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Aspirin and Prostaglandins
 
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Aspirin, or acetylsalicylic acid, is one of the oldest and most well-known medications for headaches, fever, pain, and even prevention of heart attack and stroke. How does this drug cause relief of these symptoms? Check out this episode of Medicurio to learn about the quite interesting mechanism of aspirin in the body. Detailed Mechanism of Aspirin: There are two major forms of cyclooxygenase (COX) in cells. COX-1 is always made in the cell, while COX-2 is only made during inflammation. Aspirin permanently inhibits the COX-1 isoform (version) by acetylation of its active site. Therefore, aspirin’s effect lasts however long it takes for the cell to transcribe and translate new COX-1 enzymes, which usually takes a few hours. COX-1 decreases fever, pain, and inflammation, but also increases the risk of gastric ulcers by decreasing clotting and stomach mucous production. The COX-2 isoform is thought to only produce prostaglandins involved in fever, pain, and inflammation but not other functions; therefore, making a drug that inhibits COX-2 instead of COX-1 would give all the anti-inflammatory effects of aspirin without the risk of gastric ulcers. Such a drug would be a major upgrade and many companies came up with possible COX-2 inhibitors. One such drug, called rofecoxib or Vioxx, entered the market claiming that it would not cause gastric ulcers. What the drug company did not reveal was that during clinical trials, many patients suffered from heart attacks after chronic use. These problems began to surface once the general public began using Vioxx, leading to withdrawal of the drug and lawsuits against the company. Moral of the story? Research integrity is important, especially for a drug company as people’s lives are at stake. Trivia about Aspirin: It is debated if Felix Hoffmann was the true “inventor” of aspirin. Arthur Eichengrün, a fellow Bayer employee, claimed that he was the one who came up with the procedure and that Hoffmann simply performed the reaction following his guidelines. Bayer has denied this claim. Hoffmann synthesized aspirin for his father, who complained about the taste of salicylic acid that he was taking to treat his arthritis. Aspirin is extremely toxic to cats (which cannot break down aspirin) and to a lesser extent, dogs. Despite this, aspirin can still be used, just at low doses, to treat inflammation in animals. You can overdose on aspirin – at lethal doses, aspirin interferes with energy production in the mitochondria which leads to eventual death. Before death, unique symptoms such as ringing in the ears, hyperventilation, and dizziness, as well as non-specific symptoms such as vomiting and nausea appear. Overdoses are often due to chronic aspirin use, so if any of these symptoms apply to you, speak to a doctor immediately. Aspirin’s effect is increased by ingesting it with caffeine because caffeine is a stimulant, which increases blood flow to carry aspirin around the body faster and begin acting on tissue quicker. Acetaminophen (Tylenol) is not technically an NSAID because it does not decrease inflammation; however, it also works on COX enzymes so I have lumped it with the other NSAIDs in this video for simplicity.
Views: 69322 Medicurio
NSAIDs and Heart Disease - Mayo Clinic
 
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Have a headache? Chances are, when life causes aches and pains, many of us reach for the ibuprofen. But if you also take aspirin to protect against heart disease, there are some things you need to know.
Views: 16542 Mayo Clinic
Inflammatory response | Human anatomy and physiology | Health & Medicine | Khan Academy
 
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Overview of the inflammatory response. Created by Sal Khan. Watch the next lesson: https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/rn-blood-cell-lineages?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Missed the previous lesson? https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/how-white-blood-cells-move-around?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Health & Medicine on Khan Academy: No organ quite symbolizes love like the heart. One reason may be that your heart helps you live, by moving ~5 liters (1.3 gallons) of blood through almost 100,000 kilometers (62,000 miles) of blood vessels every single minute! It has to do this all day, everyday, without ever taking a vacation! Now that is true love. Learn about how the heart works, how blood flows through the heart, where the blood goes after it leaves the heart, and what your heart is doing when it makes the sound “Lub Dub.” About Khan Academy: Khan Academy is a nonprofit with a mission to provide a free, world-class education for anyone, anywhere. We believe learners of all ages should have unlimited access to free educational content they can master at their own pace. We use intelligent software, deep data analytics and intuitive user interfaces to help students and teachers around the world. Our resources cover preschool through early college education, including math, biology, chemistry, physics, economics, finance, history, grammar and more. We offer free personalized SAT test prep in partnership with the test developer, the College Board. Khan Academy has been translated into dozens of languages, and 100 million people use our platform worldwide every year. For more information, visit www.khanacademy.org, join us on Facebook or follow us on Twitter at @khanacademy. And remember, you can learn anything. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s Health & Medicine channel: https://www.youtube.com/channel/UC1RAowgA3q8Gl7exSWJuDEw?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Views: 1133918 Khan Academy
The Role of Molecular Clocks in Cardiovascular Disease
 
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Josh Beckman, MD, chair of the council on Peripheral Vascular Disease, interviews Distinguished Lecturer Garret FitzGerald, MD about his research on the role of molecular clocks in cardiometabolic disease.
Views: 253 AHAScienceNews
What are prostaglandins? -- FabFats Clip: Mary Toscano Healthy Living
 
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http://www.marytoscano.com/fabulousfats/video This clip from nutrition education video "Fabulous Fats: Setting the Record Straight" has Mary Toscano explaining prostaglandins and their role in the body. To watch the whole presentation, pick up a copy at http://www.marytoscano.com/fabulousfats/video. ABOUT FABULOUS FATS: In this dynamic, musical and highly visual talk, discover the vital role fats play in feeling energized, slim and strong. See which fats are essential for the heart, brain, eyes and reducing painful inflammation. Discover which fats help with joint pain, arthritis, memory and mood swings, and which damaged fats must be avoided! Certified Nutrition Educator Mary Toscano has taken a complicated, confusing subject and made it accessible. Answers the questions: *** I'm eating low-fat and no-fat foods so why am I still gaining weight? *** How do I know if a fat is good or bad? *** What's the big deal about trans fats? *** Are there oils I shouldn't cook with? For over thirty years, fat in our diet has been associated with obesity, heart disease, and high cholesterol. Recent studies dispel these beliefs and prove that good fats are absolutely essential to our health and well-being. But which fats are good? Sifting through all the information on fats can leave you with even more questions. No one has made this information simple. Until now... Produced by Mary Toscano Healthy Living. Playing Time: 65 min.
Views: 30800 HealthyLivingABCs
TheSynapse eLearning - Role of Aspirin in Prevention of Cardiovascular Disease
 
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Aspirin was discovered in 1897. Since then it has been used extensively in the prevention of Cardiovascular disease. The ESC Guidelines 2012 state that 'Aspirin cannot be recommended in primary prevention due to its increased risk of major bleeding' This video highlights the role of aspirin in current practice.
Views: 377 TheSynapse
NSAID Pharmacology: What is a Prostaglandin?
 
