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Primary hemostasis | Advanced hematologic system physiology | Health & Medicine | Khan Academy
During primary hemostasis, a platelet plug is formed to rapidly stop the initial bleeding after injury. Learn about the different steps involved in primary hemostasis: vasoconstriction, platelet adhesion, activation and degranulation, platelet aggregation. Created by Gricelda Gomez. Watch the next lesson: https://www.khanacademy.org/science/health-and-medicine/advanced-hematologic-system/bleeding-and-impaired-hemostasis/v/secondary-hemostasis?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Missed the previous lesson? https://www.khanacademy.org/science/health-and-medicine/advanced-hematologic-system/bleeding-and-impaired-hemostasis/v/introduction-to-hemostasis?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Health & Medicine on Khan Academy: No organ quite symbolizes love like the heart. One reason may be that your heart helps you live, by moving ~5 liters (1.3 gallons) of blood through almost 100,000 kilometers (62,000 miles) of blood vessels every single minute! It has to do this all day, everyday, without ever taking a vacation! Now that is true love. Learn about how the heart works, how blood flows through the heart, where the blood goes after it leaves the heart, and what your heart is doing when it makes the sound “Lub Dub.” About Khan Academy: Khan Academy is a nonprofit with a mission to provide a free, world-class education for anyone, anywhere. We believe learners of all ages should have unlimited access to free educational content they can master at their own pace. We use intelligent software, deep data analytics and intuitive user interfaces to help students and teachers around the world. Our resources cover preschool through early college education, including math, biology, chemistry, physics, economics, finance, history, grammar and more. We offer free personalized SAT test prep in partnership with the test developer, the College Board. Khan Academy has been translated into dozens of languages, and 100 million people use our platform worldwide every year. For more information, visit www.khanacademy.org, join us on Facebook or follow us on Twitter at @khanacademy. And remember, you can learn anything. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s Health & Medicine channel: https://www.youtube.com/channel/UC1RAowgA3q8Gl7exSWJuDEw?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Просмотров: 283196 khanacademymedicine
Hemostasis: Lesson 2 - Platelet Activation and Aggregation
Part 1 of a 2 part video on normal hemostasis, focusing on the role of the endothelium and platelets.
Просмотров: 73030 Strong Medicine
Platelet Adhesion and Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc. Animation description: Platelet adhesion and aggregation. In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets. However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium. Collagen is one of the most thrombogenic components of the subendothelial matrix responsible for the initiation of platelet adhesion. A number of adhesive receptors on the platelet surface membrane interact either directly or indirectly with collagen. Initial binding of platelets is considered to occur via the integrin α2β1 (GPIa-IIa) receptor, which allows for further binding to collagen via the GPVI receptor, initiating transmembrane and, subsequently, intracellular signalling. Adhesion of platelets to the exposed subendothelium is influenced by shear rates. At high shear, α2β1 and GPVI are not sufficient to initiate binding to collagen, and binding of the GPIb-IX-V receptor to von Willebrand factor -- abbreviated here as V.W.F. -- that is immobilized on collagen, becomes essential in platelet adhesion. Platelet adhesion at the site of vessel wall damage initiates activation events that result in aggregation. Adherent platelets undergo a dramatic shape change to an irregular sphere with multiple filipodia spreading on the subendothelium increasing their area of surface contact. Adherent platelets also secrete or release the contents of their storage granules -- the alpha- and dense granules -- by an exocytic process. This provides a high local concentration of effector molecules essential for platelet plug formation at the site of vascular injury. For example, the aggregating agent A.D.P. is released from the dense granules. Platelet activation stimulates the formation of another aggregating agent, thromboxane A2 -- abbreviated here as T.X.A2 -- via the arachidonic acid cascade -- details are shown in Figure 26-5. A.D.P., thromboxane A2 and thrombin bind to specific platelet membrane receptors -- details are shown in Table 26-1 -- and stimulate aggregation on and around the platelets adherent to the subendothelium via receptor-mediated signal transduction events. Aggregation is an active metabolic process: binding of any of the agonists to their respective membrane receptors initiates signalling pathways that ultimately convert integrin αIIbβ3 -- or GPIIb-IIIa - from a low affinity resting state to a high-affinity activated state for binding extracellular soluble ligands such as plasma fibrinogen and von Willebrand factor -- fibrinogen is shown here. The transmission of an intracellular signal leads to disruption of the complex between the cytoplasmic tails of αIIbβ3, followed by a conformational change in its extracellular globular head domains from a bent to an extended state, promoting the binding to fibrinogen and von Willebrand factor. Divalent fibrinogen and multivalent von Willebrand factor function as bridges between αIIbβ3 receptors on adjacent activated platelets, thus allowing platelet aggregation to proceed. In this way, the large and complex metabolic repertoire of platelets allows them to effectively perform their primary physiological role, that of supporting hemostasis upon tissue trauma to form a platelet plug that arrests blood loss from a vascular injury. To learn more, go to http://www.MechanismsInHematology.com -- a freely available, educational resource that combines the clinical expertise of hematologists, oncologists, and related researchers with instructive visuals and animations. Essential concepts pertaining to the science and biology of clinical hematology are presented.
Просмотров: 239604 Mechanisms in Medicine
Inhibiting Platelet Aggregation with Berries
One of the ways plants help keep platelets in their place may be their aspirin content. See Aspirin Levels in Plant Foods (http://nutritionfacts.org/video/aspirin-levels-in-plant-foods/). Why would a plant make a human drug? It’s so cool, check out Appropriating Plant Defenses (http://nutritionfacts.org/video/appropriating-plant-defenses/). Subscribe to Dr. Greger’s free nutrition newsletter at https://www.nutritionfacts.org/subscribe and get a free recipe from his new HOW NOT TO DIE COOKBOOK. (All proceeds Dr. Greger receives from the sales of his books, DVDs, and speaking engagements go to support the 501c3 nonprofit that runs NutritionFacts.org.) Is the Standard American Diet really so bad that we could save 100,000 people by just getting up to minimum fruit and veggie recommendations? Even cynics might be surprised: Nation’s Diet in Crisis (http://nutritionfacts.org/video/nations-diet-in-crisis/). Even more plants may cut deaths even more, though. See One in a Thousand: Ending the Heart Disease Epidemic (http://nutritionfacts.org/video/one-in-a-thousand-ending-the-heart-disease-epidemic/). For more on lowering cholesterol see my video Trans Fat, Saturated Fat, and Cholesterol: Tolerable Upper Intake of Zero (http://nutritionfacts.org/video/trans-fat-saturated-fat-and-cholesterol-tolerable-upper-intake-of-zero/). And it’s never too early to start eating healthier. Check out: Heart Disease Starts in Childhood (http://nutritionfacts.org/video/heart-disease-starts-in-childhood/). Heart disease may be a choice. See: Cavities and Coronaries: Our Choice (http://nutritionfacts.org/video/cavities-and-coronaries-our-choice/). Berries are the healthiest fruits, shown to maintain our brain power (How to Slow Brain Aging By Two Years http://nutritionfacts.org/video/how-to-slow-brain-aging-by-two-years/) and improve our immune function (Boosting Natural Killer Cell Activity http://nutritionfacts.org/video/boosting-natural-killer-cell-activity/). That’s one of the reasons we want to eat Antioxidant Rich Foods With Every Meal (http://nutritionfacts.org/video/antioxidant-rich-foods-with-every-meal/). Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/inhibiting-platelet-aggregation-with-berries/ and he'll try to answer it! http://www.NutritionFacts.org • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Podcast: http://nutritionfacts.org/audio/ • Subscribe: http://http://nutritionfacts.org/subscribe/ • Donate: http://www.NutritionFacts.org/donate
Просмотров: 36503 NutritionFacts.org
Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: basic pathophysiology of blood clot formation, platelet function; activation, aggregation, cross-linking, ADP receptors, glycoprotein IIb/IIIa receptors, cyclooxygenase-1 enzyme, fibrinogen, fibrin mesh, coagulation cascade; intrinsic & extrinsic pathways, clotting factors, antithrombin, heparin induced thrombocytopenia, INR, plasmin, plasminogen. Mechanism of action of platelet inhibitors, anticoagulants, thrombolytic agents, drugs used for treatment of bleeding. Drugs mentioned include; Aspirin, Clopidogrel, Ticagrelor, Ticlopidine, Prasugrel, Abciximab, Eptifibatide, Tirofiban, Heparin, low molecular weight heparins; Enoxaparin, Dalteparin, Protamine sulfate, Apixaban, Rivaroxaban, Univalent & Bivalent direct thrombin inhibitors; Argatroban, Dabigatran, Bivalirudin, Desirudin, Warfarin, Vitamin K, Alteplase, Reteplase, Tenecteplase, Urokinase, Streptokinase, Aminocaproic acid, Tranexamic acid.
