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Sometimes, studying uncommon maladies can reveal larger insights into how our bodies work!
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SciShow I have a somewhat mild version of hypophosotasia. My dentist actually found it out because my teeth were unuaully thin on enammal and were actually floating in my gums instead of being rooted in my jaw or something. (can't remember. Ages ago)
Because of the version I have, I am prone to foot fractures in later life, but it currently already affects my hips, knees and feet after long walks. I'm not on medication, because it's only a mild gene. But I can't have certain medications if I get something like osteoarthritis (I think... Something to do with the bones....)
Most of the smartest peoples including me agrees that the biggest threat to humanity are not nukes, asteroid or even an AI the biggest threat is that on a some sunny day a deadly plague will spread on earth and it would wipe out all the 8 billion peoples on earth or can even make them zombie we got to prepare for such situation and the thing that can protect the humanity from this extinction threat from diseases is having a insurance of humanity on mars.
#best wishes John Greens' best friend.
Ah, good ol IGF. I remember doing a mock project that focused on that and how it can be a possible target for stopping abnormal cell growth. Watching this video has me wishing that I finished that project now.
Update on Bisphosphonate treatment -- Unfortunately osteoclasts and osteoblasts have complimentary roles in bone maintenance. When bisposphonate inhibits the bone osteoclasts from their dissolving and restructuring role while the osteoblasts continue their bone formation function it is the equivalent of resurfacing a road without the preparatory step of grinding out the cracks and stabilizing the substructure of the road bed, where needed, before the new top coat. This in practice then actually causes more bone fractures and fragility. The bone density appears to be increased, but the occurrence of catastrophic fracturing is higher than in untreated osteoporosis patients.
You don't get to invent the light bulb from looking at a candle.
By being too focused on a specific problem, it's easy to end up running in circles. Other horizons must be explored to find new ways to solve a problem.
Immediately signed up to skillshare, two months free is not to be sniffed at.
Also I appreciate the explanation of the new sponsorship thing, changing the business model of scishow a bit to include sponsorship must have been a difficult decision. I'm not generally opposed to sponsorship because as far as I can tell it generally allows people who make good things to make great things (or in this case, continue making great things), which I think is the part we should focus on.
Thanks Hank et. al. for keeping me informed and entertained
It should be mentioned that the first thing on the list didn't have the intended positive benefit. The problem caused by osteoporosis is that your bones become weaker, more likely to break, as a result of the larger air pockets in them. Drugs like Osteobiflex fulfill the symptom of light bones by stopping the osteoclasts and making them denser, but that doesn't lead to healthier bones, nor make the bones less likely to suffer a fracture or break.
Osteoclasts are important members of your team, along with the osteoblasts that build the bone. Simply preventing them from doing their job is like building a house and, instead of leveling out the ground through excavation to reveal the compacted earth that's good for building on, you just start building right on the top soil. And building and building, only adding, never subtracting, and it becomes like this awful game of stacking stones.
Still cool that they found something out from the rare disease though, and hopefully they can put it to better use in the future. (Thumbs up for video)
These advancements are amazing, but I take the opportunity to remind people that although they are good options they are not easy for the patients. Bisphosphonates do wonderful things but have absolutely terrible side effects including severe gastric bleeding and not being able to eat or drink , nor lie down for hours either side of taking them. They can also cause horrific bone pain.
Ehler's Danlos Syndrome... PLEASE. Please talk about it. It's a rare disease that's severely misdiagnosed, underdiagnosed and poorly understood. Lots of people with fibro actually have it. Many doctors think it's a circus disease that just makes you bendy and stretchy skinned. It's so much more than that. It's disabling, has every comorbidity under the sun, comes with other "sibling" diseases and vascular type inevitably kills you, as can the others indirectly. They're extremely painful and can put you in and out of the hospital your whole life, while others with EDS live completely normal and painless lives, so it has an incredibly wide spectrum of possible damage. It's SO important that this is discussed by media with large followings, we need to help those lacking answers and raise money to do research into genetic markers, and treatment plans because we currently have no set treatment or even a solid guide or help from doctors. They give us a dx and send us off without any clue how to help us. It's slowly gaining attention in the medical field and doctors are catching up to the new criteria, but we need to educate ourselves and know it exists so we can advocate.
Matthew Vu I know how to have fun lol but this only made me chuckle for a second.
It's the type of joke that makes people laugh at your perceived ignorance rather than the joke itself. Not my type of humour lol but that matters little if you found it funny which is more important. 😜
Matthew Vu well that one word only shows that inbreeding can cause mutations and problems that are now rareish due to most people not inbreeding.
However this does not prove inbreeding is the cause of all rare diseases.
I wasn't arguing that inbreeding doesn't cause issues now was I? Now do you have proof of your actual claim that "all" rare diseases are caused by inbreeding?
I study genetics in my own time and enjoy looking up rare cases such as fibrodysplasia ossificanse progressiva and I'm well aware you're indeed wrong and rather ignorant.
That is fine but to parade it on a public site is not desirable if you think you're smart.
In laymen terms mutations happen due to a variety of factors including inbreeding, environment, drug or alcohol abuse of the pregnant mother, and random interactions with hormones in a scenario we call non nucleotide reaction.
Any of which can cause a rare disease.
Cancers can also cause secondary "rare" disorders called paraneoplastic syndrome.
