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A new study from Vanderbilt University School of Medicine found that sildenafil (brand name Viagra) may improve insulin sensitivity and reduce a biomarker that signals an increased risk of heart and kidney disease in prediabetes patients. In prediabetes, blood sugar levels are higher than normal but not high enough to be classified as type 2 diabetes.
"We need additional strategies to help slow the progression from prediabetes to diabetes," said study author Nancy J. Brown, MD, a professor of medicine at Vanderbilt, in a press release. "Weight loss and exercise regimens can be difficult to maintain, and some current medications have been limited by concerns about adverse effects. Sildenafil and related drugs could offer a potential avenue for addressing the rising number of diabetes diagnoses."
Type 2 diabetes is a chronic condition that affects the way the body metabolizes sugar. In this condition, the body either resists the effects of insulin (a hormone that regulates the movement of sugar into the cells) or doesn't produce enough insulin to maintain normal blood sugar levels. Insulin resistance precedes type 2 diabetes.
According to the Endocrine Society, more than 29 million Americans have diabetes. And for every 1,000 US adults, 300 have prediabetes. Without intervention, it is estimated that between 15 and 30 percent of people with prediabetes will develop type 2 diabetes within five years.
For this study, Dr. Brown and team looked at 51 overweight patients with prediabetes. These patients were randomly assigned to treatment with sildenafil or a placebo for three months.
Tests were then performed to assess insulin sensitivity. Urine samples were also collected to measure albumin and creatinine (markers of heart and kidney health) concentrations.
Among the patients on sildenafil, Dr. Brown and team found higher levels of insulin sensitivity and lower levels of albumin compared to patients on placebo. Raised levels of albumin in the urine suggest an increased risk of heart and kidney disease.
This study was published online Nov. 18 in the Journal of Clinical Endocrinology & Metabolism.
IMPORTANT SAFETY INFORMATION
Do not take V.I.A.G.R.A (sildenafil citrate) if you:
take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas (riociguat) for pulmonary hypertension. Your blood pressure could drop to an unsafe level
are allergic to sildenafil, as contained in VIAGRA and REVATIO, or any of the ingredients in VIAGRA
Discuss your health with your doctor to ensure that you are healthy enough for sex. If you experience chest pain, dizziness, or
nausea during sex, seek immediate medical help
Before you take V.I.A.G.R.A, tell your healthcare provider if you:
have or have had heart problems such as a heart attack,
irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
have had heart surgery within the last 6 months
have pulmonary hypertension
have had a stroke
have low blood pressure, or high blood pressure that
is not controlled
have a deformed penis shape
have had an erection that lasted for more than 4 hours
have problems with your blood cells such as sickle cell
anemia, multiple myeloma, or leukemia
have retinitis pigmentosa, a rare genetic (runs in families)
have ever had severe vision loss, including an eye problem
have bleeding problems
have or have had stomach ulcers
have liver problems
have kidney problems or are having kidney dialysis
have any other medical conditions
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins,
and herbal supplements.
VIAGRA may affect the way other medicines work, and other medicines may affect the way VIAGRA works, causing side effects.
Especially tell your healthcare provider if you take any of the following:
medicines called nitrates
medicines called guanylate cyclase stimulators such as Adempas (riociguat)
medicines called alpha-blockers such as Hytrin (terazosin
HCl), Flomax (tamsulosin HCl), Cardura (doxazosin
mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl),
Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin).
Alpha-blockers are sometimes prescribed for prostate
problems or high blood pressure. In some patients, the use
of VIAGRA with alpha-blockers can lead to a drop in blood pressure or to fainting