)
7:10 LOL good God. Look at that 🐁 I also love how the other 🐁 looks like he is trying not to stare.
Ashley Marie (1 month ago)
I had cat scratch fever (yes it’s real) and apparently that was a rare disease 🧐 neat
LulitaInPita (1 month ago)
Do an episode on fibromyalgia please!
erudis morningstar12 (1 month ago)
LulitaInPita there isn't much new information on fibromyalgia. Interestingly there is one new hypothesis regarding the nerves in your vascular system that tell vessels to contract or relax letting blood flow more or less freely into arms, legs and such acting like nociceptors (pain receptors.) Too when they shouldn't. This could explain why sufferers are more sore and sensitive to pain than healthy individuals and why swelling (a reaction to perceived injury.) Can Accur. This hasn't been studied thoroughly yet and confirmed but it's the most interesting development I have heard on the subject of fibromyalgia in along while. For now though it is still classed as cryptogenic meaning they aren't sure of it's origins and cause. I'd like to also see them cover things like this as a category if they haven't already.
El Psy (1 month ago)
I love hearing about these potential cures for cancer and stuff. Superhuman's here we come! Can't wait for the day that losing an arm is a temporary inconvenience, and not a life time loss.
david shmilowitz (1 month ago)
The first disease reminds me of what Joker from Mass Effect had
Kalexandrian1010 (1 month ago)
#1 also causes phossy mouth! Please issue a correction. You will lose your jaw and stopping the drug WILL NOT HELP. It’s a disease that first showed up in insufrializing UK. Horrible factory conditions led to phosphorus poisoning, and jaw loss. It looks like really bad meth mouth.
Andrew Straub (1 month ago)
Anyone else hear the voice crack at 6:45??
Suede Fredrick (1 month ago)
As someone with Gaucher's, was surprised it made the list. That's pretty neat.
Jacob G (1 month ago)
I now feel fragile and self conscious.
IANF126 (1 month ago)
if we cure diabeetus that kills a meme, i can't let this happen.
Brittany Moneymaker (1 month ago)
I have the gene mutation for Gaucher's disease

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