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This video examines a fascinating class of endogenous hormones called prostaglandins. It is a general introduction to the characteristics of these signalling molecules as well as some of their chemical properties. The lecture ends by placing prostaglandins in the context of the NSAID mechanism of action. Enjoy! #khanacademytalentsearch
Views: 63636 Armaan Malhotra
Prostaglandins in Health and Disease
 
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The prostaglandins, a group of physiologically active compounds having diverse hormone-like effects. They have been found in almost every tissue in humans and other animals
Endothelial Secretions for Cardiovascular Regulation - Prostaglandins - Nitric Oxide - Endothelins
 
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Check out the following links below! Over 1000+ Medical Questions: http://www.5minuteschool.com DONATE + SUPPORT US: http://paypal.me/5minuteschool Patreon: https://goo.gl/w841fz Follow us on Twitter: http://twitter.com/5MinuteSchool Follow us on Instagram: http://instagram.com/5minuteschool My personal Instagram: http://instagram.com/shahzaebb Contact us: contact@5minuteschool.com ______ ◅ Donate: http://www.5minuteschool.com/donate ◅ Website: htttp://www.5minuteschool.com ◅ Twitter: http://www.twitter.com/5minuteschool ◅ Instagram: http://www.instagram.com/5minuteschool ◅ Facebook: http://www.facebook.com/5minuteschool ◅ Email: contact@5minuteschool.com
Views: 4671 5MinuteSchool
Dietary Fats: Healthy Fat vs. Bad Fat- Thomas DeLauer
 
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http://ThomasDeLauer.com Click here to subscribe to my YouTube Channel : https://www.youtube.com/thetdelauer?sub_confirmation=1 Monounsaturated Fats: Oleic Acid - Omega 9- These Protect Cell Membranes from Free Radicals. Oleic acid replaces other omega fatty acids in cell membranes. Since oleic acid is less susceptible to oxidation damage than omega-6 and omega-3 fatty acids, replacing these fatty acids with oleic acid protects your cell membranes from free radicals and other oxidative stressors (1) Palmitoleic Acid - Omega 7- These Reduce Insulin Resistance. Omega-7 protects the insulin-producing cells of the pancreas from glucose-induced toxicity - enhances proliferation of pancreatic beta cells, helping your body optimize blood sugar control with its own natural insulin (2) Reduce Inflammation- Study from the Cleveland Clinic Wellness Institute in Ohio conducted the first randomized, controlled trial in humans of supplementation with purified omega-7. Subjects were randomly assigned to receive either an omega-7 supplement providing 220 mg palmitoleic acid or a placebo - capsules were taken once daily, with a meal, and blood testing was done at the beginning of the study and again after 30 days. At 30 days, the supplemented group showed a significant mean lowering in C-reactive protein with a 44% reduction compared with the control group. Omega-7-supplemented subjects also had 15% reductions in triglyceride levels (3) Polyunsaturated Fats: Omega 3 & 6- Omega 3’s- Eicosapentaenoic acid (EPA): This 20-carbon fatty acid's main function is to produce chemicals called eicosanoids, which help reduce inflammation. EPA also helps reduce symptoms of depression. Docosahexaenoic acid (DHA): A 22-carbon fatty acid, DHA makes up about 8% of brain weight and is extremely important for normal brain development and function. EPA and DHA support cellular membranes and keep them flexible - maintaining the fluidity of the cell membranes allows for proper communication between nerve cells and, therefore, helps to support focus and mental clarity. Alpha-linolenic acid (ALA): This 18-carbon fatty acid can be converted into EPA and DHA, although the process is not very efficient. ALA is mainly used by the body for energy (4) Omega 6’s: The most common omega-6 fat is linoleic acid, which can be converted into longer omega-6 fats such as arachidonic acid (ARA) Like EPA, ARA is used to produce eicosanoids - however, the eicosanoids produced by ARA are more pro-inflammatory. Pro-inflammatory eicosanoids are important chemicals in the immune system, but when too many of them are produced, they can increase inflammation - modern Western diet contains far more omega-6 fatty acids than necessary (4) Trans Fats: Trans fats block the production of Type 1 and 3 prostaglandins (PGs), which are derived from the omega 6 and omega 3 fats, respectfully. Type 1 and 3 PGs help you fight inflammation and benefit your hormonal and nervous system (5) Saturated Fats: Studies in favor of saturated fats- A meta-analysis study, published 2010, which pooled data from 21 studies and included nearly 348,000 adults, found no difference in the risks of heart disease and stroke between people with the lowest and highest intakes of saturated fat (6) A Japanese prospective study that followed 58,000 men for an average of 14 years found no association between saturated fat intake and heart disease, and an inverse association between saturated fat and stroke (i.e. those who ate more saturated fat had a lower risk of stroke) (7) References: 1) Oleic Acid Health Benefits: MooScience. (n.d.). Retrieved from http://mooscience.com/Oleic-Acid.html 2) Omega-7 Protects and Metabolic Syndrome - page 1 | Life Extension. (n.d.). Retrieved from http://www.lifeextension.com/Magazine/2014/4/Omega-7-Protects-Against-Metabolic-Syndrome/Page-01 3) Omega-7 An Overlooked Fatty Acid - Life Extension. (n.d.). Retrieved from http://www.lifeextension.com/Magazine/2016/5/Omega-7-An-Overlooked-Fatty-Acid/Page-01 4) Omega-3-6-9 Fatty Acids: A Complete Overview. (2017, January 15). Retrieved from https://www.healthline.com/nutrition/omega-3-6-9-overview#section4 5) Hydrogenated Fat Dangers | Understand Trans Fats Dangers. (n.d.). Retrieved from http://www.drgangemi.com/health-topics/nutrition-and-supplements/hydrogenated-fat-dangers/ 6) Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation ... - PubMed - NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20685950?dopt=AbstractPlus 7) PubMed. (n.d.). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20071648?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2%20Am%20J%20Clin%20Nutr
Views: 125886 Thomas DeLauer
Garret FITZGERALD: "Eicosanoid modulation and atherothrombosis"
 
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http://www.fondazione-menarini.it Garret FITZGERALD - Philadelphia (USA)  Eicosanoid modulation and atherothrombosis Chieti (Italy), July 13th-15th, 2017  International Summit on - Atherothrombosis: 2017 Update
The Endocannabinoid System [ECS] and its Role in Metabolic Processes
 
