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Breast Cancer    BRCA1 & BRCA2 Gene Mutations HD
 
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www.elarasystems.com October is breast cancer awareness month, and while most people are aware of breast cancer, they may be unaware of certain factors which increase the risk of developing the disease. Individuals with a strong family history of breast cancer may choose to receive a gene test to assess these risks. A gene test looks for specific mutations in your BRCA1 or BRCA2 gene. A mutation in these genes can be inherited from either your mother or your father. BRCA1 and BRCA2 help control normal cell growth. Mutations in these genes may increase the risk of developing breast cancer. According to the National Cancer Institute: About 12% of women in the general population will develop breast cancer. However, about 45% of women who have inherited a BRCA2 mutation will develop breast cancer, and about 55-65% of women with a BRCA1 mutations will develop breast cancer. Consider putting together an early detection plan and be proactive about your health.
Просмотров: 15092 Elara Systems
BRCA mutation
 
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This breast cancer lecture explains about the brca gene (brca1 and brca2 mechanism) mutation which leads to the development of breast cancer. A BRCA mutation is a mutation in both of the genes BRCA1 and BRCA2. Detrimental mutations in these tumor suppressor genes produce a hereditary breast-ovarian melanoma syndrome in affected families. Mutations in BRCA1 and BRCA2 are distinctive, and breast cancer is relatively original, so these mutations consequently account for only five to ten percent of all breast cancer cases in women. 1000s of distinctive types of mutations in these genes have been recognized. Excessive-danger mutations, which disable an primary error-free DNA repair procedure (homology directed repair), tremendously develop the character's threat of setting up breast cancer, ovarian melanoma and specific different cancers. Why BRCA1 and BRCA2 mutations lead preferentially to cancers of the breast and ovary is not identified, but lack of BRCA1 function seems to result in non-useful x-chromosome inactivation. No longer all mutations are excessive-chance; some show up to be harmless editions. The cancer hazard related to any given mutation varies greatly and depends on the distinctive variety and area of the mutation and in all probability different person reasons. Ladies with unsafe mutations in either BRCA1 or BRCA2 have risk of breast melanoma that is about five occasions the average chance, and a hazard of ovarian cancer that's about ten to thirty occasions common. BRCA1 mutations typically confer a higher danger of breast and ovarian melanoma in females than BRCA2 mutations. Having a high-threat mutation does no longer guarantee that the girl will increase any sort of cancer, or warranty that any melanoma that appears was once genuinely induced through the mutation, alternatively than every other element, like alcohol consumption. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Просмотров: 22281 Shomu's Biology
What chromosome is cancer found on ? | Good Health FAQ
 
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But in a cancer cell this genetic copying process often goes out 10, giant chromosomes that grow by sucking up promoting genes some of the neochromosomes, they found dna belonged to all chromosomal instability causes and consequences at progression towards higher malignancy these tumours, complex structural numerical submit your paper genes, as well molecular cellular findings relevance for management patients most cells have acquired clonal chromosome abnormalities. Mutations in the gene are transmitted an about 5. The chromosomal basis of cancer berkeley mcb. 10 11, massive chromosomes in cancer cells are stitching together our shattered dna to drive tumour growth, a new study has found 22, cancers can be caused by changes in dna (mutations) that turn on the philadelphia chromosome is found in the leukemia cells of almost all brca1 and brca1 are a human gene and its protein product, respectively. Theodor boveri first conceptualized that malignancy result due to chromosomal. The human brca1 gene is located on the long (q) arm of chromosome 17 at region 2 band 1, from base breast cancer genes and inheritance ndsu. Brca1 is located on chromosome 17. That have been characterised at the molecular level found to exert their action 3, 2008 but three groups disagree on whether variant long arm of chromosome 15 causes disease directly or by increasing 29, inside nucleus are 23 pairs chromosomes. Chromosome 13 brca2 gene for breast cancer susceptibility, matt. Breast cancer genes and inheritance ndsu. New chromosomal instability in cancer atlas of genetics and genes, chromosomes wiley online library. Learn cancer chromosome abnormalities visualized in living cells nih. Chromosome 13 brca2 gene for breast cancer susceptibility, matt visualizing how chromosome abnormalities form in living cells. These chromosome aberrations are caused by genomic instabilities inherent to most cancers germline mutations in brca1 or brca2 genes increase a woman's risk of developing hereditary breast ovarian. The human brca1 gene is located on the long (q) arm of chromosome 17 at region 2 band 1, from base breast cancer most common that affects women in united and brca2 genes are 13 18, every cell a woman's body inactivates one its two x chromosomes. Germline' or 'breast cancer' to search within chromosome 17each somatic cell contains two sets of chromosomes which can be arranged into magazine. In 1960, peter nowell and david hungerford discovered the first chromosomal abnormality associated with cancer using cytogenetics (nowell & hungerford, 19, scientists found that most chromosome breaks reattached correctly, as cells have built in repair machinery to fix dna. To date, clonal chromosome aberrations have been found in all major interviewee matt ridley. Cancer chromosomal abnormalities encyclopedia of life sciences. Mutations in cancer often affect the x chromosome sciencedailystanford health care. P53 has been found to be the most common mutation in cancers, spite of these improvements, mammalian cytogenetics did not blossom until 1950s, when hypotonic treatment was facilitate chromosome prostate cancer is frequently diagnosed malignancy occurring as many three them are located on 1 (hpc1, pcap and capb) role genetics a matter debate over time. Breast cancer risk factors genetics breastcancercancer web cancerindexacquired chromosome abnormalities the cytogenetics of prostate lsu school medicine. Chromosomal translocations in cancer sciencedirect. Monster cancer chromosome is made from shattered dna. Chromosome abnormalities and cancer cytogenetics. However two prominent features of cancer cells are abnormal numbers chromosomes (aneuploidy) and large scale structural rearrangements. Genetic link to lung cancer found on chromosome 15. The most commonly mutated gene in people who have cancer is p53 14, 2008 cytogenetic abnormalities are a characteristic attribute of cells. Scientists have discovered that monster chromosomes are fuelling do we know what causes chronic myeloid leukemia? . 15, genes linked with cancer (125) search box e. Are chromosomes linked to cancer? Science museum. Brca2, on chromosome 13, is one of the genes associated with hereditary breast cancer. Gov cancer chromosome abnormalities visualized living cells url? Q webcache. Although gender, age and environmental 8, for the first time, scientists have directly observed events that lead to formation of a chromosome abnormality is often found in cancer when cells multiply, each new cell usually gets an exact copy all 46 chromosomes (23 pairs). Cancer susceptibility genes' and 'breast cancer proteins'. Scientists have found these genes to be damaged in some human cancers, including bowel 22, 1998 release prostate ca gene mapped x chromosome the newly discovered is second cancer located derstanding of involvement this cancer, since other studies loh for regions chromo somebased on their chromosomal constitution cells are new cell species with mutations that also been (s
Просмотров: 118 BEST HEALTH Answers
BREAST CANCER: ABNORMAL CHROMOSOMES
 
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BREAST CANCER: ABNORMAL CHROMOSOMES
Просмотров: 279 Walter Jahn
What is BRCA1 and BRCA2?
 
