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Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: role of cyclooxygenases (COX-1 & COX-2) in inflammation, thromboxane, prostaglandins; mechanism of action, therapeutic uses and side effects of NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) and various prostaglandin analogs. Drugs mentioned include; Selective COX-1 inhibitors; Ketorolac, Flurbiprofen, Ketoprofen, Indomethacin, low-dose Aspirin; Non-selective COX inhibitors; Naproxen, Ibuprofen, Piroxicam, Diflunisal; Selective COX-2 inhibitors; Meloxicam, Diclofenac, Celecoxib, Etodolac; Prostaglandin E1 analogs; Alprostadil, Lubiprostone, Misoprostol; Prostaglandin F2α analogs; Bimatoprost, Latanoprost, Travoprost; Prostacyclin analogs; Iloprost, Treprostinil
Просмотров: 155067 Speed Pharmacology
Endothelial Secretions for Cardiovascular Regulation - Prostaglandins - Nitric Oxide - Endothelins
Check out the following links below! Over 1000+ Medical Questions: http://www.5minuteschool.com DONATE + SUPPORT US: http://paypal.me/5minuteschool Patreon: https://goo.gl/w841fz Follow us on Twitter: http://twitter.com/5MinuteSchool Follow us on Instagram: http://instagram.com/5minuteschool My personal Instagram: http://instagram.com/shahzaebb Contact us: contact@5minuteschool.com ______ ◅ Donate: http://www.5minuteschool.com/donate ◅ Website: htttp://www.5minuteschool.com ◅ Twitter: http://www.twitter.com/5minuteschool ◅ Instagram: http://www.instagram.com/5minuteschool ◅ Facebook: http://www.facebook.com/5minuteschool ◅ Email: contact@5minuteschool.com
Просмотров: 6207 5MinuteSchool
Aspirin and Prostaglandins
Aspirin, or acetylsalicylic acid, is one of the oldest and most well-known medications for headaches, fever, pain, and even prevention of heart attack and stroke. How does this drug cause relief of these symptoms? Check out this episode of Medicurio to learn about the quite interesting mechanism of aspirin in the body. Detailed Mechanism of Aspirin: There are two major forms of cyclooxygenase (COX) in cells. COX-1 is always made in the cell, while COX-2 is only made during inflammation. Aspirin permanently inhibits the COX-1 isoform (version) by acetylation of its active site. Therefore, aspirin’s effect lasts however long it takes for the cell to transcribe and translate new COX-1 enzymes, which usually takes a few hours. COX-1 decreases fever, pain, and inflammation, but also increases the risk of gastric ulcers by decreasing clotting and stomach mucous production. The COX-2 isoform is thought to only produce prostaglandins involved in fever, pain, and inflammation but not other functions; therefore, making a drug that inhibits COX-2 instead of COX-1 would give all the anti-inflammatory effects of aspirin without the risk of gastric ulcers. Such a drug would be a major upgrade and many companies came up with possible COX-2 inhibitors. One such drug, called rofecoxib or Vioxx, entered the market claiming that it would not cause gastric ulcers. What the drug company did not reveal was that during clinical trials, many patients suffered from heart attacks after chronic use. These problems began to surface once the general public began using Vioxx, leading to withdrawal of the drug and lawsuits against the company. Moral of the story? Research integrity is important, especially for a drug company as people’s lives are at stake. Trivia about Aspirin: It is debated if Felix Hoffmann was the true “inventor” of aspirin. Arthur Eichengrün, a fellow Bayer employee, claimed that he was the one who came up with the procedure and that Hoffmann simply performed the reaction following his guidelines. Bayer has denied this claim. Hoffmann synthesized aspirin for his father, who complained about the taste of salicylic acid that he was taking to treat his arthritis. Aspirin is extremely toxic to cats (which cannot break down aspirin) and to a lesser extent, dogs. Despite this, aspirin can still be used, just at low doses, to treat inflammation in animals. You can overdose on aspirin – at lethal doses, aspirin interferes with energy production in the mitochondria which leads to eventual death. Before death, unique symptoms such as ringing in the ears, hyperventilation, and dizziness, as well as non-specific symptoms such as vomiting and nausea appear. Overdoses are often due to chronic aspirin use, so if any of these symptoms apply to you, speak to a doctor immediately. Aspirin’s effect is increased by ingesting it with caffeine because caffeine is a stimulant, which increases blood flow to carry aspirin around the body faster and begin acting on tissue quicker. Acetaminophen (Tylenol) is not technically an NSAID because it does not decrease inflammation; however, it also works on COX enzymes so I have lumped it with the other NSAIDs in this video for simplicity.
Просмотров: 87130 Medicurio
NSAIDs and Heart Disease - Mayo Clinic
Have a headache? Chances are, when life causes aches and pains, many of us reach for the ibuprofen. But if you also take aspirin to protect against heart disease, there are some things you need to know.
Просмотров: 19447 Mayo Clinic
Inflammatory response | Human anatomy and physiology | Health & Medicine | Khan Academy
Overview of the inflammatory response. Created by Sal Khan. Watch the next lesson: https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/rn-blood-cell-lineages?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Missed the previous lesson? https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/how-white-blood-cells-move-around?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Health & Medicine on Khan Academy: No organ quite symbolizes love like the heart. One reason may be that your heart helps you live, by moving ~5 liters (1.3 gallons) of blood through almost 100,000 kilometers (62,000 miles) of blood vessels every single minute! It has to do this all day, everyday, without ever taking a vacation! Now that is true love. Learn about how the heart works, how blood flows through the heart, where the blood goes after it leaves the heart, and what your heart is doing when it makes the sound “Lub Dub.” About Khan Academy: Khan Academy is a nonprofit with a mission to provide a free, world-class education for anyone, anywhere. We believe learners of all ages should have unlimited access to free educational content they can master at their own pace. We use intelligent software, deep data analytics and intuitive user interfaces to help students and teachers around the world. Our resources cover preschool through early college education, including math, biology, chemistry, physics, economics, finance, history, grammar and more. We offer free personalized SAT test prep in partnership with the test developer, the College Board. Khan Academy has been translated into dozens of languages, and 100 million people use our platform worldwide every year. For more information, visit www.khanacademy.org, join us on Facebook or follow us on Twitter at @khanacademy. And remember, you can learn anything. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s Health & Medicine channel: https://www.youtube.com/channel/UC1RAowgA3q8Gl7exSWJuDEw?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Просмотров: 1212164 Khan Academy
TheSynapse eLearning - Role of Aspirin in Prevention of Cardiovascular Disease
Aspirin was discovered in 1897. Since then it has been used extensively in the prevention of Cardiovascular disease. The ESC Guidelines 2012 state that 'Aspirin cannot be recommended in primary prevention due to its increased risk of major bleeding' This video highlights the role of aspirin in current practice.