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The Endocannabinoid System: An Overview 'Marijuana has been used as a medicine for thousands of years with evidence dating back to 2000 BC, but only in the past few decades have scientists truly understood how it works. What led to this understanding was the discovery of the endocannabinoid system; a unique biological system that facilitates the effects of marijuana within the human body. The endocannabinoid system is a central regulatory system that affects a wide range of biological processes. It consists of a group of molecules known as cannabinoids as well as the cannabinoid receptors that they bind to. Although marijuana is a source of over 60 cannabinoids (including THC and CBD), the human body produces a number of cannabinoids as well. These endogenous cannabinoids include anandamide and 2-arachidonoylglycerol (2-AG) and are present in all human beings. Decades of scientific research on the endocannabinoid system has resulted in the discovery of two types of cannabinoid receptors, CB1 and CB2. These receptors are found in various parts of the body, but are most prominent in the brain and immune system. Cannabinoid receptors act as binding sites for endogenous cannabinoids as well as cannabinoids found in marijuana. When cannabinoids bind to CB1 or CB2 receptors, they act to change the way the body functions. While cannabinoid receptors are primarily expressed in the brain and immune system, researchers have identified cannabinoid receptors in a variety of other places as well, including the peripheral nervous system, cardiovascular system, reproductive system, and gastrointestinal and urinary tracts. Cannabinoid receptors continue to be identified in unique parts of the body as research on the endocannabinoid system progresses.' Full article ~ http://www.truthonpot.com/2013/03/22/the-endocannabinoid-system-an-overview/ Wiki - Endocannabinoid System 'The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as "endocannabinoids" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems. The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of physiological processes, including motor learning, synaptic plasticity, appetite, and pain sensation.' Full article ~http://en.wikipedia.org/wiki/Endocannabinoid_system National Center for Biotechnology Information (NCBI) - The Endocannabinoid System as an Emerging Target of Pharmacotherapy 'The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease. Such studies have been greatly facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, as well as mice deficient in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase. In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.' Full overview ~ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/ Copyright Disclaimer - allowance is made for "Fair Use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. All rights and credit go directly to its rightful owners.
Nonsteroidal Anti Inflammatory Drugs (NSAIDs) and Cardiovascular Risk
 
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Article Here: http://www.quantumday.com/2012/05/nonsteroidal-anti-inflammatory-drugs.html After nearly 13 years of study and intense debate, a pair of new papers from the Perelman School of Medicine, at the University of Pennsylvania have confirmed exactly how a once-popular class of anti-inflammatory drugs leads to cardiovascular risk for people taking it. Credit: Perelman School of Medicine, University of Pennsylvania
Views: 1276 Quantum Day
Histamine, Prostaglandin, Leukotrienes, Bradkinin, PGE2 LTB4 Chemotactic Factors
 
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http://www.stomponstep1.com/histamine-prostaglandin-leukotrienes-bradkinin-pge2-ltb4-chemotactic-factors/ There are a groups of inflammatory signals that play key roles in the early phases of acute inflammation. These signals cause the cardinal signs of inflamation and are involved in the inflammatory mechanism. The Cardinal Signs of Inflammation are the signs and symptoms that results directly from acute inflammation. * Fever is associated with inflamation and is caused by the release of PGE2 (Prostaglandin E2), however it is not a cardinal sign of inflammation. Histamine is released from mast cells in response to cell injury, complement activation, or membrane bound IgE being crosslinked by antigen. Histamine then increases venule permeability, dilates the arterioles and prepares the vessel wall for neutrophil extravasion. In other words, Histamine is the main signal that initiates the fluid phase (But it gets helps from other cytokines). Histamine is the mediator of type 1 hypersensitive reactions (anaphylaxis & allergies) and signals stomach acid to be secretion. Antihistamines that primarily antagonize the H1 Histamine receptors are used to treat allergic symptoms, while antihistamines that primarily antagonize the H2 Histamine receptor are used to treat things like GERD and Peptic Ulcer Disease. Histamine has the help of other signals during acute inflammation. Following injury, Coagulation Factor XII (Hageman Factor) is activated by exposed collagen in the vessel wall. Factor XII then initiates the Kinin-Kallikrein System that creates Bradykinin. Bradykinin plays an important role in pain, arteriole dilation and increased venule permability during acute inflammation. We will cover elsewhere the effect coagulation factor 12 has on clotting. Angiotensin Converting Enzyme (ACE) breaks down bradykinin. Therefore, ACE Inhibitors increase bradykinin levels which can cause cough, angioedema and vasodilation. Arachidonic Acid is created when cell membrane phospholipids are acted upon by Phospholipase A2. Arachidonic Acid which is acted upon by Cycloxygenase to create Prostaglandins or Lipoxygenase to create Leukotrienes. Both classes of signal molecule play a role in acute inflammation by contributing to the fluid phase (arteriole dilation and venule permeability). PGE2 (Prostaglandin A2) is involved in the signaling process for pain and fever. LTB4, a specific type of leukotriene, is also a Chemotactic Factors which means it attracts neurtophils to the site of injury (AKA leukocytosis). The other main Chemotactic Factors are IL-8 and C5a. We will discuss prostaglandins and leukotrienes in many other videos as they are involved with the pathophysiology and treatment of many disease. Leukotrienes are involved in the pathophysiology of Asthma and their action is antagonized by receptor blocker Montelukast. Both class of molecule can be reduced to lessen the pain and inflammation. Corticosteroids inhibit Phospholipase A2 to decrease the levels of prostaglandins and Leukotrienes. NSAIDs inhibit Cyclooxygenase to decrease prostaglandin levels. Synthetic prostaglandins can be used to keep a Patent Ductus Arteriosus open in a newborn (if they have a congential heart defect that requires that route of blood flow), while an NSAID like Indomethacin can be used to close a PDA. Nuetrophils are the predominant inflammatory cell in acute inflammation. They phagocytose (engulf) infected or necrotic cells and use free radicals to destroy them. They also release granules full of proteins and enzymes that help fight infection or clear cellular debris. Neutrophils are attracted to and activated by chemotactic factors (Leukotriene B4, C5a, and Interleukin-8) created during acute inflammation. Neutrophil extravasation (AKA Leukocyte extravasation) is the process by which neutrophils exit the circulatory system into the damaged tissue. Later in the inflammatory process Macrophages use these same steps to get to the effected tissue. Pictures Used: • Derivative of “Leukozytenmigration 01” by Armin Kübelbeck available at http://commons.wikimedia.org/wiki/File:Leukozytenmigration_01.png via Creative Commons Attribution • “Lips Mouth Smile Teeth Happy Laugh Red White” available at http://pixabay.com/en/lips-mouth-smile-teeth-happy-156991/ via Public Domain
Views: 36026 Stomp On Step 1
Autacoids - 03 - Prostaglandins, TXA2, leukotrienes
 
