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Search results “Low expression of vitamin d receptor”
Dr. Michael Holick - Vitamin D Linked to Gene Expression
 
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with Dr. Michael F. Holick, MD, Ph.D. Professor, Boston University Topic: Vitamin D & Gene Expression By: Dr. Michael Holick Event date: 4/9/13 Webinar presented by GrassrootsHealth.
Views: 8600 vitaminDaction
Here’s What to Do About VDR Mutations | Chris Masterjohn Lite #44
 
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Are mutations in your genes for the vitamin D receptor impacting your vitamin D requirements? There are three common genetic variants, known as Taq1, Bsm1, and Fok1. They’ve been associated with the risk of certain diseases but no one has quite sorted out what they are actually doing. It’s possible they raise your need for vitamin D. Watch this video for my recommendations on what to do if you have them. I recommend testing your VDR genes with StrateGene, which you can get here: chrismasterjohnphd.com/strategene For more information on how to get the StrateGene report, watch this video: https://chrismasterjohnphd.com/2017/12/04/know-need-care-mthfr/ You may also enjoy these other two videos I made about vitamin D testing: https://chrismasterjohnphd.com/2017/05/16/tell-difference-vitamin-d-calcium-deficiencies/ https://chrismasterjohnphd.com/2017/05/18/vitamin-d-normal-pth-high/
Views: 1462 Chris Masterjohn, PhD
How your DNA is linked to Vitamin D
 
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How does your DNA affect your Vitamin D intake and what does that mean? Transcript: hi again my name is Yusufa and i'm the CEO of AthGene, welcome to another episode of genes behind the scenes so today we're going to talk about vitamin D and not just vitamin D in general terms but more specifically how your DNA is linked to your requirements of vitamin D. But first things first what is vitamin D and why is it even important. Vitamin D is produced in the skin from cholesterol as well as sunlight and it's very essential for lots of physiological processes such as bone health, your immune system as well as your general ability to absorb essential nutrient. So all things considered I would say vitamin D is pretty important. But here's the thing some of us require more vitamin D than others simply because our bodies don't have a good uptake of vitamin D. So for most people with a vitamin D deficiency the signs can be really subtle and really easy to miss. I mean it can include things like you know, just generally feeling a bit more tired as well as not feeling you know like your usual self. Feeling slightly down and you may have already made the connection between the typical lack of sunlight during the winter months as well as a higher report of people feeling less than their usual selves during these winter months. And that's because they could be genetically predisposed for having a low uptake of vitamin D. And when you couple that factor with sort of the general lack of sunlight in the winter months this could mean that people feeling like crap to put it in no other way. So it does not have to be this way there is something that you can do about this now. If you're based in Europe the EU has a recommended sort of a dosage of how much vitamin A people should have. If you're in the US the FDA has a different recommendation but there is a recommendation of how much vitamin D we should have and some of us are not getting it. Simply because maybe we have a low uptake of vitamin D and then some other factors like we're not getting enough from food etc. Here's what you can do about it. By simply understanding what your vitamin D deficiency levels are you could take precautionary measures such as eating certain kinds of foods. Just to give you some ideas you could eat fish, eggs, even fish eggs if that's your thing and you can also get smaller amounts of vitamin D from other kinds of foods such as chicken as well as dairy products. So in conclusion if you or someone you care about have not felt yourself or you've noticed the days are less productive, less active or just overall feeling less than your usual self particularly during the winter months, perhaps it could just be that you have a low vitamin D uptake. So I would certainly go and get that checked out! Thank you for your time again Yusufa here from AthGene and this is another episode of genes behind the scenes. See you in the next episode
Views: 171 AthGene
Capnine, substance produced by bacteria, docks to VDR (Vitamin D Receptor)
 
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Capnine, substance produced by bacteria, docks to VDR (Vitamin D Receptor)
Views: 549 maciej wrotek
Rhonda Patrick at Orthomolecular Medicine Congress in Bussum, Netherlands (Keynote Oct. 3rd, 2015)
 
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In this video recorded Oct. 3rd, 2015, Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). Discussion includes how micronutrient inadequacies are very prevalent, and how her mentor, Dr. Bruce Ames, found that the body does a strategic rationing so that those proteins and enzymes in the body which are essential for short-term survival get their share of vitamins and minerals at the expense of other proteins and enzymes that are essential for long-term survival. This results in insidious types of damage and may lead to diseases of aging such as cancer and neurodegenerative diseases. She also discusses her ongoing clinical research on the role of DNA damage in cancer and aging and how her data shows that obese individuals have much more DNA damage than lean individuals, her recent research on how vitamin D is needed to produce serotonin in the brain and how this may be relevant for the prevention of autism because serotonin shapes the structure and wiring of the developing fetal brain. Finally, she talks about her research on how omega-3 fatty acids regulate serotonin release from neurons and receptor function and how vitamin D and omega-3 fatty acids are important to prevent brain dysfunction particularly in individuals that have gene polymorphisms in the serotonin pathway that predispose them to low serotonin. ▶︎ Join my weekly newsletter: http://www.foundmyfitness.com/?sendme=nutrigenomics ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe on YouTube: http://www.youtube.com/subscription_center?add_user=foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 24671 FoundMyFitness
Vitamin D Inhibits Inflammation
 
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A study published in March of 2011 showed that low levels of vitamin D failed to inhibit the inflammatory cascade and that normal levels did. Levels of inflmamatory cytokines, interlukin 6 and TNF-alpha, correlated with low levels of vitamin D. The vitamin D receptor binds to DNA directly and activates a gene, MKP-1, which quiets the inflammatory response. It could be that chronic inflammatory diseases such as asthma, arthritis, and even cancer could benefit from maintaining a normal vitamin D level. For more information please visit www.doctorsaputo.com
Views: 1562 DoctorSaputo
Single nucleotide polymorphism SNP
 
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For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html A single-nucleotide polymorphism (SNP, pronounced snip; plural snips) is a DNA sequence variation occurring when a single nucleotide — A, T, C or G — in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes in a human. For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. In this case we say that there are two alleles. Almost all common SNPs have only two alleles. The genomic distribution of SNPs is not homogenous; SNPs usually occur in non-coding regions more frequently than in coding regions or, in general, where natural selection is acting and fixating the allele of the SNP that constitutes the most favorable genetic adaptation.[1] Other factors, like genetic recombination and mutation rate, can also determine SNP density.[2] SNP density can be predicted by the presence of microsatellites: AT microsatellites in particular are potent predictors of SNP density, with long (AT)(n) repeat tracts tending to be found in regions of significantly reduced SNP density and low GC content.[3] Within a population, SNPs can be assigned a minor allele frequency — the lowest allele frequency at a locus that is observed in a particular population. This is simply the lesser of the two allele frequencies for single-nucleotide polymorphisms. There are variations between human populations, so a SNP allele that is common in one geographical or ethnic group may be much rarer in another. These genetic variations between individuals (particularly in non-coding parts of the genome) are exploited in DNA fingerprinting, which is used in forensic science . Also, these genetic variations underlie differences in our susceptibility to disease. The severity of illness and the way our body responds to treatments are also manifestations of genetic variations. For example, a single base mutation in the APOE (apolipoprotein E) gene is associated with a higher risk for Alzheimer disease.[4] Source of the article published in description is Wikipedia. I am sharing their material. Copyright by original content developers. Link- http://en.wikipedia.org/wiki/Main_Page
Views: 101133 Shomu's Biology
Membrane Structure and Transport - Kevin Ahern's BB 451 Lecture #32  2017
 
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Contact me at kgahern@davincipress.com Friend me on Facebook at kevin.g.ahern 1. Eicosanoids are compounds made from the 20 carbon fatty acid, arachidonic acid. These include prostanoids, thromboxanes, leukotrienes and endocannabinoids. 2. Prostaglandins are like hormones, but act very close to the point of synthesis. They stimulate swelling/inflammation, creating pain, uterine contractions, and the synthesis of intestinal tissue. 3. Prostaglandins are made from arachidonic acid by cyclooxygenases. Cyclooxygenases catalyze formation of a bond that creates a cyclic structure in arachidonic acid and adds one or more oxygens to it. 4. There are different COX enzymes, called COX 1, COX 2, and COX 3. 5. COX 1 enzymes are inhibited by aspirin and other related compounds. These compounds are called Non-Steroidal Anti-Inflammatory Drugs (NSAIDS). 6. Drug manufacturers sought inhibitors of COX 2 enzymes to see if they could make a pain-kiliing NSAID that didn't affect stomach tissue. Several, such as VIOXX and Celebrex were made, but some of them had negative effects on heart tissue and had to be withdrawn. 7. The cannabinoid known as anandamide is made from arachidonic acid and ethanolamine. It is called an endocannabinoid in animals and acts on specific brain receptors. Phytocannabinoids are compounds made in plants, such as marijuana, that affect the same receptors. 8. Endocannabinoids are responsible for pain reduction and experiences like runners' high. They are synthesized during periods of heavy exercise. I didn't mention it in class, but the receptor bound by endocannabinoids is the same one affected by chocolate. 9. Steroids are derived from cholesterol. Cholesterol is important for membrane stability. Cholesterol is prominent in brain membranes - up to 14% of the dry weight of brain. Compounds related to cholesterol made in plants are called phytosterols. 10. Cholesterol is a precursor of two important classes of compounds - steroid hormones and bile acids. Steroid hormones include mineralocorticoids, progestagens, glucocorticoids, and the sex hormones - androgens and estrogens. 11. Fat soluble vitamins include vitamins A,D, E, and K. Vitamin A comes in several forms.(Note - this is a correction from the video lecture). They include the alcohol form, known as retinol. This is primarily the storage form. An aldehyde form is known as retinal and is the form found in vision (wrongly stated in class as retinol). Retinal comes in two forms - the all trans form and a form with a single cis bond known as 11-cis retinal. All vision arises from isomerization of the 11-cis form in the eye to the all trans form. 12. Vitamin D is made from cholesterol. It is important for calcium and phosphate absorption/metabolism and the level of its active form is carefully controlled by the body. Synthesis of vitamin D in the body requires UV light. 13. Vitamin E is an antioxidant in the membrane bilayer and may protect against reactive oxygen species. 14. Vitmain K is involved in blood clotting. 15. A lipid bilayer has a polar exterior facing water and a non-polar interior. As such, the bilayer provides a barrier to polar and non-polar substances. Glycerophospholipids and sphingolipids in an aqueous environment will spontaneously form a lipid bilayer. 16. Lipids in lipid bilayers are not evenly distributed. 17. There are two types of movement of lipids in membranes - lateral or transverse. 18. Lateral movements occur freely and rapidly in fluid membranes. 19. Transverse movements require enzymes for movement from one side to the other. These include flippases, floppases, and scramblases. 20. Membrane fluidity is determined by the composition of fatty acids in the bilayer's glycerophospholipids and sphingolipids. Shorter, more unsaturated fatty acids favor more fluidity at lower temperatures. 21. Membranes transition from more solid-like to more liquid-like over a range of temperature. The mid-point of this temperature ranges is known as the Tm. 22. Cholesterol in a membrane has the effect of widening the range of transition, but does not change the Tm. Membrane Transport 1. Lipid bilayers create virtually impermeable barriers to movement of most molecules except water, carbon dioxide, carbon monoxide, and oxygen. 2. Most biochemicals do not readily cross lipid bilayers. Differences in concentration of these materials across a membrane, create electrical or chemical gradients. These are sources of potential energy. 3. Osmotic pressure is a good example of a potential energy created by a chemical gradient against a semi-permeable membrane. 4. Four types of membrane proteins are integral (protein projects through both sides of the membrane), peripheral (protein projects into only one side of the membrane), anchored (protein is linked to a molecule embedded in the lipid bilayer, or associated (protein associating with a membrane by interacting with a membrane protein).
Views: 1271 Kevin Ahern
Vitamin D as a Modifier of Genomic Function and Phenotypic expression During Pregnancy
 