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Women who have no family history of breast cancer and don’t carry the BRCA1 or 2 gene mutation, have only a 12% chance of getting breast cancer in their lifetime. But, women with BRCA1 have about a 65% chance of developing it by the time they turn 70; the likelihood is a little lower for women with BRCA2 at 45%. Now that you know how important BRCA1 & BRCA2 is and how it affects your cancer risk, what exactly is it? Scottsdale Healthcare’s Gynecologic Oncologist Dr. Mike Janicek explains what BRCA1 & BRCA2 is in the video below. SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS http://www.youtube.com/user/drjayharness VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS http://www.breastcanceranswers.com/news SUBMIT A QUESTION http://www.breastcanceranswers.com/ DOWNLOAD DR. HARNESS' 15 QUESTIONS TO ASK YOUR DOCTOR http://www.breastcanceranswers.com/ CONNECT WITH US! Google+: http://bit.ly/16nhEnr Facebook: https://www.facebook.com/BreastCancerAnswers Twitter: https://twitter.com/BreastCancerDr
Просмотров: 29927 Breast Cancer Answers®
Stopping Breast Cancer’s Spread Through Gene Regulators
 
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American Cancer Society-funded researcher Douglas Hurst, Ph.D., is studying the possibility of stopping the spread of breast cancer by changing the activity of molecules that are helping control whether certain genes get turned on or turned off.
Просмотров: 709 American Cancer Society
The cancer gene we all have - Michael Windelspecht
 
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View full lesson: http://ed.ted.com/lessons/the-cancer-gene-we-all-have-michael-windelspecht Within every cell in our body, two copies of a tumor suppressor gene called BRCA1 are tasked with regulating the speed at which cells divide. Michael Windelspecht explains how these genes can sometimes mutate, making those cells less specialized and more likely to develop into cancer. Lesson by Michael Windelspecht, animation by Zedem Media.
Просмотров: 211235 TED-Ed
Chromosome 13 - BRCA2 and DNA Damage
 
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EXPLORE THE RI ADVENT CALENDAR: http://rigb.org.uk/advent Mistakes in the "recipe" of your DNA -- if bits of code go missing, or get swapped or damaged -- could spell the difference between life and death. DNA often gets damaged by everyday processes within our bodies, but also from external factors such as UV radiation or tobacco smoke. Luckily, our bodies are well equipped to fix this damage thanks, in part, to the BRCA2 gene, found on chromosome 13. BRCA2 encodes for a large protein which carries out repair work on damaged DNA. It's no surprise then that if the BRCA2 is faulty, or missing, our cells can't repair themselves properly. As a result, the damaged DNA builds up and this can lead to cancer. In turns out, however, that faults on BRCA2 aren't necessarily such an advantage to cancer cells. As their BRCA2 gene is faulty, the only remaining "tool" in a cancer cell's molecular repair kit is another gene known as PARP. Dr Kat Arney from Cancer Research UK explains how by using drugs to block PARP function, scientists are hoping to prevent cancer cells from repairing themselves, causing them to die off. Whilst developing cancer treatments is certainly no piece of cake, drugs with PARP inhibitors are already showing great promise in trials. You can find out more about research into PARP inhibitors on the Cancer Research UK science blog at the following links: http://scienceblog.cancerresearchuk.org/2008/07/10/a-%E2%80%98lethal-weapon%E2%80%99-in-the-search-for-new-cancer-treatments/ http://scienceblog.cancerresearchuk.org/2011/07/12/widening-the-net-for-parp-inhibitors/ For more information on related cancer research visit: www.cruk.org With thanks to BBSRC: http://bbsrc.ac.uk/ Don't miss the 2013 CHRISTMAS LECTURES on BBC Four and BBC iPlayer: http://rigb.org/christmas-lectures The Ri is on Twitter: http://twitter.com/ri_science and Facebook: http://www.facebook.com/royalinstitution and Tumblr: http://ri-science.tumblr.com/ Our editorial policy: http://www.rigb.org/home/editorial-policy Subscribe for the latest science videos: http://bit.ly/RiNewsletter
Просмотров: 16944 The Royal Institution
What is Gene Positive Breast Cancer?
 
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Did you know that breast cancer genes can be passed down through family? Dr. Harness explains the BRCA1 and BRCA2 genes and who should be tested for them in this video. Click Here To Get Dr. Harness' 15 Breast Cancer Questions To Ask Your Doctor http://www.breastcanceranswers.com/what-breast-cancer-questions-to-ask/# Breast Cancer Answers is a social media show where viewers submit a question and get the answer from an expert. Submit your question now at, http://www.breastcanceranswers.com/ask This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk.  If you have any concerns about your health, please consult with a physician.
Просмотров: 5715 Breast Cancer Answers®
DEFECTS IN DNA REPAIR, DNA repair genes & Associated Cancers
 
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In this short tutorial, i have described how defects in DNA repair results in cancer and various DNA repair genes which are involved in the repair of damaged DNA. ****Follow me***** http://ilovepathology.com/ Twitter : https://twitter.com/VijayPatho https://twitter.com/ilovepathology2 Facebook: https://www.facebook.com/ilovepathology/ Defects in DNA repair& Cancer DNA damage is ubiquitous DNA damage is not the same as mutation though it can lead to mutation DNA damage is a chemical alteration ( can be corrected) Mutation is a change in the sequence of base pairs ( cannot be corrected ) If any kind of DNA damage is likely to lead to a mutation, we call it genotoxic There are Mechanisms to repair the types of DNA damage The Effective DNA repair is the backbone of cancer free survival Genome instability is an Important hallmark of cancer INSTABILITY: could be point mutations, trinucleotide repeat expansions and contractions, gene duplications, deletions, and inversions, to large-scale chromosome changes including translocations and whole chromosome gains and losses. DNA repair systems play critical roles in genome stabilization Defects in DNA repair pathways contribute to specific instabilities Erroneous DNA repair leads to mutations or chromosomal aberrations The Genes for DNA repair Individuals with inherited defects in DNA repair genes are at increased risk of developing cancer. Base Excision Pathway (BER):MDB4,Colorectal Ovary Multiple myeloma NER Pathway:XPC, Bladder Skin Cancer Direct reversal of Damage:MGMT,Colon Gastric Glioblastoma Mismatch excision repair (MMR):MSH 6Colorectal Non Homologous End joining: XRCC5, lung Homologous recombination: BRCA 1,Breast Ovary Gastric -~-~~-~~~-~~-~- Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?" https://www.youtube.com/watch?v=LXaO59IqQm8 -~-~~-~~~-~~-~-
Просмотров: 6851 ilovepathology
TUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.
 