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Video lectures in clinical pharmacology by Dr. Abdel-Motaal Fouda, associate professor of clinical pharmacology, Mansoura Faculty of Medicine. 2016. foudaamm@mans.edu.eg
Views: 10305 Abdel-Motaal Fouda
Anatomy of the Heart
 
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http://www.handwrittentutorials.com - This tutorial explores the gross anatomy of the heart. It covers the chambers, vessels and valves of the heart. For more entirely FREE medical tutorials, visit http://www.handwriitentutorials.com
Views: 90493 Handwritten Tutorials
NSAIDS PRESENTATION
 
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This video is about NSAIDS PRESENTATION
Views: 15023 stefany maldonado
ECG 3 - Segments, Intervals & Diseases
 
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http://www.handwrittentutorials.com - This tutorial is the third in the ECG series. This video explores the various segments and intervals seen on an ECG trace and how changes in these divisions can be indicative of various heart diseases. For more entirely FREE tutorials and their accompanying PDFs, visit http://www.handwrittentutorials.com
Views: 112152 Handwritten Tutorials
Prostaglandins & NSAIDs - Part 2 of 2
 
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How are prostaglandins produced and what is their role in inflammation and pain? How do the non-steroidal anti-inflammatory drugs (NSAIDs) reduce prostaglandin production?
NSAIDs and Renal Function
 
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See how non-steroidal anti-inflammatory drugs (NSAIDs) can affect kidneys with some degree of dysfunction and potentially further compromise renal function. For more information on the safety differences of OTC analgesics, visit http://www.tylenolprofessional.com/the-tylenol-difference.html This video is intended for U.S. healthcare professionals only. ©McNEIL-PPC, Inc. 2013. All rights reserved.
Views: 17242 TYLENOLOFFICIAL
Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk
 
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, https://plus.google.com/communities/115462130054650919641?sqinv=VFJWaER0c2NCRl9ERzRjZWhxQmhzY09kVV84cjRn , ,https://plus.google.com/u/0/+AlexandrosGSfakianakis , https://www.youtube.com/channel/UCQH21WX8Qn5YSTKrlJ3OrmQ , https://www.youtube.com/channel/UCTREJHxB6yt4Gaqs4-mLzDA , https://twitter.com/g_orl?lang=el, https://www.instagram.com/alexandrossfakianakis/, Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients Guillermo Gervasini, Enrique Luna, Guadalupe Garcia-Pino, Lilia Azevedo, Sonia Mota-Zamorano & Juan José Cubero https://doi.org/10.1080/03007995.2017.1391757 Abstract Objective: Arachidonic acid metabolism by cytochrome P450 (CYP) epoxygenases leads to epoxyeicosatrienoic acids (EETs), which are eicosanoids with vasodilator and anti-inflammatory properties. We aim to determine whether genetic variability in these routes may contribute to cardiovascular (CV) risk in renal transplant recipients. Methods: In a cohort of 355 patients, we determined the presence of two polymorphisms, CYP2C8*3 and CYP2J2*7, known to affect eicosanoid levels. Associations with CV mortality, CV event-free long-term survival and graft survival were retrospectively investigated by logistic regression models. Results: CYP2J2*7 showed a statistical trend towards higher CV mortality (p = .06) and lower cardiac or cerebral event-free long-term survival (p = .05), whilst CYP2C8*3 displayed a significant inverse association with the risk of CV event (hazard ratio [HR] = 0.34 [0.15–0.78], p = .01). The association of CYP2J2*7 with CV mortality became significant when the analysis was restrained to 316 patients without a history of CV events prior to transplantation (HR = 15.72 [2.83–91.94], p = .005). In this subgroup of patients both single nucleotide polymorphisms (SNPs) were significantly associated with event-free survival. HR values were 5.44 (1.60–18.51), p = .007 and 0.26 (0.09–0.75), p = .012 for CYP2J2*7 and CYP2C8*3, respectively. Conclusions: Our results show, for the first time to our knowledge, that two SNPs in CYP2C8 and CYP2J2, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events. Keywords: Epoxyeicosatrienoic acids, cardiovascular disease, genetic polymorphisms, renal transplant, CYP450 - video upload powered by https://www.TunesToTube.com
Heart Disease and Inflammation
 
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Get to the HEART of the matter.... It's NOT Fat!!! (Healthy fat doesn't cause inflammation.)
Views: 78 mWell Solutions
Inflammation in 100 Seconds
 
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While routine lipid screening plays an important role in cardiovascular risk assessment it does not provide a complete picture of your health. In fact, nearly 50% of all heart attacks and strokes occur in patients with ‘normal’ cholesterol levels. Recent evidence goes beyond lipids to suggest that inflammation within the artery wall is the primary contributor to this residual risk for heart attack and stroke. Inflammation contributes to both vulnerable plaque formation and to plaque rupture.
Views: 222 Cleveland HeartLab
What is the Omega-3 Index?
 
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The Omega-3 Index is a blood test that measures the amount of omega-3 fatty acids (EPA and DHA) in red blood cell membranes. An Omega-3 Index in the range of 8%-12% is an indicator of better overall health. This is based on studies reporting that people with a higher Omega-3 Index are at decreased risk for heart disease, loss of cognitive function, bipolar disorder, ADHD, depression and age-related macular degeneration. Importantly, people with higher levels live longer than those with lower levels. The Omega-3 Index is an actionable biomarker that changes quickly by increasing omega-3 intake. To order your Omega-3 Index test visit www.omegaquant.com.
Views: 169 OmegaQuantLab
HEART DISEASE: GENETIC VARIATIONS IN CHOLESTEROL TRANSPORT
 
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HEART DISEASE_GENETIC VARIATIONS IN CHOLESTEROL TRANSPORT
Views: 1281 Walter Jahn
Part II - Nitric Oxide and Shear Stress
 
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In this part, I discuss the important role of nitric oxide for vasodilatation and maintaining an atheroprotective environment. I also provide some insight on how shear stress stimulates the endothelial cells to release nitric oxide. PLEASE ALSO SEE MY IN-DEPTH VIDEO ABOUT THE CELLULAR MECHANISMS OF VASODILATATION: https://youtu.be/Ojla4MCvs1Y More information can be found in my review paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040999/pdf/TOCMJ-4-302.pdf
Lipoprotein-Associated Phospholipase A2 Activity, Serum
 
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The new Lipoprotein-Associated Phospholipase A2 Activity, Serum, test is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. This test should be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of coronary heart disease events. Leslie Donato, Ph.D., gives a video overview of the test:
Bilirubin 2 - Bilirubin Metabolism & Diseases
 
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http://www.handwrittentutorials.com - This tutorial is the second of the Bilirubin series. It explains the process of Bilirubin Metabolism in the liver. This tutorial also discusses the hereditary diseases associated with failure of metabolism. For more entirely FREE medical tutorials and accompanying PDFs visit http://www.handwrittentutorials.com
Views: 139041 Handwritten Tutorials
Correct Arachidonic Acid Levels
 
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Correct Arachidonic Acid Levels Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He has published more than 30 scientific articles and holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 13 books, including the New York Times #1 best-seller "The Zone". These books have sold more than 5 million copies in the U.S. and have been translated into 22 different languages. For more, go to zonediet.com
Views: 4045 Dr. Barry Sears
Prudence Sinclair interviews Dr. Barry Sears -  What would you do if you got cancer?
 
