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It's interesting that you didn't mention Moxonidine as a centrally acting adrenergic drug. Maybe because it's used in Europe and not in the U.S.A? He is similar to Clonidine (has the same effect on imidazoline receptors, but less affinity for Alfa-2 receptors). I think methyldopa is only used in pregnancy hypertension. P.S. I like your videos, it helps me to watch them after studying. :)
So, do renin inhibitors actually increase bradykinin destruction? Renin inhibitor inhibits production of Angiotensinogen I. Angiotensinogen I is lowered. Therefore, ACE enzyme has higher chance to act on bradykinins in the body, thus destroying them. Can anyone verify this?
Awesome video :) I have a question about methyldopa and clonide though.
I understand that clonidine serves as an alfa-2 agonist in presynaptic neurons in the brain (however there is a dilemma as some sources it works on postsynaptic neurons? and other sources say it works not only in the brain- plz clarify) which therefore causes less release of NE,E-> less stimultion of alfa and beta = decreased blood pressure through a decrease in cardiac output + total peripheral resistance. However since normally we have compensatory mechanisms that prevent a decrease in blood pressure (baroreceptors) we would have reflex tachycardia but because clonidine works on receptors in nucleus solitarius and imidazole receptors (as an agonist?) these prevent the reflex from activating???? is this correct?
How come clonidine is used in ADHD- apparently it raises norepinephrine levels in the prefrontal cortex (it doesnt make any sense since its an alfa-2 agonist so it should inhibit norepinephrine)
and when it comes to methyldopa, i read that it is a L-dopa analogue. You say it is converted to an active metabolite which then works on alfa-2 receptors in presynaptic neurons = less NE+E (basically like clonidine). however since it is an analogue, it surely competes with L-dopa for the enzyme dopa decarboxylase, meaning less dopamine + noradrenaline is made-> this should be the main mechanism of action? or is it both???? HELP.
hi everyone ,if anyone else trying to find out how to treat blood pressure try Nevolly Overcome BP Nerd ( search on google ) ? Ive heard some great things about it and my colleague got excellent success with it.
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