Просмотров: 398 TheSynapse
The Endocannabinoid System [ECS] and its Role in Metabolic Processes
The Endocannabinoid System: An Overview 'Marijuana has been used as a medicine for thousands of years with evidence dating back to 2000 BC, but only in the past few decades have scientists truly understood how it works. What led to this understanding was the discovery of the endocannabinoid system; a unique biological system that facilitates the effects of marijuana within the human body. The endocannabinoid system is a central regulatory system that affects a wide range of biological processes. It consists of a group of molecules known as cannabinoids as well as the cannabinoid receptors that they bind to. Although marijuana is a source of over 60 cannabinoids (including THC and CBD), the human body produces a number of cannabinoids as well. These endogenous cannabinoids include anandamide and 2-arachidonoylglycerol (2-AG) and are present in all human beings. Decades of scientific research on the endocannabinoid system has resulted in the discovery of two types of cannabinoid receptors, CB1 and CB2. These receptors are found in various parts of the body, but are most prominent in the brain and immune system. Cannabinoid receptors act as binding sites for endogenous cannabinoids as well as cannabinoids found in marijuana. When cannabinoids bind to CB1 or CB2 receptors, they act to change the way the body functions. While cannabinoid receptors are primarily expressed in the brain and immune system, researchers have identified cannabinoid receptors in a variety of other places as well, including the peripheral nervous system, cardiovascular system, reproductive system, and gastrointestinal and urinary tracts. Cannabinoid receptors continue to be identified in unique parts of the body as research on the endocannabinoid system progresses.' Full article ~ http://www.truthonpot.com/2013/03/22/the-endocannabinoid-system-an-overview/ Wiki - Endocannabinoid System 'The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as "endocannabinoids" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems. The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of physiological processes, including motor learning, synaptic plasticity, appetite, and pain sensation.' Full article ~http://en.wikipedia.org/wiki/Endocannabinoid_system National Center for Biotechnology Information (NCBI) - The Endocannabinoid System as an Emerging Target of Pharmacotherapy 'The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease. Such studies have been greatly facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, as well as mice deficient in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase. In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.' Full overview ~ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/ Copyright Disclaimer - allowance is made for "Fair Use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. All rights and credit go directly to its rightful owners.
Просмотров: 58598 Decriminalise it - Jersey
Anatomy of the Heart
http://www.handwrittentutorials.com - This tutorial explores the gross anatomy of the heart. It covers the chambers, vessels and valves of the heart. For more entirely FREE medical tutorials, visit http://www.handwriitentutorials.com
Просмотров: 93083 Handwritten Tutorials
Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, https://plus.google.com/communities/115462130054650919641?sqinv=VFJWaER0c2NCRl9ERzRjZWhxQmhzY09kVV84cjRn , ,https://plus.google.com/u/0/+AlexandrosGSfakianakis , https://www.youtube.com/channel/UCQH21WX8Qn5YSTKrlJ3OrmQ , https://www.youtube.com/channel/UCTREJHxB6yt4Gaqs4-mLzDA , https://twitter.com/g_orl?lang=el, https://www.instagram.com/alexandrossfakianakis/, Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients Guillermo Gervasini, Enrique Luna, Guadalupe Garcia-Pino, Lilia Azevedo, Sonia Mota-Zamorano & Juan José Cubero https://doi.org/10.1080/03007995.2017.1391757 Abstract Objective: Arachidonic acid metabolism by cytochrome P450 (CYP) epoxygenases leads to epoxyeicosatrienoic acids (EETs), which are eicosanoids with vasodilator and anti-inflammatory properties. We aim to determine whether genetic variability in these routes may contribute to cardiovascular (CV) risk in renal transplant recipients. Methods: In a cohort of 355 patients, we determined the presence of two polymorphisms, CYP2C8*3 and CYP2J2*7, known to affect eicosanoid levels. Associations with CV mortality, CV event-free long-term survival and graft survival were retrospectively investigated by logistic regression models. Results: CYP2J2*7 showed a statistical trend towards higher CV mortality (p = .06) and lower cardiac or cerebral event-free long-term survival (p = .05), whilst CYP2C8*3 displayed a significant inverse association with the risk of CV event (hazard ratio [HR] = 0.34 [0.15–0.78], p = .01). The association of CYP2J2*7 with CV mortality became significant when the analysis was restrained to 316 patients without a history of CV events prior to transplantation (HR = 15.72 [2.83–91.94], p = .005). In this subgroup of patients both single nucleotide polymorphisms (SNPs) were significantly associated with event-free survival. HR values were 5.44 (1.60–18.51), p = .007 and 0.26 (0.09–0.75), p = .012 for CYP2J2*7 and CYP2C8*3, respectively. Conclusions: Our results show, for the first time to our knowledge, that two SNPs in CYP2C8 and CYP2J2, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events. Keywords: Epoxyeicosatrienoic acids, cardiovascular disease, genetic polymorphisms, renal transplant, CYP450 - video upload powered by https://www.TunesToTube.com
Просмотров: 10 Alexandros G. Sfakianakis
ECG 3 - Segments, Intervals & Diseases
http://www.handwrittentutorials.com - This tutorial is the third in the ECG series. This video explores the various segments and intervals seen on an ECG trace and how changes in these divisions can be indicative of various heart diseases. For more entirely FREE tutorials and their accompanying PDFs, visit http://www.handwrittentutorials.com
Просмотров: 115703 Handwritten Tutorials
Correct Arachidonic Acid Levels
Correct Arachidonic Acid Levels Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He has published more than 30 scientific articles and holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 13 books, including the New York Times #1 best-seller "The Zone". These books have sold more than 5 million copies in the U.S. and have been translated into 22 different languages. For more, go to zonediet.com
Просмотров: 4228 Dr. Barry Sears
Heart Disease and Inflammation
Get to the HEART of the matter.... It's NOT Fat!!! (Healthy fat doesn't cause inflammation.)
Просмотров: 81 mWell Solutions
NSAIDs and Renal Function
See how non-steroidal anti-inflammatory drugs (NSAIDs) can affect kidneys with some degree of dysfunction and potentially further compromise renal function. For more information on the safety differences of OTC analgesics, visit http://www.tylenolprofessional.com/the-tylenol-difference.html This video is intended for U.S. healthcare professionals only. ©McNEIL-PPC, Inc. 2013. All rights reserved.