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Find out what Dr. Barry Sears would do if God forbid he was diagnosed with Cancer. Subscribe to my channel to get more interviews. wwwprudenncesinclair.com Dr. Barry Sears: Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. A turning point in his research occurred in 1982. That year the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones known as eicosanoids play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug-delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug. This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug-delivery system to modulate eicosanoids, especially for cardiovascular, diabetic, and neurological patients.
Pharma Tube - 38 - CNS - 2 - Insomnia, Anxiolytic and Hypnotic Drugs [HD]
 
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فارما تيوب Pharma Tube هى سلسلة من الفيديوهات تحتوى على محاضرات فى علم الفارماكولوجى الأساسى والإكلينيكى يقدمها الصيدلى دهشان حسن دهشان الشرح من كتاب فارما جايد Pharma Guide Pharma Tube is a videos by Ph; Dahshan Hassan Dahshan containing lectures about basic and clinical pharmacology which prepared from Pharma Guide book ** هذة الحلقة تنقسم الى جزئين: - الجزء الأول: * التعريف بكتاب DSM-5 ومعرفة انواع Sleep Disorders بالكتاب. * الحديث عن Physiology of Sleep وتفاصيل Sleep-Wake Cycle * التعريف ب circadian biological clock * العلاقة بين الضوء وهرمون الميلاتونين و Suprachiasmatic Nucleus * شرح Sleep Stages * التعريف بمرض الأرق Insomnia * DSM-5 Criteria of Insomnia * انواع الأرق Types of Insomnia وشرح كل نوع * مسببات الأرق Causes * شرح طرق Cognitive Behavioral Therapy for Insomnia (CBT-I - الجزء الثانى : * رصد أدوية Anxiolytic and Hypnotic Drugs o Barbiturates; which are no longer indicated; o Non-barbiturates; e.g., Chloral Hydrate (limited indications). o Benzodiazepines; which are widely used sedative-hypnotics. o Non-benzodiazepines; e.g., Zolpidem, Zaleplon, Zopiclone and Eszopiclone. o Serotonin Agonists; Buspirone is a partial agonist on 5-HT1A receptors. o Melatonin Agonists; Ramelteon is a melatonin receptor 1 and 2 agonist. o Orexin Antagonists; Suvorexant; is an orexin receptor antagonist. o First Generation Antihistamines; e.g., Doxylamine. o Antidepressants; e.g., Doxepin. o Herbal Agents; e.g., Kava-Kava ******************** لمعلومات أكثر عن الكتاب For more information about Pharma Guide book, click here https://goo.gl/izPQDe للتواصل مع المؤلف For contact with the author https://goo.gl/6qRWyN (CNS) Playlistجميع حلقات جزء https://goo.gl/3n6ZbT هذه المحاضرات للمختصين في المجال الطبي، الصيادلة أو الأطباء وعلى الرغم من هذا فقد لا تتوافق مع النظم الصحية المعمول بها في بلدك فبرجاء مراجعتها أولاً. These lectures for specialists in the medical field, pharmacists or physicians and although this may not conform with applicable in your country health systems sure to first review.
Views: 22955 Dhshan Hassan Dhshan
Prostaglandins and Their Inhibitors
 
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Garret A. FitzGerald, M.D. Professor Medicine and Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania Associate Dean Translational Research Perelman School of Medicine University of Pennsylvania
Views: 121 UCLA CTSI
Endothelium Dependent Vasodilation Part 3
 
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In this video we discuss the mechanisms underlying endothelium dependent vasodilatation, specifically looking at nitric oxide, prostacyclin and endothelium dependent hyperpolarization..
Views: 790 Ben1994
Fats and Oils Demystified by Steve Blake, ScD
 
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Americans are facing epidemics of heart disease, cancer, diabetes, and arthritis. Rather than spending trillions on treatments, why not address the causes of these modern scourges? This is an explanation of the roles of cholesterol, omega-3s, saturated fats, and trans fats in health and disease. The quantity and balance of dietary fats influence immune response and inflammation through eicosanoids and prostaglandins. The best oils are rich in vitamin E and contain the healthiest ratio of omega-6 to omega-3 essential fatty acids. Modern research is helping us find the best and worst dietary fats and oils. Steve Blake, ScD has just finished a book on dietary fats: Fats and Oils Demystified.
Views: 28 Steve Blake, ScD
How Many People Are Affected By Heart Disease?
 
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Heart disease world heart federation. Cdc 200,000 heart disease deaths could be prevented each year and stroke statistics 2017 update american 2013 global, local, gender, more. Taking up to 800,000 next year, more people will have access preventative care and doctors who 'even one preventable death is too many,' said frieden feb 9, 2017 the following are 10 points remember about updated report from american heart association on disease stroke 28, 2014 learn latest statistics, number cause of in u. Suffer heart attacks each year. Number of heart disease deaths per 100,000 population by gender in america facts & statistics close the gap. Coronary heart disease (ischaemic disease) nhs choices. Heart disease facts & statistics aug 10, 2015 about 610,000 people die of heart in the united states every year that's 1 4 deaths. One in 9 deaths 2009 included heart failure as contributing cause. Adults national jun 16, 2016 about 5. Heart disease and stroke statistics at a glance american heart association associationwho. Million adults in the united states have heart failure. Of these, 515,000 are a first heart attack and 205,000 happen in people who have already had jan 25, 2017 here few key statistics about disease, stroke, other for the health is association's disease stroke dec 17, 2014 2015 prevalence an estimate of how many specific condition or risk factor at given point time. Million were due to coronary heart disease and obesity, physical inactivity harmful use of alcohol using population wide people in low middle income countries who suffer from cvds other each year, is at the top list country's most serious health problems. Government agencies periodically in 2008, 405,309 people died from coronary heart disease. Heart disease heart health canada. Lack of exercise people who do not regularly are at greater risk having heart have had a attack, high cholesterol, or blood pressure sep 3, 2013 disease is the leading cause death in u. Ssince death rates are affected by the population composition of a given area, age adjusted get facts about heart disease in america and learn why we need to 'close gap' on cardiovascular care disparities 2014, 3. About half of people who develop heart failure die within 5 years diagnosis about 720,000 in the u. Remember me jan 30, 2017 there are many factors that increase the risk of heart disease. Every year about 785,000 americans have a first coronary attack. In order to access member content you have be a of the world heart federationpassword. Heart disease and stroke statistics 2017 at a glance. Heart disease statistics the heart foundation. Age adjusted rates per 100,000 u. More than half of the deaths due to heart disease in 2009 were men may 3, 2017 number adults with diagnosed 28. Cardiovascular diseases (cvds)johns hopkins medicine health affected by cardiovascular disease? Secondscount. Million; Percent of source summary health statistics tables for u. Quick facts heart disease in minnesota. In fact, stati
Views: 21 Cash for Question
3 Ways A Ketogenic Diet Improves Brain Function
 
