Hank delves into the details about that very popular substance: caffeine.
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withdrawal from caffeine is much worse than nicotine!...nicotine ha sno withdrwal for me at all! i just want to smoke thats it!....but caffeine withdrawl makes me feel like dying ...i get such severe depression i cry all day long i cannot think i cannot eat my head hurts
Hank said that adenosine calms the brain's nerve cells, and caffeine stimulates those cells by blocking adenosine receptors. My question is, does caffeine actively stimulate nerve cells further, or just keep them from calming down? In other words, let's set the brain's normal activity level at 10. Adenosine comes in and calms the brain to, say, 5. Caffeine blocks adenosine, so does caffeine keep the brain's activity level at 10, or raise it to 15?
Actually, caffeine is addictive - by a very similar mechanism to cocaine. Caffeine indirectly causes the release of dopamine, a neurotransmitter which serves several purposes in the brain, including enhancing focus and as a reward for good behaviors (meaning that, working together with the neurotransmitter glutamate, dopamine helps your mind learn what behaviors are beneficial to you). By raising dopamine levels, drugs essentially mimic behaviors like eating or having sex, but to a far greater degree, hence why they are so pleasurable, and why people become addicted to them.
Caffeine causes dopamine release, so it, like cocaine, is addictive. However, so are sugar, food and sex. The thing is, caffeine does not cause as much dopamine to be released - so it isn't anywhere near as addictive. But caffeine is indeed addictive, like cocaine.
The mechanism by which opiate addiction occurs is different. While opiates do cause dopamine release, their primary mechanism of action is through decreased norepinephrine release in the locus coeruleus, part of the brainstem. Norepinephrine is a neurotransmitter which leads to alertness and stimulates many of your body's systems, such as your respiratory and circulatory systems. Taking a large amount of an opiate will decrease the norepinephrine in your brainstem, leading you to feel drowsy, relaxed, and can lead to overdose primarily by respiratory depression.
When you keep taking the opiate, your brain raises its levels of norepinephrine to counteract the drug. When you stop taking the drug, your levels of norepinephrine are then too high, leading to physical withdrawals - including insomnia, restless leg syndrome, diarrhea, muscle aches, etc.
Alcohol and benzopdiazepenes, such as Xanax, have perhaps the most dangerous physical addiction. They increase the GABA in your brain, making you feel relaxed, reducing anxiety, allowing you to overcome your inhibitions. GABA essentially counteracts the over-stimulation of your nervous system. Your brain adjusts to the presence of the drug by over time reducing its normal level of GABA. Then, when an addict stops drinking alcohol or taking a benzo, the levels of GABA are too low in their brain, leading to extreme over-stimulation of their nervous system, which can lead to delerium tremens (shaking, hallucinations, confusion), and even seizures.
So caffeine and cocaine are both addictive, although both are primarily psychologically addictive. Due to dopamine-glutamate feedback, you train your mind to associate caffeine/cocaine with survival (your brain thinks you need it to live), so you compulsively seek it and take it. Caffeine is of course far less extreme than cocaine, but it is essentially the same.
Heroin, alcohol and benzodiazepenes, and various other drugs, act through different mechanisms. Most do indirectly cause dopamine increase, which can lead to psychological addiction. However, these drugs also act on other neurotransmitters - heroin on opioid receptors and thus norepinephrine, alcohol and benzos on GABA - so they have far more intense physical withdrawals.
The question for mainly dopaminergic drugs like caffeine and cocaine is, where do you draw the line between addictive and not addictive? Eating food causes a dopamine spike; so does having sex. Yet most people wouldn't consider these addictive - although, clearly, some people still do them compulsively. Yet everyone considers cocaine addictive, although it really is no different - just causes a lot larger of a dopamine release. Caffeine, I'd assume, is somewhere between eating food and taking cocaine, although I'm not sure where it is (in terms of how much dopamine it causes your brain to release). So the designation of something as addictive is rather arbitrary and non-scientific.
But the fact that people are willing to pay 4 or 5 dollars for a Starbucks coffee that they don't NEED (unlike food, which is a biological necessity) every single day, suggests to me that caffeine is indeed addictive. At least, I would personally call caffeine addictive - of course, as I just mentioned, the line between addictive and not addictive is very arbitrary, so I understand that some people might disagree.
weird, I drink two cups of black coffee each work day (4 days a week) and am fine the rest of the day, if I dont drink any caffeine, I just yawn a ton through the entire morning. but on days I dont drink any, and where I can sleep longer, I feel fine, no head aches or "withdrawal" symptoms.
Caffeine helps clear my brain fogginess which are caused by lesions, and helps regulate my randomly low blood pressure (caused by basically the same reason as the fogginess). It may not be the best solution, but it works for now.
According to my psychologist I have a caffeine addiction - I'm up to 2 or so strong pots per day (I think that puts me close to 2 grams per day of caffeine). So while caffeine is not a mentally addictive substance, it can create a strong physical dependence/addiction. And in people more prone to addiction, it can be addictive.