Просмотров: 223168 Speed Pharmacology
What is Abciximab? (ReoPro)
What is Abciximab? (ReoPro) (Intravenous) Learn more: https://healthery.com/drug/abciximab-intravenous/ A platelet aggregation inhibitor used to stop platelets from causing blood clots. It is a glycoprotein IIb / IIIa receptor agonist. Abciximab is primarily used during and after invasive heart treatments, such as: Angioplasty, for artery protection to lower risk of heart attack. It prevents arteries from becoming blocked post-operation. It’s not suitable for emergency surgery because it takes 12 hours to normalize. The use of Abciximab is for patients who are undergoing coronary intervention. Its administered intravenously via bolus or drip, with a short plasma half-life. Research suggests it can be useful in the treatment of patients with: Chronic renal insufficiency, thrombus, angina and diabetes. What are the side effects? Not all side effects are serious, some may require medical attention. Most common include: blurred vision, dizziness, confusion, and weakness. Also, light-headedness, feeling faint, tiredness, excess sweating and bleeding. Usually, all side effects will subside as medication adjusts. Contact your doctor immediately if side effects worsen. Most patients will experience minimal side effects. Other side effects include: tarry, black stools, bleeding gums, and sneezing. As well as blood in stools and urine, rash, sore throat, pale skin, and fever. More include: weight gain, eye pain, chills, and unusual bleeding or bruising. Follow the prescribed dosage by your healthcare professional. In the event of an overdose contact Poison Control or the Emergency Services. Doing so can prevent serious risk of injury or death. If you take other medications be sure to tell your doctor regarding interactions. Drug interactions can cause serious complications and can even be fatal. If you've recently suffered a health problem be sure to tell you doctor. Additionally, tell you doctor if you have any addictions regarding drug use. Abciximab has been classified as a category C risk by the FDA. Such classification means it hasn't been tested regarding fetal harm. Abciximab should be stored in a refrigerator between 2C and 8C (36F to 46F). And should be destroyed if the drug is ever frozen. It is also marketed as Reopro, which is a colorless solution. It should only be used on adults and in conjunction with your medical specialist Abciximab has been used since its approval by the FDA in November 1997. Its effective in preventing clots and assists surgeons in balloon angioplasty. As well as stent placement, atherectomy and used in invasive procedures. Website: https://healthery.com/ Facebook: https://www.facebook.com/healthery Twitter: https://twitter.com/MyHealthery
Просмотров: 52 healthery
Platelets (Step 1 and 2)
Watch all drbeen lectures at https://www.drbeen.com Blood clotting is a critical mechanism to understand for all health professionals. In this video our up and coming rock star Abdullah Mazin presents Platelets and their functions. Presenter Abdullah Mazin
Просмотров: 10696 Drbeen Medical Lectures
Lion's Mane: A Nootropic Mushroom that can Improve Diabetes, Brain function, and Nuerons
Bio Hacking Newsletter: http://eepurl.com/cw1X81 | Lion's Mane:: Fertilizer for Neurons https://therevisionist.org/reviews/lions-mane-fertilizer-for-neurons-repairs-the-brain/ :: How it Benefits Diabetes https://therevisionist.org/reviews/can-lions-mane-treat-diabetes/ :: Its effect on Brain Function https://therevisionist.org/bio-hacking/lions-manes-powerful-healing-effects-on-health-cognition/ --- Follow me ┴┬┴┤( ͡° ͜ʖ├┬┴┬ ✪ My Subreddit: https://www.reddit.com/r/Bio_Hacking/ ✪ Facebook: https://www.facebook.com/profile.php?id=100010037778391 ✪ Twitter: https://twitter.com/raqib_zaman ✪ Google+: https://plus.google.com/+RaqibZaman --- In this video, I will be covering the medicinal properties of a Mushroom called Lion’s Mane. Lion´s mane, also known as Hericium erinaceus, is a wellknown edible and medicinal mushroom found throughout eastern Asia. Its fruiting bodies, meaning the mushroom heads, and fungal mycelia, meaning the root-like structures, exhibit various pharmacological activities, including the enhancement of the immune system as well as anti-tumor, hypoglycemic, and anti-aging properties. Scientific analysis has shown that the aromatic compounds hericenones C–H and erinacines A–I isolated from the fruiting body and mycelium promote nerve growth factor (NGF) synthesis in cultured astrocytes. These results highlight the usefulness of H. erinaceus for the treatment and prevention of dementia. However, the biochemical mechanism responsible for this action is not yet totally understood. In Japan, the fungus is known colloquially as yamabushitake, while it is called the monkey’s head mushroom in China and the lion’s mane mushroom in the US. Hericium erinaceus colonizes both living and dead broadleaf trees and is distributed around the world. This video will briefly explore some of the medically useful properties of Lion’s Mane, including its effects on nerve growth factor and cognitive function. Also I will be discussing the anti-cancer, immune-enhancing, and hypoglycemic effects of the mushroom. Finally, the effects of Lion’s Mane mushroom on platelet aggregation and its function as an antioxidant will be illuminated. Lion’s Mane Improvement of cognition To test the effects of orally administered Lion’s Mane on cognitive function, a double-blind, parallel-group, placebo-controlled trial was performed on mildly cognitively impaired 50-80 year-old Japanese men and women. A cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS-R) was used. So in this study, 14 individuals received Lion’s Mane while the remaining 15 individuals received placebo (5). The researchers observed that the Lion’s Mane group increased their HDS-R score relative to controls depending on the time period when Lion’s Mane was consumed. Specifically, significant differences in cognitive function appeared at weeks 8, 12, and 16 of the trial. During the 4 week follow-up period, however, the score of the Lion’s Mane group dropped back down compared with the week 16 score (figure 1). Thus, Lion’s Mane is effective at reducing mild cognitive impairment but continuous intake may be necessary to maintain the beneficial effects of the fungus (5). Anti-cancer effect It has been demonstrated that Lion’s Mane, which primarily consists of polysaccharides, has tumor-fighting properties. However, the mechanisms by which Lion’s Mane inhibits growth of human hepatocellular carcinoma (HCC) is largely unknown. However, two studies performed by Lee et al. (8, 9) demonstrate that Lion’s Mane acts as an enhancer to sensitize apoptotic signaling mediated by doxorubicin (Dox). These findings suggest that Lion’s Mane in combination with Dox serves as an effective tool for treating drug-resistant human hepatocellular carcinoma. Immune-enhancing properties Polysaccharides are the best known and most potent mushroom-derived substances that display immuno-pharmacological properties. In a trial done by Lee et al. (9), the water soluble crude polysaccharide of lion’s mane was found to upregulate or increase macrophage (ie. White blood cell) activities, like the production of nitric oxide (NO) and the expression of cytokines. Conclusions Hericium erinaceus is a well-known edible and medicinal mushroom. Its fruiting bodies and the fungal mycelia exhibit various pharmacological properties, including factors that enhance the immune system, fight cancer, lower blood glucose, and promote nerve growth. This video reviewed evidence showing that Lion’s Mane reduces mild cognitive impairment, although continuous intake of the fungus may be necessary to maintain the beneficial effects. It has also been discovered that some hericenone compounds improve NGF. A study by Mori et al. (6) reports that Lion’s Mane contains active compounds that are not hericenones but nevertheless stimulate NGF synthesis. Even growth of adrenal nerve cells and extension of neurites were shown to be enhanced by fungus exo-biopolymers.
Просмотров: 4580 Raqib Zaman
Malaria - causes, symptoms, diagnosis, treatment, pathology
What is malaria? Malaria's a mosquito-borne infectious disease common in tropical and subtropical regions of the world, that's caused by a parasitic protozoan of the genus Plasmodium. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Просмотров: 430854 Osmosis
Hemophilia - causes, symptoms, diagnosis, treatment, pathology
What is hemophilia? Hemophillia is most often an inherited disorder that involves the body's ability to form blood clots. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Просмотров: 282387 Osmosis
Platelet disorder lecture by Dr hemant
Please watch: "Type 1 Diabetes Melitus lecture by Dr.hemant" https://www.youtube.com/watch?v=5Z8a0XJb2uE --~-- this video helps you to crack neetpg usmle pgi Chandigarh plab upsc mci and so many other exams
Просмотров: 1414 Dr.Hemant sharma
Rouleaux Red blood cell (RBC) rouleaux formation is a reversible phenomenon that occurs during low blood flow and small shearing forces in circulation. Certain pathological conditions can alter the molecular constituents of blood and properties of the RBCs leading to enhanced rouleaux formation, which results in impaired perfusion and tissue oxygenation (Fayruz Kibria et. al.) Normally Blood flow is anechoic due to the size of the RBC's inability to reflect the sound waves. However when they aggregate or stack they become mobile reflectors. The flow is typically slow and sluggish. Compression of the vessel is still feasible and will clear the rouleaux momentarily. This phenomenon can be seen in a "normal" patient, however it is associated with many conditions including, malignancies, connective tissue disorders, inflammation, diabetes and pregnancy to name a few. Henry Suarez Further Reading: Washko, Patrick A., et. al.. "Rouleaux Flow SVU Las Vegas 2015." (n.d.): n. pag. 16 July 2015. Web. http://bit.ly/2fujttV Kibria, Fayruz.et. al. Identification of Red Blood Cell Rouleaux Formation Using Photo-acoustic Ultrasound Spectroscopy (n.d.): n. pag. Web. http://bit.ly/2fa3yiQ
Просмотров: 6465 Practical Sonography
Inhibiting Platelet Activation with Garlic and Onions
Why we should wait 10 minutes after chopping or crushing garlic before cooking unless we’re going in for elective surgery within the next week? Subscribe to Dr. Greger’s free nutrition newsletter at https://www.nutritionfacts.org/subscribe and get a free recipe from his new HOW NOT TO DIE COOKBOOK. (All proceeds Dr. Greger receives from the sales of his books, DVDs, and speaking engagements go to support the 501c3 nonprofit that runs NutritionFacts.org.) For background on what platelets are, what they do, and why we should care, see Inhibiting Platelet Aggregation with Berries (http://nutritionfacts.org/video/inhibiting-platelet-aggregation-with-berries/) and Inhibiting Platelet Activation with Tomato Seeds (http://nutritionfacts.org/video/inhibiting-platelet-activation-with-tomato-seeds/). What else can garlic do? Check out: • Cancer, Interrupted: Garlic & Flavonoids (http://nutritionfacts.org/video/cancer-interrupted-garlic-flavonoids/) • Garlic and Raisins to Prevent Premature Birth (http://nutritionfacts.org/video/garlic-and-raisins-to-prevent-premature-birth/) • #1 Anticancer Vegetable (http://nutritionfacts.org/video/1-anticancer-vegetable/) What’s that about mustard powder boosting the benefits of broccoli? See my Second Strategy to Cooking Broccoli (http://nutritionfacts.org/video/second-strategy-to-cooking-broccoli/) video. For whether it’s better to cook vegetables or eat them raw, see Best Cooking Method (http://nutritionfacts.org/video/best-cooking-method/) and for a surprise update, The Best Way to Cook Sweet Potatoes (http://nutritionfacts.org/video/the-best-way-to-cook-sweet-potatoes/). Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/inhibiting-platelet-activation-with-garlic-and-onions and he'll try to answer it! http://www.NutritionFacts.org • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Podcast: http://nutritionfacts.org/audio/ • Subscribe: http://http://nutritionfacts.org/subscribe/ • Donate: http://www.NutritionFacts.org/donate
