heightened sensory perception,
dysosmia distortion of smell,
clouded sensorium inability to think clearly or concentrate,
appetite decrease, and weight loss.
Other symptoms, such as anxiety and insomnia, were frequently seen during discontinuation
Seizures attributable to XANAX were seen after drug discontinuance or dose reduction in 8 of 1980 patients
The risk of seizure seems to be greatest 24-72 hours after discontinuation
Interdose Symptoms Early morning anxiety and emergence of anxiety symptoms between doses of XANAX
Ketoconazole Nizoral and itraconazole Brand Name: Sporanox are potent CYP3A inhibitors and have been shown in vivo to increase plasma alprazolam concentrations 3.98 fold and 2.70 fold, respectively
Nefazodone (Dutonin, Nefadar, Serzone) —Coadministration of nefazodone increased alprazolam concentration two-fold
Fluvoxamine—Coadministration of fluvoxamine approximately doubled the maximum plasma concentration of alprazolam,
Cimetidine is used for:
Treating and preventing ulcers of the stomach and small intestine, and treating gastroesophageal reflux disease
Coadministration of cimetidine increased the maximum plasma concentration of alprazolam by 86%,
Side effects of Xanax from the FDA info sheet.
dystonia, irritability, concentration difficulties, anorexia, transient amnesia or memory impairment, loss of coordination, fatigue, seizures, sedation, slurred speech, jaundice, musculoskeletal weakness, pruritus, diplopia, dysarthria, changes in libido, menstrual irregularities, incontinence and urinary retention
Older : risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes in older adults.