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This short tutorial explains the general concepts of tumor suppressor genes and a detailed explaination of Retinoblastoma gene ****Follow me***** http://ilovepathology.com/ Twitter : https://twitter.com/VijayPatho https://twitter.com/ilovepathology2 Facebook: https://www.facebook.com/ilovepathology/ Tumor suppression genes- general aspects Retinoblastoma gene Knudson’s two Hit Hypothesis Role of RB in regulation of cell cycle Mechanism of inactivation of RB Tumors associated with RB gene mutations Tumor suppressor proteins( products of TSG) Regulate cell growth by applying brakes to cell proliferation ( Growth Inhibition) Failure of growth inhibition is seen in carcinogenesis Loss of function of these genes is a key event in carcinogenesis Retinoblastoma Gene ( RB Gene) First discovered Tumor suppressor gene Chromosome 13q14 Retinoblastoma: is a childhood tumor with inactivation of this gene. Knudson’s two-hit hypothesis Two mutations ( hits) involving both the alleles of TSG ( here RB gene) is a basic requisite for the development of tumor Retinoblastoma can occur as hereditary or sporadic form Explanation for the same is given by Knudson’s two-hit hypothesis RB protein- product of RB gene Key role in regulation of the cell cycle “Governor” of the cell cycle So, How does RB gets inactivated ?OrHow does the Antiproliferative activity of RB is nullified? 1. Germline & somatic Loss of function Mutations of RB Gene 2. Gene Amplifications of CDK 4 and Cyclin D genes 3. Functional inactivation of RB Tumors associated with RB Gene mutations Retinoblastoma Osteosarcoma Glioblastomas Small cell carcinomas of lung Breast cancers & Bladder cancers -~-~~-~~~-~~-~- Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?" https://www.youtube.com/watch?v=LXaO59IqQm8 -~-~~-~~~-~~-~-
Просмотров: 22744 ilovepathology
What chromosome is affected ? | Health News and FAQ
 
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Each time a cell 4, these changes affect protein production by changing the genes on chromosome. Chromosome 21 is the smallest human autosome, with 48 million nucleotides representing all of chromosomes together make up our entire genetic information and can be since gene on x chromosome, none his sons will affected 22, through further analysis dna from families, researchers have now identified a single that chromosome as root cause 25, 2011 what are by sickle cell disease? The 1 their 11s (chromosomes come in pairs) 1, for huntington's diseases, htt which encodes protein huntingtin (htt). Can changes in the number of chromosomes affect health and can structure region chromosome 22 linked to bipolar disorder, again. Chromosome 21 genetics home reference ghr. Single gene disorder? Caused by mutations In the fgfr3 On chromosome. This gene is located on chromosome 2 at the cytogenic location 2q11. Every boy inherits an x chromosome from his mother and a y generation was affected, relatives not have known what disease he had 10, in linked recessive manner therefore mainly affects male offspring. Do we know what causes chronic myeloid leukemia? . Chromosomes which of these problems affected your parents or grandparents? The segments our dna, genes are neatly packaged within structures called chromosomes. Chromosome 21 genetics home reference. Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Explore the genes and chromosomes from home version of merck mutations that affect reproductive cells be passed on to offspring recall hemoglobin is protein affected in thalassemia. Since males only have one x chromosome, they will develop cystic fibrosis affects both and females, but is not contagious to on chromosome 7, of the 23 pairs chromosomes that children inherit from their 22, are long molecules dna in each cell. Which chromosome is affected by huntington's disease and how what causes hemophilia? What are chromosomes? Genes chromosomes fundamentals merck manuals genetic inheritance of thalassemia. Gov chromosome 21 url? Q webcache. It occurs as a random event during cell division early in fetal development 4 common form of aneuploidy is trisomy, or the presence an extra chromosome cells. If a mutation occurs on the x 19, affects about 1 in 25,000 individuals of all ethnic groups. Tri ' is greek for 'three'; People with trisomy have three copies of a particular chromosome in cells instead the normal two. Identifying genetic variants on the y chromosome of males with affects about 1 in 25,000 individuals all ethnic groups. The instructions for beta globin production are on chromosome 11, one gene each 2, 2006 thereby the women usually not affected because of normal copy, second x. How chromosome mutations occur thoughtcomultiple sclerosis (ms) fact sheet 7. Because females have two copies of the x chromosome and multiple sclerosis (ms) is a chronic disease that affects fatty substance called on 6 known as major histocompatibility complex (mhc) 30, an autosomal gene located numbered usually males in same way. Down syndrome is an example of a condition caused by trisomy (illustration) 4 changes that affect the structure chromosomes can cause problems with growth, development, and function body's systems 2, 2001 in addition to chromosome 22 region, researchers found regions among affected unaffected individuals, brca2, on 13, one genes associated hereditary overview cancer disease affects people all nationalities age are made dna located inside nucleus each cell impact, but other individuals 21 23 pairs humans. What causes cystic fibrosis child life society. Chromosomes involved in color blindness epilepsy action. Down syndrome genetics home reference. Ask an expert sicke cell what chromosomes are affected? . Htt is located in the short arm of 29, chromosomes are blocks dna (deoxyribonucleic acid). Chromosome structure changes are often harmful to an a male with mutation in gene on the x chromosome is typically affected condition. Single gene disorder? Caused by mutations In the fgfr3 On chromosome Duchenne muscular dystrophy (dmd) causes inheritance duchenne hunter syndrome genetics news medical. Autosomal recessive inheritance this fact all about genetics kidshealth. Two copies of chromosome 21, one copy inherited from each 4 people who inherit an unbalanced translocation involving 21 have extra genetic material which causes down syndrome. In early childhood from hemophilia or any other cause who were not affected more than 50 different mutations in this gene have been shown to affect color vision. Men in contrary can not oversteer the ring chromosome 20 (r20) is a rare condition and one that often causes it happens sporadically (by chance) therefore does usually affect more than therefore, if genetic alteration (called mutation) occurs on y lead to autism, only men will be affected. Dna is the chemical but our genes affect more than way we look. Chromosome 13 brca2 gene for breast cancer suscep
Просмотров: 132 BEST HEALTH Answers
BREAST CANCER: BRCA1 and p53
 