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3 Ways A Ketogenic Diet Improves Brain Function The ketogenic diet remerged in recent years when people realized they would have more energy and elevated mental acuity when following it. After years of sideways science claiming that the body must have a constant intake of carbohydrate to be healthy, people are discovering the truth. On top of improved mental performance, the ketogenic diet is now being highlighted as a therapeutic strategy for mental illness and neurodegenerative diseases. Here I am going to break down the benefits and applications of the ketogenic diet for brain-related disorders. There are several clinical applications for a ketogenic diet. understanding what happens inside the body when you are burning ketones instead of sugar as your primary source of energy. 1. Less Oxidative Stress. Oxidative stress is beneficial in small amounts, however in excess it can be very damaging to your mitochondria. Excessive oxidative stress creates inflammation and hampered mitochondrial energy output. Because oxidative stress causes damage on the mitochondrial level, this can negatively impact every cell in your body. Also, because your brain is so reliant on healthy mitochondria, it is the first to suffer consequences of excess oxidative stress. Oxidative stress is a natural byproduct of energy production in the mitochondria. Ketone metabolism has been shown to create much lower levels of oxidative stress in comparison to glucose metabolism, effectively lowering inflammation and supporting mitochondrial health . Ultimately, this results in improved energy production. Neurodegenerative disorders that are characterized by demyelination, such as multiple sclerosis, are thought to be heavily influenced by chronic inflammation, making the ketogenic diet a desirable therapy for yet another reason. 2. Omega 3 Favoring. Most people today following the standard American diet are consuming lots of oxidized omega-6 fats and very little omega-3 fats from fish and pastured-raised meats. Omega-6 fatty acids are utilized in the eicosanoid pathway in the body which is important for producing inflammation. While temporary inflammation is helpful for stimulating healing in the body, an excessive omega-6 level can contribute to chronic inflammation that only causes more problems. The way I teach a ketogenic diet includes plenty of HEALTHY fats that help bring this ratio back to a balanced level and help lower inflammation. Increasing your ratio of omega-3 to omega-6 fatty acids can lower heart disease risk, improve arthritis, lower cancer risk, and improve brain function. 3. Mitochondrial Biogenesis. When it comes down to it, your body needs energy to perform its functions. This energy comes in the form of ATP that is produced primarily by structures called mitochondria that inhabit just about every cell in your body. Cells in certain areas of the body have way more mitochondria than the rest and this reflects the amount of energy they need to function properly. Among these areas is the brain. By improving the number and energetic output of the mitochondria in your brain, you provide a significantly higher amount of energy. This in of itself, may provide much of the brain boosting benefits. Fasting and a ketogenic diet are some of the most promising methods for upregulating mitochondrial biogenesis. Subscribe our channel : https://www.youtube.com/channel/UCCnPhOx7d2SjLjzV_32BYJg Watch this : https://www.youtube.com/watch?v=6UEoE7GnZyU&feature=youtu.be https://www.youtube.com/watch?v=xPC0ybCaTRk&feature=youtu.be https://www.youtube.com/watch?v=C-F9C1X9yeo&feature=youtu.be Keywords : chiropractic, natural cures, owners-guide.com, wellness, chiropractor, john, bergman, family, health, healthy, cure, cause, solution, problem, disease, illness, education, teaching, seminar, lecture, body, heal, healing, brain, Mike, Vanderschelden, Michael, Van, mind, function, Intermittent, Fasting, Fat, Ketones, Ketosis, Sugar, Blood, Glucose, Insulin, Diabetes, Alzheimer's, Dementia, memory, cognitive, increased, Exercise, adjustment, physiology, proprioception, nervous, system, improve, nutrition, food 3 Ways A Ketogenic Diet Improves Brain Function
Views: 16 healthylife
Coagulation Cascade - Part 7/12
 
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Watch 700+ videos at https://www.DrNajeebLectures.com ★★ Get Lifetime access for $10 ONLY! ★★ ───────────────── OUR YOUTUBE CHANNEL ───────────────── Here on YouTube, we only upload our Free sample videos. If you like these free videos then check out our complete video library on our website at https://www.DrNajeebLectures.com ──────────────────── ABOUT DR. NAJEEB LECTURES ──────────────────── Dr. Najeeb Lectures are the World’s Most Popular Medical Lectures. Trusted by 80% of Medical, Dentistry, Nursing & Pharmacy students in 190 countries. Over 10 million minutes of videos are watched every month. Visit our website to access 700+ videos on Basic Medical Sciences & Clinical Medicine with thousands of hand-drawn illustrations and pneumonics. ────────────────────── WHY SIGN UP FOR MEMBERSHIP? ────────────────────── ► 700+ Medical Lectures. ► Basic Medical Sciences. ► Clinical Medicine. ► New videos every week in HD. ► Download videos for offline access. ► Watch videos at 1.5x fast speed. ► Watch videos on any device. ► Fanatic customer support. ► Trusted by 80% of Medical Students. Learn more at https://www.DrNajeebLectures.com
Views: 135148 Dr. Najeeb Lectures
OmegaQuant Test for Silent Inflammation
 
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OmegaQuant Test is a finger prick test for silent inflammation, risk for heart disease, depression, weight gain, weight loss resistance. Omega 6 fats in our diet increases inflammation by increasing Arachadonic acid, and messengers that cause illness. Fish oil counters this. OmegaQuant test helps to guide your omega3 intake.
Views: 982 concordweightloss
Why Omega-6 Fat Matters for Your Health by Bill Lands, PhD
 
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Learn how most chronic diseases could be prevented by lowering omega-6 fats in the diet and why supplementing with fish oil and omega-3 fats is not enough. Scientist, Bill Lands, PhD, cuts to the chase, and provides compelling reasons Americans need to re-think what constitutes a healthy diet. This is a trailer/clip of Dr. Lands talk delivered at the National Institute's of Health two-day conference omega-3 fatty acids. For the full presentation (37 minutes) and a 19-Page Handout click on this link (it's free): http://bit.ly/38mnAM For more information on omega-6 news and food resources, see www.Omega-6-News.org
Views: 6175 Omega6News
11 PM1 MOA of nsaids
 
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Mechanism of action of Non-steroidal anti-inflammatory drugs
Views: 20395 Health Pod
Omega 3 Fatty Acids and Inflammation
 
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How the ratio of Omega-3 to Omega-6 fatty acids can cause inflammation in your body and lead to disease down the road.
Views: 841 KehresHealth
Book Review: "Perfect Health Diet" by Paul Jaminet 2012 PH.D.
 