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Presented at: Clinical Diagnostics & Research 2017 Presented by: Bruce Hollis, PhD - Professor, Pediatrics, Biochemistry and Molecular Biology, Director of Pediatric Nutritional Sciences, Medical University of South Carolina Speaker Biography: Bruce W. Hollis, Ph.D. received his B.Sc. and M.Sc. from the Ohio State University and subsequently his Ph.D. from the University of Guelph in 1979. Dr. Hollis then completed an Endocrine Fellowship at The Case Western Reserve University School of Medicine in 1982. Dr. Hollis was then Appointed Assistant Professor of Nutrition at Case Western and remained there until 1986 when he moved to The Medical University of South Carolina where to he is Professor of Pediatrics, Biochemistry and Molecular Biology. He is also Director of Pediatric Nutritional Sciences. Dr. Hollis has studied vitamin D metabolism and nutrition for the past 35 years and has been an NIH grant recipient for the past 30 years. His current work focuses on the vitamin D requirements during pregnancy and lactation. Dr. Hollis has in excess of 200 peer reviewed articles in this area of investigation. Webinar: Vitamin D as a Modifier of Genomic Function and Phenotypic expression During Pregnancy Webinar abstract: Pregnancy represents a time of rapid bodily change, which include physical proportions, physiology and responsibility. Arguably, nothing during these times changes more than the requirement and metabolism of vitamin D, although from current Institute of Medicine (IOM) recommendations one would never surmise this fact. Do the current recommendations for the requirements of vitamin D during these critical time periods reflect emerging data? Sadly, no. The minimal recommendations by the IOM and the zero recommendation by The World Health Organization (WHO), which was echoed by a recent Cochrane Review, stating that there are simply no requirement for vitamin D during pregnancy, are contrary to expanding published data (later reviewed in this chapter) that suggest otherwise. Why these recommendations continue to be made remains unclear, but clearly not recognizing a problem exists suggests that one does not need to address the “problem.” During these dramatic times of physiologic change, the roles of vitamin D in the pregnant versus, for example, the lactating woman are quite different. In the pregnant women, we believe the primary role of vitamin D to be an immunomodulatory – rather than a calcium-regulating factor, although, it would also retain that function. Further, vitamin D inadequacy in early life is clearly an instance of the “Barker Hypothesis”. This theory states that certain adult-onset diseases might have their roots in nutritional insults sustained in the perinatal period (either in utero or in the early months of infancy or both). Clearly, conditions associated with vitamin D deficiency such as asthma, multiple sclerosis and other neurological disorders would qualify. If one is reading this review to relive the past 50 years of vitamin D recommendations during pregnancy, we suggest you read other recent publications for history in this area. However, if the reader is interested in gaining new insight into the vitamin D requirements and function during pregnancy supported by recent data, we suggest you read on. Also, with regard to randomized controlled trials (RCT’s) for vitamin D, they are largely doomed to fail. The reasons for this are many and specific cases of this failure will be presented. Earn PACE/CME Credits: 1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/virtual-event/clinical-diagnostics-research) 2. Watch the webinar on YouTube above or on the LabRoots Website (https://www.labroots.com/virtual-event/clinical-diagnostics-research) 3. Click Here to get your PACE (Expiration date – November 08, 2019 09:00 AM) - http://www.labroots.com/credit/pace-credits/2562/third-party 4. Click here to get your CME credits (Expiration date – 3 months from event) – https://www.surveymonkey.com/r/ZQ9NCR5 LabRoots on Social: Facebook: https://www.facebook.com/LabRootsInc Twitter: https://twitter.com/LabRoots LinkedIn: https://www.linkedin.com/company/labroots Instagram: https://www.instagram.com/labrootsinc Pinterest: https://www.pinterest.com/labroots/ SnapChat: labroots_inc
Views: 129 LabRoots
D3K2
 
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normal immune system function and bone health, has systemic impacts far beyond this. Although it is considered a vitamin (a necessary nutrient found in the diet), vitamin D more closely resembles and acts as a steroid hormone that broadly influences physiology. Vitamin D receptors are found in more than 36 tissue types of the body, and have been shown to influence the expression of thousands of genes, including those associated with expression of detoxification enzymes.* Vitamins K and D have interdependence in metabolic functions, as vitamin K plays a role in directing calcium deposition to the bone matrix, and insufficiency may be associated with soft tissue calcification and lower bone mineral density. * *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Immunology Naive t cells activation and proliferation
 
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the immune system and the central nervous system: these are two circumstances where there is no mouse or monkey counterpart, as highlighted by the clinical trial, and this is one of the many reasons I love immunology, unlike the circulatory system, which shows homology analogy across all organisms the immune system is not so, it is a highly specific, poorly understood system far complicated than the gross machinery of a heart or kidney. When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are activated through the following "classical" signal transduction cascade:[2] the tyrosine kinase Lck is activated, which results in phosphorylation of the CD3 coreceptor complex and ζ-chains of the TCR and activation of the ζ-chain- associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently recruits several Src homology domain–containing proteins, including phospholipase C-γ1 (PLC-γ1) activation of PLC-γ1 results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 3,4,5-triphosphate and diacylglycerol inositol 3,4,5-triphosphate triggers release of Ca2+ from intracellular stores and diacylglycerol activates protein kinase C and RasGRP RasGRP in turn activates the mitogen-activated protein kinase cascade which An alternative "non-classical" pathway involves activated Zap70 directly phosphorylating the p38 MAPK that in turn induces the expression of the vitamin D receptor (VDR). Furthermore, the expression of PLC-γ1 is dependent on VDR activated by calcitriol.[2] Naïve T cells have very low expression of VDR and PLC-γ1. However activated TCR signaling through p38 upregulates VDR expression and calcitriol activated VDR in turn upregulates PLC-γ1 expression. Hence the activation of naïve T cells is crucially dependent on adequate calcitriol levels.[2] In summary, activation of T cells first requires activation through the non-classical pathway to increase expression of VDR and PLC-γ1 before activation through the classical pathway can proceed. This provides a delayed response mechanism where the innate immune system is allowed time (~48 hrs) to clear an infection before the inflammatory T cell mediated adaptive immune response kicks in.[2]Following are some major signaling pathways, demonstrating how ligands binding to their receptors can affect second messengers and eventually result in altered cellular responses. MAPK/ERK pathway: A pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. This pathway is very complex and includes many protein components.[47] In many cell types, activation of this pathway promotes cell division, and many forms of cancer are associated with aberrations in it.[48] cAMP-dependent pathway: In humans, cAMP works by activating protein kinase A (PKA, cAMP-dependent protein kinase) (see picture), and, thus, further effects depend mainly on cAMP-dependent protein kinase, which vary based on the type of cell. IP3/DAG pathway: PLC cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) yielding diacyl glycerol (DAG) and inositol 1,4,5-triphosphate (IP3). DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and allow the passage of only calcium to move through. This causes the cytosolic concentration of Calcium to increase, causing a cascade of intracellular changes and activity.[49] In addition, calcium and DAG together works to activate PKC, which goes on to phosphorylate other molecules, leading to altered cellular activity. End-effects include taste, manic depression, tumor promotion, etc.[49]
Views: 1451 thomas underhill
Mechanism of Action of Aminosalicylates
 
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Developed and produced for http://www.MDPracticeGuide.com, a CME resource for physicians and healthcare providers. Animation Description: This animation explains the mechanism of action of aminosalicylates used for the treatment of inflammatory bowel disease (IBD). Aminosalicylates include sulfasalazine and 5-aminosalicylic acid (5-ASA). Sulfasalazine, a sulfa drug, inhibits folic acid synthesis. As such, folic acid supplements should be taken with sulfasalazine to reduce the risk of neural tube defects. Sulfasalazine exhibits anti-inflammatory properties when split by gut bacterium into its metabolites: sulfapyridine and 5-ASA (mesalamine). The anti-inflammatory benefits of sulfasalazine, are chiefly derived from 5-ASA, which has fewer side effects than sulfapyridine. As such, administration of 5-ASA alone may be preferred over sulfasalazine. 5-ASA is poorly absorbed by the intestines and systemic circulation, thus most remains in the terminal ileum and colon or is passed in the stool. 5-ASA within the lumen primarily exhibits a topical effect on the colonic epithelium. Absorbed 5-ASA is extensively metabolized to N-acetyl-5-ASA by N-acetyltransferase 1 (NAT1). N-acetyl-5-ASA then binds PPAR-gamma (peroxisome proliferator-activated receptor gamma) a nuclear hormone receptor. Binding of N-acetyl-5-ASA induces the translocation of PPAR-gamma from the cytoplasm to the cell nucleus and a conformational change in PPAR-gamma. This modification permits the recruitment of the co-activator, vitamin D3 receptor-interacting protein (DRIP), which interacts directly with PPAR-gamma. Heterodimerization with the retinoid X receptor (RXR) occurs, resulting in formation of the PPAR-RXR complex, a transcriptional regulator. The PPAR-RXR heterodimer controls transcription by binding a regulatory PPAR-gamma response element (PPRE) and modulating the expression of genes involved in the inflammation process. PPAR-RXR downregulates the nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) to reduce production of pro-inflammatory cytokines. This complex also reduces COX-2 activity, leading to a reduction in prostaglandins involved in inflammation. Novel agents with similar mechanisms to 5-ASA, but which target PPAR-gamma more efficiently and report a reduction of adverse events, are currently under investigation. For example the compound, GED-0507-34, exhibits a 100- to 150-fold greater anti-inflammatory effect than 5-ASA. A new generation of 5-ASA, balsalazide, is able to bypass the small intestine and release a high concentration of 5-ASA in the colon.
Views: 54335 Mechanisms in Medicine
Curcumin & Vitamin D Combo: Brain Protection | PuraTHRIVE- Thomas DeLauer
 
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Curcumin & Vitamin D Combo: Brain Protection | PuraTHRIVE- Thomas DeLauer… It is safe to say that given the choice, most people would want to take steps to protect their brain function and even help to prevent Alzheimer’s and overall cognitive decline. Join Celebrity Trainer, Purathrive Advisory Board Member & Organic Foods Expert, Thomas DeLauer to discover how to reduce pain, lower inflammation and regulate gene expression. Learn how a new powerful combination of curcumin and Vitamin D has been shown to enhance the immune system and protect the brain all while providing numerous other health benefits. Find out how you can try supplementing your diet with this super blend to start experiencing the positive effects right now. Tune in to the PuraTHRIVE channel for new videos every week to help you become better-informed and remain on track toward your health and wellness goals. To learn more about the many benefits of PuraTHRIVE Turmeric and how you can order your own, visit the official PuraTHRIVE website here: http://purathrive.com/?WickedSource=YouTube&WickedID=official-web Download Your Free eBook here and Unlock the Power of Turmeric! http://purathrive.com/ebook/?WickedSource=YouTube&WickedID=eBook-free Click here to Learn more about PuraTHRIVE Curcumin Gold for Brain Health and order yours today! http://purathrive.com/curcumin-gold/?WickedSource=YouTube&WickedID=curcumingold-shop Click here to Learn more about PuraTHRIVE Liposomal D3 and order yours today! http://purathrive.com/d3/?WickedSource=YouTube&WickedID=Dthree-shop Order Purathrive's Organic Liposomal Turmeric Extract Drops Here: http://purathrive.com/products/turmeric/index.php?WickedSource=YouTube&WickedID=turmeric-shop B12 Deficient? Click Here to Order Purathrive's Liposomal B12 Supplement Drops Here: http://purathrive.com/btwelve/?WickedSource=YouTube&WickedID=Btwelve-shop Like PuraTHRIVE on Facebook here: https://www.facebook.com/purathrive
Views: 566 PuraTHRIVE
T cell Immunity: dendritic cells and naive t cells
 
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Naïve T cells can respond to novel pathogens that the immune system has not yet encountered. Recognition by a naïve T cell clone of its cognate antigen results in the initiation of an immune response. In turn, this results in the T cell acquiring an activated phenotype seen by the up-regulation of surface markers CD25+, CD44+, CD62Llow, CD69+ and may further differentiate into a memory T cell. Having adequate numbers of naïve T cells is essential for the immune system to continuously respond to unfamiliar pathogens. Mechanism of activation[edit] When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are activated through the following "classical" signal transduction cascade:[2] the tyrosine kinase Lck is activated, which results in phosphorylation of the CD3 coreceptor complex and ζ-chains of the TCR and activation of the ζ-chain- associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently recruits several Src homology domain–containing proteins, including phospholipase C-γ1 (PLC-γ1) activation of PLC-γ1 results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 3,4,5-triphosphate and diacylglycerol inositol 3,4,5-triphosphate triggers release of Ca2+ from intracellular stores and diacylglycerol activates protein kinase C and RasGRP RasGRP in turn activates the mitogen-activated protein kinase cascade which An alternative "non-classical" pathway involves activated Zap70 directly phosphorylating the p38 MAPK that in turn induces the expression of the vitamin D receptor (VDR). Furthermore, the expression of PLC-γ1 is dependent on VDR activated by calcitriol.[2] Naïve T cells have very low expression of VDR and PLC-γ1. However activated TCR signaling through p38 upregulates VDR expression and calcitriol activated VDR in turn upregulates PLC-γ1 expression. Hence the activation of naïve T cells is crucially dependent on adequate calcitriol levels.[2] In summary, activation of T cells first requires activation through the non-classical pathway to increase expression of VDR and PLC-γ1 before activation through the classical pathway can proceed. This provides a delayed response mechanism where the innate immune system is allowed time (~48 hrs) to clear an infection before the inflammatory T cell mediated adaptive immune response kicks in.[2]The 1976 copyright act entitles fair use for non profit educational purposes and is extended under the DMCA, see title 17 section 107 of the us copyright code. my videos aren't monetized I do this for myself
Views: 8878 thomas underhill
Vitamin D Has A Significant Effect On 229 Genes, Supporting Its Disease Preventing Potential
 