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BREAST CANCER: BRCA1 and p53
Просмотров: 4774 Walter Jahn
Genes and the Microenvironment: Two Faces of Breast Cancer
 
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In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy — a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular "conversation" triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.
Просмотров: 5497 Berkeley Lab
Genetic variants that modify breast cancer risk in women who carry a BRCA2 mutation:
 
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Darwin Lunchtime Lectures by Karoline Kuchenbaecker Women carrying a pathogenic mutation in the BRCA2 gene have an increased risk of breast cancer. However, risk varies considerably between affected families. Our aim was to understand why risk can differ and what the predictors are. Our approach focused on other genetic variants that modify breast cancer risk We tried to identify some of these by comparing a large number of genetic variants in 4,330 BRCA2 mutation carriers with breast cancer and in 3,881 without. We analysed whether carrying a certain allele of a genetic variant was associated with increased or decreased likelihood of developing cancer. A variant on chromosome 6 was significantly associated with risk of cancer. Those who carried the minor allele of this variant had a 25% decreased risk of breast cancer. Risk predictors can be used to derive refined risk estimates for individuals carrying a BRCA2 mutation. These estimates are crucial in clinical management which can include decisions regarding preventive treatments. Furthermore, identification of genetic risk modifiers could help us improve our understanding of the biology of breast cancer development in these women.
Просмотров: 407 Darwin College
Something You Need To Know About Genetic Links To Cancer! Watch Out For Your Genes
 
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DISCOVERIES OF THE DAY Genetic links found to ovarian cancer. Aggressive form of breast cancer linked to gene. Another gene linked to increased risk of breast cancer. Hidden Red Head Gene May Increase Risk Of Skin Cancer. Hereditary Links to cancer. Watch and learn new discoveries in technologies and advancement in science, strange things and many more earth and beyond discoveries here at AllAboutDiscovery. SUBSCRIBE HERE FOR MORE UPDATES https://www.youtube.com/channel/UCy0wP3-4ZgfTAHqQhzxG-Nw?sub_confirmation=1 Don't forget to subscribe, like, share and leave a comment on this channel and be excited to learn more things from here. Thanks for watching.... #CancerGene #Cancer #HereditaryCANCER #CancerCells
Просмотров: 25 AllAboutDiscovery
8.2.4 - The Cell Cycle and Cancer: Tumor Suppressor Genes
 
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Biology 122 Week8.Lecture2.Part4: The Cell Cycle and Cancer: Tumor Suppressor Genes
Просмотров: 83197 dmflyboy
Genetic Testing for Breast Cancer with Dr. John Anagnost
 
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Dr. Anagnost, an oncologist with Cape Fear Cancer Specialists - NHRMC Physician Group, talks about the purpose of the genetic testing for breast cancer and who should consider it.
Просмотров: 218 New Hanover Regional Medical Center
Breast Cancer Biopsy - 3D Medical Animation
 
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http://www.amerra.com. Cancer is fundamentally a disease of regulation of tissue growth. In order for a normal cell to transform into a cancer cell, genes which regulate cell growth and differentiation must be altered. Genetic changes can occur at many levels, from gain or loss of entire chromosomes to a mutation affecting a single DNA nucleotide.
Просмотров: 18261 AmerraMedical
The Three B's; BRCA1, BRCA2, and Breast Cancer
 
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A multimedia project for the 2014 Student Bio Expo by Rachael Sise. Exploring the definition of cancer, how breast cancer risks increase, genetic heredity, and mutations of BRCA1 and BRCA2.
Просмотров: 10777 Marketa Hnilova
Genetic Test For Breast Cancer: How Much Does It Cost?
 
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As Kimberly Banks explains, the genetic test typically costs around $3,500 but if the test is recommended by a specialist it is usually covered by insurance. Click Here & Get The 15 Breast Cancer Questions To Ask Your Doctor http://www.breastcanceranswers.com/what-breast-cancer-questions-to-ask/# Breast Cancer Answers is a social media show where viewers submit a question and get the answer from an expert. Submit your question now at, http://www.breastcanceranswers.com/ask. This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. If you have any concerns about your health, please consult with a physician.
Просмотров: 3041 Breast Cancer Answers®
Michelle Heaton having cancer gene BRCA2 interview - Lorraine 9th October 2012
 
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Michelle found out she has a gene which gives her high chances of breast and ovarian cancer, meets women with similar issues and talks to Lorraine about it with Dr Hilary Jones
Просмотров: 17238 spikeyroberto
On what chromosome is the BRCA 2 gene located?
 
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Oncology: Breast cancer: The BRCA2 gene is located on the long (q) arm of chromosome 13 at position 12.3 (13q12.3).
Просмотров: 10 Flash-Med: Medical Questions and Answers
BRCA Gene Mutations & Breast Cancer
 
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A woman with a genetic mutation in her BRCA gene has a 50-80% greater risk of developing breast cancer. There are many different treatment options for these women, according to Dr. Emily Bellavance. - UMGCCC Breast Center: http://umm.gd/21Vc8lQ - Dr. Bellavance's Physician Profile: http://umm.gd/2ebsibS
Просмотров: 256 UMMCVideos
Research news: 'breast cancer gene' quadruples risk of prostate cancer
 
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Men with a faulty gene known to increase the risk of breast cancer in women are four times more likely to develop prostate cancer, according to a study part-funded by Prostate Action and carried out by the Institute of Cancer Research. Prostate Action CEO Emma Malcolm and Professor Ros Eeles, who led the study, discuss the findings. For the full story please visit http://www.prostateaction.org.uk/news
Просмотров: 409 ProstateAction
BRCA2 Cancer Gene Positive
 
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My name is Angie and I'm 31 years old. I'm a mom of four and recently diagnosed BRCA 2 positive. Life surely has changed. Here's my story. Continue to watch for daily and weekly updates.
Просмотров: 457 Angie Mom of Four
What are the Risks of Genetic Testing?
 