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If you eat in the wrong proportions, lean tissue will reject some of the excess energy and it will have to be stored as fat in adipose tissue. Compared to other primates, humans have a 12 percent smaller liver and a 40 percent smaller gut. Compared to Europeans, Africans have slightly larger colons. Sugar is easily obtained today and the "food reward system" still encourages us. But our "lazy forager system" no longer discourages us. The standard zoo diet for gorillas has not met their natural diet. In rats given a low dose of aflatoxin daily, after six months all rats on a 20 pecent protein diet were still alive, but half the rats on a 5 percent protein diet had died. When protein intake exceeds 45 percent of calories, nausea and diarrhea begin in days and death can follow in weeks. Rabbit diet When starches (potatoes) are cooked in boiling water, their GI is low, 50 or 60; but roasted, their GI reaches 100. 97 Low carbs improve heart disease problems, compared to high carbs Omega-3 fats originate in green leaves and algae, while omega-6 fats mostly come from seeds. Coldwater fish, salmon, arctic char, have a lot of PUFA in order to maintain flexible membranes at cold body temps. the body uses oxidated HUFA to sense and regulate the local level of oxidative stress. The pattern is obvious: give sugar or alcohol in combination with either omega-6 or omega-3 PUFA, and mice develop fatty liver and metabolic syndrome. Give a diet without PUFA, and the liver does fine. Olso Diet-Heart Study shows that omega 3 lowers heart attacks, but increases cancer. aspirin works by preventing omega-6 fats from being turned into eicosanoids. Totally eliminate vegetable seed oils. We recommend making fish, shellfish, and ruminant meats your principal meats, eaten five days of the week. Eat chicken and pork only occassionally for variety. Muscles grows the primary body body component that grows in order to store excess fat. A typical adult male contains 66 pounds of skeletal muscle, or about 200,000 calories- enought to maintain life for sixty to seventy days without food. blueberry fiber is more beneficial than rye or oat bran. Eating less makes us preoccupied with food. Hunger is danger. The brain can't drectly monitor nutrient status, but it can monitor whether tissues are functioning properly. Intracellular magnesium levels are les than half as high in the obese than in the nonobese. Iron deficiency is associated with obesity. 73.8 percent of obese were zinc deficient. Animal foods are generally nontoxic rickets were commonly associated with mortality. If a processed food has an unusually small serving size, it may be because it has a lot of trans fat! Some of the most dangerous toxins in cereal grains are destroyed by boiling, but not dry by dry heat. Fruit flies live longer on organic bananas. Hormone dependent cancers, such as breast, ovarian, colon cancer were 50 to 80 percent less frequent in Okinawa than in the United States. Start by excluding four major toxic food groups: grain, legumes, sugars, vegetable oils. A study found that copper levels in UK foods have declined by 90 percent in dairy products, 55 percent in meat and 76 percent in vegetables. Weston Price said that facial structures are different because of butter, magnesium, calcium, phosphorous, K2.
Views: 203 Travis Heinze
What is the link between aspirin and asthma ?
 
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A short #FOAMed video about the interesting pharmacology of aspirin and its role in exacerbating symptoms of asthma, allergic rhinitis and nasal polyps.
Views: 3682 Lyndal Parker-Newlyn
Quantitative Study on the Arachidonic Acid Metabolic Network Dynamics || Dance Your PhD 2016
 
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My PhD work was focusing on the arachidonic acid metabolic network, which produces key inflammatory mediators that contribute to many major diseases such as rheumatoid arthritis, inflammatory bowel disease, asthma, and even cancer. In the United States, more than 1% of the population uses nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, or naproxen, daily to relieve aches and pains. Although NSAIDs do alleviate the aches and pains, these drugs have undesirable side effects on the gastrointestinal tract and the central nervous system. The withdrawal of VIOXX from Merck in 2004 has given a good lesson on safety problems. How to design effective anti-inflammatory drugs with less toxicity remains a great challenge. My PhD work at Peking University Chemistry Department mainly focused on quantitative study on the arachidonic acid metabolic network dynamics, as well as dual-functional inhibitor design against cyclooxygenase and 5-lipoxygenase. The dance mainly shows my dual-functional inhibitor design work. During the first part of the dance, we show the audience one of the key enzymes in the arachidonic acid metabolic network — cyclooxygenase (COX). This enzyme can convert its substrate arachidonic acid (AA) into prostaglandin, which is an inflammatory mediator. In the second part, we introduce the concept of “competitive inhibitor”. Drug A was designed as COX “competitive inhibitor”, which binds the active site of COX, preventing a real substrate (AA) from binding and a product (prostaglandin) from being formed. In the third part of the dance, we introduce a dual functional inhibitor — drug B. Drug B was designed based on the structure of drug A. Moreover, drug B can bind two targets in the arachidonic acid metabolic network. Drug B also has a higher binding affinity against the two targets, therefore has a better control of the network balance and lead to safer treatment.
Views: 8269 Aditya Vempaty
Can cortisol cause inflammation ? | Best Health Channel
 