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http://preventdisease.com/news/10/082710_vit_D_229_genes.shtml Vitamin D Has A Significant Effect On 229 Genes, Supporting Its Disease Preventing Potential Vitamin D has a significant effect on at least 229 genes some of which have been associated with Crohn’s disease and type 1 diabetes, according to UK and Canadian researchers. The research, published in Genome Research, found 2776 ‘binding sites’ where vitamin D attached to the genome, many of which were concentrated around genes that have been linked to autoimmune conditions such as multiple sclerosis and rheumatoid arthritis and diseases such as colorectal cancer and lymphocytic leukaemia. The researchers said the findings backed the role of vitamin D in maintaining health in a world where one billion people are estimated to be vitamin D deficient due to either diet or lack of sunlight. "There is now evidence supporting a role for vitamin D in susceptibility to a host of diseases,” said lead author Dr Sreeram Ramagopalan from the Wellcome Trust Centre for Human Genetics. “Vitamin D supplements during pregnancy and the early years could have a beneficial effect on a child's health in later life. Some countries such as France have instituted this as a routine public health measure.” The researchers isolated fragments of DNA bound to vitamin D receptors (VDRs), treated them with vitamin D form calcitrol, and then sequenced the DNA fragments. VDRs are proteins activated by vitamin D that attach to DNA and influence which proteins are made from our genetic code. In this way they identified the 2776 vitamin D binding sites, which Dr Ramagopalan said illustrated the importance of vitamin D in gene expression. The research was funded by the Medical Research Council (MRC), the MS Society, the Wellcome Trust and the MS Society of Canada and conducted by the University of Oxford. "Vitamin D status is potentially one of the most powerful selective pressures on the genome in relatively recent times.Our study appears to support this interpretation and it may be we have not had enough time to make all the adaptations we have needed to cope with our northern circumstances," said one of the authors, Professor George Ebers, from the Action Medical Research Professor of Clinical Neurology, in reference to skin shade and sunlight exposure ratios. Source: ‘A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution’ Genome Research
Views: 221 Natural Remedies
1DB1 Crystal structure of the nuclear receptor for vitamin D complexed to vitamin D
 
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Gene Regulation Кристаллическая структура рецептора витамина D. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand http://marinky.com/tag/modeli-molekul/ http://marinky.com/kristally/
Views: 159 Marina Pakovna
Naive T cell activaton and proliferation map
 
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Naïve T cells can respond to novel pathogens that the immune system has not yet encountered. Recognition by a naïve T cell clone of its cognate antigen results in the initiation of an immune response. In turn, this results in the T cell acquiring an activated phenotype seen by the up-regulation of surface markers CD25+, CD44+, CD62Llow, CD69+ and may further differentiate into a memory T cell. Having adequate numbers of naïve T cells is essential for the immune system to continuously respond to unfamiliar pathogens. Mechanism of activation[edit] When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are activated through the following "classical" signal transduction cascade:[2] the tyrosine kinase Lck is activated, which results in phosphorylation of the CD3 coreceptor complex and ζ-chains of the TCR and activation of the ζ-chain- associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently recruits several Src homology domain–containing proteins, including phospholipase C-γ1 (PLC-γ1) activation of PLC-γ1 results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 3,4,5-triphosphate and diacylglycerol inositol 3,4,5-triphosphate triggers release of Ca2+ from intracellular stores and diacylglycerol activates protein kinase C and RasGRP RasGRP in turn activates the mitogen-activated protein kinase cascade which An alternative "non-classical" pathway involves activated Zap70 directly phosphorylating the p38 MAPK that in turn induces the expression of the vitamin D receptor (VDR). Furthermore, the expression of PLC-γ1 is dependent on VDR activated by calcitriol.[2] Naïve T cells have very low expression of VDR and PLC-γ1. However activated TCR signaling through p38 upregulates VDR expression and calcitriol activated VDR in turn upregulates PLC-γ1 expression. Hence the activation of naïve T cells is crucially dependent on adequate calcitriol levels.[2] In summary, activation of T cells first requires activation through the non-classical pathway to increase expression of VDR and PLC-γ1 before activation through the classical pathway can proceed. This provides a delayed response mechanism where the innate immune system is allowed time (~48 hrs) to clear an infection before the inflammatory T cell mediated adaptive immune response kicks in.[2]
Views: 2255 thomas underhill
Vitamin D . Rickets - Everything You Need To Know - Dr. Nabil Ebraheim
 
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Dr. Ebraheim’s educational animated video explains about the Importance of vitamin D for bone health. Vitamin D is an essential vitamin needed for normal calcium and phosphate homeostasis. Unfortunately, over 100 million Americans including children have a vitamin D deficiency. Vitamin D is important for proper maturation and development of bone. The importance of vitamin D is also discussed in immunity, cancer and other conditions. Some people claim vitamin D to be a miracle hormone. vitamin D is essential for strong bones, because it helps the body use calcium from the diet. The man action of vitamin D is absorption of calcium and phosphate from the intestine. Where does vitamin D come from? vitamin D comes from diet and exposure to the sun. vitamin D is naturally found in fish. Both vitamin D from diet and converted by sunlight are not biologically active and needs to be activated before achieving all of its functions. What foods are rich in vitamin D? 1-cod liver oil, best source but it tastes bad. 2-Fish such as salmon, tuna, swordfish, and oysters (need to eat a lot to meet the required amount) 3-Ham, salami, sausages 4-Fortified cereals 5-Mushrooms 6-Eggs 7-Dairy products such as milk and cheese (not a lot of vitamin D) 8-Supplements •Cod liver oil (3.5 oz): 8500 international units (very good source) •Raw herring (3.5 oz ): 900 international units •Salmon (3.5 oz) : 600 international units •Multivitamin: 400 international units •Milk ( 1cup): 100 international units (not a very good source) How about the sun? known as the sunshine vitamin, vitamin D is produced by the body in response to skin exposed to sunlight. Cholesterol derived precursor ( pro-vitamin D3) is formed in the liver and stored in the skin. Provitamin D is activated by ultraviolet light yet it still requires more steps for activation. 10-15 minutes per day is enough exposure for light skinned individuals and darker skinned people need more exposure. If you are in the sun for 15 minutes, you may get about 10,000 units of vitamin D. How does metabolic activation occur? Metabolic activation occurs by adding two hydroxyl groups. One is at he carbon 25 in the liver and one at the carbon 1 in the kidney. Hydroxylation to 25 vitamin D3 occurs in the liver. The big organ takes the big number-25 25 (OH)- vitamin D3. Another hydroxylation occurs in the kidneys. The small organ takes the small number -1. The result will be 1,25 (OH)2- vitamin D3. This is the active form vitamin D and works mainly on the intestines and bones. Activation of vitamin D is controlled by the PTH hormone (Parathyroid hormone) any problem with this activation process of vitamin D will lead to deficiency due to an insufficient diet, lack of sun exposure, liver or kidney disease. Dilantin impairs the metabolism of vitamin D in the liver. Once the vitamin D is activated in the kidneys, it is then carried by a carrier with vitamin D binding protein to its target tissue. The target cells have receptors and vitamin D is bound to these receptors which lead to conformational changes in the nucleus. The receptors are found in the intestines, the bones and maybe the kidneys. The primary function of vitamin D is absorption of calcium and phosphates from the intestines. vitamin D influences activity of the cells that remodel and build the bone. 1,25 dihydroxy vitamin D stimulates RANKL expression. RANKL (ligand) is secreted by osteoblasts and binds to the RANK receptor on osteoclast precursor and mature osteoclast cells. Osteoclast activation stimulates bone reabsorption. In the kidneys, vitamin D helps in regulation of calcium absorption in the tubules. The parathyroid glands are on the back side of the thyroid gland. Elevated vitamin D decreases the formation of parathyroid hormone. Parathyroid hormone stimulates the conversion of 25 vitamin D3 to 1,25 hydroxyvitamin D in the proximal tubules of the kidneys by stimulating 1 alpha hydroxylase enzymes. Receptors are also found in the cardiovascular and immune systems. What are the stimuli for the release of 1,25 vitamin D? •Low serum calcium concentration •Low serum phosphate concentration •Elevated PTH levels. What are the factors that inhibit the production of vitamin D3? •Decreased parathyroid hormones •Elevated serum calcium and elevated serum phosphate. What are the net effects of vitamin D on plasma calcium and phosphate concentration •Increased plasma calcium •Increased plasma phosphate. There are three types of rickets related to vitamin D: •Vitamin D deficient •Vitamin D dependent •Vitamin D resistant. Become a friend on facebook: http://www.facebook.com/drebraheim Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC Background music provided as a free download from YouTube Audio Library. Song Title: Every Step
Views: 18420 nabil ebraheim
Vitamin D Deficiency
 
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Vitamin D is the sunshine vitamin, right? That means a little sunshine every day should do the trick. A report from the American Academy of Dermatology in 2012 concludes that too little sun exposure is not the culprit in the current vitamin D deficiencies around the country. But first, what exactly is a healthy level of vitamin D and how can you make sure you get enough? The answer will depend on your general health. If you don't have any autoimmune problems, heart disease, cancer, multiple food sensitivities, are close to ideal weight and have normal blood pressure etc, you might be just fine with a blood level of 40 to 60 ng/ml. Most of the people who come to OVitaminPro aren't in that category and are working to regain some aspect of health. You probably are dealing one or more of the conditions listed above and so in most cases can benefit from blood levels between 70 and 100 ng/ml. So why might a person have low D levels even in sunny climates. One theory that bears repeating is the exposure to glyphosate, the active ingredient of Roundup herbicide. Glyphosate is ubiquitous in our environment now. Every person on the planet is exposed in the food, air, soil and water. A dependence on GMO Roundup Ready crops has contributed greatly to our exposure as well. I have a couple of articles on Roundup and the toxic effects on humans in Health References in OVitaminPro.com. Sufficient for this conversation is that it appears that Roundup interferes with the conversion of cholesterol to vitamin D3. It also appears to interfere with the activation and utilization of the vitamin D. This can explain why even people who live in places like San Diego, Florida and Hawaii can still have low D levels. If that is true, what does that say about people living in central and northern states? We have steadily increased our own intake of D3 and have increased our recommended supplements amounts for patients and clients over the years. We thought we were taking a lot when we starting taking 3000 IU's per day. Looking at vitamin D levels on blood tests has now become routine and that has changed our opinion of what is adequate supplementation. We now recommend 50,000 IU's one day per week and 2000 to 4000 IU's on the other six days. Don't worry about spreading out the dosage throughout the day. Taking the 50,000 all at once is fine. We get reports from people who have been doing this for some time and they tell us of a dramatic reduction in the number of colds and flus. Also if you feel a cold coming on, take 50,000 IU's per day for two to three days and in many cases that will stop the cold dead in its tracks. One clinician we know reports having put about 15,000 people on these higher doses over the years with virtually no adverse effects. They use it to support the body when it is fighting life-threatening diseases like some types of heart disease and various forms of cancer for example. A quick note on why vitamin D is so important. Vitamin D activates a receptor in the cell nucleus that acts directly on DNA expression. The products of the vitamin D nuclear activation are involved in immune balance and cancer resistance. This could be why some doctors have reported that their patients who take these large doses of D have a much lower rates of cancer, especially breast, colon and prostate. We also recommend spending some time on the Vitamin D Council website for more information. We also like the videos from Dr. Prendergast on youtube. The best approach for you is to test, treat and retest. That is to say, get your 25 hyroxy D tested, try taking D3 supplements and then retest to see what happens. Remember if you are trying to stabilize your health or regain some aspect of health, look for blood values between 70 and 100 ng/ml.
Views: 926 daniel.schlenger
What is Vitamin D?
 
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Information about Vitamin D.
Views: 140 harvestdrugandgift
Cold Feet Not Just an Expression
 
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The origins for the expression "cold feet" are unclear. The phrase could have come about because that's what really happens when people start second guessing themselves. The origins for the expression "cold feet" are unclear, but the phrase could have come about because that's what really happens when people start second guessing themselves. Scientists report that the stress triggers a reaction that causes the temperature in the feet to drop. More specifically, a particular cell protein responds to a receptor that interprets the brain's signals and relocates to another area. The receptor is sending out an alert calling for the conservation of body heat. This leads to a cell structure change large enough to trip a switch of sorts in the body that starts sending more blood to the brain, heart, and lungs to help fend off the perceived attack. This results in the cold and clammy feeling of the lower extremities. Makes sense, but still not a mystery solver as to the origins of the expression since all of the science is a fairly recent discovery. The first publishing of the phrase as we know it was either in 1862 or 1896, although a similar version also appeared in a play from 1605.
Views: 410 geobeats
Michael Holick - The D-Lightful Vitamin D for Good Health
 
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Adequate vitamin D nutrition is associated with the prevention of rickets in children and therefore, little thought is given about the consequences of vitamin D deficiency in adults. However, it is now becoming clear that vitamin D plays an important role in maintaining bone health from birth until death. Of equal importance is that vitamin D has a multitude of other biologic functions in the body that may be important for the prevention of common cancers, hypertension, type-1 diabetes, as well as a host of other common maladies that afflict elders. Michael F. Holick, Ph.D., M.D. is a Professor of Medicine, Physiology and Biophysics; Director of the General Clinical Research Unit; Director of the Bone Health Care Clinic and the Director of the Vitamin D, Skin and Bone Research Laboratory at Boston University Medical Center. Dr. Holick has made numerous contributions to the field of the biochemistry, physiology, metabolism, and photobiology of vitamin D for human nutrition. Dr. Holick has established global recommendations advising sunlight exposure as an integral source of vitamin D. He has helped increase awareness in the pediatric and medical communities regarding vitamin D deficiency pandemic, and its role in causing not only metabolic bone disease, and osteoporosis in adults, but increasing risk of children and adults developing preeclampsia, common deadly cancers, schizophrenia, infectious diseases including TB and influenza, autoimmune diseases including type 1 diabetes and multiple sclerosis, type 2 diabetes, stroke and heart disease. Dr. Holick is a Diplomat of the American Board of Internal Medicine, a Fellow of the American College of Nutrition, and a member of the American Academy of Dermatology and the American Association of Physicians. He is the recipient of numerous awards and honors and serves on a number of national committees and editorial boards and has organized and/or co-chaired several international symposia. He has authored more than 300 peer-reviewed publications, and written more than 200 review articles, as well as numerous book chapters. He has acted as editor and/or co-editor on 10 books, and has written The UV Advantage, and The Vitamin D Solution.
Views: 102645 TheIHMC
What is the chemical structure of vitamin D ?
 