Do you have Recurrent Apthous Stomatitis?
While some people are lucky to go their entire lives without a canker sore, most people will experience these ulcers (which are NOT herpes or Behcet's) at some point in their life, usually as the result of high stress. A handful of very unlucky people, however, may have as many as twelve in their mouth at a time, or experience an outbreak on their genitals. Due to its rarity, RAS is not widely researched. It baffled DuPont Children's hospital and University of Pennsylvania. At University of California San Fransisco, however, I've finally found knowledgeable doctors who are running research programs. I actually learned most about my disease online... from SciShow, in fact. Here is what little I know:
Inflammation is supposed to appear in the mouth as the result of abrasions, I assume to prevent infection. White blood cells collect at the scene of the injury, die, and form white dots in the mouth. However, an excess (or depletion?) of the hormone cortisol can result in an autoimmune disorder where these white blood cells are released and attack the soft mucosal tissue of the body, because.... ??? Strictly going off feeling, these spontaneous ulcers hurt worse than a typical injury-based ulcer because they appear deeper, closer to major nerve endings, and they hurt both because they are putting pressure on the nerve endings, and because the immune system attacks the nerve endings as well. Cortisol is supposed to be released by the adrenal glands in response to stress, but this release may be disrupted by a dysfunction of the endocrine system. Unlike "adrenal failure", "adrenal fatigue" is not a scientifically proven disease, but I still regard the theory as plausible if misunderstood. Especially since my metabolism has rapidly fluctuated in the past. An imbalance of estrogen and/or progesterone is also likely a contributing factor to this disease, since it is notably more common in females and outbreaks tend to correlate with menstrual cycle. Vitamin B deficiency is a common cause, although supplements didn't help me. Genetics are also being identified as a factor. Celiacs/Gluten Sensitivity is common among RAS patients, and symptoms have been observed to improve on a gluten free diet. Ulcers come in three different patterns: small (most common), large (relatively exclusive to RAS sufferers), and "herpetiform" or clusters of small blisters (extremely rare).
If you suffer with this, have hope that it usually becomes less severe after adolescence. Acquire a topical medication containing benzocaine and clobetasol. If you're lucky enough to just now become aware of this disease, please remember the name, repeat what you know when someone complains of canker sores, stand up for women who are accused of exaggerating their pain, and PLEASE LIKE THIS COMMENT. If this comment is pushed to the top of the thread, it might save many people thousands of dollars and decades of their lives. That's how long it took me to learn this much.
I was disappointed last time I tried to visit skillshare. There were only two channels on game design, and the audio quality was very bad on both of them. Like most platforms that use crowdsourced content to get off the ground, there's a bit of a paradox when it comes to quality assurance.
So my step mom has Behçet's disease, and there is no known cause, origin, or cure. They suspect it is an autoimmune disorder because it causes similar symptoms, but they don't know for sure. It's crazy to think about the fact that there are people in the world that probably don't know anyone that has the same disorder or disease... It's crazier to know someone who has it, and know that I'm probably the only person I know, outside of my family, that knows someone who has Behçet's disease or has even heard of it.
I absolutely love this channel, I've watched almost all of the videos. If you guys did a video about it within the list show, that would be amazing. I never see any videos of anyone talking about, or many articles about it. I feel like if more people heard about it, maybe it would inspire more people to research it.
erudis morningstar12 I'm glad that there are some out there. I agree, it's also scary that a someone could have it and the doctor doesn't even know what it is. So they can't even diagnose it, or they misdiagnose it. It definitely needs more coverage and research.
MatthewsJocelyn I have watched videos and read articles on behçet disease and other rare disorders such as fibrodysplasia ossificanse progressiva. They are indeed interesting and in need of more coverage and understanding.
It's unnerving to think some doctors that are diagnosing you might of never heard of some of these diseases and syndromes and could if not careful misdiagnose.
LulitaInPita there isn't much new information on fibromyalgia. Interestingly there is one new hypothesis regarding the nerves in your vascular system that tell vessels to contract or relax letting blood flow more or less freely into arms, legs and such acting like nociceptors (pain receptors.) Too when they shouldn't. This could explain why sufferers are more sore and sensitive to pain than healthy individuals and why swelling (a reaction to perceived injury.) Can Accur.
This hasn't been studied thoroughly yet and confirmed but it's the most interesting development I have heard on the subject of fibromyalgia in along while.
For now though it is still classed as cryptogenic meaning they aren't sure of it's origins and cause.
I'd like to also see them cover things like this as a category if they haven't already.
#1 also causes phossy mouth! Please issue a correction. You will lose your jaw and stopping the drug WILL NOT HELP.
It’s a disease that first showed up in insufrializing UK. Horrible factory conditions led to phosphorus poisoning, and jaw loss. It looks like really bad meth mouth.
The class of drugs that Levitra, Viagra, Stendra, and Cialis belong to are called PDE5 inhibitors. They work by relaxing tight blood vessels, allowing more blood to surge into the penis and cause an erection, says Gregory Bales, M.D., an associate professor of urology at the University of Chicago.
The little pills do the trick for more than two-thirds of men with Viagra protects the heart (ED). They also work for guys who simply need them for a short time to get their “confidence back,” says Michael Eisenberg, M.D., director of male reproductive medicine and surgery at Stanford University.