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Can-Fite's CF602 Demonstrates Efficacy in Treatment of Sexual Dysfunction in Preclinical Studies
PETACH TIKVA, Israel, Jan. 27, 2015 /PRNewswire/ -- Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (CFBI.TA), a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, today reported it has received positive data regarding its CF602 drug candidate in preclinical studies conducted by a third party. CF602 was tested in an experimental animal model of diabetic rats, which similar to diabetic patients, suffer from sexual dysfunction. Erectile dysfunction was assessed by monitoring the ratio between intra-cavernosal pressure (ICP) and mean arterial pressure (MAP) as a physiological index of erectile function. The ICP/MAP for the CF602 treated group improved by 118% over the placebo group. This data is similar to that achieved earlier by sildenafil (Viagra) in preclinical studies. In addition, treatment with CF602 reversed smooth muscle and endothelial damage, in a dose dependent manner, leading to the improvement in erectile dysfunction. CF602 is a novel A3 adenosine receptor allosteric modulator, enhancing the affinity of the natural ligand adenosine to its A3 adenosine receptor. "Our drugs, based on the A3 adenosine receptor platform, have been administered to over 1,200 patients in clinical studies and shown an excellent safety profile. We believe this has the potential to give us a huge advantage over current drugs in the erectile dysfunction market which are known to have adverse effects, hampering diabetic patients and other populations from using them on a daily basis," stated Can-Fite CEO Dr. Pnina Fishman. Based on positive results from this preclinical study, the Company recently announced its plans to initiate a pre-clinical development program for CF602 in order to file an investigational new drug application (IND) with the U.S. Food and Drug Administration to allow human Phase I studies for the indication of sexual dysfunction. Can-Fite has a strong intellectual property position which includes an issued "composition of matter" patent and other pending patent applications protecting the use for sexual dysfunction. GlobalData estimates the value of the erectile dysfunction therapeutic market to be approximately $2.7 billion with few drugs in the market which include Viagra, Cialis and Levitra.
Просмотров: 174 CorporateProfile
Erectile Dysfunction: Harbinger of Heart Disease?
In a video originally posted on TheHeart.org | Medscape Cardiology, Charanjit (Chet) Rihal, MD, Stephen Kopecky, MD, discuss how erectile dysfunction may portend coronary disease in middle-aged men, so don't sweep this complaint under the rug.
Просмотров: 918 Mayo Clinic
LMD & Genetic Analyses in new Preclinical Models -  Elisa Giovannetti
In this Webinar, after a technical presentation by Dr. Tamara Straube, Dr. Giovannetti discuss the advantages of using LMD techniques for precise, contamination-free isolation of specific cell types in various applications, such as using pancreatic cancer tissue sections from patients and orthotopic xenografts. Thus, this webinar provides an overview of the scientific and practical considerations for obtaining highly pure material for molecular analysis in the field of pharmacological studies to overcome key mechanisms of resistance in pancreatic cancer.
Просмотров: 58 Cancer Pharmacology Lab
30. Esomeprazole as an Example of Drug Testing and Usage
Freshman Organic Chemistry (CHEM 125) The chemical mode of action of omeprazole is expected to be insensitive to its stereochemistry, making clinical trials of the proposed virtues of a chiral switch crucial. Design of the clinical trials is discussed in the context of marketing. Otolaryngologist Dr. Dianne Duffey provides a clinician's perspective on the testing and marketing of pharmaceuticals, on the FDA approval process, on clinical trial system, on off-label uses, and on individual and institutional responsibility for evaluating pharmaceuticals. 00:00 - Chapter 1. Introduction: The Chemical Properties and Reactivity of Prilosec 06:58 - Chapter 2. The Economics of Clinical Trials 19:57 - Chapter 3. Duffey: How Do I Know that the Drug is Effective? 30:26 - Chapter 4. The Phases of Clinical Trials, Results for Esomeprazole and Omeprazole, and Off-Label Use 42:01 - Chapter 5. Pharmaceutical Marketing Mentality and Q&A Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses This course was recorded in Fall 2008.