Просмотров: 90676 NutritionFacts.org
Disseminated intravascular coagulation - causes, symptoms, diagnosis, treatment, pathology
What is disseminated intravascular coagulation (DIC)? DIC's a condition where the body has both widespread clotting, leading to organ ischemia, while at the same time has a depletion of clotting factors, leading to bleeding. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Просмотров: 302475 Osmosis
Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: role of cyclooxygenases (COX-1 & COX-2) in inflammation, thromboxane, prostaglandins; mechanism of action, therapeutic uses and side effects of NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) and various prostaglandin analogs. Drugs mentioned include; Selective COX-1 inhibitors; Ketorolac, Flurbiprofen, Ketoprofen, Indomethacin, low-dose Aspirin; Non-selective COX inhibitors; Naproxen, Ibuprofen, Piroxicam, Diflunisal; Selective COX-2 inhibitors; Meloxicam, Diclofenac, Celecoxib, Etodolac; Prostaglandin E1 analogs; Alprostadil, Lubiprostone, Misoprostol; Prostaglandin F2α analogs; Bimatoprost, Latanoprost, Travoprost; Prostacyclin analogs; Iloprost, Treprostinil
Просмотров: 169162 Speed Pharmacology
Platelet adhesion,activation, aggregation & plug formation - Confusion Solving
These 3 terms should be cleared for conception of hemostasis. let me know about my video - criticize in comment section
Просмотров: 779 Medi Scope
9 Best Foods That Increase Platelets Count in Blood #BloodPlatelets
9 Amazing Foods to Increase Blood Platelets Count in our Body . This Video Have All Answers Must watch and Share #Heath #IncreaseBloodPlatelets SUBSCRIBE for Updates - http://goo.gl/on2M5R SHORT FILMS - http://goo.gl/Sa6jhA FULL LENGTH MOVIES - http://goo.gl/m8ls2H DAILY SCHEDULE - http://goo.gl/aO58iB SPOOF VIDEOS - http://goo.gl/RgyyUV COMEDY VIDEOS - http://goo.gl/h4R3JK and http://goo.gl/bzF2Tf VIDEO JUKE BOX - http://goo.gl/1EplqA KIDS VIDEOS - http://goo.gl/QceIoa RADIO - http://goo.gl/W6WXGI DEVOTIONAL - http://goo.gl/Y2OsqS
Просмотров: 121021 TeluguOne
Platelet Rich Plasma Therapy - Everything You Need To Know - Dr. Nabil Ebraheim
Educational video describing the specifics of platelet rich plasm therapy. Plasma rich plasma or PRP is a volume of the plasma of autologous blood having a platelet concentration above the baseline. Platelets facilitate healing by stimulating the release of different growth factors. The growth factors recruit stem cells that facilitate healing, repair, or regeneration of the injured tissue. PRP is injected directly into injured tissue stimulating a healing response in a more powerful form. Platelets are components of blood cells. The development of PRP focuses on concentration of patient’s own blood platelets to create an active mixture of growth factors. Blood components 1-Red blood cells carry oxygen from the lungs and deliver it to the body tissues. 2-White blood cells form our immune system and help the body to fight against infection and foreign material. 3-Platelets: function of platelets: •Help in hemostasis (Stop bleeding) •Helps in the building of new tissue, act as scaffold for tissue regeneration. •Stem cell attraction and binding Platelets are directors (boss). Stem cells are the workers. Platelets divide, multiply and differentiate to become the healing cells for injured tissues. The platelets become activated by thrombin and other factors which cause a change in their morphology and the release of multiple growth factors. These growth factors bind themselves to the receptors of the cell causing intracellular changes down to the nucleus and affecting its DNA. The result is changed in the performance and function of the cell. Production of PRP •30-60 ml of the patient’s own blood is drawn from the antecubital vein. •The blood is then placed into a device to be centrifuged which separates the blood into platelet poor plasma (PPP), red blood cells (RBC) and platelet-rich plasma (PRP). •The blood is then placed in a centrifuge for 15 mins at 3,200 rpm. The centrifuge spins and separates the platelets from the rest of the blood components and increases the concentration of platelets and growth factors. The more platelet concentration, the greater the healing power. •After the centrifuge process is complete, the plasma has been separated from the blood producing the PRP. The platelet poor plasma is withdrawn and discarded. Platelet-rich plasma is withdrawn for injection. Sodium bicarbonate is used to neutralize the acidity of the sample. PRP sample has at least 4x the normal concentration of platelets needed for PRP to be effective. The more the platelet concentration the more growth factors and healing power. Ultrasound helps to deliver a concentrated sample of platelets to the injured tissue. Ultrasound increases the accuracy of delivering the sample to the injured tissue. Partial tear of the supraspinatus tendon •Injections should be performed preferably with the aid of ultrasound imaging. •Needling induced injury release thrombin which activates platelets. Platelets help in hemostasis and produce growth factors as well as chemotactic factors. •Platelets act as a scaffold for mesenchymal stem cells which start the process of tissue regeneration. •Patient typically experiences minimal to moderate discomfort which may last up to 1 weeks following the injection. •Avoid the use of anti-inflammatory medications for 6 weeks after injection. Become a friend on facebook: http://www.facebook.com/drebraheim Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC
Просмотров: 8573 nabil ebraheim
6 Natural Blood Thinners
6 Natural Blood Thinners 1. Garlic Aside from giving your grandmother’s spaghetti sauce the “kick” it needs, garlic can also be good for your health. For one, it’s capable of limiting the collection of platelets, one of the primary steps in the formation of a blood clot. In small amounts, it’s unclear if garlic actually has the potential to prevent a devastating heart attack or stroke caused by a blood clot. However, in much larger amounts — such as when taken in supplement form — garlic may play a role in helping limit platelet aggregation. In short, if you’re in a position where blood clots may present a health problem, it’s a good idea to work more garlic into your diet. 2. Fish Oil There’s a good chance that, by now, you’ve heard about the health benefits of fish oil, and specifically that containing omega-3 fatty acids. These acids, which can be found in many types of fish, such as salmon, have been shown to help boost brain functionality and work against serious health problems, like stroke. But omega-3 fatty acids can also help thin the blood by preventing the formation of substances that encourage platelet formation. For people who need to be aware of the threat posed by blood clots, this makes fish oil a valuable contribution to their diet. Should you not be a fan of the taste of fish, omega-3 fatty acids can be found in supplement form. 3. Vitamin E When you were a kid, chances are your parents spent much of their time encouraging you to get all your vitamins, either through a health diet or physically taking a multivitamin. But they may not have explained that each type of vitamin is different. Take vitamin E for example. Available in a wide range of foods, including almonds, whole grains, sunflowers, eggs, seeds, and nuts, it’s been shown to help discourage the formation of blood clots and limit the chances of heart attack or stroke. Not a big fan of eggs, nuts, seeds or whole grains? Like most vitamins, vitamin E is widely available in supplement form. 4. Herbs with Coumarin There are literally hundreds of thousands of medications available to help prevent or treat serious health problems, like heart attack or stroke. But do you know where many of these medications come from? You may be surprised to hear that some, such as the medication warfarin — which is designed to help prevent blood clots — are made from easily acquired herbs. In fact, warfarin contains a compound known coumarin, which can be found in plants like angelica root, arnica flower, anise, chamomile, fenugreek, licorice root, parsley and red clover. That said, consuming these herbs may be a problem if you’re already on a blood-thinning medication like warfarin, so be sure to talk to your doctor before adding them to your diet. 5. Ginger You’ve probably heard that ginger can help reduce digestive inflammation and aid someone in overcoming mild upset stomach or indigestion, but did you know it can also help thin the blood? That’s because ginger contains salicylate, a type of acid that’s found in a few types of plants. In fact, salicylic acid is the technical name for aspirin, which can help reduce inflammation in the human body and may event assist in preventing a stroke. Ginger is readily available in root, spice or tea forms, so it’s easy to make it a regular part of your diet. Just be sure to check with your doctor to ensure it doesn’t present problems for any medications you may have been prescribed. 6. Avocado Avocado can help prevent blood clots in two ways: first, it contains omega-3 fatty acids, which have been shown to limit the formation of platelets and the development of blood clots. Second, like ginger it contains salicylate, which has also been shown to limit the chances of blood clots from forming. Avocadoes are easy to find at most grocery stores and make an excellent addition to just about any dish, from guacamole to sandwiches and salads. Just be sure to check with your family doctor to ensure it won’t interact negatively with any blood-thinning medications you may have been prescribed. See Our Another Vedeos: 1. Signs and Symptoms of Fibromyalgia,....: https://www.youtube.com/watch?v=dNrjXC3jMfI Subcribe my chanel: https://www.youtube.com/channel/UCYWEoxZsBePnM-qQ3b5Ew9g?sub_confirmation=1
Просмотров: 153 Health Zone +
Preeclampsia | Reproductive system physiology | NCLEX-RN | Khan Academy
Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Nauroz Syed. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/placenta-previa?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/postpartum-physiology?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
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Your blood platelets can cause both blood clots and inflammation.
We know blood platelets form blood clots, but they are also involved in producing inflammation. http://tissuerecovery.com/uncategorized/your-blood-platelets-can-cause-both-blood-clots-and-inflammation/ Didrik J Sopler, Ph.D., L.Ac. https://tissuerecovery.com/ Learn to Eat Program A simple program that explains food. helps you lose weight and become healthy. https://tissuerecovery.com/learn-to-eat/ References: Alexandru N1, Popov D, Georgescu A. Platelet dysfunction in vascular pathologies and how can it be treated. Thromb Res. 2012 Feb;129(2):116-26. doi: 10.1016/j.thromres.2011.09.026. Epub 2011 Oct 27. O'Kennedy N1, Crosbie L, van Lieshout M, Broom JI, Webb DJ, Duttaroy AK. Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: a time-course cannulation study in healthy humans. Am J Clin Nutr. 2006 Sep;84(3):570-9. Palomo I1, Fuentes E, Padró T, Badimon L. Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.). Exp Ther Med. 2012 Apr;3(4):577-584. Epub 2012 Feb 9.
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Acidic pH Causes Cells in Body to Aggressively Clump Together
A recent study found that an acidic pH causes cells in body to aggressively clump together. John Ossipinsky explains how aggressive clumping of cells can create many health problems like diabetes, insomnia, Huntington's disease, Parkinson's and Alzheimer's. Learn how to balance pH to help cells stop clumping.