Просмотров: 19126 TYLENOLOFFICIAL
Pharma Tube - 22 - Autacoids - 4 - Eicosanoids (Prostaglandins - Thromboxanes - Leukotrienes)
- فارما تيوب Pharma Tube هى سلسلة من الفيديوهات تحتوى على محاضرات فى علم الفارماكولوجى الأساسى والإكلينيكى يقدمها دهشان حسن دهشان الشرح من كتاب فارما جايد Pharma Guide - لمعلومات أكثر عن الكتاب www.facebook.com/Pharma.Guide.book - الموقع الرسمى للفيديوهات www.pharmatube.blogspot.com - للتواصل مع المؤلف www.facebook.com/Dr.Dhshan Pharma Tube is a videos by Dahshan Hassan Dahshan containing lectures about basic and clinical pharmacology which prepared from Pharma Guide book For more information about Pharma Guide book, click here www.facebook.com/Pharma.Guide.book Official Pharma Tube website www.pharmatube.blogspot.com For contact with the author www.facebook.com/Dr.Dhshan
Просмотров: 17707 Dhshan Hassan Dhshan
Omega-3 fatty acids and inflammatory processes by Philip Calder
Webcast of the presentation entitled 'Omega-3 fatty acids and inflammatory processes: From molecules to man' given by Philip Calder (University of Southampton, United Kingdom) at the joint Biochemical Society/British Society for Immunology Hot Topic Event 'Nutrient mechanisms in inflammation, infection and immunity'.
Просмотров: 11652 Biochemical Society
Hypertension Regulation
Prof. Michal Laniado Schwartzman presents how cytochrome P450-derived eicosanoids play a role in the regulation of hypertension, based on a new research project that she is carrying out. The lecture was one of the faculty lectures at the Rambam Health Care Campus. View this and other programs on the Academic Channel- www.actv.haifa.ac.il/programs
The Role of Molecular Clocks in Cardiovascular Disease
Josh Beckman, MD, chair of the council on Peripheral Vascular Disease, interviews Distinguished Lecturer Garret FitzGerald, MD about his research on the role of molecular clocks in cardiometabolic disease.
Просмотров: 257 AHAScienceNews
Dietary Fats: Healthy Fat vs. Bad Fat- Thomas DeLauer
http://ThomasDeLauer.com Click here to subscribe to my YouTube Channel : https://www.youtube.com/thetdelauer?sub_confirmation=1 Monounsaturated Fats: Oleic Acid - Omega 9- These Protect Cell Membranes from Free Radicals. Oleic acid replaces other omega fatty acids in cell membranes. Since oleic acid is less susceptible to oxidation damage than omega-6 and omega-3 fatty acids, replacing these fatty acids with oleic acid protects your cell membranes from free radicals and other oxidative stressors (1) Palmitoleic Acid - Omega 7- These Reduce Insulin Resistance. Omega-7 protects the insulin-producing cells of the pancreas from glucose-induced toxicity - enhances proliferation of pancreatic beta cells, helping your body optimize blood sugar control with its own natural insulin (2) Reduce Inflammation- Study from the Cleveland Clinic Wellness Institute in Ohio conducted the first randomized, controlled trial in humans of supplementation with purified omega-7. Subjects were randomly assigned to receive either an omega-7 supplement providing 220 mg palmitoleic acid or a placebo - capsules were taken once daily, with a meal, and blood testing was done at the beginning of the study and again after 30 days. At 30 days, the supplemented group showed a significant mean lowering in C-reactive protein with a 44% reduction compared with the control group. Omega-7-supplemented subjects also had 15% reductions in triglyceride levels (3) Polyunsaturated Fats: Omega 3 & 6- Omega 3’s- Eicosapentaenoic acid (EPA): This 20-carbon fatty acid's main function is to produce chemicals called eicosanoids, which help reduce inflammation. EPA also helps reduce symptoms of depression. Docosahexaenoic acid (DHA): A 22-carbon fatty acid, DHA makes up about 8% of brain weight and is extremely important for normal brain development and function. EPA and DHA support cellular membranes and keep them flexible - maintaining the fluidity of the cell membranes allows for proper communication between nerve cells and, therefore, helps to support focus and mental clarity. Alpha-linolenic acid (ALA): This 18-carbon fatty acid can be converted into EPA and DHA, although the process is not very efficient. ALA is mainly used by the body for energy (4) Omega 6’s: The most common omega-6 fat is linoleic acid, which can be converted into longer omega-6 fats such as arachidonic acid (ARA) Like EPA, ARA is used to produce eicosanoids - however, the eicosanoids produced by ARA are more pro-inflammatory. Pro-inflammatory eicosanoids are important chemicals in the immune system, but when too many of them are produced, they can increase inflammation - modern Western diet contains far more omega-6 fatty acids than necessary (4) Trans Fats: Trans fats block the production of Type 1 and 3 prostaglandins (PGs), which are derived from the omega 6 and omega 3 fats, respectfully. Type 1 and 3 PGs help you fight inflammation and benefit your hormonal and nervous system (5) Saturated Fats: Studies in favor of saturated fats- A meta-analysis study, published 2010, which pooled data from 21 studies and included nearly 348,000 adults, found no difference in the risks of heart disease and stroke between people with the lowest and highest intakes of saturated fat (6) A Japanese prospective study that followed 58,000 men for an average of 14 years found no association between saturated fat intake and heart disease, and an inverse association between saturated fat and stroke (i.e. those who ate more saturated fat had a lower risk of stroke) (7) References: 1) Oleic Acid Health Benefits: MooScience. (n.d.). Retrieved from http://mooscience.com/Oleic-Acid.html 2) Omega-7 Protects and Metabolic Syndrome - page 1 | Life Extension. (n.d.). Retrieved from http://www.lifeextension.com/Magazine/2014/4/Omega-7-Protects-Against-Metabolic-Syndrome/Page-01 3) Omega-7 An Overlooked Fatty Acid - Life Extension. (n.d.). Retrieved from http://www.lifeextension.com/Magazine/2016/5/Omega-7-An-Overlooked-Fatty-Acid/Page-01 4) Omega-3-6-9 Fatty Acids: A Complete Overview. (2017, January 15). Retrieved from https://www.healthline.com/nutrition/omega-3-6-9-overview#section4 5) Hydrogenated Fat Dangers | Understand Trans Fats Dangers. (n.d.). Retrieved from http://www.drgangemi.com/health-topics/nutrition-and-supplements/hydrogenated-fat-dangers/ 6) Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation ... - PubMed - NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20685950?dopt=AbstractPlus 7) PubMed. (n.d.). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20071648?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2%20Am%20J%20Clin%20Nutr
Просмотров: 171388 Thomas DeLauer
Bilirubin 2 - Bilirubin Metabolism & Diseases
http://www.handwrittentutorials.com - This tutorial is the second of the Bilirubin series. It explains the process of Bilirubin Metabolism in the liver. This tutorial also discusses the hereditary diseases associated with failure of metabolism. For more entirely FREE medical tutorials and accompanying PDFs visit http://www.handwrittentutorials.com
Просмотров: 144813 Handwritten Tutorials
Autacoids - 03 - Prostaglandins, TXA2, leukotrienes
Video lectures in clinical pharmacology by Dr. Abdel-Motaal Fouda, associate professor of clinical pharmacology, Mansoura Faculty of Medicine. 2016. foudaamm@mans.edu.eg
Просмотров: 14186 Abdel-Motaal Fouda
Pharmacology - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Where do I get my information from: http://armandoh.org/dig Facebook: https://www.facebook.com/ArmandoHasudungan Support me: http://www.patreon.com/armando Instagram: http://instagram.com/armandohasudungan Twitter: https://twitter.com/Armando71021105 SPECIAL THANKS: Patreon members
Просмотров: 37282 Armando Hasudungan
Prudence Sinclair interviews Dr. Barry Sears -  What would you do if you got cancer?