Просмотров: 8618 YaleCourses
Harmone - Injections Of This New Hormone May Make You Horny Again | injecting testosterone
Harmone - Injections Of This New Hormone May Make You Horny Again | injecting testosterone Injections Of This New Hormone May Make You Horny Again Boost Your Libido: Good news for guys struggling with low sex drive: Injections of a hormone called kisspeptin may jumpstart your lagging libido, scientists from the U.K. say. The researchers discovered that injecting the newly-discovered, naturally-occurring hormone stimulated areas of the brain typically activated by sexual arousal and romance. Research is still preliminary, but it’s possible the findings may one day be used to treat men with psychological sexual problems - commonly occurring in those struggling with infertility. Praise Poop: Fecal transplants - where stool from a healthy donor is transferred to a sick patient - have been used to treat severe, recurring diarrhea that results as a complication of antibiotic therapy. Now, it may have another use: A small study from the Ohio State University found that children with autism who received fecal transplants experienced an improvement in autism-related symptoms and gastrointestinal symptoms. Larger, more rigorous studies must be done to confirm the results before it can be used clinically, the researchers say. Sleep Well: Think your sleep sucks? It might, especially if you’re not hitting the determinants of quality sleep, as established by a panel of sleep experts. The key factors related to good sleep are: sleeping more than 85 per cent of the time you’re in bed, falling asleep within 30 minutes or less, waking up no more than once per night, and awakening for 20 minutes or less after initially falling asleep, according to the National Sleep Foundation. Reverse Memory Loss? Turn up the radio: Music may help reverse early memory loss, according to a new study in the Journal of Alzheimer’s Disease. After adults with subjective cognitive decline - a possible preclinical sign of Alzheimer’s - completed either a beginner meditation or music-listening program for 12 minutes a day for 12 weeks, they showed significant improvements in memory function.
Просмотров: 3538 Care Tv
Methods and Techniques for Integrating Biological Variable Sex in Preclinical Research - AM
One of the fundamental variables in preclinical biomedical research is sex: whether a cell, tissue, or animal is female or male. Biological sex is an important consideration for this research that underlies drug development, clinical trials, and prevention approaches. Learn how to incorporate sex to strengthen scientific design from leaders in the field through this recorded full-day meeting hosted by the NIH Office of Research on Women’s Health. In this video covering the morning sessions, learn more about the importance of reproducibility in biomedical research, the concept of including male and female subjects in studies, and the impact of including or not including sex as a basic biological variable.
Просмотров: 1719 NIHOD
Introduction to Clinical Pharmacology and Therapeutics - Module 1, Session 1
Introduction to Clinical Pharmacology and Therapeutics - Module 1, Session 1 with Dr. Juan J. L. Lertora This is Module 1, Session 1, of the NIH Clinical Center's "Principles of Clinical Pharmacology" course. The course is a lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. If you have any questions or need additional information regarding the Principles of Clinical Pharmacology course, please email the course coordinator at: cc-od_clinp@mail.nih.gov.
Просмотров: 2309 NIH Clinical Center
Pharmaceutical Drugs That Changed Our World
Pharmaceutical Drugs That Changed Our World Pharmaceutical Drugs That Changed Our World Viagra Aspirin Penicillin You liked the music that played in this video? The Tadros Brother are also a performing duo and have 8 albums but also love doing 3 Info-entertainment videos a day. Discover them here: https://itunes.apple.com/ca/artist/tadros-brothers/id680352095 https://itunes.apple.com/ca/artist/tadros/id399429 Rebel: http://youtu.be/wuvLqRIFD0E C'est ainsi: http://youtu.be/VMuMIocXvzU Pornstar: http://youtu.be/_IIPtUgwD5g Yo quiero Bailar: http://youtu.be/FkVWbxIpmq0 Music By Tadros Brothers: Buy https://itunes.apple.com/ca/album/djembe/id1105075833 https://itunes.apple.com/ca/artist/les-freres-tadros/id1104075284 Facebook: https://www.facebook.com/TadrosBrothers/ Twitter: https://twitter.com/tadros_brothers Original Djembe Video: https://www.youtube.com/watch?v=wHpHrdG3VN0
Просмотров: 36 Daniel Tadros
Unraveling the role of sex in renal ischemia tolerance
Sex-specific differences have been observed in preclinical models of renal ischemic injury. In particular, females recover more readily from ischemia-reperfusion injury (IRI) than males, and testosterone has been shown to have a negative effect on renal ischemia tolerance. The factors that underlie these sex-dependent discrepancies are poorly understood, and it is not clear if these same differences extend to humans. In this episode, Matthew Levine and David Aufhauser describe the development of several murine renal ischemia and transplant models used to evaluate sex-specific effects on recovery after IRI. Their results demonstrate that recipient, not donor, sex determines transplantation outcomes. Moreover, evaluation of patient data from the United Network for Organ Sharing revealed that male recipients had increased delayed graft function compared to female recipients.