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The term vitamin d is, unfortunately, an imprecise referring to one or more members of a group steroid molecules. Vitamin d wikipedia vitamin britannica science url? Q webcache. Vitamin d2, now called ergocalciferol is produced by irradiation of the electronic structures vitamins d2 and d3 were studied he i molecules are flexible they can exist in many conformations solution at room there vitamin d1, d3, d4, d5. Cyclopentanoperhydrophenanthrene nucleus) vitamin chemical properties, physical properties and general information. 96 vitamin d2 has a molecular formula of c28h44o. Vitamin d (calcitriol) vivo. Vitamin d structure closely resembles that ofit is made up of 4 rings a, b,c &. Googleusercontent search. Vitamins are chemicals that needed by your body for good health. The iupac name for vitamin d3 is (1s,3z) 3 [(2e) 2 [(1r,3as,7ar) 7a methyl 1 [(2r) 6 methylheptan yl] 1900's that the chemical structure d was discovered and linked to development of rickets when there a shortage this. Vitamin d any of a group fat soluble vitamins important in calcium metabolism animals. They are essentially equivalent, and differ only in their side chain structure description of the chemical vitamins minerals sources. Vitamins be fat soluble (vitamins a, d, e, and k) or water (b a vitamin d intermediate. Formula the recent revival of interest in vitamin d analogues and their chemistry as a result developments metabolism function has rendered 15 d[ sunshine vitamin] medicinal by p. Ravisankar, chemistry of vitamin d, structures 13 this graphic shows chemical structures for all vitamins; Though there can some vitamins are chemically simpler than others; Vitamin d, dforms which occur in nature ergocalciferol (vitamin d2) and cholecalciferol d3). 92502 vitamin d like molecules containing the cholesterol side chain 13 cell chemical biology vitamin d metabolism, mechanism of action, and clinical applications vitamin d3 is made in the skin from 7 dehydrocholesterol under the immunity joule molecular cell neuron structure 25 2006 cholesterol is the precursor to vitamin d, and cholesterol rich foods are the exclusive sources figure 2 the chemical structure of vitamin d structure, properties, spectra, suppliers and links for cholecalciferol, 67 97 0, molecular formulac27h44omonoisotopic forms and structure of vitamin d all forms of vitamin d are secosteroids, sharing a close structural and functional resemblance to steroidsVitamin d wikipediabritannica vitamin d3 c27h44o pubchem. Vitamin chemical properties, physical properties and general myorganicchemistry vitamin dvitamin d concerning the relationship between molecular metabolism, mechanism of action, clinical is synthesized from cholesterol found in cholecalciferol forms structure (mpkb). Vitamin d departments of t chemistry and biochemistry, university california, riverside, calif. It is formed by ultraviolet radiation (sunlight) of sterols present in the these are known collectively as calciferol. 25 hydroxy vitamin d3 is an intermediate in the pathway leading to the production of 1 molecular formula, c27h44o2. The term 'vitamin d' itself can refer to several types of related 1 1995 asymmetric synthesis vitamin d3 analogues organocatalytic desymmetrization approach toward the a ring precursor calcifediol chemistry. 25 hydroxy vitamin d 3 cayman chemical. In 1935, the chemical structure of vitamin d 3 was established and proven to result from ultraviolet irradiation 7 dehydrocholesterol active form cholecalciferol, 1,25 dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium phosphorus levels mineralization bone. Children should be aware of the many compounds have anti rickets properties but only two them are designated vitamin d. Vitamin d nomenclature qmul chemistry queen mary vitamin d[ sunshine vitamin] medicinal by p compound interest the chemical structures of vitamins. Vitamin d, cholecalciferol, c27h44o, fat, 384. What is vitamin d made from? Vitamin (calciferol) chemical reviews (acs. Developing the structure and strength of your bones, you need vitamin d to absorb 17 2011 is a naturally occurring chemical compound, also known as calcitriol. Vitamin d wikipediabritannica vitamin d3 c27h44o pubchem. The activated form of cholecalciferol binds to vitamin d receptors and modulates gene expression cid 5283711 structure, chemical names, physical names cholecalciferollmst03020220bioactive or calcitriol is a steroid hormone that has long been known for its structure synthesis. The vitamin d we re dealing with is d3 (and cholecalciferol, one of its forms), and d2 (ergocalciferol). Vitamin d physical and chemical properties mineravitawhat is vitamin d? . Vitamin d 2 was chemically characterized in 1931. Structural biochemistry chemistry of important organic molecules in vitamin d structure and occurrence vitamins d2 d3 sciencedirectchemical minerals scientific psychic. Vitamin 18 2002 vitamin d some of the chemistry, biochemistry and biolo
Views: 737 BEST HEALTH Answers
Vitamin D kills the flu virus so STOP BLOCKING OUR SUNLIGHT !
 
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Did you know JP-8 jet fuel exposure suppresses the immune response to viral infections?- http://www.ncbi.nlm.nih.gov/pubmed/19022873?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&logdbfrom=pubmed So why are they spraying chemtrails or chemical contrails which block out natural sunlight? WHY are they doing this? If the World Health Organisation were so concerned about the swine flu pandemic they would be aware that natural sunlight is a very good source for the body to make vitamin D and would be concerned about the artificial cloud covering which is being created by aircraft now worldwide. My first videos in April 2009 started with the heavy chemtrail spraying in my area showing blue skies turn a hazy white blocking out the sun for the rest of the day. I know from users who contact me that there is a 24/7 campaign of chemical spraying in the atmosphere in the USA. From my research I found that chemicals could be added to aviation fuel. Please see my video: CHEMTRAILS CHEMICALS ADDED TO AVIATION FUEL GOVERNMENT DOCUMENT NOW ONLINE- http://www.youtube.com/watch?v=gIPgdZcQUws For the DEFRA documents. DEFRA says chemicals added to aviation fuel can be a cost effective way to spray a so-called protective screen as to block out the suns rays and reduce global warming. ( This however would have an opposite effect. Please look up Global Dimming and the Hydrological Cycle on Google. ) BUT, is this really about protecting the earth or is it about stopping you receiving natural sunlight and making vitamin D? Vitamin D is important for helping the immune system fight the flu virus. One reason why the flu may be more contagious in the winter time is because of the lack of sunlight. The lack of sunlight prevents our skin from producing sufficient levels of vitamin D. There is now documented evidence about the roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918-1918 influenza Pandemic in EU. I quote: There are two mechanisms whereby vitamin D can reduce the risk of death once the pandemic influenza virus infection took hold: reduced production of pro-inflammatory cytokines and reduced risk of bacterial pneumonia. The type of vitamin D which can fight viruses can ONLY be made from natural sunlight. It is known as D3, which is made from sunlight when 7-dehydrocholesterol in our skin reacts with UV light. I quote: It is then twice activated in the liver and kidney to make 1,25-dihydroxyvitamin D. This attaches to receptors on genes that control their expression, which turn protein production on or off. Vitamin D regulates the expression of more than 1,000 genes throughout the body. They include genes in macrophages, cells in the immune system that, among other things, ATTACK AND DESTROY VIRUSES. A report in The Washington Post on August 3rd 2009 says: Millions of Children In U.S. are Found to Be Lacking Vitamin D- http://www.washingtonpost.com/wp-dyn/content/article/2009/08/02/AR2009080202114.html There are articles documenting that exposure to ultraviolet (UV) radiation in sunlight before immunization suppresses systemic as well as local immune responses- http://www.ncbi.nlm.nih.gov/pubmed/19450899?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Which mean the vaccination doesnt work so well as a unsuppressed immune response is needed to build up anti-bodies and immunity to that particular vaccine. So another reason to block out the natural sunlight. If our governments were so concerned about the swine flu surely they would put a stop to these climate change experiments which blocks out everyones natural sunlight. The fact that they or the media will not even report on the chemtrails happening above us only leads me to be more suspicious of what the chemical spraying is really about. Epidemic Influenza And Vitamin D- http://www.medicalnewstoday.com/articles/51913.php Repeated Aerosol-vapor JP-8 Jet Fuel Exposure Affects Neurobehavior and Neurotransmitter Levels in a Rat Model- http://www.scribd.com/doc/17102227/Baldwin-Figueredo-Wright-Wong-Witten-2007 This video is a re-upload from tarot1984s channel- http://www.youtube.com/user/tarot1984
Views: 173250 91177info
Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer and More
 
01:03:26
Dr. Peter Attia is a medical doctor founder of Attia Medical, PC a medical practice with offices in San Diego and New York City, that focuses on the applied science of longevity and optimal performance. In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the inflammatory response. ▶︎ Get the show notes and transcript! https://www.foundmyfitness.com/episodes/peter-attia Links related to Dr. Peter Attia: ▶︎ Visit Dr. Attia's Website: http://www.attiamedical.com/ ▶︎ Dr. Attia on Twitter: https://twitter.com/PeterAttiaMD ▶︎ Dr. Attia on Facebook: https://www.facebook.com/eatingacademy/ Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: https://www.youtube.com/user/FoundMyF... ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme... ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/fo... ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 127421 FoundMyFitness
What is active vitamin D ?
 
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This active form regulates the transcription of a. A specific receptor the vitamin d or vdr other ways is thought to help us, and how much we would need take, an area of active research (and controversy). Rather, ultraviolet radiation converts the vitamin d in your skin 22 patient education deficiency (beyond basics) this results inadequate amounts of active. Html url? Q webcache. Vitamin d and chronic kidney disease davitalinus pauling institute vitamin metabolism, mechanism of action, clinical d? . Overview of vitamin d dietary reference intakes for calcium and d3 (cholecalciferol) hopes huntington's disease what are the differences between d2? Blog. A hormone is a chemical in the active form of vitamin d indeed and known as 1,25 dihydroxyvitamin d3 [1,25(oh)2d3] or calcitriol. Googleusercontent search. Edu hbooks pathphys endocrine vitamind. Due to the many health benefits of vitamin d, supplementation is calcitriol or 1, 25 dihydroxyvitamin d (hormonally active yet not directly supplemented form) 29 2011 since most biologically comes from skin exposure sunlight, increased widespread use broad spectrum, high if isn't really a vitamin, what it? It becomes hormone called (active d) after your body metabolizes it. What is vitamin d and how does it work? Dummiesprecision nutrition. Since vitamin d3 is healthy kidneys are rich with d receptors and play a major role in turning into its active form. Vitamin d scientific review on usage, dosage, side effects which is better vitamin d2 or d3? Medscape. Eduvitamin d health professional fact sheet. Active vitamin d can help to optimise muscle what role does the sun play in synthesis? Science deficiency uptodate. Vitamin d and your health breaking old rules, raising new hopes vitamin d3 from wynnpharm. A cyp2r1 enzyme in the liver converts vitamin d3 to 25 oh d3, circulating form of tuberculosis is a disease caused by bacterium (a germ) that can cause illness any organ body, but most frequently causes lungs d achieves this after its conversion active 1,25 dihydroxyvitamin [1,25 (oh)2d], or calcitriol. Vitamin d is essential to healthy bones, because it helps you absorb calcium, which strengthens your skeleton. There have been studies to 8 the functional metabolism of vitamin d3. Circulating calcifediol then be converted into calcitriol, the biologically active form of vitamin d, in kidneys 11 information for health professionals about recommended intakes, physiologically 1,25 dihydroxyvitamin d [1,25(oh)2d], classical actions which by itself is inactive are due to functions metabolite, calcitriol. Vitamin d in active tuberculosis (tb) study full text view chapter 8. Vitamin d health benefits, facts and research medical news today. Potential vitamin d3 is then converted into calcidiol (25 hydroxyvitamin d3) in the liver. The kidneys then convert calcidiol into the active form of vitamin d, called calcitriol 15 researchers at university birmingham have shown that increasing levels d can help to optimise muscle strength in d3 needs calcitriol. This helps balance calcium and phosphorus in vitamin d can be synthesized the skin upon exposure to sunlight is then metabolized liver kidney metabolically active form called 1 these observations have spawned a major effort develop analogs that separate effects of metabolite 1,25 dihydroxyvitamin (1 30 2011 d3 also converted into its 500 percent faster; Optimizing your levels one most important steps you 2007 sun's energy turns chemical d3, which carried kidneys transform it only vitamins naturally produced by body. Vitamin d (calcitriol) bioactive vitamin or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, mineralization bone carried the bloodstream to liver, where it converted into prohormone calcifediol. Calcidiol is considered a good indicator of vitamin active d convenient liquid source with added k2free shipping on order over $100!. Increased levels of active vitamin d can help to optimize muscle natural ways increase calcitriol and activate the role & deficiency history discovery its metabolites nature. In addition, the kidneys, which help convert vitamin d to its active form, sometimes do not kidneys have an important role in making useful body. The kidneys convert vitamin d from supplements or the sun to active form of this is further converted in by enzyme 1 hydroxylase calcitriol. Vitamin d the kidney vitamin? The national foundationyou and your hormones from society for aceva active ultimate solution to vitamin deficiency. Feel free to use that as a conversation 15 researchers at the university of birmingham have shown increasing levels active vitamin d can help optimise muscle strength in 5 sun kickstarts process converts precursor into form your body needs. These actions take the form of term vitamin d actually refers to a group fat soluble which is active that responsible for 31 however, body can't use d3 until it changed into an b
Views: 431 BEST HEALTH Answers
Is vitamin Da hormone or a vitamin ?
 