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Genetic testing and understanding our genes seem to be a big part of detecting cancer advancements. We are finding out how likely we are to develop cancer based on our genetics and family history. Scottsdale Healthcare Medical Center's Dr. Mike Janicek shares if there are any risks associated with genetic testing. SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS http://www.youtube.com/user/drjayharness VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS http://www.breastcanceranswers.com/news SUBMIT A QUESTION http://www.breastcanceranswers.com/ DOWNLOAD DR. HARNESS' 15 QUESTIONS TO ASK YOUR DOCTOR http://www.breastcanceranswers.com/ CONNECT WITH US! Google+: http://bit.ly/16nhEnr Facebook: https://www.facebook.com/BreastCancerAnswers Twitter: https://twitter.com/BreastCancerDr
Просмотров: 700 Breast Cancer Answers®
Genetic Testing: What Diseases Can It Reveal?
 
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People often undergo a genetic testing when they have a family history of breast cancer. Genetic testing may help to show if you’ve inherited a tendency to get certain diseases. But people don’t just use genetic testing to find out more about breast cancer. According to Scottsdale Healthcare’s Dr. Mike Janicek, “Breast cancer is only twice as prevalent in the world of genetics, ovarian cancer is actually a more important gene in terms of its potency related to a genetic mutation. It’s important not to forget about ovarian cancer.” Find out what other diseases you can find out from genetic testing. SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS http://www.youtube.com/user/drjayharness VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS http://www.breastcanceranswers.com/news SUBMIT A QUESTION http://www.breastcanceranswers.com/ DOWNLOAD DR. HARNESS' 15 QUESTIONS TO ASK YOUR DOCTOR http://www.breastcanceranswers.com/ CONNECT WITH US! Google+: http://bit.ly/16nhEnr Facebook: https://www.facebook.com/BreastCancerAnswers Twitter: https://twitter.com/BreastCancerDr
Просмотров: 3191 Breast Cancer Answers®
What Is the Difference between Genetics and Genomics?
 
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Watch Breast Cancer Answers Medical Director Dr. Harness as he explains the difference between genetics & genomics. SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING BREAST CANCER NEWS http://www.youtube.com/user/drjayharness VISIT BREASTCANCERANSWERS.com FOR THE LATEST IN BREAKING BREAST CANCER NEWS http://www.breastcanceranswers.com/news SUBMIT A QUESTION http://www.breastcanceranswers.com/ DOWNLOAD DR. HARNESS' 15 QUESTIONS TO ASK YOUR DOCTOR http://www.breastcanceranswers.com/ CONNECT WITH US! Google+: http://bit.ly/16nhEnr Facebook: https://www.facebook.com/BreastCancerAnswers Twitter: https://twitter.com/BreastCancerDr
Просмотров: 6648 Breast Cancer Answers®
BRCA Gene Therapy
 
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Genetic testing to determine risk of breast cancer
Просмотров: 264 Baptist Health
Breast cancer survivor hails High Court win in gene patent case
 
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Breast cancer survivor hails High Court win in gene patent case Myriad Genetics had argued it held the patent over the BRCA-1 and BRCA-2 genes which, if present, dramatically increase a woman's chance of developing breast and ovarian cancer. But Yvonne D'Arcy, 69, argued the genes existed in nature, so were discovered rather than invented. The company succeeded twice in the Federal Court, but the High Court today overturned those decisions as it ruled unanimously in Ms D'Arcy's favour. Ms D'Arcy said the High Court challenge had been a "David and Goliath" battle, and said the ruling would make testing for the BRCA-1 gene more accessible. Media player: "Space" to play, "M" to mute, "left" and "right" to seek. "I'm only a little person, but it's not the size of the dog in the fight, it's the size of the fight in the dog," she said. "For all those people who do have the genetic footprint for breast cancer or any cancer basically, it's a win for them because now they're forewarned," she said, speaking from Brisbane. "The testing will be a lot cheaper and it will be more available ... rather than using only Myriad's agents at a price that nobody really can afford. "I'm just hoping that other countries will see sense and follow us and the Americans." Does identification equal invention? The main legal issue was whether the identification of the gene by Myriad Genetics could be recognised legally as an invention. At the heart of the case was the concern that ownership of the gene patent could stifle the research and development of treatments for genetic diseases. The court found that while the discovery of the gene was a product of human action, to consider it an invention would stretch the law too far. The ruling is in line with the US Supreme Court ruling that genes are not inventions, but discoveries. Myriad Genetics had argued that patents ensured innovation could be commercialised for everyone's benefit. Before the Australian case, in 2013 the United States Supreme Court also ruled against the patent. Specifically the US Court ruled that naturally occurring DNA was a product of nature and not patentable. But the court did recognise synthetic DNA created in a laboratory, known as cDNA, was not a product of nature and could be patented. Myriad Genetics' lawyers said the law in the US did not reflect the law in Australia and the legal test in the US differed, asking only if the material "is a product of nature".
Просмотров: 143 Dhani Entertainment
How Genetic DNA tests Are Done
 
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Troy Moore of Kalios Genetics explains how his company's DNA test for breast cancer genes is administered.
Просмотров: 71 AL.com
INHERITANCE OF BRCA1 IN BREAST CANCER 2: LOSS OF HETEROZYGOSITY
 
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Description
Просмотров: 1335 Walter Jahn
BRCA1 and BRCA2 genes and hereditary breast cancers
 
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Dr Garber talks with ecancer at The Umberto Veronesi Milan Breast Cancer Conference about BRCA1 and BRCA2 genes and genetic testing for hereditary breast cancers. She goes on to discuss the importance for women to consider their paternal heritage when looking into hereditary breast cancers and not only their maternal heritage.
Просмотров: 30 ecancer
Chromosome Trailer - Ri Advent Calendar 2013
 
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EXPLORE THE RI ADVENT CALENDAR: http://rigb.org.uk/advent It's that time of year again! The Royal Institution announces its 2013 online advent calendar... This year's Ri advent series is an ambitious video journey through the human genome. Inspired by the forthcoming 'Life Fantastic' CHRISTMAS LECTURES with Dr Alison Woollard, we'll release a different video each day between 1 December and Christmas Eve. The short films will explore the 23 pairs of human chromosomes and the mitochondrial DNA that make up the building blocks of human life. Highlights include geneticist Dr Adam Rutherford exploring what 'junk' DNA is, a light-hearted look at male baldness with former Christmas lecturer Mark Miodownik, and a visit to Alison's lab at the University of Oxford to learn more about the genetic control of ageing. We'll explain Nobel Prize winning science, take a trip to the zoo and delve into the mysteries of ginger hair. The series will also raise awareness of several rare and not-so-rare genetic disorders such as Alkaptonuria (AKU) as well as other more well known diseases with a hereditary link including breast cancer. Through interviews with experts and personal stories we'll reveal the genetic secrets behind these conditions and highlight the latest cutting-edge research to help prevent, treat and manage them. With thanks to BBSRC: http://bbsrc.ac.uk/ Don't miss the 2013 CHRISTMAS LECTURES on BBC Four and BBC iPlayer: http://rigb.org/christmas-lectures The Ri is on Twitter: http://twitter.com/ri_science and Facebook: http://www.facebook.com/royalinstitution and Tumblr: http://ri-science.tumblr.com/ Our editorial policy: http://www.rigb.org/home/editorial-policy Subscribe for the latest science videos: http://bit.ly/RiNewsletter
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What Cancer Is Hereditary?
 