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Until now, it has not been clear exactly how stress influences disease and health. Googleusercontent search. Avoid these 10 foods that increase cortisol & impede optimal top 5 causes of chronic inflammation youtube. Cortisol its role in stress, inflammation, and indications for diet cortisol todaysdietitian newarchives 111609p38. A silent killer in our midst the christian broadcasting network. Systemic inflammation, as noted previously, causes elevated cortisol levels. Each of these three hormones contributes to silent inflammation. From stress to inflammation and major depressive disorder a the anti inflammatory effects of cortisol wilson's wikipedia. 9 2008 a study now reveals that stress causes deterioration in everything from your prolonged exposure to cortisol inhibits the growth of new neurons, and can cause ordinarily, inflammation is how the healthy body deals with 16 low cortisol levels can greatly affect the quality of your life, causing such as inflammatory disorders, certain types of cancers, psoriasis, and 17 some types of inflammation can cause so much stress on our body cortisol decreases the inflammatory pathways within the body's tissue as you can see, inflammation is quite common and caused by more than just emotional or physical stress raises the level of cortisol, creating inflammation these disorders are caused by the inflammation and cortisol we produce to fight most people with untreated cushing's syndrome will die from heart disease 7 most of us can probably guess that stress affects the body negatively cortisol plays a significant role in turning off inflammatory reactions 17 by planning your diet wisely, you can help lower cortisol causing inflammation, activating the immune system, and altering stress hormone 23. Eicosanoids how can the type of fat you eat cause silent inflammation? As a lipid 29 2011 stress hormone cortisol elevates during stress, and in short term this internally caused inflammation take toll on skin however, chronically high levels blood decrease white cells glucocorticoids, since they reduce inflammatory response this, causes atrophy muscle (mainly fast twitch 2) bone learn fibromyalgia trigger pain to overcome it so does come into picture? . Inflammation skin enemy number one youbeauty precision nutrition. This can trigger the hyperkalemia of metabolic shock from surgery while both physical and emotional stress inflammation, turning off process is controlled by cortisol, our body's anti hormone 20 in this way, chronic inflammation lurk like a silent enemy with these hormones then cause body to produce more cortisol (the 24 do you know what does why need it, though? The decreased blood flow gi tract also incredible problems decreases reducing secretion 23 medication use, poor sleep diet high levels altering hormonal balances negatively 6 2007 order understand just how affect immune system, standpoint, delayed inflammatory response caused cortisol's however, elevated prolonged or side lower your immunity 11 causes cortisolwhat increases inflammatory, but it arthritis addition, either intestinal chemicals imbalances due fatigue findings about role play? In patients undergoing cardiac surgery, procedure that lot steroid regulates wide range processes acting as an influencing memory formation, controlling salt water over time lack sex drive and. Cortisol helps to mobilize blood sugar so that you can run effectively and efficiently. Revealing the fundamentals of chronic inflammation and adrenal ups downs cortisol what you need to know. Inflammatory findings about cortisol dartmouth medicine magazineyou and your hormones from the society for endocrinology. Does stress cause digestive problems? Kelsey kinney. Inflammation the real cause of all disease and how to reduce cortisol potbelly syndrome. From gut to brain the inflammation connection kelly. Shtml url? Q webcache. If we can naturally decrease inflammation in the body and minimize stress, decreased cortisol levels should follow, resulting chronic disease risk improved wellness 2 summary stress wreaks havoc on mind. Cortisol top 10 negative health effects and surprising benefits the stress effect richard weinstein, dc benjamin designs. Breaking cortisol levels under control naturally drstress, cortisol, and the immune system what makes us get sick? The stress connection. Cortisol and fibromyalgia triggers pain & inflammation learn how stress causes whole body deterioration news medical. When used as a examples include inflammatory and rheumatoid diseases, well allergies. Cohen argued that prolonged stress alters the effectiveness of cortisol to regulate inflammatory response because it decreases tissue sensitivity hormone adrenal fatigue can play havoc with your levels, sending them either too this causes inflammation, which is often a good thing (it means immune 13 increases in inflammation turn elicit profound changes altered or prolonged, actually cause conceptual model these cytokine dynamics depicted fig
Views: 315 BEST HEALTH Answers
What Does Fish Oil Do To Your Body
 
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Omega-3 fish oil contains both docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Omega-3 fatty acids are essential nutrients that are important in preventing and managing heart disease. Findings show omega-3 fatty acids may help to: Lower blood pressure.Fish oil comes from the tissues of oily fish. ... When it comes to human consumption of fish oil, you can get it from fish themselves or from a fish oil supplement. Fish oil is a concentrated source of omega-3 fats, which are also called ω-3 fatty acids or n-3 fatty acids.Fish Oil May Have Skin Benefits. The skin is the largest organ in the human body, and it contains a lot of omega-3 fatty acids (67). Skin health can decline throughout your life, especially during old age or after too much sun exposure.There are few supplements on the market that offer as many benefits as fish oil does. Regardless of who you are, it's almost ... oil capsules as much or as often. However, you should remember that many fish varieties do contain higher levels of mercury, which also needs to be monitored in the human body.Salmon, mackerel, herring, sardines, lake trout, and tuna are especially high in omega-3 fatty acids. While foods are your best bet for getting omega-3s in your diet, fish oil supplements are also available for those who do not like fish. The heart-healthy benefits of regular doses of fish oil supplements are ...Volunteers who were given fish oil in their diet showed greater weight loss as compared to those who did not regularly consume it. Fish oil contains omega-3 fatty acids, which help to promote the weight loss, so a combination of physical workout and intake of this oil helps in reducing body fat significantly faster.What does fish oil do for you? We all need a diet rich in ... fish oil do I need? The SIDE EFFECTS of Omega 3 deficiency on your health can be taxing. .... Omega-3 and Omega-6 fatty acids have shown to be effective in controlling the amount of cytokines and eicosanoids in your body. 23. Anti-Inflammatory: ...In honor of Mother's Day, here's a look at the benefits of fish oil for women. ... For the best results, take at least 3,000 milligrams of a quality supplement every day - liquid fish oil is stronger than capsule, and your body absorbs it more effectively ... Moms have a lot to do, so they need a strong immune system. Reasons You Should Be Taking Fish Oil. It may not boost your heart health, but the supplement does yield benefits for your brain, lungs, skin, and muscles. by Brittany ... and 15-25 percent less fat than the control mice. The researchers believe in humans, fish oil supplements might help reduce weight gain later on in life. Docosahexaenoic acid (DHA): In humans, this omega-3 fatty acid is a key part of sperm, the retina, a part of the eye, and the cerebral cortex, a part of the brain. DHA is present ... PLoS One. However, another study indicated that high levels of omega-3 do not prevent cognitive decline in older women.Studies show fish oil offers a range of health benefits, including promoting heart health. Learn more about fish oil and what it can do at Everyday Health.Supplementing your diet with fish oil may prevent the muscle loss that commonly occurs in cancer patients who undergo chemotherapy. The trial involved 16 patients who took fish oil (2.2 g of eicosapentaenoic acid/day) and 24 patients who did not. Patients who did not take fish oil lost an average of 2.3 kg ...Fish oil contains omega-3 fatty acids, which are essential fatty acids that your body needs for optimal health. Because fish oil supplements can cause side effects, the University of Maryland Medical Center recommends that you should take no more than 3 grams of omega-3 fatty acids per day from supplements, unless your ...“One of the most special things about omega-3s in fish oil is that it caters to the natural oils we produce in our body helping us to be maintained and balanced,” says Pekar. “Topical use does not affect your skin like it would if your body would to digest it.” This is largely in part because most people need ...
Views: 16 Health Care