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10 Health Benefits of Nectarines || nectarine good for diabetes || plum health benefits
Health Benefits Of Nectarines Antioxidant Defense Nectarines have a wonderful antioxidant power with a good amount of polyphenols, vitamin C content and carotenoids such as beta-carotene and cryptoxanthin. The skin of the nectarine fruit has a higher concentration of such components as compared to the pulp so, just wash the fruit properly and eat unpeeled. Treat Obesity Nectarines may prove useful in condition of obesity and its associated complications. Research studies have shown that stone fruits such as nectarines contain bioactive compounds such as anthocyanins, catechin, chlorogenic acid and quercitin derivatives which have the potential to combat obesity related medical conditions like diabetes and cardiac disorders. Improve vision Nectarines contains lutein, an important nutrient which encourages eye health and helps reduce the risk of a disease like age-related macular degeneration. Various investigative researches have shown that lutein is also an extremely powerful antioxidant which helps in reducing the risk of nuclear cataract. Lutein dwells in the macular pigmet of the eye and assists in protecting the retinal tissues from the damage caused by oxidative stress and high-wavelength light. In addition to this, beta-carotene present in the fruit encourages the synthesis of vitamin A and contributes in maintaining healthy eyesight and prevents diseases like blindness and xeropthalmia. Prevent Hypokalemia Nectarines contain potassium, which is essential for proper nerve and cellular function. Potassium present in stone fruits such as nectarine helps in proteins synthesis, functioning of the muscles, maintain electrolyte balance, and optimally utilize carbohydrates and supports metabolic processes. Deficit of potassium in the body may lead to disorders like hypokalemia which may degrade the muscular health and may cause cardiac arrthymia. Improve Cardiac Health Regular consumption of stone fruits such as nectarines may prove beneficial in maintaining cardiovascular health attributing to the presence of heart friendly antioxidants. Chlorogenic acid and anthocyanins present in nectarines exert inhibitory action against the oxidation of LDL cholesterol, prevents hardening of arteries and encourages proper circulation of human platelets. Flavonoids found in nectarines may help in preventing rise in the aggregation of platelets and reduce the risk of developing atherosclerosis. Prevent Cancer As stated above, nectarines contain chlorogenic acid, a natural compound which has multiple health benefits including prevention of various tumors and cancer such as colon cancer. Chlorogenic acid, as suggested by studies, possesses chemopreventive properties which inhibit the proliferation of colon carcinogenesis. Boost Immunity Inclusion of drupes such as nectarines aids in enhancing the immune defense mechanism of the body. Abundance of antioxidants such as vitamin C, zinc and other protective phenolic components in the fruit increase body’s ability to fight various infections by promoting the synthesis of antibodies. Skin Care Bioflavonoids present in the fruit contributes productively in the skin care. Anti-oxidative components such as vitamin C, lutein and beta- carotene found in nectarines take up the credit for such defensive effect. Beta-carotene, which is a precursor of vitamin A, is instrumental in exerting protective action against the skin damage caused by the exposure to UV radiations... Aid Digestion Presence of dietary fiber and alkaline nature of nectarine makes it perfect for maintaining digestive, as well as overall health. Fiber content present in nectarine absorbs water, adds bulk to the diet, regulates the bowel movements and prevents problems like gastritis, constipation and ulcers. Food for Pregnancy Expectant mothers can benefit from the vitamin and mineral treasure present in nectarines, especially the folate content, which helps in reducing the risk of neural tube defects like spina bifida, and also contributes in overall health of the mother and the baby. Abundance of potassium assists in preventing muscle cramps and keeps up the energy levels by building up the proteins. Fiber keeps up the digestive health and vitamin C content contributes in the proper growth and development of the muscles, teeth and blood vessels of the growing baby. So if you’re pregnant, the next time you feel hungry, just grab a nectarine and feel enriched! Cellular Health Nectarines contains phosphorus, an essential mineral which plays an important role in the normal functioning of cells and tissues. Phosphorus in the fruit helps in the formation of strong teeth and bones and assists in the metabolism of carbohydrates and fats. It extends its support in the cellular maintenance and repairs and also assists in renal functioning, muscular contraction, normal heart rate and nerve communication.
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Himalaya Medicine For Piles | Pilex Tablet Full Review in hindi | पाइलेक्स टैबलेट
Himalaya Medicine For Piles | Pilex Tablet Full Review in hindi | पाइलेक्स टैबलेट What is Pilex? Pilex Tablet is used for Hemorrhoids, Bleeding hemorrhoids, Piles, Bleeding piles, Haemorrhoids, Digestive disorders and other conditions. Pilex Tablet may also be used for purposes not listed in this medication guide. Pilex Tablet contains Azadirachta Indica, Bauhinia Variegata, Bauhinia Variegata, Berberis Aristata, Cassia Fistula, Commiphora Wightii, Emblica Officinalis, Mesua Ferrea, Shilajit, Terminalia Bellirica and Terminalia Chebula as active ingredients. Pilex Tablet works by decreasing the hepatic steroid production; scavenging free radicals and initiating the lipid peroxidation; activating through opioid receptors; stimulating the cell-mediated immune mechanisms to elicit an enhanced response to subsequent mitogenic or antigenic challenge; lowering blood sugar level; inhibiting the mucus depletion and mast cell degranulation; stimulating cell-mediated immune reaction; retarding the growth and development of asexual and sexual stages of drug sensitive and resistant strains of the human malarial parasite; inhibiting the oral squamous cell carcinoma induced by 7, 12-dimethylbenz[a]anthracene; inhibiting carcinogenesis in dose dependent manner; inhibiting platelet-activating factor induced aggregation of platelets in dose dependent manner; possessing hepatoprotective action through inhibition of hepatic microsomal enzymes; inhibiting serum and hepatic mitochondrial thiobarbituric acid-reactive substance levels; increasing the expressions of hepatic (necrosis factor) NF-kappaB; inducing NO synthase (iNOS), and cyclooxygenase-2 (COX-2) protein levels; blocking the T- lymphocyte-mediated cytotoxicity; increasing the gastric emptying time; increasing the humoral antibody production; possessing the hypolipidemic, hypoglycemic effects; possessing the strong inhibitory activity on pancreatic lipase; suppression of absorption mediated by gallic acid; suppressing the formation of 1, 1-diphenyl-2-picrylhydrazyl radical and hydroxyl radicals; suppressing the enzymes that are activated in the inflammatory process; retarding the growth of cancer cell lines including human cervical cancer, breast adenocarcinoma and hepatocellular carcinoma; activating the cell-mediated immunity; decreasing the growth rate of tumor cells; inhibiting the cytokines; showing immunomodulatory activity; possessing the haemostatic activity; possessing the activities due to the presence of 4-phenyl coumarin analogues, oleic acid, stearic acid, palmitic acid, beta-sitosterol, bioflavonoids and lupeol triterpenoid constituent; possessing the analgesic activity; decreasing the growth rate of tumor cells; inhibiting the cytokines; showing immunomodulatory activity Pilex Tablet - Precautions & How to Use Before using Pilex Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below. Breastfeeding Diabetes Pregnant, planning to become pregnant or breastfeeding #onlinemedicine,#medicine,#ayurveda,#ayurved ,#Ayurvedic
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Quantifying Platelet Margination in Diabetic Blood Flow
In silico study of near-wall platelet dynamics in diabetic blood flow with an adhered white blood cell (WBC), showing a platelet sliding over a WBC and undergoing a flipping motion. Such WBCs  tend to reduce platelet margination while increasing the probability of platelet-WBC aggregation. See the article by Chang et al. (https://www.cell.com/biophysj/fulltext/S0006-3495(18)31008-7) in the October 2 issue of Biophysical Journal.