Find out what Dr. Barry Sears would do if God forbid he was diagnosed with Cancer. Subscribe to my channel to get more interviews. wwwprudenncesinclair.com Dr. Barry Sears: Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. A turning point in his research occurred in 1982. That year the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones known as eicosanoids play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug-delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug. This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug-delivery system to modulate eicosanoids, especially for cardiovascular, diabetic, and neurological patients.
3 Essential Fats You Need For Intermittent Fasting (AVOID The #1 Poisonous Fat)
Train With The Most Effective Methods For Six Pack Abs: http://go.sixpackabs.com/scienf9ed Check Out Thomas' Channel: http://www.YouTube.com/TheTDeLauer What's going on, SixPackAbs.com? Thomas here to talk about fat - or rather, fats - both good and bad ones. I want you to take this knowledge about fats moving forward and incorporate into the fasting lifestyle I've broken down for you in all my videos. Let's dive right in: 2:21 - Monounsaturated Fats -Monounsaturated fats are fat molecules that have one unsaturated carbon bond in the molecule, also known as a double bond. -Oils that contain monounsaturated fats are typically liquid at room temperature but start to turn solid when chilled. -Oleic Acid - Omega 9 - helps to reduce blood pressure, but occupies a particular part of a cell, making it become extra protected. -Palmitoleic Acid - Omega 7 - helps the body utilize fats more efficiently and dramatically reducing insulin resistance. -Omega-7 protects the insulin-producing cells of the pancreas from glucose-induced toxicity. -Omega-7 & Inflammation: http://www.ncbi.nlm.nih.gov/pubmed/25499944 4:35 - Polyunsaturated Fats - Omega 3 & 6 -Eicosapentaenoic Acid (EPA) in Omega 3 is a 20-carob fatty acid and its main function is to produce chemicals called eicosanoids, which help reduce inflammation. -Docosahexaenoic Acid (DHA) in Omega 3 is a 22-carbon fatty acid that makes up about 8% of brain weight and is extremely important for normal brain development and function. -Alpha-linolenic Acid (ALA) in Omega 3 is an 18-carbon fatty acid that can be converted into EPA and DHA, although the process is not very efficient. -Omega 6 is found in the so-called "healthy fats" like vegetable oil, safflower oil, canola oil, etc. -Like EPA, Omega 6 is used to produce eicosanoids - however, the eicosanoids it produces are more pro-inflammatory. 6:54 - Trans Fats -Mechanically-altered fats. -It takes 51 days to begin breaking down trans fats... -Trans fats block the production of Type 1 and 3 prostaglandins, which are derived from the omega-6 and omega-3 fats. -Stay away from Cool Whip and things that have "partially-hydrogenated soybean oil." 7:48 - Saturated Fats -Coconut oil, palm oil, and fats that come from animals that are sustained and ethically raised. -These are NOT bad. -There is zero correlation between stroke and cardiovascular risk for those that consume high levels of saturated fats as opposed to those who consume a high level of regular fats: http://ajcn.nutrition.org/content/91/3/535 The point of today's video is MODERATION. Saturated fats are good for your immune system, tremendously powerful for your brain health, and yield a plethora of other health benefits the mainstream media has led you to think otherwise about. Thanks for tuning in with me, guys. Don't forget - "LIKE" "SHARE" & "SUBSCRIBE" to SixPackAbs.com. Train Smart, -Thomas Achieve Six Pack Abs The Fastest Way Possible - Using Science: http://go.sixpackabs.com/scienf9ed P.S. Make sure to "Like" & "Share" this video on Facebook: http://sixpackabs.com/3-essential-fats-you-need-for-intermittent-fasting-avoid-the-1-poisonous-fat/
Просмотров: 175315 SixPackAbs.com
Microbiome – Your Microbiome and Relief From Chronic Inflammation
http://www.oursynergyfamily.com/microbiomejudy/ To contact Judy Feldhausen for a free 30 minute consultation, please click on the above link. http://www.oursynergyfamily.com/microbiomedan/ To contact Dan Hammer for a free 30 minute consultation, please click on the above link. Almost every lifestyle disease today is affected by chronic inflammation. Some researchers would say that if you can eliminate chronic inflammation, then you can significantly reduce all diseases. If this is true, then the question is: How Do You Get Relief From Chronic Inflammation? And more importantly: How Do You Prevent Chronic Inflammation? And the answer to both of these questions is centered in what is called the (icosanoid) eicosanoid pathway. Just as there is an endothelial pathway for the creation of nitric oxide for improved cardiovascular health. There is also an eicosanoid pathway that significantly influences inflammation in your body. The easiest way to understand the eicosaniod pathway is to view it as a light switch. If you want the lights on in your room (inflammation), then you flip the switch to “ON.” If you want the lights off, then you flip the switch to “OFF.” The eicosaniod pathway works the same way. This pathway helps turn on inflammation when it's needed. And once your body has used inflammation to help in the healing process, then it turn off this process. As in nitric oxide therapy were nitric oxide is the signaling molecule used to create vasodilation for improved blood flow, the eicosaniod pathway uses two signaling molecules. One that is pro-inflammatory. And one that is anti-inflammatory. Pro-inflammatory signaling molecules are produced from omega-6 fatty acids. And anti-inflammatory signaling molecules are mainly produced from omega-3 fatty acids. As outlined in our video titled how your microbiome impacts weight loss, you will remember that steps 1 and 2 directly center on this issue of omega-6 and omega-3 fatty acids. As I shared in that video: https://www.youtube.com/watch?v=NTtsjq3ks7s&t=25s Step #1 – Eliminate omega-6 vegetable oils from your diet. Ones like Corn Oil Soybean Oil Canola Oil Vegetable Oil Peanut Oil While the food industry, and our government, have tried to convince us that these omega-6 vegetable oils are safe and heart-healthy, they are not. These oils are inflammatory, and help create an environment that allow Firmicutes to flourish, which then creates toxins that your body has to address. The easiest way for your body to remove these toxins from your system is to store them in fat cells. And the more toxins your gut microbiome produces, the more fat cells your body needs to store them. The result is weight gain through larger and more fat cells. Not only do the omega-6 vegetable oils affect your microbiome and weight management, they are also the main trigger that turns on inflammation. When used properly inflammation can be a good thing as it's involved in the wound healing process. But when the “light switch” is left on, then it becomes chronic inflammation, which contributes to almost all disease processes. Now you need to do more than just eliminate these omega-6 vegetable oils from your diet. You need to do: Step #2 – Replace the omega-6 vegetable oils with omega 3 healthy fats like Coconut Oil Avocados