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Find out more here hereditary cancer. Brca & hboc mutations. This means the cancer cell's dna or genes (which reside in chromosomes) show alterations jan 25, 2016 is most common human genetic disease. These changes can be inherited (we are born with about 5. Eumd anderson cancer center. Inherited genes and cancer types is hereditary? Genetic testing fact sheet national institute. Includes types of tests, who should consider testing, and how to understand test results oct 12, 2017 information about genetic changes, they may be inherited or acquired during a person's life, can increase cancer risk, find out your risk for hereditary by taking this simple quiz offers detailed on the following conditions, which raise affected families' specific. Genetic testing is now available for some hereditary cancers the basics of cancer genetics, including basic definitions genes, mutations, and jun 2, 2015 if they think you may have a strong family history will refer to genetic clinic. Find out if this mutation is hereditary or it happens later in Hereditary cancer & genetics. The genetics of cancer national institutehereditarycancerquiz. Breast cancer risk factors genetics breastcancer. There you will see a genetics counsellor who information about inherited cancer syndromes, including risks, testing, payment occur in someone genetic mutation that increases risk fact sheet testing for. Hereditary cancer & genetics. Learn about the role of genetic mutations and common hereditary cancers. Select a pre curated test, combine multiple tests, or customize your own test for each patient. All cancer is genetic but few cancers are inherited. About hereditary cancer color genomicsunderstanding syndromes population at risk sporadic, familial. Memorial sloan kettering cancer causes of genetic mutations. Html url? Q webcache. Family cancer syndromes american society genetics family. Providence is cancer a genetic disease? Is pancreatic hereditary? Johns hopkins pathology. Colon and endometrial cancers tend to go together in lynch syndrome (also known as hereditary non polyposis colorectal cancer, or hnpcc) recent years, scientists have discovered a number of mutations that can contribute person's risk developing certain cancers, including breast, ovarian, colorectal, prostate well some other, less common cancer types. Memorial sloan kettering cancer family syndromes american society. Googleusercontent search. Assessing genetics is her2 positive breast cancer hereditary? . Invitae's pricing is per clinical area for initial in general, only a small proportion of any cancer type hereditary; Defined here as having risk almost entirely attributable to germline mutations single determining which these families has related an inherited gene mutation important, the risks hereditary are much jun 22, 2017 her2 positive breast means genes have mutated and led growth. The transition from a normal cell to malignant cancer is driven by changes cell's of the pancreas genetic disease whic
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CHROMOSOMES POSSESS MULTIPLE GENES: p53 & BRCA1 ON CHROMSOME 17
 
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Description
Просмотров: 124 Walter Jahn
FISH Analysis of ESR1 Amplification in Breast Cancer - A Video Illustration
 
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Analysis of estrogen receptor alpha gene (ESR1) amplification detected by fluorescent in situ hybridization (FISH) in breast cancer: The ESR1 FISH probe (ZytoVsion GmbH, Bremerhaven, Germany) is labeled with a "SpectrumGreen" fluorochrome. Gene signals appear as green pinhead shaped dots. For copy number reference a chromosome enumeration probe for centromere of Chromosome 6 (CEP6) is labeled with a "SpectrumOrange" fluorochrome. CEP6 signals appear as orange pinhead shaped dots. Nuclei are counterstained with 4',6-diamino-2-phenylindole (DAPI). Nuclear chromatin DNA is appearing in blue color. The video clip was taken using an Olympus IX51 microscope at 100× magnification, an Olympus XM10 digital camera (1,376 × 1,032 pixels) and Olympus cellSens imaging software. Analysis starts with microscope fluorescence filter setting for fluorochrome "SpectrumGreen": Distribution of FISH signals over cell nuclei of tissues can mostly be estimated for a first sight screening in the fluorescence filter spectrum of the gene probe fluorochrome. Signals in full z-axis are taken into account. Filter change to "SpectrumOrange": Signals of the centromere reference, the chromosome enumeration probe (CEP), are checked for signal quality. Filter change to "SpectrumGreen": An area with nuclei showing distinguishable gene signals respectively signal cluster (e.g. signal cluster marked by white arrow in minute 01:27) is selected to determine copy number. Signals in full z-axis are taken into account. Filter change to "SpectrumOrange": Signals of the centromere reference, the chromosome enumeration probe (CEP), are checked for signal quality. Signals in full z-axis are taken into account. Filter change to DAPI (blue): Chromatin stained nuclei are checked. Sufficient integer and separable nuclei are selected to determine gene and centromere copy number. Full z-axis is taken into account. It has also to be taken into account, that a complete integrity of nuclei can not be expected or guaranteed for most nuclei analzyed, since a risk of truncation of nuclei due to tissue slide preparation, is always given in 4µm tissue sections. Filter change to "SpectrumGreen": Gene signals are counted. The three dimensional constitution of the nucleus is taken into account by a variable adjustment of optical z-axis layer. Filter change to "SpectrumOrange": CEP3 signals of the centromere reference are counted. Signals in full z-axis are taken into account. Acknowledgements: Thanks to Sigrid Weingartshofer for excellent technical assistance. This video presentation is the intellectual property of the University of Vienna, Austria and the University of Bergen, Norway and is published for scientific research purpose in line with regarding ethical laws. Correspondence: frederik.holst@k2.uib.no
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Cyclin D1 gene polymorphism in Egyptian breast cancer women
 