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Platelet Disorders
This clip is going to discuss platelet disorders: -ITP -Heparin Induced Thrombocytopenia
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natural diabetes cure
►►http://diabetestreatment.fboks.com◄◄ Natural Treatment For Diabetes!!! natural diabetes cure Fenugreek for diabetes treatment is an ideal natural cure for diabetes , which can be easily implemented into your diet plan. Fenugreek is a plant that is grown in India, Egypt and the Middle East and has been used in Indian medicine since ancient times to cure many diseases natural diabetes cure. The part of the fenugreek plant that has the greatest benefit is in the seeds. These seeds contain an amino acid that is called 4 - hydroxyisoleucine , this amino acid is known that the secretion of insulin from the pancreas stimulating , it is also a reduction of insulin resistance natural diabetes cure, will allow you to have low blood sugar levels will have . Fenugreek contains antioxidant and anti-inflammatory compounds , quercetin, apigenin , genistein, rutin, kaempferol and selenium . Other compounds are alkaloids such gentianine , carpaine and trigonelline natural diabetes cure, which is known to prevent the degeneration of nerve cells. Fenugreek is to plan a perfect complement to your diabetes treatment , it has some very beneficial medicinal properties that include: Fenugreek has diabetic -like ants potentency like cinnamon, it is one of the most beneficial spices that with the control of glucose metabolism , which helps with the prevention and treatment of type 2 diabetes , helps Fenugreek has some great results , where it has the ability cholesterol, lower triglycerides, and LDL cholesterol levels , while increasing able HDL levels shown Fenugreek has a large modulatory effect on blood lipid levels , which can reduce the risk of atherosclerosis significantly . Fenugreek has the ability to reduce platelet aggregation , which may increase the risk of blood clotting, which reduces drastically with strokes and heart attacks The seeds of fenugreek are fiber rich blood sugar levels modulated by delaying the absorption of sugar in the intestine. Fibre is known that the absorption of fat and cholesterol from the intestine to reduce the protection against the risk of heart disease and obesity has natural diabetes cure Fenugreek has shown that the ability of both the metabolic changes that occur in your lens and the ability to reduce the density of cataract have reversed in part, therefore, fenugreek could be effective in diabetics against cataract formation. The reason why diabetics develop cataracts is not right on the enzymes that functions control the glucose uptake into the lens of the eye Fenugreek has the ability to reduce cellular insulin resistance and control the blood glucose homeostasis natural diabetes cure. Fenugreek is shown in recent studies that it has the ability to reduce blood sugar levels in people with type 2 diabetes by 46 percent It is easy to see that fenugreek for diabetes treatment is a remarkable spice that should be included in your diabetic diet . Fenugreek is definitely a positive natural cure for diabetes natural diabetes cure, which should not be more sought than in the management plan for diabetes. Sue Kennedy is the author of the physician -endorsed e- book " Defeat Diabetes Now ," and operates a membership channel devoted to health & wellness. Readers of her book also receive instant access to expert interviews , articles, diet plans and other resources to maintain optimum health and prevent disease . Learn how you can defeat diabetes now natural diabetes cure
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Myocardial Infarction and Angina for USMLE Step 1 and USMLE Step 2
Handwritten Video lecture on Myocardial Infarction/Angina for the USMLE Step 2. Will be covering Pathogensis, Clinical Signs and Symptoms, ECG and Diagnosis as well as Management Coronary Artery Disease occurs when there is an imbalance between oxygen supply of the heart with the oxygen demands of the heart. ETIOLOGY/CAUSES Decreased Oxygen supply - Atherosclerosis, Prinzmetal Angina, Arterial Thrombi, Coronary Emboli, Aortitis, Dissection Increased Oxygen Demand - Hypertrophy, Catecholamines, Tachycardia RISK FACTORS Modifiable - LDL and HDL, Hypertension, Diabetes, Obesity, Smoking Non-Modifiable - Family History, Male, Greater than 64 years old CLINICAL SIGNS AND SYMPTOMS Pain - tightness, squeezing, knot in chest, heavy weight, toothache and jaw ache, lump in the throat. Exacerbated with exertion and recumbency, sleeping. Percipitated by heavy meal, cold, sexual activity. Radiation to epigastric, shoulders down to fingers, lower jaw, subscapular space in the back. Relieved with nitroglycerin, rest. Usually occurs in the early morning due to increase sympathetic acitivity and platelet aggregation Angina Equivalent - dyspnea, nausea, fatigue. Usually seen in elderly and diabetic. PHYSICAL EXAMINATION Tachycardia and hypertensive due to pain. Auscultation may show S3/S4 or paradoxical S2 split. Levine's Sign will show clenched fist on the chest. ECG Findings Subendocardial ischemia shows ST Depression or T wave inversion. Transmural Infarct shows ST Elevation or hyperacute T wave. Pathological Q wave develops along with R wave depression. Usually takes a few hours to develop. After a few days there is a much deeper Q wave and t wave inversion. CARDIAC BIOMARKERS Troponin T and Troponin I are more specific than CKMB. Troponin peaks at 12 hours and last for weeks. CKMB rises in a 2-3 hours and goes down in 2-3 days. STRESS ECG Patient walks on treadmills while being monitored by ECG until reach 85 percent of maximum heart rate. Positive if symptoamtic, ECG changes, drop in blood pressure, ventricular tachycardia. ECHO Shows wall function and may show akinesia or hypokinesia. Used for patients with chronic angina, prior MI, pathologic Q wave and Heart Failure Electron Beam CT Calculate Calcium to calculate aggetson score which is prognostic Coronary Angiography Detects which arteries is occluded. MANAGEMENT First 10 minutes - Check for hemodynamic stability. Ask for recent bleeding neurological condition, and aortic dissection. Use of cocaine or Ergotamine (prinzmetal angina). Determine if RV or LV Infarction. Initial treatment consists of aspirin, clopidogrel, B-blocker, ACE Inhibitor, Statin, and Morphine. Nitroglycerin. Oxygen is only given if saturation is less than 94 percent. CLASSIFICATION STABLE ANGINA - Pain only at rest. Patient should be stress ECG or Echo. If positive than perform angiography. Minimize risk factors by decreasing LDL, increasing HDL, statins, beta-blockers ACUTE CORONARY SYNDROME - Constant Pain UNSTABLE ANGINA - No elevation of cardiac markers and No ST Elevation. Anti-coagulate, B-Blockers, Nitroglycerin. TIMI SCORE - Age greater than 65, Markers, ECG Changes, Risk Factors, Ischemia in 24 hours, CAD, Aspirin in last 7 days. Score of 0-4 is low risk and can be treated medically. 5-7 shoudl undergo cathetrization. NSTEMI - No ST elevation, but positive cardiac biomarkers STEMI These patients require PCI within 90 minutes. Especially if high risk. If symptoms greater than 24 hours, than fibrinolysis is ineffective because clot is too strong. FIBRINOLYSIS - not preffered due to high bleeding risk. Use aleteplate, tenecteplase. Only indicated if PCI is unavailable. If fibrinolysis doesn't work than must do rescue PCI. CORONARY ARTERY BYPASS GRAFT - Done after complicated PCI, Left main Artery involvement or three vessels involved. Severely LV ejection fraction. Or complications such as septal rupture, papillary muscle rupture and aneurysm. NON-ACUTE MANAGEMENT Continue anti-platelets - aspirin, clopidogrel Nitrates - prophylactic Anti-coagulants - risk of emboli Increase ambulation
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If You Eat Melon Fruit Daily Then what Happens to your Body | Melon Health Benefits | Skin Whitening
↪►Video Link= https://youtu.be/1EFpFSECueI If You Eat Melon Fruit Daily Then what Happens to your Body | Melon Health Benefits | Skin Whitening melon health benefits melon for weight loss melon for diabetes melon for skin whitening watermelon benefits ●▬▬▬▬▬▬▬▬▬▬▬ஜ۩۞۩ஜ▬▬▬▬▬▬▬▬▬▬▬● Also, Check More Videos Related Skin Whitening, Long Hair Tips, Extra Hair Remove From All Body & Every Types Of Serums ●▬▬▬▬▬▬▬▬▬▬▬ஜ۩۞۩ஜ▬▬▬▬▬▬▬▬▬▬▬● I am using this tool to viral videos. Best Youtube Keyword Tool. ❤https://www.tagsyoutube.com ▶=Just Boil 2 Ingredients & Drink This Before Bedtime and https://goo.gl/K4g4pg ▶=No exercise No Diet Use these 3 Steps To Reduce 2 Inches https://goo.gl/omw1wz ▶=How to get a Slimmer Face | Remove Double Chin | 8 https://goo.gl/ShM1ch ▶=No-Diet No-Exercise 100% effective | Fat Cutter Drink For https://goo.gl/tdSDgy ▶=YOU WILL NEVER EAT STRAWBERRIES AGAIN AFTER https://goo.gl/vG6YNV ▶=Remove "WRINKLES" Permanently from Face at Home | https://goo.gl/dNQnhP ▶= Home Remedy to Remove Cracked Heels | How To Remove https://goo.gl/zhCnQ1 ▶=Apply This Mask Before Going To Party & See The Magic https://goo.gl/P9qaNj ▶= No-Diet No-Exercise 100% effective | Fat Cutter Drink For https://goo.gl/jJtWNu ▶=She Is 51 Years Old But Looks Like Just 20 Years | Asian https://goo.gl/FvK1eG ↪►► Social Engagment ★ Facebook ➜ https://web.facebook.com/Desihealthtv/ ★ Twitter ➜https://twitter.com/jingling_giggle ★ Google+ ➜ goo.gl/tR9xuc ★ Youtube ➜ goo.gl/QuBkPF Watch our playlists Skin Whitening Home Remedies https://goo.gl/QBMWSQ Weight Loss Tips In Urdu https://goo.gl/m5b5bq Hair Fall Control Tips-How To Get Long Hair Fast https://goo.gl/xEG95h ---- https://goo.gl/nV6wpe Motapa kam karne ka tarika https://goo.gl/m3hdyF Copyrights: All material is copyrighted by the respected publishers. It is published on the internet only for the sake of promoting Urdu throughout the world. A complete detail of respected publishers can be given on request. If you believe that your work has been copied in a way that constitutes copyright infringement. Desi Health TV is not responsible for any content linked to or referred to from these pages. All videos, live TV’s blogs or video links point to content hosted on third party websites or members. We are using third party links for live TV’s and our Featured Video’s. Users who upload these videos or blogs agree not to upload illegal content when creating their user accounts.