Grass-fed Butter Fish Rich in Omega 3s Grass-fed Beef Extra-virgin Olive Oil When used in weight management studies, these healthy, anti-inflammatory omega 3 fats create an environment where healthy gut flora can dominate, which lowers inflammation levels, produces significantly less toxins, and increases the probability of weight loss. And as we've seen, they also act as signaling molecules to turn off inflammation. Omega-3 fats also play a significant role in the prevention of: Cardiovascular Disease Neurodegenrative Disorders like Alzheimer's Disease Type II Diabetes Osteoporosis Atherosclerosis Atrial Fibrillation Osteoarthritis The bottom line to all of this information is that the key to the “relief of” and “prevention of” chronic inflammation is eliminating omega-6 fats from your diet. And replacing them with omega-3 fats. This one change can have a profound health benefit for every organ and organ system in your body. As well as helping to improve your endothelial health and function for improved blood flow. And by implementing these two steps into your diet you will also significantly influence your microbiome in a positive way. If you have any questions about this material, then please either email me at dan@agingnomore.com or call me directly at 630-936-8079. Or you can email Judy at Judy@CardioWellnessGroup.com or call her directly at 630-289-2750.
Просмотров: 104 Daniel Hammer
Histamine, Prostaglandin, Leukotrienes, Bradkinin, PGE2 LTB4 Chemotactic Factors
http://www.stomponstep1.com/histamine-prostaglandin-leukotrienes-bradkinin-pge2-ltb4-chemotactic-factors/ There are a groups of inflammatory signals that play key roles in the early phases of acute inflammation. These signals cause the cardinal signs of inflamation and are involved in the inflammatory mechanism. The Cardinal Signs of Inflammation are the signs and symptoms that results directly from acute inflammation. * Fever is associated with inflamation and is caused by the release of PGE2 (Prostaglandin E2), however it is not a cardinal sign of inflammation. Histamine is released from mast cells in response to cell injury, complement activation, or membrane bound IgE being crosslinked by antigen. Histamine then increases venule permeability, dilates the arterioles and prepares the vessel wall for neutrophil extravasion. In other words, Histamine is the main signal that initiates the fluid phase (But it gets helps from other cytokines). Histamine is the mediator of type 1 hypersensitive reactions (anaphylaxis & allergies) and signals stomach acid to be secretion. Antihistamines that primarily antagonize the H1 Histamine receptors are used to treat allergic symptoms, while antihistamines that primarily antagonize the H2 Histamine receptor are used to treat things like GERD and Peptic Ulcer Disease. Histamine has the help of other signals during acute inflammation. Following injury, Coagulation Factor XII (Hageman Factor) is activated by exposed collagen in the vessel wall. Factor XII then initiates the Kinin-Kallikrein System that creates Bradykinin. Bradykinin plays an important role in pain, arteriole dilation and increased venule permability during acute inflammation. We will cover elsewhere the effect coagulation factor 12 has on clotting. Angiotensin Converting Enzyme (ACE) breaks down bradykinin. Therefore, ACE Inhibitors increase bradykinin levels which can cause cough, angioedema and vasodilation. Arachidonic Acid is created when cell membrane phospholipids are acted upon by Phospholipase A2. Arachidonic Acid which is acted upon by Cycloxygenase to create Prostaglandins or Lipoxygenase to create Leukotrienes. Both classes of signal molecule play a role in acute inflammation by contributing to the fluid phase (arteriole dilation and venule permeability). PGE2 (Prostaglandin A2) is involved in the signaling process for pain and fever. LTB4, a specific type of leukotriene, is also a Chemotactic Factors which means it attracts neurtophils to the site of injury (AKA leukocytosis). The other main Chemotactic Factors are IL-8 and C5a. We will discuss prostaglandins and leukotrienes in many other videos as they are involved with the pathophysiology and treatment of many disease. Leukotrienes are involved in the pathophysiology of Asthma and their action is antagonized by receptor blocker Montelukast. Both class of molecule can be reduced to lessen the pain and inflammation. Corticosteroids inhibit Phospholipase A2 to decrease the levels of prostaglandins and Leukotrienes. NSAIDs inhibit Cyclooxygenase to decrease prostaglandin levels. Synthetic prostaglandins can be used to keep a Patent Ductus Arteriosus open in a newborn (if they have a congential heart defect that requires that route of blood flow), while an NSAID like Indomethacin can be used to close a PDA. Nuetrophils are the predominant inflammatory cell in acute inflammation. They phagocytose (engulf) infected or necrotic cells and use free radicals to destroy them. They also release granules full of proteins and enzymes that help fight infection or clear cellular debris. Neutrophils are attracted to and activated by chemotactic factors (Leukotriene B4, C5a, and Interleukin-8) created during acute inflammation. Neutrophil extravasation (AKA Leukocyte extravasation) is the process by which neutrophils exit the circulatory system into the damaged tissue. Later in the inflammatory process Macrophages use these same steps to get to the effected tissue. Pictures Used: • Derivative of “Leukozytenmigration 01” by Armin Kübelbeck available at http://commons.wikimedia.org/wiki/File:Leukozytenmigration_01.png via Creative Commons Attribution • “Lips Mouth Smile Teeth Happy Laugh Red White” available at http://pixabay.com/en/lips-mouth-smile-teeth-happy-156991/ via Public Domain
Просмотров: 39205 Stomp On Step 1
7 Things That Will Happen To Your Body If You Take Fish Oil Daily
Fish oil can be obtained from eating fish or by taking supplements. Fish that are especially rich in the beneficial oils known as omega-3 fatty acids includes mackerel, herring, tuna, salmon, cod liver, whale blubber, and seal blubber. Two of the most important omega-3 fatty acids contained in fish oil are Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). According to research conducted at Harvard University, omega-3 fatty acid deficiency ranked as the sixth highest killer of Americans. If you don't eat a lot of oily fish, taking a fish oil supplement could help you get enough omega-3 fatty acids and the amazing health benefits that comes with it. 1. Clearer, Younger-Looking Skin. Fish oil also benefits the skin in a number of ways, including nourishing it with fats and fat-soluble vitamins that help give it a smoother, soft and elastic texture. There is even some scientific evidence that it can help prevent premature aging and signs of aging like wrinkles and fine lines. 