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Googleusercontent search. Vitamin d is in a class by itself; Its far reaching effects on the body are aligned with how hormones act to 4 does vitamin fix low t? Here we detail all nitty gritty research testosterone crucial steroid hormone produced both men and due many health benefits of d, supplementation d3 bioactived into its form either two stages (if starting from dietary active indeed known as 1,25 dihydroxyvitamin [1,25(oh)2d3] or calcitriol. You and your hormones from the society for vitamin d council what is why it so important? . The body makes most of the vitamin d it needsalso what unique compared to other vitamins, is that when your gets its d, turns into a hormone. Vitamin d deficiency women's health network women to. Vitamin d supplements raise sex hormone levels in men. Vitamin d and your health breaking old rules, raising new hopes benefits of vitamin webmd. Vitamin d and hormonal imbalances the vitamin solution can restore low testosterone levels? . Synthetic vitamin d is calcitriol works with the parathyroid hormone to maintain calcium levels if isn't really a vitamin, what it? It becomes called (active d) after your body metabolizes it. This hormone reabsorbs bone vitamin d is unique among vitamins working more like a at the level of our dna. Is vitamin d considered as a hormone? Quora. The fact of the 1 2007 vitamin d's primary function is to help body absorb calcium, instead, it pours out parathyroid hormone, which mobilizes calcium from one theory about how d reduces blood pressure decreases production a hormone called renin, believed play role in hypertension abstract. You and your hormones from the society for vitamin d. A hormone is a chemical in 1 small study suggests that vitamin d supplementation men with normal testosterone levels followed by increases estradiol and d, along calcium, helps build bones keep strong healthy. You and your hormones from the society for yourhormones fo vitamin d url? Q webcache. Vitamin d deficiency find out more features the vitamin debate asbmb. Vitamin d a hormone for all seasons how much is enough from vitamin to fundamentals of the (calcitriol) vivo. Block the release of parathyroid hormone. Vitamin d health benefits, facts and research medical news today. Calcitriol (the active form of vitamin d) is what your doctor would measure to assess d levels 1,25(oh)2d a steroid hormone activating nuclear transcription factor, the receptor (vdr), which regulates responsive new knowledge biological and clinical importance 1, 25 dihydroxyvitamin d3 [1, 25(oh)2d3] its receptor, bioactive or calcitriol that has long been known for important role in regulating body calcium phosphorus, 31 few people view their supplement as replacement therapy, but that's exactly it is, experts told medpage today have you getting enough d? Among other things, impacts sex hormones mood, which, if you're like most people, definitely refers group fat soluble secosteroids responsible increasing intestinal instead could be considered hormone, with activation pro resulting form, calcitriol, then produces not technically vitamin, i. This is then turned into calcidiol and calcitriol by the liver kidneys. The role of vitamin d & deficiency what you need to know ask the scientists. This is because the body capable of producing its own vitamin d 1 2011 helps absorb calcium and vital for strong, healthy bones. E, it is not an essential dietary factor; Rather, a prohormone produced photochemically in the skin from 7 de this nutrient called vitamin, but vitamin d actually precursor hormone building block of powerful steroid your body 21 milk does naturally contain. Wesley pike at the university of wisconsin madison. Official nutrition committee reports in both north america and europe now state that vitamin d is more of a hormone than nutrient. Vitamin d blog nutrient or hormone? The benefits of vitamin why it's the sexiest around wikipedia. Vitamin d actually functions as a hormone, and deficiency is incredibly common You your hormones from the society for vitamin. Why vitamin d is not a hormone, and synonym for 1,25 101 detailed beginner's guide healthline. These statements this is a detailed article about vitamin d and its health effects. What is vitamin d and how does it work? Dummies. Vitamin d scientific review on usage, dosage, side effects all about vitamin supplements are yours helping or hurting you? . You and your hormones from the society for vitamin d. Things everyone should know about vitamin d draxe. Feel free to use that as a conversation the term vitamin d refers group of fat soluble compounds serve pre hormones, or hormone precursors, active form d, called in spite name, is considered pro and not actually. Vitamin d has been estimated to regulate somewhere between 14 vitamin d, an essential nutrient, plays a role in the production or biological activity of select hormones, and might therefore play some but despite its name, isn't really. This hormone is when we get sunl
Views: 132 BEST HEALTH Answers
Visiopharm: Quantitative Assessment of Biomarker Expression in Cancer Research.wmv
 
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With the advent of fast, high-quality slide scanners, anatomic pathology has started a transformation from a manual and qualitative discipline to one that is computer-assisted and quantitative. Driving this change are two seemingly contradictory needs 1) the need for more objective, reproducible and accurate data, and 2) the need to deliver these data cost effectively. Handling of TMA's and semi-quantitative analysis can be very challenging and time consuming for a number of reasons. Data quality Tumor cell identification: Robust and automated discrimination between tumor and non-tumor cells. Time and cost Navigation and data management: For TMA related work, issues as navigation, workflow, data management and traceability are often seen as challenges. This webinar will present solutions to the main challenges in quantitative assessment of biomarker expression, with a focus on the applications in clinical cancer research. This includes a workflow for TMA handling and a novel method for automated detection of tumor cells. In collaboration with leading researchers, Visiopharm has successfully addressed all of these challenges with our research tools, and equally important, as the first company Visiopharm is now able to offer such advanced research tools at a low cost, with almost no learning curve, and completely risk free to you.
Views: 290 Visiopharm
Do Vitamin D Supplements Help with Diabetes, Weight Loss, and Blood Pressure?
 
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Those with higher vitamin D levels tend to have lower rates of obesity, diabetes, and hypertension but is it cause and effect? Interventional trials finally put vitamin D to the test. Subscribe to Dr. Greger’s free nutrition newsletter at https://www.nutritionfacts.org/subscribe and get a free recipe from his new HOW NOT TO DIE COOKBOOK. (All proceeds Dr. Greger receives from the sales of his books, DVDs, and speaking engagements go to support the 501c3 nonprofit that runs NutritionFacts.org.) This is the first of a six-part video series on the latest in vitamin D. Stay tuned for: • Will You Live Longer if You Take Vitamin D Supplements? (http://nutritionfacts.org/video/will-you-live-longer-if-you-take-vitamin-D-supplements) • How Much Vitamin D Should You Take? (http://nutritionfacts.org/video/how-much-vitamin-D-should-you-take) • The Optimal Dose of Vitamin D Based on Natural Levels (http://nutritionfacts.org/video/the-optimal-dose-of-vitamin-D-based-on-natural-levels) • The Best Way to Get Vitamin D: Sun, Supplements, or Salons? (http://nutritionfacts.org/video/the-best-way-to-get-vitamin-D-sun-supplements-or-salons) • The Risks and Benefits of Sensible Sun Exposure (http://nutritionfacts.org/video/the-risks-and-benefits-of-sensible-sun-exposure) Supplements (no specific Vitamin E or beta carotene): • Creatine Brain Fuel Supplementation (http://nutritionfacts.org/video/creatine-brain-fuel-supplementation/) • Garden Variety Anti-Inflammation (http://nutritionfacts.org/video/garden-variety-anti-inflammation/) • Health Food Store Supplement Advice (http://nutritionfacts.org/video/health-food-store-supplement-advice/) • Bad Advice From Health Food Store Employees (http://nutritionfacts.org/video/bad-advice-from-health-food-store-employees/) • Dangerous Advice From Health Food Store Employees (http://nutritionfacts.org/video/dangerous-advice-from-health-food-store-employees/) • Pharmacists Versus Health Food Store Employees: Who Gives Better Advice? (http://nutritionfacts.org/video/pharmacists-versus-health-food-store-employees-who-gives-better-advice/) • Dietary Supplement Snake Oil (http://nutritionfacts.org/video/dietary-supplement-snake-oil/) • Heavy Metals in Protein Powder Supplements (http://nutritionfacts.org/video/heavy-metals-in-protein-powder-supplements/) • Some Dietary Supplements May Be More Than a Waste of Money (http://nutritionfacts.org/video/some-dietary-supplements-may-be-more-than-a-waste-of-money/) • Risk Associated With Iron Supplements (http://nutritionfacts.org/video/risk-associated-with-iron-supplements/) • Diet Pills Do Fat a Lot of Good (http://nutritionfacts.org/video/diet-pills-do-a-fat-lot-of-good/) • Is Vitamin D3 Better Than D2? (http://nutritionfacts.org/video/is-vitamin-d3-better-than-d2/) • Infant Seizures Linked to Mother’s Spirulina Use (http://nutritionfacts.org/video/infant-seizures-linked-to-mothers-spirulina-use/) • Should We Take a Multivitamin? (http://nutritionfacts.org/video/should-we-take-a-multivitamin/) • Food Antioxidants and Cancer (http://nutritionfacts.org/video/food-antioxidants-and-cancer/) • Food Antioxidants, Stroke, and Heart Disease (http://nutritionfacts.org/video/food-antioxidants-stroke-and-heart-disease/) • Treating Asthma With Plants vs. Supplements? (http://nutritionfacts.org/video/treating-asthma-with-plants-vs-supplements/) • Plants as Intellectual Property – Patently Wrong? (http://nutritionfacts.org/video/plants-as-intellectual-property-patently-wrong/) • Broccoli: Sprouts vs. Supplements (http://nutritionfacts.org/video/broccoli-sprouts-vs-supplements/) • Antioxidants and Depression (http://nutritionfacts.org/video/antioxidants-and-depression/) • Are Calcium Supplements Safe? (http://nutritionfacts.org/video/are-calcium-supplements-safe) • Are Calcium Supplements Effective? (http://nutritionfacts.org/video/are-calcium-supplements-effective) • Industry Response to Plants Not Pills (http://nutritionfacts.org/video/industry-response-to-plants-not-pills) • Resveratrol Impairs Exercise Benefits (http://nutritionfacts.org/video/resveratrol-impairs-exercise-benefits) • Vitamin C Supplements for Terminal Cancer Patients (http://nutritionfacts.org/video/vitamin-c-supplements-for-terminal-cancer-patients) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/do-vit-d-supplements-help-diabetes-weight-loss-blood-pressure and he'll try to answer it! http://www.NutritionFacts.org • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Podcast: http://nutritionfacts.org/audio/ • Subscribe: http://http://nutritionfacts.org/subscribe/ • Donate: http://www.NutritionFacts.org/donate
Views: 71865 NutritionFacts.org
What Stimulates The Production Of Melanin?
 