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10 Healthy Foods for Weight Loss
Healthy Foods for weight loss Healthy foods are an essential part as adhering to a good diet is critical to great well being. You need healthy food for getting energy, to keep your blood sugar balanced, for weight control and for keeping away from poor health conditions. http://getmaxhealth.com/diet-and-fitness Our FB: https://www.facebook.com/getmaxhealth/ Related items: 1. Absolutely Avocados Hardcover http://amzn.to/2qmP1SK 2. Bragg Organic Raw Apple Cider Vinega http://amzn.to/2qn1Bl3 3. Peter Reinhart's Whole Grain Breads: New Techniques, Extraordinary Flavor Hardcover http://amzn.to/2qmECqf 4. Kirkland Signature Walnuts, 3 Pounds(#1 Best Sellerin Walnuts) http://amzn.to/2oTdFKx When you come up with the idea of eating healthy food, it ends up noticeably difficult to pick the things that would be tasty as well as healthier for your body. You will surely want to have the nutritious food in your diet that keeps you fit. Healthy foods are those that provide nutritious value to your body. Healthy foods are an essential part as adhering to a good diet is critical to great well being. You need healthy food for getting energy, to keep your blood sugar balanced, for weight control and for keeping away from poor health conditions. We will discuss the healthy foods that are essential for weight loss. 1. Eggs. Eggs are among the most nutritious food on this planet. Previously, they are considered a high cholesterol diet, but recent studies shows that are perfectly healthy. Eggs are rich in Vitamin D, Vitamin E, Vitamin K, Vitamin B6, Calcium and Zinc. Eggs are also rich in Lutein and Zeaxanthin that is very effective cell to develop in the retina of the eye. Research says it is among the best food in weight loss. 2. Nuts. Nuts and seeds can help you get thinner, despite the fact that they are high in fat. They provide good sources of fat and protein. Nuts additionally contain various vitamins and minerals, including magnesium and vitamin E. Walnuts are profoundly nutritious and rich in fiber and a wide range of vitamins. Peanuts are very healthy, tasty and high in antioxidants and nutrients. 3. Cruciferous and leafy green Vegetables. Vegetables are among the world's most concentrated source of nutrients. They are low in calories, which make them a good choice for weight loss. You can make the salad of leafy greens like spinach and lettuce in your diet to lose weight quickly. 4. Avocados. An avocado is among the healthiest food diet. It is loaded with healthy fats and is high in monounsaturated oleic acid. Avocados are perfect to use as a salad. Studies show that the fast present in avocados increases the nutrient uptake. They additionally contain numerous essential nutrients, including fiber and potassium. 5. Apple Cider Vinegar. Apple juice vinegar is well known in the health community for weight loss. It is very popular to use in dressings and some people use it by diluting it with water and then drinking it. Studies also show that the apple cider vinegar is useful for weight loss. It increases the feeling of fullness and help in eating less amounts of meal. 6. Fruits. Most health experts agree that fruits are healthier in weight loss. People who eat more fruits tend to be healthier. The fruits that are best in weight loss include watermelon, apple, pomegranate, guava, orange, grapefruit, bananas, and pear. 7. Yogurt. Yogurt is an excellent dairy food that contains probiotic bacteria that improve the functioning of a gut. It also protects against inflammation. Researches show that the full fat dairy yogurt reduces risk of obesity and type II diabetes. 8. Whole Grains. Individuals who eat a lot of whole grains are tending to be leaner and have lower chances of certain heart disease. The whole grains are rich in antioxidants, phytoestrogens and phytosterols that are defensive against coronary disease. The fiber in them has a number of benefits like high fiber that lower heart disease. 9. Beans. Eating beans regularly is useful for your heart, and you don't have to eat it in a large quantity to get the maximum benefits. Beans contain heart-defensive chemicals, including flavonoids that provoke the adhesion of platelets in the blood. By eating them on the regular basis, your risk of heart attack and strokes will be reduces. 10. Fish and Seafood. Fish and seafood are very healthy and nutritious and you can eat them in reducing weight. They are rich in Omega 3 fatty acids and iodine. Studies show that people who eat seafood tend to live longer and have a lower risk of heart diseases and depression. http://getmaxhealth.com/diet-and-fitness Our FB: https://www.facebook.com/getmaxhealth/ Keywords: Weight Loss Programs Weight Loss Tips Diet Belly Fat Healthy Weight Loss Burn Fat Fast
Просмотров: 9139 Get Healthy Everyday
Bilal Siddiqui has a brother who donated his platelets, now he himself is on death bed, do you
Bilal Siddiqui has a brother who donated his platelets, now he himself is on death bed, do you know a kidney specialist ? Can you pass this to them so His brother can be cured ? #english #kidney
Просмотров: 4 Rehan Allahwala
Useful Treatment For Cirrhosis Of The Liver Is Picrorhiza - How TO Use
A review of plants used in the treatment liver disease part 1. Of plants include silybum marianum (milk thistle), picrorhiza kurroa (kutkin), a 1996 report made the case that silymarin may be useful even three days 3 aug 2015 hepatic cirrhosis, especially if complicated by ascites, causes remarkable (in context of this paper, though for reader not familiar with wms another medicinal plant in is royle ex benth (p. 10 jun 2015 benefits of kutki or picrorhiza kurroa steroids that are useful as a strong anti inflammatory agent and also prevent aggregation of the blood platelets. Alba) holds a prominent position in the traditional use for long history of indian ayurvedic medicine treatment it is used all forms liver damage, cirrhosis and inflammation they are useful conditions vitiated kapha pitta, burning sensations, herb considered indigenous to be valuable bitter tonic, picrorhiza choice drug among adults ayurveda. Can cirrhosis of the liver be cured? Youtube. Picrorrhiza kurrora) herb description, medicinal properties. List of various materia medica how to use picrorhiza kurroa uses and benefits it is useful for liver, spleen gallbladder issues. Useful in restoration of liver functions after alcohol toxicity. Home remedies for cirrhosis of the liver authority. For liver cirrhosis, take half a tablespoon of kutki powder and have it every day in the morning evening 17 jan 2016 main reason for cirrhosis is due to long term abuse alcohol, remedies which are easy you apply at an useful herb firstly recommended list home picrorhiza 19 jun 2017. Liver diseases herbal treatment, prevention, symptoms, causes picrorhiza kurroa herb uses, benefits, cures, side effects, nutrients. When mixed with other useful herbs in many formulations, it works wonder to cure hepatitis, keep our liver healthy and working, ayurvedic texts have mentioned the use of kutki is best known herb for treatment cirrhosis 17 jul 2014 weight loss. Ayurvedic liver cirrhosis picrorhiza herb is used for treatment of. Picrorrhiza kurrora) herb description, medicinal properties kutki picrorhiza kurroa benefits, dose, side effects, research. Liver protector ayurveda next door. Picrorhiza kurroa can be useful in treating cirrhosis of the liver, especially when it is picrorhiza helpful following ailments this herb for relieving liver cirrhosispicrorhiza one major constituents ayurvedic treatment various health benefits kutka are described article. It is the best natural treatment for liver cirrhosis and viral hepatitis these things are accomplished using flush tea a morning drink in post operative repair of alcoholic cirrhosis, and, with that mind, i use processed picrorhiza extract like picroliv listed nausea,28 which makes it useful sickness during pregnancy, without medical treatment, can lead to range potentially needs (functional iron), remainder stored later all cells, but mostly keep production this compound stable them 8. Herbs that heal natural remedies for good health google books res
Просмотров: 935 health tips
Blood 5- Platelets
Part 5 in a 9 part lecture on BLOOD in a flipped Human Physiology course taught by Wendy Riggs. CC-BY. Watch the whole lecture (all 9 videos) by going to the PLAYLIST: https://www.youtube.com/playlist?list=PL5GRRRmaGVqWOSyGO1exKHZUJGtZ037Yy
Просмотров: 2390 Wendy Riggs
Disseminated Intravascular Coagulation Diagnosis And Treatment
Disseminated intravascular coagulation, Disseminated intravascular coagulation Diagnosis, Disseminated intravascular coagulation Treatment. https://www.youtube.com/channel/UCESs38trBuiOVSf1lG-LWGw?sub_confirmation=1 In general, there is a balance between coagulation and lysis systems; In the case of disseminated intravascular coagulation, the coagulation mechanism, especially thrombin, is actively and diffuse. This can lead to thrombosis in subacute or chronic form, but more often bleeding occurs when the coagulation factors become depleted. Disseminated intravascular coagulation is characterized by evidence of thrombin and plasma activation. Disseminated intravascular coagulation is classically characterized by the concurrent appearance of generalized vascular coagulation deposition, which jeopardizes adequate blood supply to different organs and thereby contributes to organ failure. Due to the continuous activation of the coagulation system and other factors, such as altered synthesis and increased degradation of coagulation proteins and protease inhibitors, platelet excretion may occur, which may cause major bleeding in several places. In addition, high levels of fibrin degradation products may affect the function of platelets and the crosslinking of fibrin and therefore contribute to the tendency to bleed. Epidemiology The conditions arise in response to another pathology rather than as a major event. There are no predisposition factors in age, sex or race. Risk Factors Conditions that may be complicated by the spread of intravascular coagulation include: • Infections, especially septicemia, typhoid fever, rocky mountain fever and parasites. The release of meningococcal pepticemia is classical. • Malignancy, especially leukemia. • Greater trauma that includes crush syndrome and sometimes burns. • Some connective tissue diseases that include antifosfolipid syndrome. • Transfusion of incompatible blood. • Heat stroke. • Dissection of the aortic aneurysm. • Some snake bites Presentation The immediate apparent properties are usually the underlying conditions that have caused disseminated intravascular coagulation, especially if it is acute. In addition, there may be large bruises or spontaneous bleeding at the venipuncture sites, the soft palate, the legs and the trauma. In subacute or chronic disseminated intravascular coagulation, the functions may be thrombotic rather than signs of venous thrombosis. In the acute situation there are many properties that can be found: • Bleeding from at least three unrelated sites is typical and likely places include: • Ear, nose and throat • Gastrointestinal tract • Airway • Venepuncture or infusion fluid • Confusion or disorientation. • Fever. • Signs of bleeding. • Signs of anxiety disorder in adults (ARDS). • The skin can show several characters that include: • Petechia • Purple • Hemorrhagic noise • Acralcyanosis • Scalp necrosis of the lower leg (fulminating purpura) • Signs of thrombosis • Local infarction and gangways Diagnosis Blood tests can show that the number of platelets in a blood sample has decreased. Platelets are used when blood clots and blood take a long time to coagulate. The diagnosis of disseminated intravascular coagulation is confirmed if the results of the test show abnormally increased amounts of D-Dimer in plasma, a substance that releases thrombocytes when decomposed; More D-Dimer indicates that more blood clots occur than usual and often a low or decreasing level of fibrinogen. A protein consumed by blood clots. Treatment The underlying disease must be identified and corrected, whether it is an obstetric problem, an infection or a cancer. Treatment of coagulation problems when the cause is corrected. Disseminated intravascular coagulation that develops suddenly is life threatening and treated as an emergency. Platelets and coagulation factors are transfected to replace those that are depleted and stop bleeding. Heparin can be used to reduce coagulation in people who have more proliferation, more chronic intravascular coagulation, where coagulation is more of a problem than bleeding.