2. Weight Loss. Fish oil has also been proven to be effective in aiding to weight loss. Greater weight loss has been shown in adults taking fish oil supplements through out their weight loss program compared to those who didn’t take fish oils. The majority of bodybuilders and gym rats swear by fish oils in improving blood circulation and tighten skin after weight loss. 3.Good for your heart. According to the American Heart Association (AHA), clinical trials have shown that omega-3 is effective in reducing the incidence of cardiovascular diseases. Fish oil is a great source of omega-3 and therefore, reduces the risk of heart diseases and heart arrhythmias. It also lowers the level of bad-cholesterol (LDL) and increases the level of good-cholesterol (HDL). 4.Prevent Diabetes. Fish oil supplements may also help reduce the risk for type 2 diabetes, as well as prevent complications for those with the disease. The omega-3 fatty acids in fish oil are able to raise levels of a hormone called Adiponectin that’s linked to insulin sensitivity as Harvard researcher’s published in the Journal of Clinical Endocrinology & Metabolism found. 5.Improved Immunity. Fish oils aids in boosting your immune system helping in keeping your system regulated and fighting off common colds, coughs, and flu. Omega-3 and Omega-6 fatty acids have shown to be effective in controlling the amount of cytokines and eicosanoids in your body. 6.Boosting Memory. Not only can fish oil help improve mental health, but it can strengthen your brain in other ways, including boosting your memory. Research found that when a group of 18 to 25-year-olds consumed fish oil pills daily for six months, they experienced a 23 percent increase in working memory. 7.Fertility. Research has shown boars with diets high in fish oil had enhanced healthy sperm count. While it varies person to person, Many have claimed it to be the reason for their fertility to increase drastically since beginning to consume the oil. If You Do decide to take Fish Oil, please Follow the Dosage Instruction on the Bottle.
Просмотров: 727 Natural Solution
UF study strengthens concerns about long-term use of certain painkillers
Painkillers such as ibuprofen, naxopren and celecoxib provide needed relief for many patients who have chronic pain. But an ongoing source of contention is whether those drugs and others in their class known as nonsteroidal anti-inflammatory drugs, or NSAIDs, are linked to harmful health effects. Now a new study from the University of Florida raises the concern about potential risks to a higher degree than before, finding a doubling of deaths from heart attack, stroke and related events among people who have both hypertension and coronary artery disease and use the drugs long term. The findings, based on data from the international INVEST clinical study of hypertension therapies, are published in the current issue of The American Journal of Medicine. "It does strengthen our practice recommendations," said lead author Anthony A. Bavry, M.D., M.P.H., an assistant professor of cardiovascular medicine in the UF College of Medicine's department of medicine. Physicians already discourage the use of NSAIDs among the elderly and after heart attacks, on the basis of several studies showing that the drugs are linked with a higher risk of stroke and heart attack. But the UF researchers, including senior author Carl J. Pepine, M.D., a professor of cardiovascular medicine in the UF College of Medicine, advise patients to talk to their doctors before stopping use of prescribed treatments. "It's a tricky issue, because NSAIDs are useful for relieving pain, and that is much of what we do in medicine — alleviate pain and suffering," said Deepak L. Bhatt, M.D., M.P.H., an associate professor of medicine at Harvard Medical School and chief of cardiology at the VA Boston Healthcare System, who recently published findings that NSAIDs are linked to a higher risk of stroke. "Unfortunately, most medications have some potential side effects, and it's important to know what those might be." Bhatt was not involved in the UF study. Patients who have both high blood pressure and coronary artery disease are generally put on aspirin, a unique type of NSAID, to reduce their risk of a heart attack. Physicians are concerned that giving those patients other NSAIDs for pain relief could cancel out aspirin's beneficial effects and raise the risk of negative cardiovascular effects. The UF research team took advantage of the availability of INVEST study data from 882 chronic NSAID users and almost 22,000 intermittent or nonusers to try to settle the question. They looked at patients who reported using NSAIDs over an average of about three years, to see whether there was an increase in adverse events or cardiovascular-related death compared with patients who did not use those pain medicines long term. The risk of death from cardiovascular causes was 2.3 times higher among patients who chronically used the drugs than among other patients. NSAIDs are thought to act in a variety of ways to increase cardiovascular risk. They are thought to prevent aspirin's protective anti-clotting effect by preventing the aspirin from binding properly to platelets in the blood. Some NSAIDs might also increase bleeding risk. In addition, NSAIDs raise blood pressure, thus potentially raising the risk of heart attack and stroke. Some NSAIDs have already been removed from the market because of concerns about an elevated risk of heart attack and stroke.
Просмотров: 8703 UFHealth
Просмотров: 1351 Walter Jahn
What are prostaglandins? -- FabFats Clip: Mary Toscano Healthy Living
http://www.marytoscano.com/fabulousfats/video This clip from nutrition education video "Fabulous Fats: Setting the Record Straight" has Mary Toscano explaining prostaglandins and their role in the body. To watch the whole presentation, pick up a copy at http://www.marytoscano.com/fabulousfats/video. ABOUT FABULOUS FATS: In this dynamic, musical and highly visual talk, discover the vital role fats play in feeling energized, slim and strong. See which fats are essential for the heart, brain, eyes and reducing painful inflammation. Discover which fats help with joint pain, arthritis, memory and mood swings, and which damaged fats must be avoided! Certified Nutrition Educator Mary Toscano has taken a complicated, confusing subject and made it accessible. Answers the questions: *** I'm eating low-fat and no-fat foods so why am I still gaining weight? *** How do I know if a fat is good or bad? *** What's the big deal about trans fats? *** Are there oils I shouldn't cook with? For over thirty years, fat in our diet has been associated with obesity, heart disease, and high cholesterol. Recent studies dispel these beliefs and prove that good fats are absolutely essential to our health and well-being. But which fats are good? Sifting through all the information on fats can leave you with even more questions. No one has made this information simple. Until now... Produced by Mary Toscano Healthy Living. Playing Time: 65 min.
Просмотров: 31453 HealthyLivingABCs
Inflammation in 100 Seconds
While routine lipid screening plays an important role in cardiovascular risk assessment it does not provide a complete picture of your health. In fact, nearly 50% of all heart attacks and strokes occur in patients with ‘normal’ cholesterol levels. Recent evidence goes beyond lipids to suggest that inflammation within the artery wall is the primary contributor to this residual risk for heart attack and stroke. Inflammation contributes to both vulnerable plaque formation and to plaque rupture.