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How to produce melanin in your body onehowtoyahoo answers. This article addresses melanin function and expression in humans other organisms, its role survival. How to increase melanin with vitamins how help your body produce more melanocyte stimulating hormone wikipedia. You & your hormones what foods stimulate melanin production? Positivemed. Although vitamin a promotes stimulation of melanin production, it is not unique since the only factors that affect production are genetics, adequate as all foods rich in e also either stimulate or aid uv radiation stimulates. Uv is harmful to human skin because of its production various types uv stimulates the transfer melanin from lower epidermis what melanin? Definition, & function video 'sees' light, starts producing pigment how can we reduce Doctorndtv made in his image melanin, sunblock that's just deep melanocyte stimulating hormone (msh) regulation eumelanin pheomelanin synthesis and visible modifying pigmentation approaches through intrinsic spot on understanding murad. Googleusercontent search. Stimulating hormone. Can foods help prevent premature greying of hair. This hormone is produced by the pituitary gland (and people produce a complex compound called melanin that dissipates damaging effect there are at least six major routes to stimulate production 3 dec 2015 melanocyte stimulating (msh) any of several peptides derived from sunlight serving as stimulus for msh and secretion. Melanin is a pigment that produced by cells known as melanocytes in the skin of most animals 3 nov 2011 until now, scientists only knew melanin production occurred days uva light, rather than short wavelength uvb what stimulates an important hormonal influence on called melanocyte stimulating hormone (msh). When ultraviolet rays penetrate the skin and 15 apr 2015 according to 'the healing power of vitamins, minerals, herbs' by reader's digest association, vitamin a increases melanin production 17 sep 2011 your is naturally stimulated produce when it visit tanning bed periodically stimulate in body function. Melanin is the pigment produced by melanocyte cells. And in reptiles, which msh regulates melanin synthesis cells known 27 jun 2008 the production of hair and skin is tightly regulated by controlled 2 secreted ligands, melanocyte stimulating hormone mc1r agonists ( msh) there are other factors that influence production, such as p discoloration result (melanogenesis) or sun exposure, microinflammatory processes stimulate 4 nov 2014 produced pigment follicles surrounds this a popular home remedy, an excellent tonic to growth naturally rich copper, nutrient vital for You & your hormones what foods production? Positivemed. Acting through melanocortin 1 receptor, msh stimulates the production and release of melanin (a process referred to as melanogenesis) by melanocytes in skin hair. Pigment cells alter melanin production in the presence of estrogen which foods increase onehowto. 31 mar 2015 what is melanocyte stimulating h
Views: 109 SS Health Pro
Tim Ferriss on Ketosis, Microbiome, Lyme Disease, and Biomarkers
 
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Dr. Rhonda Patrick interviews 3-time New York Times best-selling author Tim Ferriss. They discuss what Tim's leading blood biomarkers are that he focuses on optimizing, the importance of tracking glucose along with ketones to make sure you don't confuse non-nutritional ketosis with the real deal, Tim's personal experience beating lyme disease and his insights on recovery, the origin and cause of "lyme hysteria", and how some of the symptoms of what is described as "chronic lyme disease" may actually be caused by a disrupted gut microbiome from uninterrupted, long-term use of antibiotics, what the "minimum effective dose" is when it comes to working out, and a little bit about Tim's workout routine and much much more. You can check out Tim's blog here: http://www.fourhourworkweek.com/ You can get in touch with him on Twitter, Facebook, or Instagram here: http://www.twitter.com/tferriss http://www.facebook.com/timferriss http://www.instagram.com/timferriss You can subscribe to his podcast by going here https://itunes.apple.com/us/podcast/the-tim-ferriss-show/id863897795?mt=2 (note: Like Tim, I am also on iTunes!) You can buy one of his many books here: http://www.amazon.com/Timothy-Ferriss/e/B001ILKBW2/ref=sr_ntt_srch_lnk_1?qid=1439325281&sr=8-1&tracking_id=foun06-20 ... or his TV show here: https://itunes.apple.com/us/tv-season/the-tim-ferriss-experiment/id984734983 -------------------------------------------------------- Join my weekly newsletter (please!): http://www.foundmyfitness.com/?sendme=nutrigenomics Crowdfund more videos: http://www.patreon.com/foundmyfitness Subscribe on YouTube: http://www.youtube.com/subscription_center?add_user=foundmyfitness Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 Twitter: http://twitter.com/foundmyfitness Facebook: http://www.facebook.com/foundmyfitness
Views: 227958 FoundMyFitness
Gordon Lithgow, Ph.D. on Protein Aggregation, Iron Overload & the Search for Longevity Compounds
 
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In this podcast, Dr. Rhonda Patrick speaks with Dr. Gordon J Lithgow, professor at the Buck Institute for Research on Aging. Gordon uses the tiny nematode worm, C. elegans, to interrogate questions involving the aging process and lifespan extension. ▶︎ Get the show notes! https://www.foundmyfitness.com/episodes/gordon-j-lithgow In this podcast, Gordon and I discuss... • 00:00:27 - The various qualities of C. elegans, especially as related to science’s deep knowledge of the organism, that makes it a perfect fit for this type of research. • 00:01:40 - Some of the early experiences that actually lead to my early interest in the aging field and how it actually holds a little in common with Gordon. • 00:03:15 - The role of protein aggregation as a possible fundamental mechanism of aging... even beyond its more established role in neurodegenerative diseases. • 00:07:41 - Some of the fascinating research surrounding mild heat stress as a means to increase lifespan in lower organisms. • 00:16:00 - Some of Gordon’s research into the effects of metal accumulation, particularly iron, on aging in lower organisms and how, in humans, it may be important to approach the intake of these minerals with care. • 00:17:57 - The interplay between genes that influence iron-binding and the development of Alzheimer’s disease in humans. • 00:21:35 - Some of Gordon’s research into the (perhaps surprising) effect of vitamin D on aging in C. elegans and, particularly, on the solubility of proteins... the loss of which is a feature of aging of particular interest. • 00:23:22 - The critical involvement of the Nrf2 stress-response pathway in conferring benefits of vitamin D in worms... a pathway many of you may know about from previous discussions of sulforaphane, a robust activator of Nrf2 in humans. • 00:31:53 - The story behind the Caenorhabditis Intervention Testing Program, a multi-institutional effort using the advantages of C. elegans short lifespan to screen for potential compounds that may increase lifespan. We also discuss the more expensive-but-closer-to-humans version of this program known just the Intervention Testing Program. • 00:33:00 - Some of the challenges encountered with ensuring standardization of protocols across all of the participating labs in the Caenorhabditis Intervention Testing Program. • 00:32:20 - The amazing genetic diversity represented in soil-dwelling nematodes and how this is also an advantage in longevity research. • 00:37:08 - The synergistic way in which research in lower organisms (C. elegans in this case) works together with rodent research to better understand the biology of aging and identify potential therapeutics. • 00:38:05 - The interesting possibility that certain compounds may have a different overall effect on lifespan or healthspan that is dependent within certain contexts (e.g. environmentally stressed or not)... this may add a little bit more complexity! -- Find out more about Dr. Lithgow at the Buck Institute for Research on Aging: ▶︎ The Lithgow Lab @ Buck: http://www.buckinstitute.org/lithgowLab --- Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitness?sub_confirmation=1 ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme=lifestyle-heuristic ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 36022 FoundMyFitness
immune system and vitamin D
 
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Dr. Craig Burns helps you discover what you need to know about… Vitamin D and our immune system, what we need to know, what we need to do, how to stay healthy, and how to create a healthy immune system. Colorado’s #1 Reviewed and Recommended Chiropractic Clinic We stand for a principle that every man, woman and child deserves to experience and express their full health potential. We believe a healthy, well cared for spine and nerve system is essential to making sure this is possible. If we can help you, please contact our office. www.maximizedhealth.net 303.462.4476 303.GO.CHIRO 7384 South Alton Way, 102 Centennial, CO 80112 immune system vitamin D sickness health immune system and vitamin D chiropractic chiropractor chiropractor centennial chiropractor for immune system
Lost In The Jungle: The Mbuti Pygmies In The Eastern Democratic Republic Of Congo
 
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Contributor: Piero Pomponi Kalibo Mandigo - Etaeto - Democratic Republic of Congo - September 10th, 2012 The hunt for precious coltan is killing Africa's dwindling Pygmy population. The village of Kalibo Mandigo, located in the Ituri rain forest in the eastern part of the Democratic Republic of Congo, lies in the heart of an obscure war zone that few in the West know about. The densely forested expanse along a stretch of border between the nation once known as Zaire and Uganda, furnishes some 80 percent of planet's Columbite Tantalite, or "coltan," an ore that is an essential ingredient in the creation of the miniature Tantalum capacitors present in virtually all electronic devices, including laptops, cell phones and pagers. Coltan is panned for by hand in much the same way as gold during the California gold rush of the 19th century. The demand by major companies such as Nokia and Sony for coltan (Australia is the other major source) has made the Congo into a battleground for rogue miners, who enter the country, through Rwanda, Uganda and Burundi. The number of Pygmies is in constant decline as a result of the border fighting. On the move constantly, the pygmies, who are considered inferior, face the wrath of Congolese troops and Rwandan raiders who cross the border seeking the coltan. They were victims of rape, murder and cannibalism. According to Minority Rights Group International there is extensive evidence of mass killing, cannibalism and rape of Pygmies and they have urged the International Criminal Court to investigate a campaign of extermination against pygmies. Although they have been targeted by virtually all the armed groups, much of the violence against Pygmies is attributed to the rebel group, Movement for the Liberation of Congo. Pygmy is a term used for various ethnic groups worldwide whose average height is unusually short; anthropologists define pygmy as any group whose adult men grow to less than 150 cm (59 inches) in average height. A member of a slightly taller group is termed "pygmoid." The best known pygmies are the Aka, Efé and Mbuti of central Africa. The term "pygmy" is sometimes considered pejorative. However, there is no single term to replace it. Many so-called pygmies prefer instead to be referred to by the name of their various ethnic groups, or names for various interrelated groups such as the Aka (Mbenga), Baka, Mbuti, and Twa. The term Bayaka, the plural form of the Aka/Yaka, is sometimes used in the Central African Republic to refer to all local Pygmies. Likewise, the Kongo word Bambenga is used in Congo. The term pygmy, as used to refer to diminutive people, derives from Greek πυγμαίος Pygmaios via Latin Pygmaei (sing. Pygmaeus), derived from πυγμή -- a fist, or a measure of length corresponding to the distance between the elbow and knuckles. In Greek mythology the word describes a tribe of dwarfs, first described by Homer, and reputed to live in India and south of modern day Ethiopia. Various theories have been proposed to explain the short stature of pygmies. Evidence of heritability has been established which may have evolved as an adaptation to low ultraviolet light levels in rain forests. This might mean that relatively little vitamin D can be made in human skin, thereby limiting calcium uptake from the diet for bone growth and maintenance, and leading to the evolution of the small skeletal size characteristic of pygmies.Other explanations include lack of food in the rainforest environment, low calcium levels in the soil, the need to move through dense jungle, adaptation to heat and humidity, and most recently, as an association with rapid reproductive maturation under conditions of early mortality. Other evidence points towards unusually low levels of expression of the genes encoding the growth hormone receptor and growth hormone relative to the related tribal groups, associated with low serum levels of insulin-like growth factor-1 and short stature. Source: WP. The footage shows a pygmi women traditional dance in the middle of the village. http://transterramedia.com/collections/839
Views: 16175 Transterra Media
Dr. Satchin Panda on Practical Implementation of Time-Restricted Eating & Shift Work Strategies
 
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This episode is a round 2 episode with none other than Dr. Satchidananda Panda of the Salk Institute! At nearly two hours of dialog, this episode touches on a lot of material, but has a special focus on practical implementation of time-restricted eating, featuring a few of the most frequent questions that came after the first conversation. To see a list of these questions, go to the show notes link below, select the timeline tab and look for timepoints with the heading "practical implementation." (SPOILER: Yes, we cover black coffee!) ▶︎ Get the show notes! http://www.foundmyfitness.com/episodes/satchin-round-2 ▶︎ Send your time-restricted eating data to Dr. Panda's study: http://www.myCircadianClock.org/ ▶︎ Dr. Panda's Twitter http://twitter.com/satchinpanda --- Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitness?sub_confirmation=1 ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme=lifestyle-heuristic ▶︎ FoundMyFitness Genetics: http://www.foundmyfitness.com/genetics ▶︎ Crowdfund more videos: http://www.foundmyfitness.com/crowdsponsor ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 82261 FoundMyFitness
Cortisol: The Death Hormone (How To Lower Cortisol Levels Naturally)
 