Просмотров: 174 Wellness Valley
Blood Clot Formation   Coagulation Factors   Platelets
Просмотров: 240 Tarek Hammam
Top Foods To Increase Your Blood Platelets || Papaya Leaves Benefits || GIGA - Aarogya Rahasyam
Top Foods To Increase Your Blood Platelets || Papaya Leaves Benefits || GIGA - Aarogya Rahasyam A low platelet count, medically known as thrombocytopenia, is a health disorder in which your blood has a lower than normal number of platelets. Platelets are the smallest of the blood cells that aid in blood clotting by forming plugs in blood vessel holes. The platelets circulate in the blood with an average lifespan of 5 to 9 days. A normal platelet count in a healthy person ranges from 150,000 to 450,000 platelets per microlitre of blood. When the count is below 150,000 per microlitre, it is considered a low platelet count. Both the papaya fruit and its leaves can help increase a low platelet count within just a few days. In 2009, researchers at the Asian Institute of Science and Technology in Malaysia found that papaya leaf juice can increase the platelet count of people diagnosed with dengue fever. Eat ripe papaya or drink a glass of papaya juice with a little lemon juice 2 or 3 times daily. You can also pound a few papaya leaves without the stalk using a pestle and mortar to extract the juice. Drink 2 tablespoons of this bitter juice 2 times a day. For More Latest Updates Please Do Subscribe My Channel GIGA - Aarogya Rahasyam : http://bit.ly/2h5A3lh ================================= Thank you for watching Our videos For more –like-comment-share & subscribe ================================= DISCLAIMER: The information provided on this channel and its videos is for general purposes only and should not be considered as professional advice. We are trying to provide a perfect, valid, specific, detailed information .we are not a licensed professional so make sure with your professional consultant in case you need. All the content published in our channel is our own work. ============================
Просмотров: 69 Telugu 24x7
Personalized Platelets in Blood Clotting
Просмотров: 577 U of U Health
Cirrhosis of the Liver Nursing Care Management Symptoms NCLEX
Cirrhosis of the liver nursing NCLEX review over the symptoms, nursing care/management, pathophysiology, complications, and treatments. Cirrhosis is a liver disease where liver cells become extremely damaged due to long-term/severe damage. This damage can be from a viral infection (Hepatitis B or C), heavy alcohol consumption, obesity, hyperlipidemia, bile duct problem, autoimmune etc. These damaged liver cells are replaced with fibrous tissue, and this leads to scarring of the liver. The role of the liver is to filter the blood and perform the following functions to it: metabolizing, detoxifying, storing, producing etc. When liver cells are damaged these processes do not happen. Complications of cirrhosis include: portal hypertension, splenomegaly, ascites, jaundice, hepatic encephalopathy, esophageal varices etc. All of these conditions are discussed in depth in the video. During the early stages of cirrhosis the patient may be asymptomatic, however, in the late stages the patient will have signs and symptoms that include: asterixis, fetor hepaticus, jaundice, reduced platelets and white blood cells, spider angiomas, ascites, gynecomastia, increase ammonia level etc. Nursing interventions for cirrhosis include monitoring for bleeding, abnormal glucose levels, implementing a proper diet: if patient has confusion (hepatic encephalopathy) they need a low protein diet, however, if patient isn't confused they need a high lean protein diet, low sodium, fluid restriction, assessing for rupture of varices, administering lactulose etc. Treatment for cirrhosis includes a liver transplant and medications such as diuretics, blood products, vitamin K, beta blocker or nitrates. In addition to a paracentesis. which helps remove fluid from the abdomen, if ascites is present. Quiz on Cirrhosis: http://www.registerednursern.com/cirrhosis-nclex-questions/ Notes: http://www.registerednursern.com/cirrhosis-nclex-review/ More GI reviews: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVVQ5TeRY7Vy1Tq3pcGTDFO Instagram: https://www.instagram.com/registerednursern_com/ Facebook: https://www.facebook.com/RegisteredNurseRNs Subscribe: http://www.youtube.com/subscription_center?add_user=registerednursern Nursing School Supplies: http://www.registerednursern.com/the-ultimate-list-of-nursing-medical-supplies-and-items-a-new-nurse-student-nurse-needs-to-buy/ Visit our website RegisteredNurseRN.com for free quizzes, nursing care plans, salary information, job search, and much more: http://www.registerednursern.com Check out other Videos: https://www.youtube.com/user/RegisteredNurseRN/videos All of our videos in a playlist: https://www.youtube.com/watch?v=pAhHxt663pU&list=PLQrdx7rRsKfXMveRcN4df0bad3ugEaQnk Popular Playlists: NCLEX Reviews: https://www.youtube.com/playlist?list=PLQrdx7rRsKfWtwCDmLHyX2UeHofCIcgo0 Fluid & Electrolytes: https://www.youtube.com/playlist?list=PLQrdx7rRsKfWJSZ9pL8L3Q1dzdlxUzeKv Nursing Skills: https://www.youtube.com/playlist?list=PLQrdx7rRsKfUhd_qQYEbp0Eab3uUKhgKb Nursing School Study Tips: https://www.youtube.com/playlist?list=PLQrdx7rRsKfWBO40qeDmmaMwMHJEWc9Ms Nursing School Tips & Questions" https://www.youtube.com/playlist?list=PLQrdx7rRsKfVQok-t1X5ZMGgQr3IMBY9M Teaching Tutorials: https://www.youtube.com/playlist?list=PLQrdx7rRsKfUkW_DpJekN_Y0lFkVNFyVF Types of Nursing Specialties: https://www.youtube.com/playlist?list=PLQrdx7rRsKfW8dRD72gUFa5W7XdfoxArp Healthcare Salary Information: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVN0vmEP59Tx2bIaB_3Qhdh New Nurse Tips: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVTqH6LIoAD2zROuzX9GXZy Nursing Career Help: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVXjptWyvj2sx1k1587B_pj EKG Teaching Tutorials: https://www.youtube.com/playlist?list=PLQrdx7rRsKfU-A9UTclI0tOYrNJ1N5SNt Dosage & Calculations for Nurses: https://www.youtube.com/playlist?list=PLQrdx7rRsKfUYdl0TZQ0Tc2-hLlXlHNXq Diabetes Health Managment: https://www.youtube.com/playlist?list=PLQrdx7rRsKfXtEx17D7zC1efmWIX-iIs9
Просмотров: 201875 RegisteredNurseRN
Top Developments in Antiplatelet Therapy: In Acute Coronary Syndrome (H&S Clinical Update P1a)
Heart and Stroke Clinical Update 2015 www.heartandstroke.ca/clinicalupdate Plenary Address 1a Top Developments in Antiplatelet Therapy: Dual Oral Antiplatelet Therapy In Canadian Acute Coronary Syndrome Patients In 2015: Twice As Nice Or Double The Trouble? Presented by: Shaun Goodman, MD, MSc, FRCPC, FACC, FAHA, FESC (see below) Hilton Toronto, December 2015 Learning Objectives 1.To review the pathophysiology of acute coronary syndromes (ACS), and the pharmacokinetics and mechanism of action of acetylsalicylic acid (ASA; Aspirin™) and the adenosine disphophate receptor inhibitors (ADPris); 2. To describe the recent use of ASA and the ADPris clopiodgrel, prasugrel, and ticagrelor in ACS in Canadian hospitals; and, 3. To review and discuss the clinical trials supporting the Focused Update of the Canadian Cardiovascular Society Antiplatelet Guideline recommendations regarding the role of dual oral antiplatelet therapy in the management of ACS patients. Session Description The pathophysiology underlying most acute coronary syndromes (ACS) includes coronary artery atherosclerotic plaque rupture, ulceration, and/or erosion. This triggers platelet activation, adhesion, and aggregation with simultaneous initiation of the coagulation (clotting) cascade that occurs on the surface of activated platelets. Thus, antiplatelet therapy is pivotal to the management of patients with ACS. Based on randomized clinical trial data, current evidence-based clinical practice guidelines (including the Canadian Cardiovascular Society Antiplatelet Guideline ) recommend dual oral antiplatelet therapy with acetylsalicylic acid and an adenosine diphosphate (ADP) receptor inhibitor (ADPri; clopidogrel, prasugrel, or ticagrelor). Two recent Canadian observational studies suggest that the most commonly employed dual oral antiplatelet therapy regimen in ACS patients is ASA and clopidogrel . However, the newer ADPris prasugrel and ticagrelor have demonstrated consistent benefits over clopidogrel in clinical trials; accordingly, there have been temporal increases in ADPri use acutely and at discharge compared to previous national experience. Balancing of the benefits (e.g., myocardial infarction [MI] and stent thrombosis reduction with prasugrel and ticagrelor, mortality reduction with ticagrelor) and risks (e.g., increased risk of non-coronary artery bypass surgery [CABG]-related bleeding with prasugrel and ticagrelor) offers the potential to further improve upon the outcomes of Canadian ACS patients. Shaun Goodman, MD, MSc, FRCPC, FACC, FAHA, FESC Associate Head, Division of Cardiology, St. Michael's Hospital Professor and Heart & Stroke Foundation of Ontario Polo Chair, Department of Medicine, University of Toronto Consultant, Canadian Heart Research Centre Adjunct Professor, Department of Medicine, University of Alberta Co-Director, Canadian VIGOUR Centre The following information was provided by speakers at the Clinical Update 2015. The information is intended for use by healthcare professionals for reference and education only and is not intended to be a substitute for a physician's advice, diagnosis or treatment. You should consult your physician for personal health matters.
Просмотров: 1947 Heart & Stroke
Making Heart Attacks History: Caldwell Esselstyn at TEDxCambridge 2011
Dr. Caldwell Esselstyn argues that heart attacks, the leading cause of death for men and women worldwide, are a "food borne illness" and explains why diet is the most powerful medicine. Be sure to check out 11:39. Veggie freestyle! Learn more about TEDxCambridge at http://www.tedxcambridge.com.
Просмотров: 288114 TEDx Talks
Pathophysiological role of platelets in acute experimental pancreatitis: influence of endothelin A
From the Springer article: Pathophysiological role of platelets in acute experimental pancreatitis: influence of endothelin A receptor blockade http://www.springerlink.com/openurl.asp?id=doi:10.1007%2fs00441-006-0319-9 by: Uhlmann, Dirk; Lauer, Heike; Serr, Frederik; Ludwig, Stefan; Tannapfel, Andrea; Fiedler, Martin; Hauss, Johann; Witzigmann, Helmut; (WMV 5250.4 KB) Journal: Cell and Tissue Research Vol. 327 Issue 3 DOI: 10.1007/s00441-006-0319-9 Published: 2007-02-07
Просмотров: 250 SpringerVideos
Platelet Physiology and Pharmacology
This video provides an overview of Platelet Adhesion, Activation, and Aggregation, a discussion of specific molecular pathways involved in platelet activation, and a discussion of pharmacological agents that target these platelet pathways. Here are timestamps for each of the video's sub-sections: Overview of Platelet Physiology: 0:31 Molecular Pathways of Platelet Activation: 5:52 Platelet Pharmacology: 11:50 As always, a big shoutout to Peter Hsieh for providing the drawings and recording the video! If you enjoyed this video, feel free to like the video and subscribe to my channel. If there are other topics you want me to cover, let me know in the comments!