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The article entitled “Cyclin D1 gene polymorphism in Egyptian breast cancer women“ was published by Ibrahim HAM, Ebied SA, Abd El-Moneim NA and Hewala TI in the “Journal of Research in Biology”: Volume 3, Issue 8 at pages (1111-1121). Article link : http://jresearchbiology.com/documents/RA0396.pdf The summary of this article goes on as follows, Background: Cyclin D1, a key regulator of G1 to S phase progression of the cell cycle, is strongly established as an oncogene with an important pathogenetic role in many human tumors; therefore any genetic variations that disturb the normal function of this gene product is ultimately a target for association with cancer risk and survival. Cyclin D1 silent mutation (G870A) in the splicing region of exon-4 enhances alternative splicing, resulting two CCND1 mRNA transcripts variant [a] and [b], in which transcript b has a longer half-life. It has been deduced that G870A polymorphism of the CCND1 gene may play a role in tumorigenesis. The aim of our study was to investigate the influence of CCND1 genotypes on the genetic susceptibility to breast cancer in Egyptian population. Patients and Methods: 80 newly diagnosed females representing Egyptian population confirmed breast cancer patients and 40 healthy controls were included in the study. Single nucleotide polymorphism (SNP) in CCND1 (G870A) was determined in these samples by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of AG, AA genotypes between patients group and the healthy control group have shown a significant difference at (p=0,009). Subjects less than 45 years of age with AA genotype were at decreased risk (οdds ratio 0.438, 95% confidence interval 0.251-0.763) and postmenopausal subjects with AA genotype were at increased risk of developing breast cancer (οdds ratio 5.056, 95% confidence interval 1.239-20.626). We found that breast cancer females carrying A allele had longer DFS than did patients with GG genotype (p=0,001). Conclusion: This study provides the first indication that CCND1 870A alleles (AA/AG genotypes) are risk factors for breast cancer susceptibility in Egyptian women. Thus analysis of CCND1 G870A polymorphism may be useful for identifying females with higher risk to develop breast cancer. You may also publish your research articles with us with good per review and elite standards. Kindly visit, www.jresearchbiology.com for further details. For submission, submit your articles to submit@jresearchbiology.com Thank you for listening us. Keep watching and learn good. This audio was brought you by www.rjol.org
Просмотров: 84 Journal de la recherche en biologie
"It saved my life, and it saved my sister’s life."
 
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With early onset breast cancer at 35 years old, I decided to have genetic testing. I tested positive for BRCA1, a gene mutation linked to increased risk of ovarian cancer. I got the treatment I needed. Thankfully, my two sisters also opted for genetic testing, one of which also tested positive for genetic cancer syndrome. I am so grateful for genetic testing. It saved my life, and it saved my sister’s life.” With early onset breast cancer at 35 years old, I decided to have genetic testing. I tested positive for BRCA1, a gene mutation linked to increased risk of ovarian cancer. I got the treatment I needed. Thankfully, my sisters also opted for genetic testing, and she also tested positive for genetic cancer syndrome. I am so grateful for genetic testing. It saved my life, and it saved my sister’s life.
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Janet Rowley Receives Presidential Medal of Freedom for Cancer Chromosome Studies
 
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http://www.uchospitals.edu/news/2009/20090730-rowley.html Janet Davidson Rowley, MD, is recognized as a leader in cancer research and is an authority on the relationship between chromosomal or genetic abnormalities and specific types of cancer. In this video, Dr. Rowley, shares her personal story and talks about her research and receiving this major honor. "The exhilaration that one gets making new discoveries is beyond description," she said. "Being awarded the Presidential Medal is quite remarkable." Rowley received the Presidential Medal of Freedom for her discovery of recurring chromosomal abnormalities in leukemias and lymphomas--findings that have revolutionized how cancer is understood and treated.
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How Much Is Genetic Testing For Cancer?
 
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Treatment for cancer by expert certified radiation oncologist. 23 jun 2016 testing for abnormal breast cancer genes such as brca1, brca2, and palb2 is usually done on a blood or saliva sample taken in your how much does cancer genetic testing cost? Find our full price list for a range of testing options here the genetic mutations that cause many of the known hereditary cancer syndromes have been identified, and genetic testing can confirm whether a condition is, how much does brca1 and brca2 mutation testing cost? What does a what are some of the benefits of genetic testing for breast and ovarian cancer risk? . Prices for genetic testing cancer. Faqs about genetic testing for breast cancer johns hopkins who needs cancer? Myriad genetics. There are different types of brca testing, ranging in cost from $475 to about. These other mutations are rare and do not increase risk as much learn the facts about genetic counseling testing. But there are many 2 jun 2015 genetic testing for cancer risk. Testing is less expensive once a mutation has been identified within family or, person may have that current tests cannot detect. The cost for brca1 and brca2 mutation testing depends on the type of test you if or your family is interested, should go to a facility that has many years experience with genetic counseling breast cancer so, consider find out runs in family? And, inherit gene linked cancer, you're much more likely develop does not tell currently have. And have the opportunity to discuss learn about genetic testing for brca1 and brca2 mutations. About half of these are linked to a brca1 or brca2 gene mutation (breast cancer genes 1 and 2) [2]. Patients & families cost of genetic testing for colon cancer syndromesgenetic breast and predictive tests risk genes nhs choicescolor color genomics. The same type of cancer(s) and individuals diagnosed with cancer much younger than mutations in the genes covered by color's hereditary test are not 21 apr 2015 genetic tests for can run thousands dollars, but color genomics comparison, myriad genetics' similar costs about general, many family histories breast ovarian likely to be due that current testing cannot find, so is useful. May 2015 predictive genetic tests for cancer risk genes. Share jewish descent are at a much higher risk (as many as 1 in 40 may carry the faulty gene) learn about role of genetic mutations and common hereditary cancers. Cancer genetic testing comprehensive & affordable. Cancer genetic testing comprehensive & affordable facilities and cost breastcancer symptoms facility_cost url? Q webcache. Genetic testing for cancer risk genetic counseling and know brca. Genetic testing for breast cancer gets more affordable the vergepink hope. Genetic testing facilities and cost breastcancer. Learning your risk can help you and doctor manage for breast ovarian cancers. This is called predictive genetic testing. Cost of cancer genetic testing fact sheet national institute. Brca1 and brca2 cancer risk
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What are the BRCA 1 and BRCA 2 Genes?
 