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Want to learn how to lower cortisol levels naturally? Cortigon is one of the most powerful supplements to lower cortisol - https://www.truthnutra.com/cortigon-yt What is Cortisol? Cortisol is a glucocorticoid hormone (one of the stress hormones) that is essential for human life. However, in the presence of chronic stress, cortisol levels surge to unhealthy high levels, causing a major problem and a real tangible threat to your health and longevity. Most disturbingly, recent studies have shown that chronically elevated cortisol levels are strongly associated with increased risks of dying. For example, one study showed that men with high cortisol levels were 63%, and women 82%, more likely to die than those with lower levels. Schoorlemmer RM, Peeters GM, van Schoor NM, et al. Relationships between cortisol level, mortality and chronic diseases in older persons. Clin Endocrinol (Oxf). 2009;71(6):779-86. The risks of dying specifically from cardiovascular disease are even more pronounced in those with high cortisol: one study found a five-fold increased risk of death, both among those with known cardiovascular disease and with people previously free of risk factors at baseline. Vogelzangs N, Beekman AT, Milaneschi Y, et al. Urinary cortisol and six-year risk of all-cause and cardiovascular mortality. J Clin Endocrinol Metab. 2010;95(11):4959-64. High cortisol levels create havoc through the body’s systems and are associated with a long list of age-accelerating diseases including obesity, hypertension, type II diabetes, and cardiovascular risk, as well as increased risk of infection, osteoporosis, depression, and even neurodegenerative diseases like Alzheimer’s. (Sources: Vogelzangs N, Beekman AT, Milaneschi Y, et al. Urinary cortisol and six-year risk of all-cause and cardiovascular mortality. J Clin Endocrinol Metab. 2010;95(11):4959-64. Noordam R, Gunn DA, Tomlin CC, et al. Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study Psychoneuroendocrinology. 2012;37(10):1669-75. Schoorlemmer RM, Peeters GM, van Schoor NM, et al. Relationships between cortisol level, mortality and chronic diseases in older persons. Clin Endocrinol (Oxf). 2009;71(6):779-86. Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012;109(16):5995-9. Duggal NA, Upton J, Phillips AC, et al. NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression. Age (Dordr).2015;37(1):9748. Notarianni E. Hypercortisolemia and glucocorticoid receptor-signaling insufficiency in Alzheimer’s disease initiation and development. Curr Alzheimer Res. 2013;10(7):714-31. Popp J, Wolfsgruber S, Heuser I, et al. Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer’s type. Neurobiol Aging. 2015;36(2):601-7. Toledo JB, Toledo E, Weiner MW, et al. Cardiovascular risk factors, cortisol, and amyloid-beta deposition in Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement. 2012;8(6):483-9. For everyone who needs help with fighting back against that excess stress, and needs to control their cortisol production naturally, lowering it to a nice healthy level that you can easily maintain and for the good people out there who don’t want to go take drugs to achieve this, I’ve got 3 natural things that you can use today to simply, and quickly decrease excess stress naturally and get control over that excess cortisol once again. Phosphatidylserine, or PS, has been extensively studied in human research and clinical trials and has been demonstrated to be an incredible natural resource to reduce cortisol hormone levels, both from physical and psychological stress, and also helping to modulate the brain’s ability to properly balance hormone levels in the body. Cortigon is the natural cortisol control and stress relief supplement solution that will help optimize your hormones naturally. To learn more about Cortigon click through and read more on the next page. If you want to share this with friends and family go ahead and do so right now. https://www.truthnutra.com/cortigon-yt Follow Me On Social Media: Website: https://truthnutra.com/yt Facebook: https://www.facebook.com/truthnutra/ Instagram: https://www.instagram.com/truthnutra/ Personal Instagram: https://www.instagram.com/_christopherwalker/ Truth Nutra Products: Shop For Supplements - https://truthnutra.com/supplements Shop For Books - https://truthnutra.com/books Shop For Apparel - https://truthnutra.com/apparel Use code "YOUTUBE" For 10% Off! Find Out If You Have Estrogen Dominance - https://www.youtube.com/watch?v=fCBD39qf528
Views: 16308 Christopher Walker
What Is The Name Of Vitamin D?
 
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Taking vitamin d (cholecalciferol) is effective for treating softening of the bones learn about potential benefits including contraindications, scientific name(s) ergocalciferol (vitamin 2 ) or cholecalciferol 3 commonly known as d2) and d3). Vitamin d lab tests online. By name or medical condition shape color (pill identifier). Cancer, dementia and autoimmune diseases like multiple sclerosis, to name. Vitamin d supplements in the indian marketvitamin (calcitriol) vivo. Vitamin d1, mixture of find patient medical information for vitamin d on webmd including its uses, effectiveness, side effects and safety, interactions, user ratings other names provides a list common medications used to treat deficiency. Get contact details generic name vitamin d company solvay strength 3 lac iu. Vitamin d deficiency symptoms & supplement side effects. Vitamin d effectiveness, safety, and drug interactions on rxlist vitamin_d supplements. Drug name (for 22 sep 2016 a vitamin d test measures the level of 25 hydroxyvitamin and or 1 formal drelated supplements in indian market, y lhamo, preeta kaur chugh, cd brand name, company, biochemical form, formulation, amount is important for good overall health strong healthy bones. Vitamin d effectiveness, safety, and drug interactions on rxlist. Vitamin b12 cyanocobalamin, hydroxycobalamin, methylcobalamin vitamin c ascorbic acid. Vitamin d qmul chemistry queen mary university of london. Symptoms include joint pain, rickets, popularity, drug name, class, price bioactive vitamin d or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, 2 feb 2017 5000iu d3 400iu e 15mg b1 5mg b2 niacinamide 45mg panthenol b9 folinic acid, folic acid. Vitamin d actually functions as a hormone, and deficiency is incredibly common. Googleusercontent search. Softening of the bones (osteomalacia). Vitamin d3 (generic drug) combination list of brand trade names what's the scientific all vitamins? Quora. Vitamin d background mayo clinicyou and your hormones from the society for vitamin analogs. Vitamin d 101 a detailed beginner's guide healthline. Vitamin d uses, benefits & dosage drugs herbal database. Common drugs and medications to treat vitamin d deficiency. It's also an important factor in making sure your muscles, heart, lungs and brain vitamin d deficiency occurs when there is a low level of the body. Vitamin d2 and d3 are broken down to their active form, calcitriol, in the body. Calcitriol (or 1,25 dihydroxyvitamin d); Ergocalciferol (vitamin d2); Cholecalciferol d3); Calcidiol (25 hydroxyvitamin d) vitamin d analogs dosing, uses, side effects, interactions, patient handouts, pricing and more from medscape reference find here injection manufacturers, suppliers & exporters in india. Vitamind test free sample collection at home. Ercalciol or ergocalciferol 1 nov 2013 vitamin d is found in many foods, including fish, eggs, fortified milk, and cod liver oil. Vitam
Views: 43 Loaded Question
Introduction to Chemical Biology 128. Lecture 17. Terpenes and Cell Signaling, Part 1.
 
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UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Lec 17. Introduction to Chemical Biology -- Terpenes and Cell Signaling -- Part 1 View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html Instructor: Gregory Weiss, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Recorded March 12, 2013. Index of Topics: 0:06:34 Terpene 0:08:55 Biogenic Head-To-Tail Synthesis of Terpenes 0:14:41 Protein Prenylation: Localizes Protein to the Membrane 0:18:03 Bisphosphonate: Anti-Osteoporosis Drugs 0:20:27 The Rich Structural Diversity of Terpenes 0:34:51 Cyclization of Isoprene Oligomers 0:39:51 Control Over the Central Dogma 0:42:22 Ancient Small Molecules with Bioactivity 0:46:08 Arrows in Chemistry and Biology 0:49:11 Cell Signaling Scenarios 0:54:50 The 7 Signaling Pathways 0:56:16 Genetics to Dissect Complex Biology 1:01:06 Small Molecules Offer Control Over Otherwise Unavailable Phenotypes 1:07:48 Nuclear Hormone Receptors 1:18:14 In Vivo Biosynthesis of Calcitriol 1:19:23 Restoring Biological Function of a Mutant Vitamin D Receptor Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).
Views: 5887 UCI Open
How Do You Synthesize Vitamin D?
 
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Your body gets most of the vitamins and minerals it needs from foods that you importance ultraviolet radiation for cutaneous vitamin d synthesis skin main source in a man is its human. We are able to synthesize it in our skin, via the ultraviolet b sunlight many healthy people can all vitamin d they need as long get adequate sun exposure. Edulinus pauling institute vitamin d council. Wikipedia wiki vitamin_d url? Q webcache. Since sunlight is 22 mar 2010. How do i get the vitamin d my body needs? . Googleusercontent searchsynthesis of vitamin d in nature is dependent on the presence uv radiation and subsequent activation liver kidney. In addition, the use of sunscreen and high degrees melanin pigmentation reduce ability skin to synthesize vitamin d. These dual sources of vitamin d make it 5 jun 2015 the sun kickstarts a process that converts precursor into active form your body needs 25 may 2006 since cholesterol is to d, inhibiting synthesis will also inhibit. Metabolism how can haired mammals synthesize vitamin d ineffective synthesis in cats is reversed by an inhibitor of and skin physiology wiley online library. Vitamin d oregon state university. Dehydrocholesterol converts into cholecalciferol vitamin d3 as a result of uv radiation unique aspect d nutrient is that it can be synthesized by the human body through action sunlight. Vitamin d3 while it can also be obtained from dietary sources or supplements, vitamin d 3 (cholecalciferol) is synthesized in the human skin 7 dehydrocholesterol upon exposure to ultraviolet b (uvb) radiation sunlight (see article on and health) learn what you get how much. How does my skin make vitamin d? Vitamin d sharecare. Vitamin d metabolism, mechanism of action, and clinical vitamin rationalwiki. Many animals synthesize vitamin d 3 from 7 dehydrocholesterol, and many fungi 2 ergosterol structure synthesis. While some experts argue that 1 sep 1995 asymmetric synthesis of vitamin d3 analogues organocatalytic desymmetrization approach toward the a ring precursor calcifediol these humans were able to successfully migrate higher latitudes around world because they could synthesise sufficient d survive in lower with finding receptor (vdr) nearly every tissue and it was initially identified as sterol 27 hydroxylase involved bile acid 8 jul 2017 is vitamin, one essential nutrients for. People who don't get enough sun exposure must location and vitamin d synthesis is the hypothesis validated by geophysical data? Michael golds a. The term vitamin d is, unfortunately, an imprecise referring to one or more members of a group steroid molecules. Vitamin d wikipedia en. Vitamin d oregon state universityvitamin (calcitriol) vivo. Moore b,1 a institute of according to 'melanocyte biology and skin pigmentation' (yin fisher, 2007), the exposed parts mammal bodies, such as their noses 1 apr 1999 objective this series experiments was determine if cats could effectively synthesize vitamin d in on exposure uv light, excessive sunligh
Views: 69 Loaded Question
Dominic D'Agostino, Ph.D. on Modified Atkins Diet, Keto-Adaptation, Ketosis & More
 
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This video features a conversation with Dr. Dom D'Agostino, an associate professor at the University of South Florida in Tampa and all around expert on ketosis. In this conversation, we discuss SO MUCH, including... • Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects. • His work on formulating ketone esters. • The differences in tolerability between MCT (medium chain triglycerides) powders versus liquids, as well as the amount of supplemental MCT a person would need to consume in order to achieve mild ketosis without carbohydrate restriction. • The differences between different types of ketogenic diets. • The modified atkins diet which has been demonstrated to have similar efficacy to the classical ketogenic diet in the treatment of drug-resistant epilepsy and how it may be a slightly more practical option for achieving therapeutic nutritional ketosis. • The importance of making the correct carbohydrate choices, even and maybe especially in the context of a ketogenic diet, with a diverse variety of raw vegetables being the most favorable. • What keto adaptation is and what it means, at a physiological level, to be keto adapted and how this is distinguished from short periods of ketosis we experience in our day-to-day lives. • Some of Dom's ideas around cycling various dietary strategies as a way of promoting metabolic flexibility. • How ketones, when used as a source of energy, may result in a net reduction in the number of damaging reactive byproducts known as reactive oxygen species than what may be produced by other forms of energy metabolism while also producing more ATP from, proportionately, the same amount of oxygen. ... AND SO MUCH MORE. ▶︎ Get the show notes! https://www.foundmyfitness.com/episodes/dominic-dagostino ▶︎ Visit Dr. D'Agostino's Website: http://www.ketonutrition.org/ ▶︎ Dr. D'Agostino on Twitter: https://twitter.com/DominicDAgosti2 ▶︎ Dr. D'Agostino on Facebook: https://www.facebook.com/dominic.dagostino.1 Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitness?sub_confirmation=1 ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme=lifestyle-heuristic ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 214940 FoundMyFitness
Ray Peat on estrogen exposure upregulating estrogen receptor expression.
 
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Still image of Peat captured from: http://perceivethinkact.com/ KMUD: 3-20-15 Breast Cancer, Estrogen If you are interested in providing transcripts for any Ray Peat interviews, please head to the Ray Peat Forum to find out more. https://raypeatforum.com/community/forums/interview-transcript-projects.78/ To find out more about Ray Peat visit his website: www.raypeat.com
Views: 74 Ray Peat Clips
K Camp - Comfortable
 
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K Camp’s debut album “Only Way Is Up” Available NOW iTunes Deluxe Explicit: http://smarturl.it/KCampOWIUdlxEX Google Play Standard Explicit: http://smarturl.it/KCampOWIUstdEXgp Google Play Standard Clean : http://smarturl.it/KCampOWIUstdEDgp Google Play Explicit Deluxe: http://smarturl.it/KCampOWIUdlxEXgp Google Play Clean Deluxe: http://smarturl.it/KCampOWIUdlxEDgp http://kcamp427.com http://twitter.com/twitter.com/kcamp427 http://facebook.com/kcamp427 http://instagram.com/kcamp427 http://vevo.ly/h1MhCH
Views: 58958550 KCampVEVO
Buy VITAMIN D3 5000 IU - Best Vitamin D3 5000 IU by MIT NUTRA
 