Просмотров: 189 Billal Ahmed
Quercetin & Vitamin C Taken Together Become More Effective Against Heart Disease, Cancer & Diabetes
Although quercetin is not one of the network antioxidants, it does interact with the network by regenerating vitamin C after it neutralizes a free radical, and help restore its antioxidant properties. From reducing inflammation to alleviating allergies to protecting the heart and brain, quercetin seems designed to selectively target disease and dysfunction – without dangerous side effects. By taking quercetin and vitamin C you may discover many beneficial effects. Quercetin is a powerful antioxidant, capable of scavenging harmful free radicals – such as reactive oxygen species – that can cause oxidative stress and trigger a wide variety of degenerative disease. Quercetin is a powerful anti-inflammatory agent, as inflammation has been shown to be at the root of many diseases, including cancer, this makes quercetin a powerful tool in nature’s disease-fighting arsenal. Quercetin has a time-honored place in herbal medicine, especially when it comes to allergy relief. Research has shown that quercetin inhibits the release of histamine from mast cells, thereby reducing allergy symptoms such as watery eyes, itching and hives. Quercetin not only reduces histamine levels, but also decreases the number of leukocytes in the lungs and bloodstream, relaxes smooth muscles in airway passages and restores elasticity of lung tissue. This group of benefits means it has possible applications for treating COPD and asthma. Quercetin helps it provide natural protection against heart disease. It protects cells that line the fragile walls of blood vessels, and also protects the extracellular collagen matrix from oxidation. In addition, it lowers levels of LDL cholesterol – while raising beneficial HDL. Quercetin also reduces the risk of heart attack and stroke by decreasing the “stickiness” of blood platelets. Furthermore, it stimulates production of beneficial nitric oxide, which dilates and relaxes blood vessels to enhance circulation. Quercetin not only helps prevent cancer by protecting cells from oxidative stress, inflammation and damage to DNA, but has been found to suppress the growth and spread of many different types of cancer cell lines, including cancers of the breast, lung, prostate, liver and esophagus. In a 2010 study, researchers found that a quercetin-rich diet could reduce the incidence of lung cancer in smokers by a stunning 65 percent. Quercetin mounts an all-out offensive on diabetes by improving insulin response, controlling blood sugar, reducing inflammatory markers, increasing the number of islets in the pancreas, and improving pancreatic and liver function. It also inhibits an enzyme, which contributes to diabetes complications such as peripheral neuropathy and cataracts. Quercetin enhances the activity of other antioxidant enzymes produced in the body. In particular, glutamate cysteine ligase, which is needed for the PRODUCTION OF GLUTATHIONE – the body’s ‘master antioxidant.’ Finally, quercetin can even help maintain the structure of bones. Research has shown that it can help prevent, and even reverse, bone loss and osteoporosis, while improving the micro-architecture of bone tissue. The richest sources of quercetin are found in plants of the allium family, including onions, scallions, chives, leeks, shallots and garlic. Onions are the richest source, which explains their use in folk medicine as a treatment for allergies and asthma. Quercetin is also found in many fruits, including citrus fruits, apples, cherries, grapes, tomatoes and berries. Vegetable sources include spinach, celery, potatoes, lettuce, broccoli, parsley, kale, red cabbage and green beans. Other sources include olive oil, tea, red wine, capers, lovage, sorrel and cocoa. Many herbs also contain quercetin, such as St. John’s wort, gingko biloba, hops, valerian, passionflower, and chamomile. To enhance the absorption of quercetin, natural health experts recommend taking it along with vitamin C. Before taking quercetin and vitamin C, discuss the matter with your healthcare provider, who can help you to decide what’s best for you, especially if dealing with a serious health issue. Furthermore, pectin, healthy fats, resveratrol, curcumin found inside turmeric and EGCG, from green tea can also promote quercetin absorption. Every day, research seems to reveal more of quercetin’s extraordinary range of benefits, confirming this versatile polyphenol’s position as an emerging superstar in the field of natural therapies. Sources: http://www.umm.edu/health/medical/altmed/supplement/quercetin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011167/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661670/ http://www.quercetin.com/overview/food-chart Thank you for watching! 💕 Good Day and Good Health The Refreshing Point Quercetin & Vitamin C Taken Together Become More Effective Against Heart Disease, Cancer & Diabetes
Просмотров: 5158 The Refreshing Point
Stroke Prevention and Care at St. Francis Health
St. Francis Health maintains an intense focus on providing high-quality, safe care to those experiencing strokes. St. Francis Health is also increasing its efforts to prevent secondary strokes through the aggressive use of medications, such as statins and anti-platelets, as indicated in the secondary stroke prevention guidelines. Other methods include the treatment of atrial fibrillation and atherosclerosis and management of smoking cessation, weight, exercise, diabetes and cholesterol.
Просмотров: 41 UKHS St. Francis Campus
Understanding the intricacies of platelet activation and inhibition
Professor Patrono discusses some of his current research at the 2015 Scientific Conference of the International Aspirin Foundation. In the interview he talks about the role of platelet activation and inhibition in diabetes mellitus and myeloproliferative neoplasms, as well as his work investigating how low-dose aspirin works to prevent colorectal cancer.
Просмотров: 114 ecancer
blood vessel, RBC and platelets
Просмотров: 135 Young Lae Moon
Immunity 10, Specific antibodies
Просмотров: 10415 Dr. John Campbell
Biomechanics of Blood Clotting
Platelets are cells in the blood whose job is to stop bleeding by sticking together to form clots and plug up a wound. Now, for the first time, scientists have measured and mapped the key molecular forces on platelets that trigger this process. The extensive results, by Emory University chemist Khalid Salaita and colleagues, are reported in two separate studies, in the Proceedings of the National Academy of Sciences and in Nature Methods: https://www.nature.com/articles/nmeth.4536 Read more about the discovery here: http://esciencecommons.blogspot.com/2017/12/new-methods-reveal-biomechanics-of.html
Просмотров: 499 Emory University
Ukon Turmeric( ORGANIC curcumin) with amazing Health  Benefits
Ukon Turmeric( ORGANIC curcumin) with amazing Health Benefits Turmeric Benefits 1. Anti-inflammatory Properties: Curcumin is an incredible anti-inflammatory agent; it influences the body’s inflammatory response by various mechanisms. One of the most powerful benefits of curcumin is its ability to inhibit the activity of NF-κB, this is a molecule that turns on multiple genes which trigger inflammation in the body. It also decreases the production of various cytokines or signaling molecules, such as TNFα, that induce an inflammatory response in the body. 2. Antioxidant Activity: When molecules interact with oxygen they can form free radicals, which are highly reactive molecules that are extremely damaging when they interact with cellular components such as DNA or the cell membrane. Curcumin is a potent antioxidant, meaning its chemical structure gives it the ability to neutralize these free radicals and ultimately reduce oxidative damage. It can also inhibit expression of iNOS, an enzyme involved with cellular damage and toxicity when there are too many free radicals in the body. 3. Orthopaedic Disorders: Curcumin’s anti-inflammatory properties reduce swelling, inflammation and pain in various joints. It has been shown to be effective for long-term treatment of osteoarthritis. It can also alleviate pain and swelling associated with rheumatoid arthritis. A clinical trial showed that curcumin was as effective as a well-known non-steroidal anti-infammatory drug (NSAID) called diclofenac in treating rheumatoid arthritis. 4. Gastrointestinal disorders: Inflammatory bowel diseases (IBD) including ulcerative colitis and Chron’s disease are normally treated with anti-inflammatory medications and immunosuppressive agents. It is a potential treatment for several gastrointestinal cancers. Infection of cells lining the GI tract by a bacterial population called H.pylori can play a key role in the initiation and progression of several gastric cancers. Curcumin has been shown to reduce the activity of H.pylori infection of epithelial cells lining the GI tract, which essentially reduces the risk of these gastric cancers. 5. Anti-carcinogenic Agent: There are three stages of carcinogenesis: initiation, promotion and progression. Curcumin has been shown to inhibit various mechanisms at all three stages of carcinogenic development! It inhibits initiation by its antioxidant and anti-inflammatory properties. Promotion is impacted by curcumin because of its ability to suppress survival and growth of cancerous cells, and induce apoptosis or programed cell-death. Curcumin inhibits cancer progression by reducing the ability for cancer cells to invade surrounding tissues and promote angiogenesis or the creation of new blood vessels. The promotion of angiogenesis would normally allow cancerous cells to spread even more! Curcumin can inhibit these mechanisms by preventing the activity of class of enzymes called MMPs; these enzymes would normally break down proteins surrounding cancer cells and provide them with extra space to proliferate and spread. Several studies have proven cucurmin to be an effective treatment for various stages of colon cancer, pancreatic cancer and many more. 6. Diabetes Management: Dietary curcumin has been shown to reduce hyperglycemia or high blood sugar and improve insulin sensitivity in type 2 diabetic rats. 7. Neurological Disorders: Various neurological disorders including Parkinson’s and Alzheimer’s disease are characterized by the formation of aggregates or clusters of protein deposits in the brain tissue. These aggregates have been shown to contribute to disease onset and progression. Curcumin has been shown to actually inhibit this protein aggregation process from happening meaning that it has neuroprotective effects! Its anti-inflammatory capabilities allow curcumin to reduce expression of inflammatory cytokines in neuronal cells, which basically protect these neurons from being damaged. It has also been shown to improve spatial memory and increase expression of genes involved with neural development in aged animal models, meaning it can improve the function of neural pathways! 8. Cardiovascular Health: Curcumin has been shown to have strong cardioprotective effects such as improved vascular endothelial function. A recent study showed that rats fed curcumin had about half the blood cholesterol as rats without curcumin. Curcumin has also been proven to be as effective at reducing cholesterol as atorvastatin or lipitor, a very well-known pharmaceutical cholesterol reducing agent. Again, curcumin can achieve the same result as atorvastin without the side effects of the drug, such as diarrhea and upset stomach! Another way in which curcumin has cardioprotective effects is that it inhibits aggregation of platelets, which basically reduces the potential for plaque formation or clots in blood vessels.
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4 Steps to Help Heal Erectile Dysfunction
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