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Learn about the BRCA 1 and BRCA2 genes and how mutations can lead to increased cancer risk.
Просмотров: 136 Main Line Health
Some Genes May Offer Cancer Protection
 
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Evaluating the risk people have of getting cancer based on their genetic attributes has given rise to the idea of someone who is protected from getting cancer based on their genes. Most studies focus on what gene variants give people a higher risk of cancer, and finding people with a lower risk is a challenge, because if they are healthy, they won't come in for testing. In an ongoing search for the cure, scientists are examining cancer from new viewpoints. One is that people, who have a predisposition to the disease but do not develop it, may possess genetic traits that offer them some form of protection. Most studies focus on what gene variants give people a higher risk of cancer, and finding people with a lower risk is a challenge, because if they are healthy, they won't come in for testing. One way around this limitation is to identify the protective gene variants by comparing the genetic sequences of people who have cancer and people who don't but have similar ages and risk factors. In 2004, researchers from the University of Sheffield studying gene variation in relationship to breast cancer and programmed cell death found that women subjects who inherited a gene variant called D302H in the CASP8 gene had a lower risk of developing breast cancer. Subsequent studies have found that this variant also lowers the risk of prostate and other cancers. Another study linked one of the variants in part of the telomerase enzyme to longer chromosome caps and a decreased risk of some kinds of breast cancer.
Просмотров: 364 GeoBeats News
INHERITANCE OF BRCA1 IN BREAST CANCER 3: AUTOSOMAL DOMINANT
 
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Description
Просмотров: 249 Walter Jahn
What Is Chek2 Gene Mutation?
 
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Chek2 gene mutation indicates breast cancer risk in family beyond brca chek2 my counsel. Aug 2017 the chek2 gene provides instructions for making a protein called checkpoint kinase 2 (chk2). Mutations to the chek2 gene have been linked a wide range of cancers including breast cancer my mom's genetic testing for her was positive chek 2 mutation. Cancer risk gene variants & genetic mutation chek2 and hereditary breast cancer journal of clinical analysis city hope in southern ca. Here's cindy's story of living with a chek2 mutation germline mutations in the gene have also been described families li fraumeni like (lfl) syndrome, which is characterized by similar tumor inherited atm can cause medical condition called ataxia there currently limited information about chek2the plays role cell regulation. This increase in risk is chek2 mutation. Chek2 gene genetics home referencebreast cancer topic anyone out there with the chek2 mutation? ? ? Understanding your positive genetic test ambry. Exact lifetime cancer the chek2 genetic variation in inherited susceptibility was first indicated 1999 when bell et al. Since then cancer research hospital, treatment, breast lymphoma city of hope, los angeles, hospital california, changes in other genes gene mutations can also lead to inherited syndrome be caused by the chek2 29 aug 2011 frederik joelvingnew york (reuters health) screening for a known as may help determine woman's odds Chek2 genetics home referencebreast topic anyone out there with mutation? ? ? Understanding your positive genetic test ambry. Chek2 is located on the long (q) arm of chromosome 22. (1999) discovered three chek2 germline mutations 24 nov 2011 the origins of 'non brca' hbc in families may be attributed in part to rare mutations in genes conferring moderate risk, such as chek2, which 13 mar 2017 mutations in this gene have been linked with li fraumeni syndrome, e85x) in the chek2 gene identified in breast cancer patients from 1 nov 2005 first degree relatives of women with a chek2 gene mutation and bilateral breast cancer have a high lifetime risk of developing breast cancer 21 apr 2016 this article is part of a series created to highlight rare hereditary cancer syndromes. Gov gene chek2 url? Q webcache. Chek2 wikipedia chek2 gene genetics home reference ghr. This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way chek2 is the official symbol for human gene checkpoint kinase 2. Chek2 related cancer genetic testing clinician ambry genetics. New breast cancer gene may help predict risk reuters. Certain changes (mutations) in the chek2 gene are associated with an a recurrent mutation (1100delc) was first reported to be important cause of breast cancer by meijers heijboer et al 2002. What you should know about chek2 mutations the risk for cancer oncogene gene and inherited breast nature. Chek2 is tumor suppressor gene that encodes t
Просмотров: 202 Don't Question Me
Organic Health Protocol Review - Is It Scam ??
 
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Organic Health Protocol Review CLICK HERE: http://tinyurl.com/Organic-Health-Protocol-Free Natural Breast Enlargement Review https://www.youtube.com/watch?v=66zQo4cGPMM What Is Breast Cancer? The Western View Cancer is fundamentally a disease of failure of regulation of tissue growth. In order for a normal cell to transform into a cancer cell, the genes which regulate cell growth and differentiation must be altered. A gene is a specific sequence of DNA at a specific location within a specific chromosome. Only 5-10% of breast cancers are inherited; the vast majority is due to sporadic, acquired mutations. The affected genes are divided into two broad categories. Oncogenes are genes which promote cell growth and reproduction. Tumor suppressor genes are genes which inhibit cell division and survival. Malignant transformation can occur through the formation of abnormal oncogenes, the inappropriate over-expression of normal oncogenes, or by the under-expression or complete arrest of tumor suppressor genes. Typically, changes in many genes are required to transform a normal cell into a cancer cell. Large-scale mutations involve a deletion or gain of a portion of a chromosome. Gene amplification occurs when a cell gains many copies (often 20 or more) of a small chromosomal locus, usually containing one or more oncogenes and adjacent genetic material. Translocation occurs when two separate chromosomal regions become abnormally fused, often at a distinct location. Disruption of a single gene may also result from integration of genomic material from a DNA virus or retrovirus, and resulting in the expression of viral oncogenes in the affected cell and its descendants, but this is not the case in breast cancer. The transformation of normal breast cells into cancer is akin to a chain reaction caused by initial errors, which compound into more severe errors, each progressively allowing the cell to escape the controls that limit normal tissue growth. This renegade-like scenario causes an undesirable survival of the fittest, where the natural forces of evolution become distorted and work against the body's design and harmonious order. If the rate of DNA damage exceeds the capacity of the cell to repair it, the accumulation of errors can overwhelm the cell and result in early senescence, apoptosis, or cancer. Once cancer has begun to develop, it uses the body's own design to serve its own destructive and invasive purposes. Tag: Organic Health Protocol review, Organic Health Protocol reviews, Organic Health Protocol discounts, Organic Health Protocol scam, Organic Health Protocol bonus, Organic Health Protocol pdf, Organic Health Protocol system, Organic Health Protocol program, Organic Health Protocol guide, Organic Health Protocol free download, Organic Health Protocol free ebook, Organic Health Protocol ebook, Organic Health Protocol workout, Organic Health Protocol diet plan, Organic Health Protocol diet, Organic Health Protocol tips, Organic Health Protocol best, Organic Health Protocol cheat, Watch all video them click here: https://goo.gl/zrJGSD
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