Poppycock! Caffeine is most definitely addictive, withdrawal is not nearly as bad as alcohol, opiates or cocaine perhaps but for me personally it is nearly a week of headaches, muscle pains and lethargy, not to mention extreme depression and lack of motivation that can nearly push me towards suicidal ideation
I was diagnosed with caffeine addiction ((yep, it’s a real mental disorder)) and I was drinking over 1000 mg a day of caffeine. I had migraines, insomnia, stomach ulcers and heart problems because of my four energy drinks a day ritual. I tried to go cold turkey and let me tell you, very very bad idea. My already almost non existent appetite decreased even more and I was no longer eating, I was unable to get out of bed or function and got very depressed. It got so bad I passed out in the middle of class due to fatigue and had to go home for two days. I started up caffeine again after that and was back into a normal routine. I then weened off the heavy caffeinating and drink only 400 mg a day. Weening is the way to go, and caffeine addiction is certainly very real and serious, especially for people with depression or decreased levels of dopamine. Your body itself also becomes dependent on it, hence why people who go cold turkey can experience physical exhaustion and very slow response to things.
Yea drink some water so your body get your electrolytes back half the time I'm on caffine but sense summer is coming hopefully I go back to work so after I'm done usually I drank water more than anything right now caffine is just a plus and also a treat.
Caffeine may not produce a strong desire, like nicotine, but the physical effects aren't slight. The headache is worse than a migraine for big coffee drinkers. I gave up at 4:30pm, and by 11am the next day I was in a lot of pain, and by 2pm it was unbearable and I downed 3 double espressos and 6 ibuprofens, and had to sit in the shower for 40 minutes as they took effect. And the tiredness from caffeine withdrawal is horrendous. My brother had blackouts. All in all, it's functionally addictive. The good news is that it tapers well, unlike alcohol and other GABA or serotonin drugs, so there's no need for all that nonsense to give it up. Just don't go cold-turkey.
It is by will alone that I set my mind in motion. It is by the juice of the bean that thoughts acquire speed, the hands acquire shakes, shakes become a warning. It is by will alone that I set my mind in motion.
Well for those of you that still drink Caffeine on a regular basis... There is NO other beverage on earth known to man that is more good for you than water. Water is the ONLY beverage that is good for the human body. In fact 2/3 of the human body IS water. Anything that has Sugar, Caffeine, Aspartame, Sucralose, Saccharine, High Fructose Corn Syrup, Sodium, Sodium Citrate, EDTA, Sodium Acetate, or Phosphoric Acid does damage to the body especially your Liver and Kidneys
What was not discussed was why some people are totally unaffected by caffeine. I can drink a pot of very strong coffee and many espresso shots and then go right to sleep. Would have been nice to know since he was talking about how caffeine stimulates the brain (OK, no wisecracks from anyone)
The DSM 5 includes caffeine withdrawal as a syndrome in its latest iteration. After consuming a large amount of it for many years, I quit cold turkey and had negative effects for approximately 2 months after. Incredible anxiety, like anxiety I've never experienced before in my life and that was every waking moment. I couldn't eat, I lost 40lbs in that period (weight I obviously had to lose anyway, but still). I realize this video is out of date now but Caffeine Withdrawal is seriously no joke.
Probably comes from this silly idea that anything stimulating is because of caffeine. I even found one person who thought tobacco had caffeine in it.😅
I have heart issues so I prefer low caffeine cocaine.😄
You guys should do a video on mitragyna speciosa commonly referred to as kratom. Kratom is in the coffee family and in some ways it's almost the opposite to coffee as it's alkaloids mainly the mitragynine alkaloids which affect the opioid receptors causing a relaxing and pain relieving effect. Kratom is increasingly becoming more popular in the United States as an alternative from dangerous pharmaceutical opiates sparking controversy as it is a great method for getting off opiates since it has many similar effects to opiates albeit much more mild, but without the debilitating health issues caused by pharmaceutical opiates such as liver damage, the high risk for addiction, and possible overdoses. Kratom is just about as addicting as coffee while also having no risk for overdose. Many pharmaceutical companies are trying to lobby against it being legal as they want to continue to capitalize off of their drugs while also producing negative media towards the plant even though several studies from universities such as the University of Florida have proven that this plant is safe and beneficial. Unfortunately our government is controlled by big corporations with lots of money. This will undoubtedly be a major blow to personal liberties, and many who use it as an alternative to stay away from opiates like Oxycontin (I being one myself). Since kratom has come into my life I'm proud to say I've been clean of prescription opiates. I've lost two cousins from Hydrocodone overdose and I know several others who have died from opiates especially heroine. Kratom could be the solution to our heroine epidemic, but unfortunately pharma companies want to keep people hooked on their drugs. You guys can be a voice for change and I do implore to do so. Myself and many others would be incredibly grateful and I really think it would make for an interesting video.
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