Просмотров: 404 Cleveland HeartLab
Lalita Ramakrishnan (Cambridge) 3: Tuberculosis as an Inflammatory Disease
https://www.ibiology.org/human-disease/tuberculosis-pathogenesis/#part-3 Lalita Ramakrishnan gives an introduction to tuberculosis (TB) pathogenesis, gives an overview of Mycobacterium tuberculosis’ life cycle, and explains how the TB bacteria gain entry into the host. Part 1: An Introduction to Tuberculosis: The Pathogenic Personality of the Tubercle bacillus: Lalita Ramakrishnan gives an introduction to tuberculosis (TB) pathogenesis, and gives an overview of Mycobacterium tuberculosis’ life cycle. Part 2: The Troublesome Tubercle in Tuberculosis: After the tuberculosis (TB) bacteria infect macrophages, a complex structure called a granuloma develops. Ramakrishnan explains how her laboratory used a zebrafish model of TB to study the involvement of granulomas in TB progression. Part 3: Tuberculosis as an Inflammatory Disease: Lalita Ramakrishnan’s laboratory has studied the molecular pathogenesis of TB using the power of forward genetics in the zebrafish. Talk Overview: In this seminar, Dr. Lalita Ramakrishnan gives an introduction to tuberculosis (TB) pathogenesis, and gives an overview of Mycobacterium tuberculosis’ life cycle. She explains how the TB bacteria gain entry into the host by using specific lipids to avoid microbicidal macrophages and recruit growth-permissive ones. Once inside the macrophage, the bacteria use multiple virulence genes to survive intracellularly. In particular, Ramakrishnan discusses bacterial efflux pumps that, in addition to promoting intracellular survival, also induce tolerance to multiple antibiotics. Most individuals have effective counterstrategies so that they are able to clear TB infection by a combination of innate and adaptive immunity. Yet scientists have not been able to understand these defense strategies enough to harness them and create an effective vaccine against TB. After the TB bacteria infect macrophages, a complex structure called a granuloma develops. Different immune cells arrive at the granuloma to surround the bacterial infection and fight the disease. In her second lecture, Ramakrishnan explains how her laboratory used a zebrafish model of TB to study the involvement of granulomas in TB progression. Although granulomas were thought to constrain infection, her laboratory showed that the bacteria hijack the granulomas to spread the disease. For example, Ramakrishnan showed that TB bacteria promote the recruitment of new macrophages to the granuloma that engulf dying infected macrophages to expand infection. Ramakrishnan’s laboratory has studied the molecular pathogenesis of TB using the power of forward genetics in the zebrafish. They discovered that mutations in LTA4H, a key enzyme in the eicosanoid pathway that alters the levels of the cytokine tumor necrosis factor (TNF), affect tuberculosis pathogenesis by regulating the inflammatory response. This work showed that a balance of TNF is required for good TB prognosis, and neither high nor low inflammation was favorable. Correspondingly, they showed that genetic variation in LTA4H in humans helps explain patterns of TB meningitis survival when patients were exposed to a treatment that suppresses the inflammatory response. Speaker Biography: Dr. Lalita Ramakrishnan is a professor of immunology and infectious diseases at the University of Cambridge, UK. She received her medical degree from the Baroda Medical College in India, and her PhD in Immunology from Tufts University in Boston. After completing her medical residency at Tufts and a fellowship in Infectious Diseases at the University of California, San Francisco, she joined the lab of Dr. Stanley Falkow at Stanford University as a postdoctoral fellow.  There she developed Mycobacterium marinum as a model for to study tuberculosis pathogenesis. She then joined the faculty at the University of Washington, where her laboratory developed the zebrafish infected with M. marinum as a model for tuberculosis. In 2014, she moved to the University of Cambridge, where her laboratory continues to unravel the molecular underpinnings of TB pathogenesis. Ramakrishnan’s work has been recognized with several awards and honors, including the NIH Director’s Pioneer Award, the Wellcome Trust Principal Research Fellowship and election to the US National Academy of Sciences (2015). Learn more about Ramakrishnan’s research here: https://www.med.cam.ac.uk/ramakrishnan/
Просмотров: 1959 iBiology
Dr. Volek & Dr. Phinney - Translating the Basic Science of Nutritional Ketosis & Keto-Adaptation
Filmed at the Emerging Science of Carbohydrate Restriction and Nutritional Ketosis, Scientific Sessions at The Ohio State University Learn more at https://blog.virtahealth.com/category/science-research/ An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their toxic label for the next 150 years. Despite work four decades ago showing ketones were highly functional metabolites, they are still misidentified as toxic byproducts of fat metabolism. The vilification of fat by regulatory and popular dogma perpetuates this myth. But the nutrition-metabolic landscape is improving dramatically. A growing number of researchers have contributed to what is now a critical mass of science that provides compelling clinical evidence that ketogenic diets uniquely benefit weight loss, pre-diabetes, and type-2 diabetes. In the last five years, basic scientists have discovered that b-hydroxybutyrate (BHB), the primary circulating ketone, is a potent signaling molecule that decreases inflammation and oxidative stress. BHB has been suggested to be a longevity metabolite, with strong support from recently published mouse studies showing decreased midlife mortality and extended longevity and healthspan. Although type-2 diabetes is often described as a chronic progressive disease, emerging evidence indicates that sustained nutritional ketosis can reverses the disease. There is growing interest in studying potential therapeutic effects of ketosis on cardiovascular diseases, cancer, and neurodegenerative diseases including Alzheimer’s and Parkinson’s. There are even reasons certain athletes may benefit from nutritional ketosis and ketone supplements ─ debunking the long-standing dogma that high carbohydrate intake is required to perform optimally. With the support of the well-established Ohio State Food Innovation Center, this conference will bring together the top experts in these fields to share what has been achieved and what remains to be done to advance this exciting field of scientific discovery.
Просмотров: 10787 Virta Health
Просмотров: 133 drjepm
PRECISION exonerates celecoxib: cardiovascular risk is no worse than that of nonselective NSAIDs
Read the article here: http://bit.ly/2mlOPAS NEW ORLEANS – The cardiovascular safety profile of the nonsteroidal anti-inflammatory drug (NSAID) celecoxib, a selective inhibitor of COX-2, is no worse than those of the nonselective NSAIDs naproxen and ibuprofen, according to a trial reported at the American Heart Association scientific sessions.
Inflammation 2, Causes of Imflammation
If you would like to get hold of my books, one on Physiology and another on Pathophysiology, check out my web site campbellteaching.co.uk Funds from selling books helps to finance distribution of resources to students in poorer countries.