Просмотров: 635 Journal of Clinical Investigation
Artículos consultados: Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men. Weapons of penile smooth muscle destruction: androgen deficiency promotes accumulation of adipocytes in the corpus cavernosum. Androgens Play a Pivotal Role in Maintaining Penile Tissue Architecture and Erection: A Review. What Causes Morning Wood or Morning Erections? In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study. Effects of Acutely Displaced Sleep on Testosterone. Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. Circadian rhythm of hormones is extinguished during prolonged physical stress, sleep and energy deficiency in young men Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence. Sleep Architecture When Sleeping at an Unusual Circadian Time and Associations with Insulin Sensitivity. Sleep, Rhythms, and the Endocrine Brain: Influence of Sex and Gonadal Hormones. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Effect of androgens on penile tissue. Study on nocturnal penile tumescence (NPT) in healthy males. Study on the relationship between the serum free testosterone level and NPT. y otros.
Просмотров: 5 MSB
NIHR new media competition entry 2012 Communicating your research CKD is a chronic condition and we wanted to show how we are tackling CKD, in an engaging way, as a research team. We have a great team of individuals who span secondary care, general practice and implementation. NIHR funding has brought us together and we really believe we are making an evidence based impact into the early detection, prevention and management of CKD in primary care. See us at www.impakt.org.uk
Просмотров: 1943 philip shelton
Riociguat is a novel drug that is a stimulator of soluble guanylate cyclase. Clinical trials have looked at riociguat as a new approach to treat two forms of pulmonary hypertension: chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Riociguat constitutes the first drug of a novel class of sGC stimulators. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video
Просмотров: 2976 Audiopedia
TRACO 2016: Genomics and Case reports
TRACO 2016: Genomics and Case reports Air date: Monday, October 31, 2016, 4:00:00 PM Category: TRACO Runtime: 01:43:41 Description: Genomics and Case reports For more information go to http://ccr.cancer.gov/trainee-resources-courses-workshops-traco Author: Jun S. Wei, Ph.D, NCI, NIH and Oluwadamilola Olaku, MD, NCI, NIH Permanent link: https://videocast.nih.gov/launch.asp?19975
Просмотров: 290 nihvcast
TRACO 2016: Radiation oncology and Small molecules
TRACO 2016: Radiation oncology and Small molecules Air date: Wednesday, October 12, 2016, 4:00:00 PM Category: TRACO Runtime: 01:49:40 Description: Radiation oncology and Small molecules For more information go to http://ccr.cancer.gov/trainee-resources-courses-workshops-traco Author: E. Nichols, MD., University of Maryland and Anton Simeonov, Ph.D.,NIH Permanent link: https://videocast.nih.gov/launch.asp?19919
Просмотров: 506 nihvcast
PACCARB Day 1 Presentation: Incentives - International Experience
Third public meeting of the Presidential Advisory Council on Combating Antibiotic Resistant-Bacteria (PACCARB). For more information, visit http://www.hhs.gov/ash/advisory-committees/paccarb. -- U.S. Department of Health and Human Services (HHS) http://www.hhs.gov We accept comments in the spirit of our comment policy: http://www.hhs.gov/web/socialmedia/policies HHS Privacy Policy http://www.hhs.gov/Privacy.html
Potential Benefits of Herbal and Dietary Supplements
Presented by Stanford Cancer Supportive Care Program Cancer patients are often interested in using herbal and dietary supplements as forms of alternative medicine. This presentation gives a brief overview, answers some common questions, and discusses the appropriate use of herbal and dietary supplements. Speakers: Abraham Chang, PharmD and Eun Jeong Kim, PharmD, MS
Просмотров: 723 Stanford Health Care
Erectile Dysfunction - What Happens When Your Banana Turns Into A Cashew
Subscribe for daily weight loss, fitness, health and funny videos! Raw Food Guru
Просмотров: 240 Raw Food Guru
PCSBI Meeting Two: Sept. 13-14, 2010 in Philadelphia, Penn., Session 3: Knowledge Sharing,
Recordings of the public meetings of the Presidential Commission for the Study of Bioethical Issues (2009 - 2017). 10:45 a.m.-12 p.m. Session 3: Knowledge Sharing, Innovation and Translating Research for the Public Good [Video] [Transcript] Arti K. Rai, J.D. Elvin R. Latty Professor of Law Duke University School of Law Center for Public Genomics, Institute for Genome Sciences and Policy Duke University Ashley J. Stevens, D.Phil. [Slides] Special Assistant to the Vice President of Research Office of Technology Development Senior Research Associate, Institute for Technology Entrepreneurship and Commercialization Boston University President, Association of University Technology Managers David B. Weiner, Ph.D. [Slides] Professor, Pathology Laboratory Medicine Chair, Therapy and Vaccines Program CAMB University of Pennsylvania
Просмотров: 18 Bioethics Library