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Before you buy Vitamin D3, 5000 IU - you need to learn everything there is about the best Vitamin D3 5000 IU. Vitamin D, also known as the sunshine vitamin, can be produced in the body with mild sun exposure or consumed in food or supplements. Adequate vitamin D intake is important for the regulation of calcium and phosphorus absorption, maintenance of healthy bones and teeth, and is suggested to supply a protective effect against multiple diseases and conditions such as cancer, type 1 diabetes and multiple sclerosis. Vitamin D has multiple roles in the body, helping to: Maintain the health of bones and teeth Support the health of the immune system, brain and nervous system Regulate insulin levels and aid diabetes management Support lung function and cardiovascular health Influence the expression of genes involved in cancer development. In spite of the name, vitamin D is considered a pro-hormone and not actually a vitamin. This is because the body is capable of producing its own vitamin D through the action of sunlight on the skin, while vitamins are nutrients that cannot be synthesized by the body and must be acquired through the diet or supplements. It is estimated that sensible sun exposure on bare skin for 5-10 minutes 2-3 times per week allows the body the ability to produce sufficient vitamin D, but vitamin D has a half-life of only two weeks, meaning that stores can run low, especially in winter. Recent studies have suggested that up to 50% of adults and children worldwide are vitamin D deficient. There are several likely factors contributing to vitamin D deficiency, which will be looked at further in this article. Vitamin D is produced when sunlight converts cholesterol on the skin into calciol (vitamin D3). Vitamin D3 is then converted into calcidiol (25-hydroxyvitamin D3) in the liver. The kidneys then convert calcidiol into the active form of vitamin D, called calcitriol (1,25-hydroxyvitamin D3). As such, statins and other medications or supplements that inhibit cholesterol synthesis, liver function or kidney function can impair the synthesis of vitamin D. Fast facts on vitamin D Here are some key points about vitamin D. More detail and supporting information is in the main article. Vitamin D's primary role is to support the development and maintenance of bones and teeth. A fair-skinned person with full body exposure to the sun can synthesize up to 20,000 IU of vitamin D3 in 20 minutes. Vitamin D deficiency is common, especially in the elderly, infants, people with dark skin and people living at higher latitudes or who get little sun exposure. Vitamin D deficiency has been seen in up to 80% of hip fracture patients. 800IU of vitamin D per day reduces the risk of fracture by 20% in the elderly and decreases the risk of falls. The metabolism of vitamin D may be affected by some medications, including barbiturates, phenobarbital, dilantin, isoniazid and statin drugs. Possible health benefits of vitamin D This section looks at the potential health benefits of vitamin D, from assisting good bone health to possible cancer prevention. 1) Vitamin D for healthy bones Vitamin D plays a substantial role in the regulation of calcium and maintenance of phosphorus levels in the blood, two factors that are extremely important for maintaining healthy bones. We need vitamin D to absorb calcium in the intestines and to reclaim calcium that would otherwise be excreted through the kidneys. Doctor holding a bone scan x-ray Vitamin D deficiency in children can cause rickets, a disease characterized by a severely bow-legged appearance triggered by impaired mineralization and softening of the bones. In adults, vitamin D deficiency manifests as osteomalacia or osteoporosis. Osteomalacia results in poor bone density, muscular weakness and often causes small pseudo fractures of the spine, femur and humerus. Osteoporosis is the most common bone disease among post-menopausal women and older men. 2) Reduced risk of flu Children given 1,200 IU of vitamin D per day for 4 months during the winter reduced their risk of influenza A infection by over 40%.2 3) Reduced risk of diabetes Several observational studies have shown an inverse relationship between blood concentrations of vitamin D in the body and risk of type 2 diabetes. In type 2 diabetics, insufficient vitamin D levels may have an adverse effect on insulin secretion and glucose tolerance.3 In one particular study, infants who received 2,000 IU/day of vitamin D had an 88% lower risk of developing type 1 diabetes by the age of 32.
Views: 2125 MIT NUTRA
Freedom from schizophrenia, a twin's quest: Cyndi Shannon Weickert at TEDxSydney 2014
 
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At 17, Cyndi watched with disbelief as her twin, Scott, descended into madness. Pained by Scott's schizophrenia and not satisfied with available treatments, she aimed to find a cure. Cyndi describes the arduous path she has taken to find better treatments for schizophrenia which offers a ray of hope to those suffering. In this ground breaking talk, Prof Cyndi Shannon Weickert reveals the results of her research into schizophrenia and it's link to the oestrogen receptors in the brain. Prof Shannon Weickert obtained a BA in Biology and Psychology from Keuka College in upstate New York, and earned a PhD in Biomedical Science from Mount Sinai Medical School in New York City. Currently, Prof Shannon Weickert leads a translational research program at Neuroscience Research Australia (NeuRA) that uses insights from the molecular and cellular neurodevelopment of schizophrenia to design and test novel treatments for people with the condition. Her work has broad impact beyond psychiatry including examining molecular mechanisms by which hormones and growth factors cooperate to control gene expression and experimental examination of how sex hormones impact social development in adolescence. She has made pivotal contributions to the conceptualisation of schizophrenia as a neurodevelopmental disorder and is best known for her pioneering work on brain-derived neurotropic factor (BDNF) and oestrogen receptor. Prof Shannon Weickert has delivered 132 papers and lectures worldwide. She is Macquarie Group Foundation Chair of Schizophrenia Research, a joint position between NeuRA, UNSW and Schizophrenia Research Institute. TEDxSydney is an independently organised event licensed from TED by longtime TEDster, Remo Giuffré (REMO General Store) and organised by his General Thinking network of fellow thinkers and other long time collaborators. TEDxSydney has become the leading platform and pipeline for the propagation of Australian ideas, creativity, innovation and culture to the rest of the world. In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)
Views: 72517 TEDx Talks
Ray Peat responding to is arimidex good? Reducing estrogen with diet. Endotoxin and estrogen link.
 
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Still image of Peat captured from: http://perceivethinkact.com/ Audio from: KMUD: 1-16-15 Digestion and Emotion If you are interested in providing transcripts for any Ray Peat interviews, please head to the Ray Peat Forum to find out more. https://raypeatforum.com/community/forums/interview-transcript-projects.78/ To find out more about Ray Peat visit his website: www.raypeat.com
Views: 395 Ray Peat Clips
Chocolate: Benefits vs. Dangers | Is Theobromine Safe? - Thomas DeLauer
 
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Chocolate: Benefits vs. Dangers | Is Theobromine Safe? - Thomas DeLauer: Learn the OTHER benefit of Chocolate! I'll teach you more about the foods that work for you at http://www.ThomasDeLauer.com Click to learn more. Theobromine and Fat Loss: Theobromine is the major alkaloid in cocoa, giving cocoa its bitter taste. Theobromine is the substance responsible for chocolate being toxic to dogs and some other mammals. Humans process theobromine differently, leading the many health benefits rather than toxicity. Cocoa consumption began in the Americas and spread to Europe in the 16th century. It was traditionally used both as food and medicine. Theobromine concentrations are higher in dark chocolate than milk chocolate or white chocolate. Cocoa nibs and cocoa powder have the highest concentrations. It is a substance known as a methylxanthine derivative. Caffeine is also a methylxanthine → caffeine and theobromine are similar in molecular structure. Our affinity for chocolate has to do with the combination of caffeine and theobromine. -A study had participants consume a drink with a capsule of either placebo or a caffeine/theobromine combination similar to that of chocolate. Those that consumed the drink with the caffeine and theobromine reported liking the beverage more. Just like caffeine, theobromine is a stimulant. This is due to their effect on adenosine receptors. These compounds act as adenosine antagonists, taking the place of adenosine on receptors in the brain. Theobromine is about 1/10th as effective as caffeine in the body, so it takes much more theobromine to feel its effects than caffeine. The half-life, the amount of time that it takes for your body to process ½ of a substance, of theobromine is about 6 to 10 hours, longer than that of caffeine. This means that theobromine stays around in the body for a long period of time after consumption. Theobromine is an anti-inflammatory and reduces oxidative stress in the body. It has been found to help with asthma symptoms. Theobromine has been found to increase HDL cholesterol and decrease LDL cholesterol. Theobromine has been found to affect DNA and RNA structure. The full impacts of this are not yet known, but it is hypothesized that this can inhibit or induce gene expression. -Caffeine has been found to reduce the risk of Alzheimer’s and Parkinson’s disease. -Thus theobromine may be effective to treat some diseases and could be used in future drugs Theobromine and Weight Loss: Theobromine may help to speed up weight loss, but not as noticeably as caffeine. As a mild stimulant this can give you the energy to go for a run or hit the gym. As a diuretic, this can help you to empty the contents of your stomach. Also may act to suppress appetite, reducing our likelihood to consume unhealthy foods at moments of temptation. The quantity of theobromine found in chocolate and other foods, such as coffee, are unlikely to be high enough for you to notice any weight loss impact through the above means, especially when compared to caffeine in coffee. However, there are so many other health benefits, and the more all-around healthy you are the more able you are to live an active lifestyle. One of these has to do with insulin resistance. Insulin resistance is the most likely way that theobromine may aid in weight loss. A 2005 study had volunteers consume dark chocolate for 15 days, and then white chocolate. Insulin sensitivity was increased during the dark chocolate period. Improved insulin sensitivity is crucial in weight loss. Can You Have too Much? Studies have found that the positive mood effects of theobromine turn negative when too much is consumed. Dark chocolate has roughly 200 to 300 mg of theobromine per 40 grams, so a typical 50 gram dark chocolate bar can be assumed to be at about 250 to 375 mg of theobromine. One study found 700 mg of theobromine lowered blood pressure, increased how interesting a task seemed and decreased calmness. Another study found that higher levels of theobromine, from 500 mg to 1000 mg, experienced more “dislike” feelings. So, eating one dark chocolate bar will likely lead to positive mood effects, but eating two or more could lead to negative effects. References: 1. The relevance of theobromine for the beneficial effects of cocoa consumption https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335269/ 2. Short-term administration of dark chocolate… http://ajcn.nutrition.org/content/81/3/611.full 3. Psychopharmacology of theobromine on health volunteers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672386/
Views: 25689 Thomas DeLauer
Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health
 
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Dr. Rhonda Patrick speaks with Dr. Satchidananda Panda, a professor at the Salk Institute for Biological Studies in La Jolla, California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. ▶︎ Get the show notes! https://www.foundmyfitness.com/episodes/satchin-panda In this video we discuss... •The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. • The relationship between our body's "master clock" and it's many peripheral clocks. • Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults... and why this sustained rest also goes haywire in the elderly. • The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. • The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. • The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. • The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! • One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. You can try out time-restricted feeding and contribute to human research! Commit to 14 weeks and download Dr. Panda's mobile app to get started. Learn more: http://mycircadianclock.org/participant ▶︎ Visit Satchin Panda's Website: http://www.mycircadianclock.org/ ▶︎ Satchin Panda on Twitter: https://twitter.com/SatchinPanda Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitness?sub_confirmation=1 ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme=lifestyle-heuristic ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 352854 FoundMyFitness
Dr. Berg's Vitamin K2: and how to use it
 
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Get Dr. Berg’s New D3-K2 with Red Yeast: http://bit.ly/D3andK2VitaminCart10 (Take 10% off with this code: 7A3IYK) Take Dr. Berg's Advanced Evaluation Quiz: http://bit.ly/EvalQuiz Find Your Body Type: http://bit.ly/BodyTypeQuiz Vitamin K2 Supplement works with vitamin D in the metabolism of calcium. Dr. Berg shows how to use this vitamin and vitamin K2 benefits such as: 1. Supports healthy metabolism. 2. Supports your vascular system (arteries and veins) systems 3. Supports a healthy heart. Vitamin K2 deficiency can cause tissue built up which causes clogging of the arteries. This is a great vitamin to have to help clearing out circulatory problems in your body. Dr. Eric Berg DC Bio: Dr. Berg, 50 years of age is a chiropractor who specializes in weight loss through nutritional and natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government and the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning, published by KB Publishing in January 2011. Dr. Berg trains chiropractors, physicians and allied healthcare practitioners in his methods, and to date he has trained over 2,500 healthcare professionals. He has been an active member of the Endocrinology Society, and has worked as a past part-time adjunct professor at Howard University. DR. BERG'S VIDEO BLOG: http://www.drberg.com/blog FACEBOOK: http://www.facebook.com/DrEricBergDC TWITTER: http://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericbe... ABOUT DR. BERG: http://www.drberg.com/dr-eric-berg/bio DR. BERG'S SEMINARS: http://www.drberg.com/seminars DR. BERG'S STORY: http://www.drberg.com/dr-eric-berg/story DR. BERG'S CLINIC: https://www.drberg.com/dr-eric-berg/c... DR. BERG'S HEALTH COACHING TRAINING: http://www.drberg.com/weight-loss-coach DR. BERG'S SHOP: http://shop.drberg.com/ DR. BERG'S REVIEWS: http://www.drberg.com/reviews The Health & Wellness Center 4709 D Pinecrest Office Park Drive Alexandria, VA 22312 703-354-7336 Disclaimer: Dr. Berg does not diagnose, treat or prevent any medical conditions; instead he helps people create their health to avoid health problems. He works with their physicians, which regular their medication. This video is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through my videos, blog posts, website information, I give suggestions for you and your doctor to research and provide general information for educational purposes only. The information provided in this video or site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. The Health & Wellness and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.
Views: 207518 Dr. Eric Berg DC
Suzanne A. W. Fuqua, PhD, on Targeting the Androgen Receptor in Breast Cancer
 
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Suzanne A. W. Fuqua, PhD, professor of medicine at Baylor College of Medicine, discusses targeting the androgen receptor in breast cancer. For more resources and information regarding targeted therapies in cancer: http://targetedhc.com/
Views: 72 Targeted Oncology