Просмотров: 20365 Dr. John Campbell
Lipoprotein-Associated Phospholipase A2 Activity, Serum
The new Lipoprotein-Associated Phospholipase A2 Activity, Serum, test is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. This test should be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of coronary heart disease events. Leslie Donato, Ph.D., gives a video overview of the test:
Просмотров: 1295 Mayo Clinic Laboratories
Fish Oil Health Benefits. Or Fish Oil Uses In Telugu.
Welcome to A to Z health and beauty tips. Amazing health benefits of Fish oil or fish liver oil. Omega 3 fatty acids benefits revealed in this video. Fish oil is oil derived from the tissues of oily fish. Fish oil contain the omega 3 fatty acids eicosapentaenoic acid and docosahexaenoic acid, precursors of certain eicosanoids that are known to reduce.Omega 3 fish oil benefits and side effects is given this video.A nutritionist explains the pros and cons of fish oil supplements.Fish oil or fish oil tablets are using heart attack and blood pressure and madhumoham are not attack in your body. Some of more fish oil uses and benefits and advantages if you see on line channel A to Z health and beauty tips. If you like this video please share to this channel and subscribe this channel. Thank you.
Просмотров: 2355 AtoZ HEALTH & BEAUTY TIPS
NSAIDs and risk of stroke -Video abstract 54159
Video abstract of Review paper "Risk of stroke associated with nonsteroidal anti-inflammatory drugs" published in the open access journal Vascular Health and Risk Managment by Park K and Bavry AA. Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs), both cyclooxygenase (COX)-2-selective and nonselective agents, have been associated with the increased risk of adverse cardiovascular events. The majority of studies have focused on myocardial infarction as the primary cardiovascular outcome. However, the association between NSAIDs and the risk of stroke events is not as clear, although an understanding of this association is important since stroke continues to be a significant cause of morbidity and mortality. Various factors may contribute to an association between NSAIDs and stroke, including hypertension and thrombosis. Additionally, the risk may vary with different NSAID types. In this review, we discuss the relevant literature assessing the possible association between NSAID use and stroke events, along with the potential mechanisms and the possible directions for future study. Read the Review paper here: http://www.dovepress.com/risk-of-stroke-associated-with-nonsteroidal-anti-inflammatory-drugs-peer-reviewed-article-VHRM
Просмотров: 513 Dove Medical Press
Garret FITZGERALD: "Eicosanoid modulation and atherothrombosis"
http://www.fondazione-menarini.it Garret FITZGERALD - Philadelphia (USA)  Eicosanoid modulation and atherothrombosis Chieti (Italy), July 13th-15th, 2017  International Summit on - Atherothrombosis: 2017 Update
Просмотров: 17 Fondazione Internazionale Menarini
Pharmacology ,  1 , HISTAMINES , Autocoids
Просмотров: 14428 Rajeev Ranjan Gupta
NSAIDs - Putting Risk into Perspective
This video outlines the benefits and risks of using NSAIDs to treat osteoarthritis. It specifically focuses on the cardiovascular and gastrointestinal risks putting them into perspective for everyone to understand.
Просмотров: 492 RheumInfo
Gastrointestinal Risk with NSAIDs
NSAID stands for non-steroidal, anti-inflammatory drug. These are anti-inflammatory medicines, medicines which decrease inflammation. They are typically used to treat pain, arthritis, and are commonly taken for either the short term or the long term. Most NSAIDs have stomach side effects because they decrease your body's natural protection against acid in the gastrointestinal tract. Additional important FDA safety information on NSAIDs: http://www.fda.gov/CDER/drug/infopage/COX2/NSAIDmedguide.htm Made possible by a grant from Pfizer, Inc.
Просмотров: 14515 AmerGastroAssn
Foods low in arachidonic acid
Dr. Barry Sears discusses foods that are low in arachidonic acid. Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He has published more than 30 scientific articles and holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 13 books, including the New York Times #1 best-seller "The Zone". These books have sold more than 5 million copies in the U.S. and have been translated into 22 different languages. For more, go to zonediet.com
Просмотров: 3001 Dr. Barry Sears
OmegaQuant Test for Silent Inflammation
OmegaQuant Test is a finger prick test for silent inflammation, risk for heart disease, depression, weight gain, weight loss resistance. Omega 6 fats in our diet increases inflammation by increasing Arachadonic acid, and messengers that cause illness. Fish oil counters this. OmegaQuant test helps to guide your omega3 intake.
Просмотров: 995 concordweightloss
Episode 166 -- Polyunsaturated fatty acids (PUFA) and their effects on human body -- Healthy Living
Are so called essential fatty acids truly essential? It's believed that PUFAs suppress the function of thyroid along with myriad of other side effects. Aram and Ruben share their wisdom.
Просмотров: 3800 Aram Hovsepian
EPA and Cox 1 Enzyme
EPA and Cox 1 Enzyme Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He has published more than 30 scientific articles and holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 13 books, including the New York Times #1 best-seller "The Zone". These books have sold more than 5 million copies in the U.S. and have been translated into 22 different languages. For more, go to zonediet.com
Просмотров: 939 Dr. Barry Sears
NSAIDs & GI Side Effects | TYLENOL® Professional
See how non-steroidal anti-inflammatory drugs (NSAIDs) can affect gastric mucosal protection, which can lead to GI side effects such as irritation and bleeding. For more information, visit TylenolProfessional.com. This video is intended for U.S. healthcare professionals only.
Просмотров: 10945 TYLENOLOFFICIAL
Pharma Tube - 21 - Autacoids - 3 - Vasoactive Peptides (Angiotensin and Bradykinin) [HD]
- فارما تيوب Pharma Tube هى سلسلة من الفيديوهات تحتوى على محاضرات فى علم الفارماكولوجى الأساسى والإكلينيكى يقدمها دهشان حسن دهشان الشرح من كتاب فارما جايد Pharma Guide - لمعلومات أكثر عن الكتاب www.facebook.com/Pharma.Guide.book - الموقع الرسمى للفيديوهات www.pharmatube.blogspot.com - للتواصل مع المؤلف www.facebook.com/Dr.Dhshan Pharma Tube is a videos by Dahshan Hassan Dahshan containing lectures about basic and clinical pharmacology which prepared from Pharma Guide book For more information about Pharma Guide book, click here www.facebook.com/Pharma.Guide.book Official Pharma Tube website www.pharmatube.blogspot.com For contact with the author www.facebook.com/Dr.Dhshan
Просмотров: 16643 Dhshan Hassan Dhshan
Parkinson's Disease and Alzheimer's Disease
This Lecture talks about Parkinson's Disease and Alzheimer's Disease
Просмотров: 556 Cec Ugc